TNF-alpha inhibitor associated myelopathies: A neurological complication in patients with rheumatologic disorders.


OBJECTIVES:Tumor necrosis factor-alpha inhibitors (TNFα-I) are biological agents used in the treatment of rheumatologic disorders. TNFα-I have been associated with demyelinating disorders mimicking multiple sclerosis. The goal of this report is to illustrate cases of myelopathy which developed during the use of TNFα-I. METHODS:We describe the clinical, neuroimaging and laboratory features of 4 cases of myelopathy associated with TNFα-I. RESULTS:The mean period of TNFα-I exposure was 27 [12-36] months. Three of the four patients exhibited active inflammatory myelopathy as the spinal cord MRI lesions enhanced with gadolinium and CSF pleocytosis or oligoclonal bands were present. All patients had normal brain MRIs at the time of presentation. CONCLUSIONS:TNFα-I may play a role in the development of myelopathies in absence of brain involvement or other features of demyelinating disease. TNFα-I associated myelopathy should be considered in patients with history of treatment with TNFα-I who exhibit symptoms of myelopathy.


J Neurol Sci


Barreras P,Mealy MA,Pardo CA




Has Abstract


2017-02-15 00:00:00












  • The kynurenine pathway in neurodegenerative diseases: mechanistic and therapeutic considerations.

    abstract::The kynurenine pathway (KP), the primary route of tryptophan degradation in mammalian cells, consists of many metabolites including kynurenic acid (KYNA), quinolinic acid (QUIN), 3-hydroxykynurenine (3-HK) and picolinic acid (PIC). The former two are neuroactive, while the latter two are molecules with pro-oxidants an...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,评审


    authors: Tan L,Yu JT,Tan L

    更新日期:2012-12-15 00:00:00

  • Pathology of behavior in PD: What is known and what is not?

    abstract::Abnormal behavior in Parkinson's disease (PD) stems from a complex orchestration of impaired neural networks that result from PD-related neurodegeneration across multiple levels. Typically, cellular and tissue abnormalities generate neurochemical changes and disrupt specific regions of the brain, in turn creating impa...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,评审


    authors: Ehgoetz Martens KA,Lewis SJ

    更新日期:2017-03-15 00:00:00

  • Whole-exome sequence analysis of ataxia telangiectasia-like phenotype.

    abstract::A number of diseases exhibit neurodegeneration with/without additional symptoms such as immunodeficiency, increased cancer risk, and microcephalus. Ataxia telangiectasia and Nijmegen breakage syndrome, for example, develop as a result of mutations in genes involved in the DNA damage response. However, such diseases ca...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Hasegawa S,Imai K,Yoshida K,Okuno Y,Muramatsu H,Shiraishi Y,Chiba K,Tanaka H,Miyano S,Kojima S,Ogawa S,Morio T,Mizutani S,Takagi M

    更新日期:2014-05-15 00:00:00

  • Unusual features of the Guillain-Barré syndrome after rabies vaccine prepared in suckling mouse brain.

    abstract::Five patients with acute polyneuritis following treatment with rabies vaccine prepared in suckling mouse brains are reported. These patients had severe and protracted disease. The extensive cranial nerve involvement, high mortality rate, and disabling longterm sequelae were in contrast to cases of the Guillain-Barré s...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Cabrera J,Griffin DE,Johnson RT

    更新日期:1987-11-01 00:00:00

  • Abnormal tissue distribution of lead in amyotrophic lateral sclerosis.

    abstract::The lead content of cerebrospinal fluid (CSF) was found to be significantly elevated in 12 patients with amyotrophic lateral sclerosis, when compared to 28 control subjects having non-degenerative neurological disorders. The difference could not be explained as being merely secondary to blood-CSF barrier damage. A hyp...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Conradi S,Ronnevi LO,Vesterberg O

    更新日期:1976-10-01 00:00:00

  • Sensorimotor network in cervical dystonia and the effect of botulinum toxin treatment: a functional MRI study.

    abstract:BACKGROUND:The evidence suggests that the origin of primary dystonia is at least partly associated with widespread dysfunction of the basal ganglia and cortico-striato-thalamo-cortical circuits. The aim of the study was to assess the sensorimotor activation pattern outside the circuits controlling the affected body par...

    journal_title:Journal of the neurological sciences

    pub_type: 临床试验,杂志文章


    authors: Opavský R,Hluštík P,Otruba P,Kaňovský P

    更新日期:2011-07-15 00:00:00

  • Machado-Joseph disease in three Scandinavian families.

