Tackling breast cancer chemoresistance with nano-formulated siRNA.


:Breast cancer is the leading cancer diagnosed in women and the second leading cause of cancer-related deaths in women. Current limitations to standard chemotherapy in the clinic are extensively researched, including problems arising from repeated treatments with the same drugs. The phenomenon that cancer cells become resistant toward certain chemo drugs is called chemotherapy resistance. In this review, we are focusing on nanoformulation of siRNA for the fight against breast cancer chemoresistance.


Gene Ther


Gene therapy


Jones SK,Merkel OM




Has Abstract


2016-12-01 00:00:00














  • Intrabodies: turning the humoral immune system outside in for intracellular immunization.

    abstract::Antibodies have long been used in biomedical science as in vitro tools for the identification, purification and functional manipulation of target antigens; they have been exploited in vivo for diagnostic and therapeutic applications as well. Recent advances in antibody engineering have now allowed the genes encoding a...

    journal_title:Gene therapy

    pub_type: 杂志文章,评审


    authors: Marasco WA

    更新日期:1997-01-01 00:00:00

  • Sustained inhibition of hepatitis B virus replication in vivo using RNAi-activating lentiviruses.

    abstract::Chronic infection with hepatitis B virus (HBV) puts individuals at high risk for complicating cirrhosis and liver cancer, but available treatment to counter the virus rarely eliminates infection. Although harnessing RNA interference (RNAi) to silence HBV genes has shown the potential, achieving efficient and durable s...

    journal_title:Gene therapy

    pub_type: 杂志文章


    authors: Ivacik D,Ely A,Ferry N,Arbuthnot P

    更新日期:2015-02-01 00:00:00

  • Foamy virus--adenovirus hybrid vectors.

    abstract::To confer adenovirus vectors (AdV), the feature of integration into the host cell genome hybrid vectors were characterized in vitro, which express vectors derived from the prototypic foamy virus (FV) in the backbone of a high-capacity AdV. FVs constitute a subfamily of retroviruses with a distinct replication pathway ...

    journal_title:Gene therapy

    pub_type: 杂志文章


    authors: Picard-Maureau M,Kreppel F,Lindemann D,Juretzek T,Herchenröder O,Rethwilm A,Kochanek S,Heinkelein M

    更新日期:2004-04-01 00:00:00

  • Tumor-specific therapeutic effect induced by an oncolytic adenoviral vector containing heat shock protein 70 and prodrug activation genes.

    abstract::We constructed a melanoma-specific oncolytic adenoviral vector Ad.MCDIRESE1.71Hsp3, in which the cytosine deaminase and adenoviral E1A genes linked by the IRES sequence were under the control of a mouse tyrosinase enhancer/promoter transcriptional element in the E1 region of the vector. We also inserted the human heat...

    journal_title:Gene therapy

    pub_type: 杂志文章


    authors: Liu Y,Ye T,Sun D,Maynard J,Deisseroth A

    更新日期:2006-08-01 00:00:00

  • Use of herpes simplex virus type 1-based amplicon vector for delivery of small interfering RNA.

    abstract::Silencing of gene expression by small interfering RNAs (siRNAs) is rapidly becoming a powerful tool for genetic analysis of mammalian cells. The use of DNA-based plasmid vectors to achieve transient and stable expression of siRNA has been developed to avoid the problems of double-stranded oligonucleotides transfection...

    journal_title:Gene therapy

    pub_type: 杂志文章


    authors: Sabbioni S,Callegari E,Manservigi M,Argnani R,Corallini A,Negrini M,Manservigi R

    更新日期:2007-03-01 00:00:00

  • Adeno-associated virus vector enables safe and efficient Cas9 activation in neonatal and adult Cas9 knockin murine cochleae.

    abstract::Adeno-associated virus (AAV)-mediated gene delivery systems have been shown to be effective tools for gene manipulation in the inner ear. For example, hair cells (HCs) and multiple other cell types can be transduced by the local injection of AAVs into the inner ear. However, application of the AAV-mediated CRISPR/Cas9...

