The Use of Integra® Dermal Regeneration Template for the Orbital Exenteration Socket: A Novel Technique.


PURPOSE:Integra® dermal regeneration template is a bilayer membrane system that acts as a scaffold for regenerating dermal skin cells. It is used for wound reconstruction following burns, extensive injuries, and a large tumor excision in multiple parts of the body. The dermal layer is made of porous matrix of bovine tendon collagen and glycosaminoglycan. The epidermal layer is made of polysiloxane layer. In this study, the authors evaluated the use of Integra® dermal regeneration template for the immediate reconstruction of the orbital exenteration socket. METHODS:Five patients who underwent exenteration and immediate reconstruction of the socket with Integra® dermal regeneration template were included in this study. Demographic and clinical features, healing time, complications, and follow-up time were recorded. RESULTS:The study included 4 male patients and 1 female patient with a mean age of 74 years (range, 49-87 years). The primary diagnoses were orbital extension of conjunctival melanoma in 2 patients, squamous cell carcinoma in 1 patient, and uveal melanoma in 1 patient, and aggressive orbital Wegener granulomatosis in 1 patient. There was no postoperative infection, necrosis, hematoma, or fluid accumulation in any patients. The mean postoperative follow-up period was 20 months (range, 11-42 months). The sockets were completely granulated by 4 weeks, and epithelized, getting ready for the prosthesis in 8 weeks. CONCLUSIONS:Integra® dermal regeneration template can be used for the immediate reconstruction of the socket following exenteration. It is easy to use, and provides a short healing time without any need for any additional reconstructive procedures.


Ozgonul C,Diniz Grisolia AB,Demirci H




Has Abstract


2018-01-01 00:00:00












  • CyberKnife radiosurgery and rituximab in the successful management of sclerosing idiopathic orbital inflammatory disease.

    abstract::A 26-year-old man presented with symptoms suggesting idiopathic orbital inflammatory disease. After a poor initial response to oral steroids, an orbital biopsy confirmed the diagnosis. A paucicellular lymphocytic infiltrate with areas of fibrosis was seen to replace normal tissue. With the development of exposure kera...

    journal_title:Ophthalmic plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: On AV,Hirschbein MJ,Williams HJ,Karesh JW

    更新日期:2006-09-01 00:00:00

  • Orbital Nasal-Type Extranodal Natural Killer/T-Cell Lymphoma: An Ongoing Diagnostic Challenge Further Confounded by Small-Cell Predominance.

    abstract:PURPOSE:To highlight the histopathologic diagnostic challenges of small-cell predominant extranodal nasal-type natural killer/T-cell lymphoma (ENTNKT) of the orbit. METHODS:Retrospective chart review and histopathologic study with immunohistochemistry and in situ hybridization of 3 cases. RESULTS:Three cases of ENTNK...

    journal_title:Ophthalmic plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Wolkow N,Jakobiec FA,Habib LA,Freitag SK

    更新日期:2019-09-01 00:00:00

  • Basal Cell Carcinoma and Eccrine Porocarcinoma of the Eyelid.

    abstract::An 81-year-old woman presented with a progressively enlarging indurated, firm lesion encompassing one-third of the left upper eyelid. Four years prior, a similar lesion at that same site had been excised and diagnosed as a basal cell carcinoma. The patient underwent a full-thickness excision of the lesion with frozen ...

    journal_title:Ophthalmic plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Shoji MK,Tran AQ,Lazzarini TA,Choi CJ,Tse BC

    更新日期:2020-06-17 00:00:00

  • Cicatricial entropion following docetaxel (Taxotere) therapy.

    abstract::We report eyelid margin changes in 3 patients after docetaxel treatment for breast cancer. These patients were referred to Cincinnati Eye Institute for eyelash abnormalities and/or epiphora and all had been treated with docetaxel in the near past. The ophthalmic complaints started soon after chemotherapy. All 3 cases ...

    journal_title:Ophthalmic plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Cetinkaya A,Hudak D,Kulwin D

    更新日期:2011-09-01 00:00:00

  • The staged management of ophthalmic complications of facial nerve palsy.

    abstract::A six-stage approach to the management of the ophthalmic complications of facial palsy was developed to aid the physician in logically organizing therapy and to provide patients with reassuring goals. This stepwise approach was applied prospectively in 120 consecutive facial palsy patients from 1986 to 1990. The six s...

    journal_title:Ophthalmic plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Seiff SR,Chang JS Jr

    更新日期:1993-12-01 00:00:00

  • Rethinking the Role of Nitroglycerin Ointment in Ischemic Vascular Filler Complications: An Animal Model With ICG Imaging.

