Abstract:
BACKGROUND:Adult living donor liver transplantation (LDLT) is one of the best treatments for hepatocellular carcinoma (HCC). However, when recurrence of HCC after LDLT occurs, the prognosis is poor because of rapid progression. Preoperative level of α-fetoprotein (AFP) and protein induced by vitamin K antagonist-II (PIVKA-II) reportedly correlate with recurrence of HCC after LDLT. METHODS:We examined AFP and PIVKA-II preoperatively as predictors of HCC recurrence in 461 patients who underwent LDLT using right liver graft for HCC from May 2007 to December 2013. RESULTS:Among these, 77 patients (16.7%) who experienced recurrence were retrospectively reviewed. Multivariate analysis revealed tumor size >5 cm, AFP >150 nag/mol and PIVKA-II >100 maul/mol as significant independent risk factors for recurrence. The median time to recurrence was 10 months. The median survival time after recurrence was 26 months, and the 1-, 3- and 5-year survival rates after recurrence were 80.5%, 58%, and 28.3% respectively. CONCLUSIONS:Preoperatively, not only morphology of the tumor but also AFP and PIVKA-II levels can offers important information for the recurrence after LDLT for HCC. Thus, combination of tumor markers might be used for expansion of pre-existing strict selection criteria of liver transplantation for HCC.
journal_name
Hepatobiliary Surg Nutrjournal_title
Hepatobiliary surgery and nutritionauthors
Kim SH,Moon DB,Kim WJ,Kang WH,Kwon JH,Jwa EK,Cho HD,Ha SM,Chung YK,Lee SGdoi
10.21037/hbsn.2016.11.05subject
Has Abstractpub_date
2016-12-01 00:00:00pages
461-469issue
6eissn
2304-3881issn
2304-389Xpii
hbsn-05-06-461journal_volume
5pub_type
杂志文章abstract::Though laparoscopic cholecystectomy (LC) was highly criticized in its early stages, it quickly grew to become a new standard of care and has revolutionized the field of general surgery. Now emerging robotic technology is making its way into the minimally invasive arena. Robotic cholecystectomy (RC) is often disparaged...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章,评审
doi:10.21037/hbsn.2017.03.01
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:The rising of individualized therapy requires nutritional risk screening has become a major topic for each particular disease, yet most of the screenings were for malignancies, less for benign diseases. There is no report on the screening of patients with benign liver tumors postoperatively. We aim to evaluat...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章
doi:10.3978/j.issn.2304-3881.2012.11.04
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abstract::The connection between pancreatic cancer and venous thrombosis has been discussed for almost 150 years. The exact pathophysiological mechanisms are still partly understood, but it is known that pancreatic cancer induces a prothrombotic and hypercoagulable state and genetic events involved in neoplastic transformation ...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章,评审
doi:10.3978/j.issn.2304-3881.2015.06.08
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journal_title:Hepatobiliary surgery and nutrition
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doi:10.3978/j.issn.2304-3881.2014.05.03
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abstract::Robotic surgery is an evolving technology that has been successfully applied to a number of surgical specialties, but its use in liver surgery has so far been limited. In this review article we discuss the challenges of minimally invasive liver surgery, the pros and cons of robotics, the evolution of medical robots, a...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章,评审
doi:10.3978/j.issn.2304-3881.2014.09.02
更新日期:2014-10-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related deaths worldwide. In the past few years, the mechanisms of hepato-carcinogenesis have been elucidated and the involvement of a number of pathways, including angiogenesis, aberrant signal transduction, and dysregulated cell cycle control ha...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章
doi:10.3978/j.issn.2304-3881.2014.06.04
更新日期:2014-08-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the sixth most common malignant tumor worldwide and the most common primary liver cancer. Liver resection or liver transplantation is the therapeutic gold standards in patient with HCC related with or without underline liver disease. We present a video case of a 68-year-old woman admi...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章
doi:10.3978/j.issn.2304-3881.2015.07.01
更新日期:2015-12-01 00:00:00
abstract::Adrenocortical carcinoma (ACC) is an uncommon and aggressive cancer occurring more frequently in women; local or distant recurrences occur in 80% of cases, typically within 1 year after curative resection. Liver is the preferred metastatic site. Herein, we report the case of a unique liver metastasis from ACC occurrin...