    journal_title:Gene therapy

    pub_type: 杂志文章


    authors: Kang W,Zhao X,Sun Z,Dong T,Jin C,Tong L,Zhu W,Tao Y,Wu H

    更新日期:2020-08-01 00:00:00

  • Production and purification of lentiviral vectors generated in 293T suspension cells with baculoviral vectors.

    abstract::Lentivirus can be engineered to be a highly potent vector for gene therapy applications. However, generation of clinical grade vectors in enough quantities for therapeutic use is still troublesome and limits the preclinical and clinical experiments. As a first step to solve this unmet need we recently introduced a bac...

    journal_title:Gene therapy

    pub_type: 杂志文章


    authors: Lesch HP,Laitinen A,Peixoto C,Vicente T,Makkonen KE,Laitinen L,Pikkarainen JT,Samaranayake H,Alves PM,Carrondo MJ,Ylä-Herttuala S,Airenne KJ

    更新日期:2011-06-01 00:00:00

  • Gene therapy progress and prospects: transcription regulatory systems.

    abstract::The clinical efficacy and safety as well as the application range of gene therapy will be broadened by developing systems capable of finely modulating the expression of therapeutic genes. Transgene regulation will be crucial for maintaining appropriate levels of a gene product within the therapeutic range, thus preven...

    journal_title:Gene therapy

    pub_type: 杂志文章,评审


    authors: Toniatti C,Bujard H,Cortese R,Ciliberto G

    更新日期:2004-04-01 00:00:00

  • Demyelination but no cognitive, motor or behavioral deficits after adenovirus-mediated gene transfer into the brain.

    abstract::Adenovirus-mediated gene transfer of interferon gamma (AdIFN) elicits rejection of intracerebral Lewis lung carcinoma. In this system, gene transfer into brain parenchymal cells is both necessary and sufficient to generate the antitumor response. Despite persistent parenchymal inflammation and demyelination, wild-type...

    journal_title:Gene therapy

    pub_type: 杂志文章


    authors: Fathallah-Shaykh HM,Kafrouni AI,Zhao LJ,Diaz-Arrastia R,Garcia JA,Frawley WH,Forman J

    更新日期:2000-12-01 00:00:00

  • Antigen design enhances the immunogenicity of Semliki Forest virus-based therapeutic human papillomavirus vaccines.

    abstract::Cellular immunity against cancer can be achieved with viral vector- and DNA-based immunizations. In preclinical studies, cancer vaccines are very potent, but in clinical trials these potencies are not achieved yet. Thus, a rational approach to improve cancer vaccines is warranted. We previously demonstrated that the r...

    journal_title:Gene therapy

    pub_type: 杂志文章


    authors: Ip PP,Boerma A,Walczak M,Oosterhuis K,Haanen JB,Schumacher TN,Nijman HW,Daemen T

    更新日期:2015-07-01 00:00:00

  • In vivo plasmid DNA electroporation generates exceptionally high levels of epitope-specific CD8+ T-cell responses.

    abstract::Based on observations that DBA/2 mice develop a highly specific response towards an HLA-Cw3-derived epitope, consisting entirely of CD8+CD62L-Vbeta10+ cells, we have established an in vivo mouse model for screening a variety of immunization approaches. Responder cells were readily detectable in small samples of the pe...

    journal_title:Gene therapy

    pub_type: 杂志文章


    authors: Paster W,Zehetner M,Kalat M,Schüller S,Schweighoffer T

    更新日期:2003-05-01 00:00:00

  • Current progress in the development of RNAi-based therapeutics for HIV-1.

    abstract::Highly active antiretroviral therapy (HAART) treatment for HIV has changed the course of AIDS in societies in which the drugs are readily available. Despite the great success of HAART, drug resistance and toxicity issues still remain a concern for some individuals. Thus, a number of investigators have been exploring o...