    abstract:PURPOSE:Soft tissue dermal fillers, both temporary and permanent, are used frequently in facial rejuvenation. As the use of fillers increases, ischemic complications including skin necrosis are becoming more prevalent. In the literature, topical nitroglycerin paste has been recommended in the early treatment of patient...

    journal_title:Ophthalmic plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Hwang CJ,Morgan PV,Pimentel A,Sayre JW,Goldberg RA,Duckwiler G

    更新日期:2016-03-01 00:00:00

  • Psychogenic unilateral pseudoptosis.

    abstract::Conversion disorders are among common psychological problems. Pseudoptosis is an uncommon presentation of this category of disorders. Herein, the authors report 2 cases of psychogenic pseudoptosis. The first case is a 21-year-old man who presented with sudden onset of ptosis in his OS 2 weeks previous. The patient rep...

    journal_title:Ophthalmic plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Bagheri A,Abbasnia E,Pakravan M,Roshani M,Tavakoli M

    更新日期:2015-05-01 00:00:00

  • Sarcoid-like granulomatous orbital inflammation induced by interferon-alpha treatment.

    abstract::A 56-year-old black woman presented with bilateral orbital swelling in the lacrimal gland region 4 months after initiation of interferon-alpha and ribavirin treatment for occupationally-acquired hepatitis C infection. Histopathologic evaluation of bilateral lacrimal gland biopsy specimens revealed granulomatous inflam...

    journal_title:Ophthalmic plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Hwang CJ,Gausas RE

    更新日期:2008-07-01 00:00:00

  • Causes of involutional ectropion and entropion--age-related tarsal changes are the key.

    abstract:PURPOSE:To measure tarsal plates across various age-groups, to determine whether tarsal size changes with increasing age and whether size correlates with involutional ectropion and entropion. METHODS:Comparative, observational, case-control study design. Data were obtained for length and height of tarsus in each of th...

    journal_title:Ophthalmic plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Bashour M,Harvey J

    更新日期:2000-03-01 00:00:00

  • Ophthalmic considerations in the management of Tessier cleft 5/9.

    abstract:PURPOSE:To describe a patient with Tessier cleft number 5 and 9 and review the literature on the ocular impairment and management of this extremely rare anomaly. METHODS:Interventional case report and literature review. RESULTS:The literature review showed that the present patient is the second case with clefts 5/9. ...

    journal_title:Ophthalmic plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Pereira FJ,Milbratz GH,Cruz AA,Vasconcelos JJ

    更新日期:2010-11-01 00:00:00

  • Primary intraosseous hemangioma of the orbit. Report of a case and review of literature.

    abstract::Orbital intraosseous hemangiomas are rare entities, with only 15 previously reported. We review these and present our own. They are benign, vascular tumors, typically found in the frontal, ethmoid, or zygomatic bones. They tend to present in the 4th or 5th decades as a mildly painful orbital rim mass. Ocular findings ...

    journal_title:Ophthalmic plastic and reconstructive surgery

    pub_type: 杂志文章,评审


    authors: Zucker JJ,Levine MR,Chu A

    更新日期:1989-01-01 00:00:00

  • Open sky Müller muscle-conjunctival resection in phenylephrine test-negative blepharoptosis patients.

    abstract:PURPOSE:To assess the efficacy of Müller muscle-conjunctival resection in patients in whom the phenylephrine test was negative. METHODS:A non-randomized, prospective clinical trial was conducted on 20 eyelids of 15 consecutive patients with blepharoptosis who showed no change in the upper eyelid margin-reflex distance...

    journal_title:Ophthalmic plastic and reconstructive surgery

    pub_type: 临床试验,杂志文章


    authors: Baldwin HC,Bhagey J,Khooshabeh R

    更新日期:2005-07-01 00:00:00

  • Malignant peripheral nerve sheath tumor of the orbit: malignant transformation from neurofibroma without neurofibromatosis.

    abstract::A 52-year-old woman suffered from progressive proptosis and vision loss due to a large tumor in her right orbit. Multiple recurrences of the tumor were treated with surgical excision. The pathologic diagnosis in each recurrence was neurofibroma, and the tumor transformed to malignant peripheral nerve sheath tumor in t...

    journal_title:Ophthalmic plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Cheng SF,Chen YI,Chang CY,Peng Y,Liao SL

    更新日期:2008-09-01 00:00:00

  • Sebaceous carcinoma of the eyelid: pitfalls in diagnosis.

    abstract::Sebaceous carcinoma of the eyelid and adnexa commonly simulates other entities both clinically and pathologically. Between 1905 and 1981, 43 patients with sebaceous carcinoma of the eyelid were seen at the Mayo Clinic. Prior to establishing the diagnosis of sebaceous carcinoma, patients commonly carried multiple clini...