journal_title:Hepatobiliary surgery and nutrition
pub_type:
doi:10.21037/hbsn.2016.03.05
更新日期:2016-06-01 00:00:00
abstract::Hepatocellular carcinoma (HCC), a disease with poor survival rates unless recognized and treated early, ranks as the fifth most common cancer worldwide. Previous researches has led some authors to choose radiofrequency ablation (RFA) as the primary treatment even the tumor is resectable. Dr. Roayaie's study retrospect...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章
doi:10.3978/j.issn.2304-3881.2014.06.01
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journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章,评审
doi:10.21037/hbsn.2016.09.07
更新日期:2017-02-01 00:00:00
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journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章,评审
doi:10.21037/hbsn.2018.12.06
更新日期:2019-04-01 00:00:00
abstract:Background:While the long-term survival rate among patients with pancreatic and periampullary carcinomas remains low, it can be influenced by various factors. The purpose of this retrospective study was to investigate the effects of body mass index (BMI) on postoperative complications and patient survival after pancrea...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章
doi:10.21037/hbsn.2019.02.05
更新日期:2019-06-01 00:00:00
abstract::In living donor liver transplantation (LDLT), an adequate hepatic venous outflow constitutes one of the basic principles of a technically successful procedure. The issue of whether the anterior sector (AS) of the right lobe (RL) graft should or should not be routinely drained has been controversial. The aim of this 10...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章,评审
doi:10.3978/j.issn.2304-3881.2015.08.01
更新日期:2016-04-01 00:00:00
abstract:Background:Although laparoscopic liver resection (LLR) has been increasingly popular worldwide, there is lack of predictive model to evaluate the feasibility and safety of LLR. The aim of this study was to establish a scoring system for predicting the possibility of conversion and complication, which could facilitate t...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章
doi:10.21037/hbsn.2018.10.09
更新日期:2018-12-01 00:00:00
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journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章
doi:10.21037/hbsn.2018.09.03
更新日期:2018-10-01 00:00:00
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journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章
doi:10.21037/hbsn.2018.11.10
更新日期:2019-02-01 00:00:00
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journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章
doi:10.21037/hbsn.2020.03.19
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:To investigate the effects of EZH2 gene on the growth and migration of hepatocellular carcinoma HepG2 cell in vitro and in vivo. METHODS:EZH2 shRNA plasmid vectors were constructed and transfected into HepG2 cells. A model of EZH2 gene-silencing HepG2 cell lines was constructed, and the experimental cells we...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章
doi:10.3978/j.issn.2304-3881.2012.12.12
更新日期:2013-04-01 00:00:00
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journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章
doi:10.3978/j.issn.2304-3881.2012.07.02
更新日期:2012-12-01 00:00:00
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journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章
doi:10.3978/j.issn.2304-3881.2014.09.15
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journal_title:Hepatobiliary surgery and nutrition
pub_type:
doi:10.3978/j.issn.2304-3881.2015.08.02
更新日期:2016-02-01 00:00:00
abstract::The 2(nd) International Consensus Conference on Laparoscopic Liver Resection (ICCLLR) was held 4(th)-6(th) October, 2014, in Morioka, Japan. The level of evidence appears to be low in the field of laparoscopic liver resection (LLR) to create strong recommendations. Therefore, an independent jury-based consensus model ...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章
doi:10.21037/hbsn.2016.03.03
更新日期:2016-08-01 00:00:00
abstract::In order to induce liver hypertrophy to enable liver resection in patients with a small future liver remnant (FLR), various methods have been proposed in addition to portal vein embolisation (PVE). Most recently, the associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) technique has gain...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章
doi:10.21037/hbsn.2016.05.02
更新日期:2016-08-01 00:00:00
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journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章,评审
doi:10.21037/hbsn-20-317
更新日期:2020-10-01 00:00:00
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journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章,评审
doi:10.3978/j.issn.2304-3881.2014.11.02
更新日期:2014-12-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the fifth leading cause of cancer mortality worldwide. It is noted that metastasis is a fundamental biological behavior of HCC and the main cause of treatment failure. The identification of somatic alterations and their specific inhibitors may contribute to reduce side effects and pro...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章
doi:10.3978/j.issn.2304-3881.2014.02.06
更新日期:2014-04-01 00:00:00
abstract::Mirizzi syndrome, known as extrinsic bile compression syndrome, is a rare complication of cholecystitis and chronic cholelithiasis, secondary to the obliteration of the infundibulum of the gallbladder or cystic duct caused by the impact of one or more calculations in these anatomical structures, which leads to compres...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章,评审
doi:10.21037/hbsn.2016.11.01
更新日期:2017-06-01 00:00:00
abstract::Chronic infection with hepatitis B virus (HBV) is the leading cause of liver cirrhosis and hepatocellular carcinoma worldwide. HBV life cycle begins with viral attachment to hepatocytes, mediated by the large HBV surface protein (LHBs). Identification of the sodium-taurocholate cotransporting polypeptide (NTCP) as a H...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章,评审
doi:10.3978/j.issn.2304-3881.2014.12.08
更新日期:2015-02-01 00:00:00
abstract::Cancer stem cell (CSC) marker CD133 was found to be upregulated in many cancers including hepatocellular carcinoma (HCC). However, the molecular mechanism of CD133 regulation in the liver tumor microenvironment has remained elusive. In this study Won and colleagues report that interleukin-6 (IL-6) mediated signal tran...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章
doi:10.21037/hbsn.2016.03.02
更新日期:2016-06-01 00:00:00