    journal_title:Gene therapy

    pub_type: 杂志文章,评审


    authors: Zhou J,Rossi JJ

    更新日期:2011-12-01 00:00:00

  • Intercellular trafficking and enhanced in vivo antitumour activity of a non-virally delivered P27-VP22 fusion protein.

    abstract::VP22, a structural protein from herpes simplex virus type I, exhibits the unique property of intercellular trafficking. This protein is exported from primary expressing cells and subsequently imported into neighbouring cells. This property is conserved when VP22 is genetically fused to a protein, making it a promising...

    journal_title:Gene therapy

    pub_type: 杂志文章


    authors: Zavaglia D,Favrot MC,Eymin B,Tenaud C,Coll JL

    更新日期:2003-02-01 00:00:00

  • Redirecting adenovirus to pulmonary endothelium by cationic liposomes.

    abstract::Somatic gene transfer to the pulmonary endothelium may be a useful strategy for modifying the phenotype of endothelium and/or vascular smooth muscle in disorders such as primary pulmonary hypertension, ARDS or pulmonary metastatic disease. Adenoviral (Ad) vectors, although highly efficient in liver gene transfer, have...

    journal_title:Gene therapy

    pub_type: 杂志文章


    authors: Ma Z,Mi Z,Wilson A,Alber S,Robbins PD,Watkins S,Pitt B,Li S

    更新日期:2002-02-01 00:00:00

  • Efficient CNS targeting in adult mice by intrathecal infusion of single-stranded AAV9-GFP for gene therapy of neurological disorders.

    abstract::Adeno-associated virus (AAV) gene therapy constitutes a powerful tool for the treatment of neurodegenerative diseases. While AAVs are generally administered systemically to newborns in preclinical studies of neurological disorders, in adults the maturity of the blood-brain barrier (BBB) must be considered when selecti...

    journal_title:Gene therapy

    pub_type: 杂志文章


    authors: Bey K,Ciron C,Dubreil L,Deniaud J,Ledevin M,Cristini J,Blouin V,Aubourg P,Colle MA

    更新日期:2017-05-01 00:00:00

  • Human urinary bladder carcinomas express adenovirus attachment and internalization receptors.

    abstract::The use of adenoviral vectors as potent gene delivery systems requires expression of the Coxsackievirus/adenovirus receptor (CVADR) on the target cell surface. This receptor is important for virus attachment to the cell surface. For effective internalization of the vector into the target cell the integrins alpha(v)bet...

    journal_title:Gene therapy

    pub_type: 杂志文章


    authors: Loskog A,Hedlund T,Wester K,de la Torre M,Philipson L,Malmström PU,Tötterman TH

    更新日期:2002-05-01 00:00:00

  • Adenovirus-mediated transfer of the PTEN gene inhibits human colorectal cancer growth in vitro and in vivo.

    abstract::The tumor-suppressor gene PTEN encodes a multifunctional phosphatase that is mutated in a variety of human cancers. PTEN inhibits the phosphatidylinositol 3-kinase pathway and downstream functions, including activation of Akt/protein kinase B (PKB), cell survival, and cell proliferation in tumor cells carrying mutant-...

    journal_title:Gene therapy

    pub_type: 杂志文章


    authors: Saito Y,Swanson X,Mhashilkar AM,Oida Y,Schrock R,Branch CD,Chada S,Zumstein L,Ramesh R

    更新日期:2003-11-01 00:00:00

  • PML has a predictive role in tumor cell permissiveness to interferon-sensitive oncolytic viruses.

    abstract::The oncotropic phenotypes of several viruses correlate with tumor-associated deficiencies within interferon (IFN) signaling pathways. This observation formed the conceptual basis for developing oncolytic viruses deleted for viral proteins that inhibit the host IFN-dependent antiviral response, such as herpes simplex v...

    journal_title:Gene therapy

    pub_type: 杂志文章


    authors: Sobol PT,Hummel JL,Rodrigues RM,Mossman KL

    更新日期:2009-09-01 00:00:00

  • An antiaggregation gene therapy strategy for Lewy body disease utilizing beta-synuclein lentivirus in a transgenic model.