    journal_title:Ophthalmic plastic and reconstructive surgery

    pub_type: 杂志文章,评审


    authors: Yeatts RP,Waller RR

    更新日期:1985-01-01 00:00:00

  • Characterization of adrenergic receptors in the accessory lacrimal glands of the upper eyelid.

    abstract:PURPOSE:To identify the histologic location as well as the exact subtype of adrenergic receptors in the accessory lacrimal glands of the upper eyelid. METHODS:Upper eyelid specimens were collected from 19 patients undergoing routine blepharoptosis correction via a posterior tarsoconjunctival mullerectomy. Immunohistoc...

    journal_title:Ophthalmic plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Esmaeli-Gutstein B,Hewlett BR,Harvey JT

    更新日期:1999-07-01 00:00:00

  • Diagnosis and management of allergic fungal sinusitis with orbital involvement.

    abstract:PURPOSE:Allergic fungal sinusitis (AFS) is a noninvasive disease characterized by recurrent sinusitis. This condition is commonly treated with surgical debridement and several months of systemic corticosteroids. The treatment of AFS is examined in this study. METHODS:A retrospective case series of three patients with ...

    journal_title:Ophthalmic plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Chang WJ,Tse DT,Bressler KL,Casiano RR,Rosa RH,Johnson TE

    更新日期:2000-01-01 00:00:00

  • Hemifacial atrophy: an unusual cause of upper eyelid retraction.

    abstract::Progressive hemifacial atrophy or Parry Romberg syndrome may present with variable ocular features, the commonest being enophthalmos. We report a mild case in a 62-year-old man who presented with upper eyelid retraction, nocturnal lagophthalmos, and symptoms of corneal exposure. Recession of the levator muscle correct...

    journal_title:Ophthalmic plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Galanopoulos A,McNab AA

    更新日期:1995-12-01 00:00:00

  • Primary orbital manifestation of Hodgkin lymphoma in a 3-year-old child.

    abstract::Hodgkin lymphoma is exceedingly rare in children, as is primary orbital manifestation of systemic Hodgkin lymphoma in any age category. The authors describe the clinicopathologic manifestations of a rare case of systemic Hodgkin lymphoma with primary orbital manifestation in a 3-year-old boy with histologically proven...

    journal_title:Ophthalmic plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Harrison AR,Mokhtarzadeh A,Melicher Larson JS,Dewan MA,Lee MS

    更新日期:2010-11-01 00:00:00

  • Evolving Minimally Invasive Techniques for Tear Trough Enhancement.

    abstract:PURPOSE:The aim of this study is to investigate whether volumetric enhancement of the infraorbital rim area or, alternatively, of the deep medial cheek, results in greater improvement of tear trough deformity. METHODS:This prospective, single-blind study recruited 12 patients seeking correction of tear trough deformit...

    journal_title:Ophthalmic plastic and reconstructive surgery

    pub_type: 杂志文章,随机对照试验


    authors: Hill RH 3rd,Czyz CN,Kandapalli S,Zhang-Nunes SX,Cahill KV,Wulc AE,Foster JA

    更新日期:2015-07-01 00:00:00

  • Chronic, Symptomatic Orbital Inflammation Resulting From Retained Bone Wax.

    abstract::A 58-year-old man presented with a 9-month history of a chronically draining surgical wound and low-grade periorbital inflammation following a right lateral orbitotomy. Imaging of the right orbit revealed a peculiar lesion in the right lateral orbit that was hypointense on both T1- and T2-weighted MRI with peripheral ...

    journal_title:Ophthalmic plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Thangamathesvaran L,Mirani N,Turbin R,Langer PD

    更新日期:2019-11-01 00:00:00

  • Successful boric acid treatment of Aspergillus niger infection in an exenterated orbit.

    abstract::Aspergillus niger infection of an exenterated orbit is a very rare occurrence. Treatment includes extensive surgical debridement with socket lavage with 0.6% hydrogen peroxide, oral itraconazole, and local amphotericin B. We describe a case of A. niger infection in an exenterated orbit, unresponsive to local amphoteri...

    journal_title:Ophthalmic plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Aviñó-Martínez JA,España-Gregori E,Peris-Martínez CP,Blanes M

    更新日期:2008-01-01 00:00:00

  • Expanding MIRAgel scleral buckle simulating an orbital tumor in four cases.

    abstract:PURPOSE:To describe four patients with an enlarging orbital mass from a swollen MIRAgel scleral buckle that simulated an orbital neoplasm. METHODS:In a retrospective, single-center case series at the Ocular Oncology Service at Wills Eye Hospital of Thomas Jefferson University, 4 eyes of 4 patients were referred for ev...