    abstract::Machado-Joseph disease (MJD) is an autosomal dominantly inherited neurodegenerative disorder characterized by varying age of onset and pronounced phenotypic heterogeneity. The clinical core features include gait ataxia, external ophthalmoplegia, nystagmus, and bulging eyes. Recently, Kawagushi et al. (1994) cloned the...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Løkkegaard T,Nielsen JE,Hasholt L,Fenger K,Werdelin L,Tranebjaerg L,Lauritzen M,Colding-Jørgensen E,Grønbech-Jensen M,Henriksen OA,Sørensen SA

    更新日期:1998-04-01 00:00:00

  • Sensory symptoms in cranial dystonia: a potential role in the etiology?

    abstract::Cranial dystonia is normally considered as a pure movement disorder. Sensory symptoms have not received much attention, but we found ill-defined pain, discomfort, distortion of sensory modalities, 'phantom' kinetic or postural sensations in the orofacial areas subsequently involved by the dyskinesia in all of 11 conse...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Ghika J,Regli F,Growdon JH

    更新日期:1993-06-01 00:00:00

  • Adoptive transfer of experimental allergic encephalomyelitis with lectin-activated spleen cells.

    abstract::Adoptive transfer of experimental allergic encephalomyelitis (EAE) was achieved in Lewis rats using spleen cells incubated in vitro with various lectins. When stimulated with concanavalin A (Con A), its derivative succinyl-Con A, Lens culinaris or Pisum sativum agglutinin, spleen cells obtained from rats immunized wit...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Takenaka A,Kaneko K,Mori R,Itoyama Y

    更新日期:1984-11-01 00:00:00

  • Cognitive fatigue in multiple sclerosis: findings from a two-wave screening project.

    abstract:BACKGROUND:Multiple sclerosis (MS) patients commonly suffer from fatigue and define it as one of their most disabling symptom profoundly disrupting their lives. However, the relationship of fatigue to cognitive functions and its impact on quality of life have not been widely studied. AIM:To define (1) "cognitive fatig...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Barak Y,Achiron A

    更新日期:2006-06-15 00:00:00

  • High-dose, frequently administered interferon beta therapy for relapsing-remitting multiple sclerosis must be maintained over the long term: the interferon beta dose-reduction study.

    abstract::Long-term trials have demonstrated the continued efficacy of interferon (IFN) beta treatment in patients with relapsing-remitting (RR) multiple sclerosis (MS) during prolonged administration. The objective of the work was to evaluate the effects of reducing IFN beta administration frequency and total weekly dose in pa...

    journal_title:Journal of the neurological sciences

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Barbero P,Verdun E,Bergui M,Pipieri A,Clerico M,Cucci A,Ricci A,Bergamasco B,Durelli L

    更新日期:2004-07-15 00:00:00

  • An epidemic of optic neuropathy in Tanzania: characterization of the visual disorder and associated peripheral neuropathy.

    abstract::An epidemic of subacute bilateral visual failure has affected large numbers of teenagers and young adult Africans in coastal Tanzania since 1988. Previous work had indicated that many patients had sensory symptoms, but the nature of the neurological involvement was uncertain. The primary objective of this study was to...

    journal_title:Journal of the neurological sciences

    pub_type: 临床试验,杂志文章


    authors: Plant GT,Mtanda AT,Arden GB,Johnson GJ

    更新日期:1997-02-12 00:00:00

  • Demyelinating Guillain-Barré syndrome recurs more frequently than axonal subtypes.

    abstract::Guillain-Barré syndrome (GBS) is considered a monophasic disorder yet recurrences occur in up to 6% of patients. We retrospectively studied an Italian-Japanese population of 236 GBS and 73 Miller Fisher syndrome (MFS) patients and searched for factors which may be associated with recurrence. A recurrent patient was de...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Notturno F,Kokubun N,Sekiguki Y,Nagashima T,De Lauretis A,Yuki N,Kuwabara S,Uncini A

    更新日期:2016-06-15 00:00:00

  • Water content, vasoactive intestinal polypeptide and substance P in intact and crushed sciatic nerves of normal and streptozotocin-diabetic rats.

    abstract::Observations on streptozotocin-diabetic rats have confirmed overhydration of peripheral nerve. As in previous studies, the sorbitol and fructose content, when expressed in terms of wet weight of nerve was found to be increased and myo-inositol decreased. The reduction in myo-inositol content was less, although still s...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Anand P,Llewelyn JG,Thomas PK,Gillon KR,Lisk R,Bloom SR