    abstract::Current experimental gene therapy approaches for Parkinson's disease (PD) and dementia with Lewy bodies (DLB) include the use of viral vectors expressing antiapoptosis genes, neurotrophic factors and dopaminergic system enzymes. However, since increasing evidence favors a role for alpha-synuclein accumulation in the p...

    journal_title:Gene therapy

    pub_type: 杂志文章


    authors: Hashimoto M,Rockenstein E,Mante M,Crews L,Bar-On P,Gage FH,Marr R,Masliah E

    更新日期:2004-12-01 00:00:00

  • Gene electrotransfer of plasmid AMEP, an integrin-targeted therapy, has antitumor and antiangiogenic action in murine B16 melanoma.

    abstract::Gene therapy with Plasmid AMEP (antiangiogenic metargidin peptide) has recently been studied as a potential targeted therapy for melanoma. This plasmid is designed to downregulate α5β1 and αvβ3 integrins. In our study, electroporation was used as a nonviral delivery system. We investigated the antiangiogenic and direc...

    journal_title:Gene therapy

    pub_type: 杂志文章


    authors: Bosnjak M,Dolinsek T,Cemazar M,Kranjc S,Blagus T,Markelc B,Stimac M,Zavrsnik J,Kamensek U,Heller L,Bouquet C,Turk B,Sersa G

    更新日期:2015-07-01 00:00:00

  • scAAV-mediated gene transfer of interleukin-1-receptor antagonist to synovium and articular cartilage in large mammalian joints.

    abstract::With the long-term goal of developing a gene-based treatment for osteoarthritis (OA), we performed studies to evaluate the equine joint as a model for adeno-associated virus (AAV)-mediated gene transfer to large, weight-bearing human joints. A self-complementary AAV2 vector containing the coding regions for human inte...

    journal_title:Gene therapy

    pub_type: 杂志文章


    authors: Watson RS,Broome TA,Levings PP,Rice BL,Kay JD,Smith AD,Gouze E,Gouze JN,Dacanay EA,Hauswirth WW,Nickerson DM,Dark MJ,Colahan PT,Ghivizzani SC

    更新日期:2013-06-01 00:00:00

  • Replication-competent retrovirus produced by a 'split-function' third generation amphotropic packaging cell line.

    abstract::We report the discovery, on routine screening, of a replication-competent retrovirus (RCR) produced from a third generation amphotropic packaging cell line, GP + envAM12. In this line, the gag-pol and env helper genes are located on separate plasmids to minimise the chances of recombination events that may lead to RCR...

    journal_title:Gene therapy

    pub_type: 杂志文章


    authors: Chong H,Vile RG

    更新日期:1996-07-01 00:00:00

  • Gene transfer into human hematopoietic progenitor cells with an episomal vector carrying an S/MAR element.

    abstract::Episomally maintained self-replicating systems present attractive alternative vehicles for gene therapy applications. Recent insights into the ability of chromosomal scaffold/matrix attachment regions (S/MARs) to mediate episomal maintenance of genetic elements allowed the development of a small circular episomal vect...

    journal_title:Gene therapy

    pub_type: 杂志文章


    authors: Papapetrou EP,Ziros PG,Micheva ID,Zoumbos NC,Athanassiadou A

    更新日期:2006-01-01 00:00:00

  • Correction/mutation of acid alpha-D-glucosidase gene by modified single-stranded oligonucleotides: in vitro and in vivo studies.

    abstract::Deficiency in acid alpha-D-glucosidase results in Pompe's disease. Modified single-stranded oligonucleotide (ODN) was designed to correct the acid alpha-D-glucosidase gene with a C1935 --> A (Asp --> Glu) point mutation which causes a complete loss of enzymatic activity for glycogen digestion in the lysosome. The ODN ...

