Abstract:
:The quest for neuroprotective drugs to slow the progression of neurodegenerative diseases (NDDs), including Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD), has been largely unrewarding. Preclinical evidence suggests that repurposing quetiapine, lithium, valproate, fluoxetine, donepezil, and memantine for early and pre-symptomatic disease-modification in NDDs may be promising and can spare regulatory barriers. The literature of these psychotropics in early stage and pre-symptomatic AD, PD, and HD is reviewed and propitious findings follow. Mild cognitive impairment (MCI) phase of AD: salutary human randomized controlled trial findings for low-dose lithium and, in selected patients, donepezil await replication. Pre-symptomatic AD: human epidemiological data indicate that lithium reduces AD risk. Animal model studies (AMS) reveal encouraging results for quetiapine, lithium, donepezil, and memantine. Early PD: valproate AMS findings show promise. Pre-symptomatic PD: lithium and valproate AMS findings are encouraging. Early HD: uncontrolled clinical data indicate non-progression with lithium, fluoxetine, donepezil, and memantine. Pre-symptomatic HD: lithium and valproate are auspicious in AMS. Many other promising findings awaiting replication (valproate in MCI; lithium, valproate, fluoxetine in pre-symptomatic AD; lithium in early PD; lithium, valproate, fluoxetine in pre-symptomatic PD; donepezil in early HD; lithium, fluoxetine, memantine in pre-symptomatic HD) are reviewed. Dose- and stage-dependent effects are considered. Suggestions for signal-enhancement in human trials are provided for each NDD stage.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Lauterbach ECdoi
10.4103/1673-5374.194708subject
Has Abstractpub_date
2016-11-01 00:00:00pages
1712-1726issue
11eissn
1673-5374issn
1876-7958pii
NRR-11-1712journal_volume
11pub_type
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journal_title:Neural regeneration research
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journal_title:Neural regeneration research
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journal_title:Neural regeneration research
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journal_title:Neural regeneration research
pub_type: 已发布勘误
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journal_title:Neural regeneration research
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pub_type: 杂志文章,评审
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journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.206633
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journal_title:Neural regeneration research
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doi:10.3969/j.issn.1673-5374.2013.27.001
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journal_title:Neural regeneration research
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journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2012.35.008
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journal_title:Neural regeneration research
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Neural regeneration research
pub_type: 杂志文章,评审
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journal_title:Neural regeneration research
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doi:10.3969/j.issn.1673-5374.2012.19.003
更新日期:2012-07-05 00:00:00
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journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.297081
更新日期:2021-05-01 00:00:00
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journal_title:Neural regeneration research
pub_type: 杂志文章
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更新日期:2012-09-05 00:00:00
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journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.244798
更新日期:2019-02-01 00:00:00