    更新日期:1988-02-01 00:00:00

  • Exploring outcomes and characteristics of myasthenia gravis: Rationale, aims and design of registry - The EXPLORE-MG registry.

    abstract:OBJECTIVES:Though much information exists about the diagnosis, treatment, and epidemiology of myasthenia gravis (MG), a comprehensive data registry and biorepository is critical to better understand disease mechanisms, treatment outcomes, and the impact of treatment strategies. We aimed to design and implement the "Exp...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Anil R,Kumar A,Alaparthi S,Sharma A,Nye JL,Roy B,O'Connor KC,Nowak RJ

    更新日期:2020-07-15 00:00:00

  • Selective staining of a subset of Purkinje cells in the human cerebellum with monoclonal antibody mabQ113.

    abstract::MabQ113 is a monoclonal antibody raised against rat cerebellum which selectively strains Purkinje cells. Likewise, in mabQ113-immunoperoxidase stained sections of human cerebellum, deposits of reaction product are found only in the Purkinje cells. The dendritic arborizations, cell body, and axonal processes are immuno...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Plioplys AV,Thibault J,Hawkes R

    更新日期:1985-10-01 00:00:00

  • Trends in resource utilization for Parkinson's disease in Germany.

    abstract:OBJECTIVE:The prevalence of Parkinson's disease (PD) and costs of healthcare resources for this disease have been increasing in recent years. The objective was to determine the trends in the resource utilization for PD in Germany. METHODS AND PATIENTS:We compared resource utilization in two cohorts of PD patients recr...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,多中心研究


    authors: Winter Y,Balzer-Geldsetzer M,von Campenhausen S,Spottke A,Eggert K,Oertel WH,Dodel R

    更新日期:2010-07-15 00:00:00

  • A census of movement disorders at a Thai university hospital.

    abstract::There is little information available on the number of patients with movement disorders seen by physicians in Thailand. The authors reviewed the medical records of all movement disorders patients seen at the Chulalongkorn Comprehensive Movement Disorders Center (CUMDS) in Bangkok, Thailand over a 4.5-year period to de...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Bhidayasiri R,Saksornchai K,Kaewwilai L,Phanthumchinda K

    更新日期:2011-02-15 00:00:00

  • Opsoclonus-myoclonus syndrome associated with human herpes virus-6 rhomboencephalitis.

    abstract::Opsoclonus-myoclonus syndrome (OMS) is characterized by opsoclonus and arrhythmic-action myoclonus that predominantly involves the trunk, limbs, and head. Human herpes virus-6 (HHV-6) can rarely cause encephalitis in immunocompetent children and adults. Here we report on a case of OMS associated with HHV-6 rhomboencep...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Belcastro V,Piola M,Binda S,Santoro D,Rezzonico M,Arnaboldi M

    更新日期:2014-06-15 00:00:00

  • Development of measures of polyneuropathy impairment in hATTR amyloidosis: From NIS to mNIS + 7.

    abstract::Hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis) is a rare, life-threatening disease, caused by point mutations in the transthyretin gene. It is a heterogeneous, multisystem disease with rapidly progressing polyneuropathy (including sensory, motor, and autonomic impairments) and cardiac dysfunction. M...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,评审


    authors: Dyck PJB,González-Duarte A,Obici L,Polydefkis M,Wiesman JF,Antonino I,Litchy WJ,Dyck PJ

    更新日期:2019-10-15 00:00:00

  • Semi-quantitative data on ethanol consumption in 354 ET cases and 370 controls.

    abstract::The notion that there is an association between essential tremor (ET) and higher ethanol consumption has crept into the literature; however, the data are limited and conflicted. A total of 354 ET cases and 370 matched controls were enrolled in a clinical-epidemiological study. Average current daily ethanol consumption...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Louis ED,Michalec M

    更新日期:2014-12-15 00:00:00

  • Serum cortisol and outcome of ischemic brain infarction.

    abstract::The predictive value of serum cortisol level on the prognosis in acute brain infarction of the carotid circulation territory was studied in 101 patients younger than 70 years. The levels of 7 a.m. and 7 p.m. serum cortisol were measured initially and at 1 week. All patients underwent a computed cerebral tomography (CT...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Murros K,Fogelholm R,Kettunen S,Vuorela AL

