Electrophysiological correlates of semantic memory retrieval in Gulf War Syndrome 2 patients.


:Gulf War veterans meeting criteria for Haley Syndrome 2 of Gulf War illness endorse a particular constellation of symptoms that include difficulty with processing information, word-finding, and confusion. To explore the neural basis of their word-finding difficulty, we assessed event-related potentials (ERPs) associated with semantic memory retrieval in 22 veterans classified as Syndrome 2 and 28 veterans who served as controls. We recorded EEGs while subjects judged whether pairs of words that represented object features combined to elicit a retrieval of an object memory or no retrieval. Syndrome 2 subjects' responses were significantly slower, and those participants were less accurate than controls on the retrieval trials, but they performed similarly on the nonretrieval trials. Analysis of the ERPs revealed a difference between retrievals and nonretrievals that has previously been detected around 750ms at the left temporal region was present in both the Syndrome 2 patients and controls. However, the Syndrome 2 patients also showed an ERP difference between retrievals and nonretrievals at the midline parietal region that had a scalp voltage polarity opposite from that recorded at the left temporal area. We hypothesize that the similarities between task performance and ERP patterns in Syndrome 2 veterans and in patients with amnestic mild cognitive impairment reflect disordered thalamic cholinergic neural activity, possibly in the dorsomedial nucleus.


J Neurol Sci


Tillman GD,Calley CS,Buhl VI,Chiang HS,Haley RW,Hart J Jr,Kraut MA




Has Abstract


2017-02-15 00:00:00












  • Quality of life and psychological impact in adult patients with hemorrhagic moyamoya disease who received no surgical revascularization.

    abstract:OBJECTIVES:Surgical treatment for adult hemorrhagic moyamoya disease (MMD) remains controversial. A large proportion of Chinese adult patients with hemorrhagic MMD still choose conservative treatment. In this study, we investigated to assess psychological function and quality of life (QoL) in adult patients with hemorr...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Su SH,Hai J,Zhang L,Wu YF,Yu F

    更新日期:2013-05-15 00:00:00

  • Coexistence of tuberous sclerosis and Friedreich ataxia.

    abstract::Tuberous sclerosis (TS) is caused by point mutations in the TSC1 or TSC2 genes on chromosomes 9q33-34 or 16p13, respectively. Clinical manifestations can be quite variable but are primarily limited to cutaneous, neurologic, and cardiovascular abnormalities. Phenotypes range from neurologically devastated to those with...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Walker M,Samii A,Bird T

    更新日期:2004-06-15 00:00:00

  • Cardiovascular event rates in patients with cerebrovascular disease and atherothrombosis at other vascular locations: results from 1-year outcomes in the Japanese REACH Registry.

    abstract::The REduction of Atherothrombosis for Continued Health (REACH) Registry is a large, international, prospective cohort of patients with atherothrombosis or multiple (>or=3) risk factors (MRFs) for atherothrombosis. Japanese patients (n=5193) were enrolled into the REACH registry between August and December 2004. One-ye...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,多中心研究


    authors: Uchiyama S,Goto S,Matsumoto M,Nagai R,Origasa H,Yamazaki T,Shigematsu H,Shimada K,Yamada N,Bhatt DL,Steg PG,Ikeda Y,REduction of Atherothrombosis for Continued Health Registry Investigators.

    更新日期:2009-12-15 00:00:00

  • Bilateral claw hand: an uncommon presentation of regional Guillain-Barré syndrome.

    abstract::We present an uncommon case of a 38-year-old man presented with bilateral subacute weakness of intrinsic hand muscles, manifesting as bilateral claw-hand, without sensory deficits and absent tendon reflexes in upper arms. Nerve conduction studies showed findings consistent with demyelinating GBS. During the fourth day...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Tsivgoulis G,Tsakaldimi S,Vadikolias K,Mantatzis M,Katsanos AH,Heliopoulos I,Piperidou C

    更新日期:2013-11-15 00:00:00

  • Activation-flow coupling differentiates between vascular and Alzheimer type of dementia.

    abstract::The activation-flow coupling describes a mechanism, which adapts local cerebral blood flow in accordance with the underlying neuronal activity. It was suggested that the mechanism helps in differentiation between Alzheimer and vascular type of dementia. We combined EEG and Doppler techniques and assessed integrity of ...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Rosengarten B,Paulsen S,Molnar S,Kaschel R,Gallhofer B,Kaps M

    更新日期:2007-06-15 00:00:00

  • Diminished emotional sweating in patients with limbic encephalitis.

    abstract:OBJECTIVE:Sweating on the palms of the hands and soles of the feet, so-called emotional sweating, is considered to be mediated by the limbic system, including the amygdala and anterior cingulate cortex. To reveal involvement of the limbic system in emotional sweating, we evaluated emotional sweating on the palms in pat...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Asahina M,Fujinuma Y,Yamanaka Y,Fukushima T,Katagiri A,Ito S,Kuwabara S