    journal_title:Gene therapy

    pub_type: 杂志文章


    authors: Lu IL,Lin CY,Lin SB,Chen ST,Yeh LY,Yang FY,Au LC

    更新日期:2003-10-01 00:00:00

  • Combination of cabazitaxel and p53 gene therapy abolishes prostate carcinoma tumor growth.

    abstract::For patients with metastatic prostate cancer, the 5-year survival rate of 31% points to a need for novel therapies and improvement of existing modalities. We propose that p53 gene therapy and chemotherapy, when combined, will provide superior tumor cell killing for the treatment of prostate carcinoma. To this end, we ...

    journal_title:Gene therapy

    pub_type: 杂志文章


    authors: Tamura RE,Lana MG,Costanzi-Strauss E,Strauss BE

    更新日期:2020-02-01 00:00:00

  • Control of parvovirus DNA replication by a tetracycline-regulated repressor.

    abstract::Autonomous parvoviruses are small, single strand DNA viruses which preferentially replicate in transformed and tumor cells, causing cell death by expression of the cytotoxic nonstructural protein, NS1. Several parvoviruses of the rodent group, including LuIII, efficiently infect human transformed cell lines. The poten...

    journal_title:Gene therapy

    pub_type: 杂志文章


    authors: Maxwell IH,Maxwell F

    更新日期:1999-03-01 00:00:00

  • Safety of a single aerosol administration of escalating doses of the cationic lipid GL-67/DOPE/DMPE-PEG5000 formulation to the lungs of normal volunteers.

    abstract::Several groups are assessing the use of cationic lipids for respiratory gene therapy. To date no human data are available regarding the safety of intra-pulmonary cationic lipid delivery. In preparation for a trial of pulmonary delivery of the CFTR gene, we have assessed the safety of nebulised lipid GL-67/DOPE/DMPE-PE...

    journal_title:Gene therapy

    pub_type: 临床试验,杂志文章


    authors: Chadwick SL,Kingston HD,Stern M,Cook RM,O'Connor BJ,Lukasson M,Balfour RP,Rosenberg M,Cheng SH,Smith AE,Meeker DP,Geddes DM,Alton EW

    更新日期:1997-09-01 00:00:00

  • MuLV-based vectors pseudotyped with truncated HIV glycoproteins mediate specific gene transfer in CD4+ peripheral blood lymphocytes.

    abstract::Human immunodeficiency virus (HIV) infection ultimately leads to the destruction of the CD4+ lymphocyte subset and the onset of AIDS. In recent years, several gene therapy procedures making use of retroviral vectors that selectively target HIV susceptible cells have been proposed in order to interfere with HIV product...

    journal_title:Gene therapy

    pub_type: 杂志文章


    authors: Lodge R,Subbramanian RA,Forget J,Lemay G,Cohen EA

    更新日期:1998-05-01 00:00:00

  • Genome medicine: gene therapy for the millennium, 30 September-3 October 2001, Rome, Italy.

    abstract::The recent surge of DNA sequence information resulting from the efforts of agencies interested in deciphering the human genetic code has facilitated technological developments that have been critical in the identification of genes associated with numerous disease pathologies. In addition, these efforts have opened the...

    journal_title:Gene therapy

    pub_type: 杂志文章


    authors: Gruenert DC,Novelli G,Dallapiccola B,Colosimo A

    更新日期:2002-06-01 00:00:00

  • Ex vivo gene therapy in autologous bone marrow stromal stem cells for tissue-engineered maxillofacial bone regeneration.

    abstract::This study examines the clinical relevance of tissue engineering integrating gene therapy and polymer science to bone regeneration. Bilateral maxillary defects (3 x 1.2 cm(2)) in 20 miniature swine were bridged with a bioresorbable internal splint. Constructs were created using ex vivo adenovirus bone morphogenetic pr...

    journal_title:Gene therapy

    pub_type: 杂志文章


    authors: Chang SC,Chuang HL,Chen YR,Chen JK,Chung HY,Lu YL,Lin HY,Tai CL,Lou J

    更新日期:2003-11-01 00:00:00