    更新日期:1993-05-01 00:00:00

  • EEG recurrence markers and sleep quality.

    abstract:OBJECTIVES:To show that EEG markers formed using the variable percent recurrence reliably quantified two related aspects of sleep quality, sleep depth and sleep fragmentation. As hypotheses, the depth marker would increase and the fragmentation marker decrease in patients where improved sleep quality occurred when asse...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Wang L,Kim PY,McCarty DE,Frilot C 2nd,Chesson AL Jr,Carrubba S,Marino AA

    更新日期:2013-08-15 00:00:00

  • Comorbid conditions associated with Parkinson's disease: A longitudinal and comparative study with Alzheimer disease and control subjects.

    abstract:BACKGROUND AND OBJECTIVE:To study what comorbid conditions were present at baseline and 3years later in a cohort of Spanish Parkinson's disease (PD) patients, to compare comorbidity with both Alzheimer's disease (AD) and control groups and to analyze the role of comorbidity as predictor of mortality. METHODS:One hundr...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Santos García D,Suárez Castro E,Expósito I,de Deus T,Tuñas C,Aneiros A,López Fernández M,Núñez Arias D,Bermúdez Torres M

    更新日期:2017-02-15 00:00:00

  • Vascular dementia among elderly Arabs in Wadi Ara.

    abstract::Dementia of the Alzheimer type (DAT) and vascular dementia (VaD) are the two major subtypes of dementia. In our epidemiological study of DAT in an Arab community in Wadi Ara, Israel, we found a high prevalence of late onset DAT. Illiteracy, smoking, diabetes mellitus (DM) and hypertension are very frequent in Wadi Ara...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Bowirrat A,Friedland RP,Korczyn AD

    更新日期:2002-11-15 00:00:00

  • Cerebral hypoperfusion correlates with mild and parenchymal loss with severe multi-infarct dementia.

    abstract::Relative contributions of two potential pathogenetic factors for cognitive impairments among patients with multi-infarct dementia (MID) are reported. Cognitive test scores were correlated with measures of cerebral hypoperfusion and loss of brain parenchyma. Local cerebral blood flow values were determined utilizing st...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Kawamura J,Meyer JS,Terayama Y,Weathers S

    更新日期:1991-03-01 00:00:00

  • Deprenyl enhances neurite outgrowth in cultured rat spinal ventral horn neurons.

    abstract::Deprenyl, a selective monoamine oxidase B inhibitor, is effective in Parkinson's disease, and can slow the cognitive deterioration in Alzheimer's disease. However, it is not known whether this agent has a trophic effect on spinal motor neurons. We have studied neurotrophic effects of deprenyl on spinal motor neurons, ...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Iwasaki Y,Ikeda K,Shiojima T,Kobayashi T,Tagaya N,Kinoshita M

    更新日期:1994-08-01 00:00:00

  • Etiological mechanisms of isolated pontine infarcts based on arterial territory involvement.

    abstract:BACKGROUND:Pontine infarcts can be classified into four regions based on the vascular anatomy: anteromedial, anterolateral, lateral and posterior. The purpose of this study was to determine if different etiological mechanisms are responsible for these four types of pontine infarcts. METHODS:We studied consecutive pati...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Kobayashi J,Ohara T,Minematsu K,Nagatsuka K,Toyoda K

    更新日期:2014-04-15 00:00:00

  • Altered resting state functional network connectivity in children absence epilepsy.

    abstract::Altered functional connectivity has been associated with the influence of epileptic activity. Abnormalities in connectivity, particularly in dorsal attention (DAN), salience (SN) and default mode (DMN) networks, might contribute to the loss of consciousness during seizures and cognitive deficits in patients with child...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Li Q,Cao W,Liao X,Chen Z,Yang T,Gong Q,Zhou D,Luo C,Yao D

    更新日期:2015-07-15 00:00:00

  • Germanium intoxication with sensory ataxia.

    abstract::Sensory ataxia in inorganic germanium intoxication is rare. A 63-year-old housewife had taken inorganic germanium preparations at a dosage of 36 mg a day for about 6 years (total dose about 80 g). She subsequently developed difficulty in writing and gait disturbance with peripheral neuropathy and renal involvement. Ge...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Asaka T,Nitta E,Makifuchi T,Shibazaki Y,Kitamura Y,Ohara H,Matsushita K,Takamori M,Takahashi Y,Genda A

    更新日期:1995-06-01 00:00:00