    journal_title:Ophthalmic plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Shields CL,Demirci H,Marr BP,Mashayekhi A,Materin MA,Shields JA

    更新日期:2005-01-01 00:00:00

  • Comparison of Two Polypropylene Frontalis Suspension Techniques in 92 Patients With Oculopharyngeal Muscular Dystrophy.

    abstract:PURPOSE:To compare the functional outcome of the polypropylene trapezoid frontalis suspension with the polypropylene modified Crawford frontalis suspension in a large cohort of patients with oculopharyngeal muscular dystrophy. METHODS:Retrospective, nonrandomized comparative case series. Patients with oculopharyngeal ...

    journal_title:Ophthalmic plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Kalin-Hajdu E,Attas-Fox L,Huang X,Hardy I,Codère F

    更新日期:2017-01-01 00:00:00

  • Laser treatment of juvenile hemangioma.

    abstract::Capillary hemangioma in the infant may result in amblyopia, refractive error, or strabismus, and is often disfiguring. Treatment is challenging with respect to maintaining vision, as well as preserving function of the eyelids and ocular adnexa and obtaining the best possible cosmetic outcome. Neodymium-YAG laser photo...

    journal_title:Ophthalmic plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Shorr N,Goldberg RA,David LM

    更新日期:1988-01-01 00:00:00

  • Bilateral Poorly Differentiated Adenocarcinoma of the Lacrimal Gland With Tumor Regression After Treatment With Pembrolizumab.

    abstract::An 85-year-old man presented with a 6-month history of worsening left proptosis and painless ophthalmoplegia. Imaging revealed an extensive intraconal and extraconal tumor extending to the level of the optic foramen, as well as the scalp, cheek, and the nasal bridge. Incisional biopsy was consistent with lacrimal glan...

    journal_title:Ophthalmic plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Tran AQ,Choi CJ,Al-Sadah Z,Yi Zhou X,Dubovy S,Rothschild NE,Lee BW

    更新日期:2020-11-01 00:00:00

  • Balloon canaliculoplasty for acquired canalicular stenosis.

    abstract:PURPOSE:Canalicular stenosis is a frequent cause of epiphora. Patients with canalicular stenosis often require timely insertion of bicanalicular silicone stents to prevent permanent and complete closure of the canaliculi. This study reports the use of balloon canaliculoplasty in conjunction with silicone tube intubatio...

    journal_title:Ophthalmic plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Zoumalan CI,Maher EA,Lelli GJ Jr,Lisman RD

    更新日期:2010-11-01 00:00:00

  • Giant cell angiofibroma, a variant of solitary fibrous tumor, of the orbit in a 16-year-old girl.

    abstract::A 16-year-old girl presented with diplopia and gradual-onset, painless proptosis of the left eye. Orbital CT showed a well-circumscribed, enhancing, extraconal mass in the superior orbit, and the surgical excision was performed. Histopathology was interpreted as capillary hemangioma. Five years later, her symptoms rec...

    journal_title:Ophthalmic plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Demirci H,Shields CL,Eagle RC Jr,Shields JA

    更新日期:2009-09-01 00:00:00

  • Inflammatory mass formation secondary to hydroxyapatite orbital implant leakage.

    abstract::A 28-year-old woman with a history of an hydroxyapatite implantation performed 2 years earlier, presented with complaints of a poorly fitting prosthesis, and fullness of the left upper eyelid accompanied by eyelid erythema. Computed tomography scan showed a mass adjacent to the implant medially. Surgical removal of th...

    journal_title:Ophthalmic plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Chee E,Kim YD,Woo KI,Lee JH,Kim JH,Suh YL

    更新日期:2013-03-01 00:00:00

  • Trichiasis associated with prostaglandin analog use.

    abstract::A previously unreported complication of the use of prostaglandin analog medications for glaucoma therapy is described. A patient with monocular open-angle glaucoma had trichiasis, a condition associated with the use of a prostaglandin analog. The patient was treated with radiofrequency cautery and is now asymptomatic....

    journal_title:Ophthalmic plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Bearden W,Anderson R

    更新日期:2004-07-01 00:00:00

  • Fibrous Hamartoma of Infancy in the Eyelid: A Rare Presentation.

    abstract::A 6-year-old girl presented with a left nodular mass around the punctum. Previous debulking in a similar location at 10 weeks and 8 months of age confirmed fibrous hamartoma of infancy. Pathology at the initial surgery revealed benign-appearing fibroadipose tissue, vasculature, and smooth muscle. Pathologic examinatio...

    journal_title:Ophthalmic plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Tran AQ,Thuro BA,Albert DM,Lucarelli MJ,Potter HD

    更新日期:2016-11-01 00:00:00