    更新日期:2011-07-15 00:00:00

  • Risk factors, management and outcome of subtypes of ischemic stroke: a stroke registry from the Arabian Gulf.

    abstract:BACKGROUND:Data on the determinants and outcome of ischemic stroke (IS) from the Arabian Gulf countries (AGC) are still scanty. The aim of this study was to characterize IS in six large stroke centers on the Arabian peninsula. METHODS:IS subtypes were evaluated in four AGC from January 2006 to December 2007 in a large...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Deleu D,Inshasi J,Akhtar N,Ali J,Vurgese T,Ali S,Rajan M,AlMutairy M,Zayed A,Paulose G,Nouri K,Thussu A,Miyares FR,Abdeen T,AlHail H,Alshubaili A,Mahmoud H

    更新日期:2011-01-15 00:00:00

  • Rare novel CYP2U1 and ZFYVE26 variants identified in two Pakistani families with spastic paraplegia.

    abstract:BAKGROUND:Hereditary Spastic paraplegias (HSPs) are a clinically and genetically heterogeneous group of degenerative disorders characterized by progressive spasticity and weakness of the lower limbs. This study aimed to identify causative gene variants in two unrelated consanguineous Pakistani families presented with 2...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Bibi F,Efthymiou S,Bourinaris T,Tariq A,Zafar F,Rana N,Salpietro V,Houlden H,Raja GK,SYNaPS Study Group.,Saeed S,Minhas NM

    更新日期:2020-04-15 00:00:00

  • The susceptibility of rat diabetic nerve to ischemia: increased or decreased?

    abstract::Diabetic nerve reveals a peculiar paradox between its physiological resistance to ischemia, in conducting impulses for longer than control nerve during ischemia, and its morphological liability to more severe pathological changes of nerve fiber when rendered ischemic. These paradoxical phenomena, however, have never b...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Nukada H

    更新日期:1993-11-01 00:00:00

  • Cryptococcal meningitis in a multiple sclerosis patient taking natalizumab.

    abstract:IMPORTANCE:Natalizumab was approved in 2004 by the US Food and Drug Administration (US-FDA) for treatment of multiple sclerosis (MS), however it was temporarily withdrawn after its use was associated with progressive multifocal leukoencephalopathy (PML). Other reported adverse events have included melanoma, primary cen...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Valenzuela RM,Pula JH,Garwacki D,Cotter J,Kattah JC

    更新日期:2014-05-15 00:00:00

  • Laryngeal stridor in multiple system atrophy: Clinicopathological features and causal hypotheses.

    abstract::Laryngeal stridor is recognized as a characteristic clinical manifestation in patients with multiple system atrophy (MSA). However, the pathogenic mechanisms underlying this symptom are controversial. Neurogenic atrophy of the posterior cricoarytenoid muscle has been identified in cases of MSA, suggesting that larynge...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,评审


    authors: Ozawa T,Sekiya K,Aizawa N,Terajima K,Nishizawa M

    更新日期:2016-02-15 00:00:00

  • Early (1 h) administration of tissue plasminogen activator reduces infarct volume without increasing hemorrhagic transformation after focal cerebral embolization in rats.

    abstract::We assessed the incidence of hemorrhagic transformation and infarct volume after early intravenous infusion of recombinant human tissue plasminogen activator (rht-PA) in a newly developed rat cerebral embolic model. Male Wistar rats (n=60) were subjected to middle cerebral artery (MCA) occlusion by a single fibrin ric...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Zhang RL,Chopp M,Zhang ZG,Divine G

    更新日期:1998-09-18 00:00:00

  • CYP2D6 phenotypes and Parkinson's disease risk: a meta-analysis.

    abstract:BACKGROUND:CYP2D6 polymorphisms have been reported to be associated with Parkinson's disease (PD) susceptibility, but the results of these previous studies were inconsistent. OBJECTIVES:To explore whether PD patients with CYP2D6 gene variation have different risk to PD to those with normal function of CYP2D6. METHODS...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,meta分析


    authors: Lu Y,Peng Q,Zeng Z,Wang J,Deng Y,Xie L,Mo C,Zeng J,Qin X,Li S

    更新日期:2014-01-15 00:00:00

  • Potassium channel antibody-associated encephalitis with hypothalamic lesions and intestinal pseudo-obstruction.

    abstract::A subgroup of limbic encephalitis is associated with antibodies against voltage-gated potassium channels (VGKC), and responds well to immuno-modulating therapies. Anti-VGKC antibodies are also found in Isaacs' syndrome and Morvan's syndrome, both of which are sometimes complicated by thymoma. We describe a 52-years-ol...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Sekiguchi Y,Takahashi H,Mori M,Ito S,Shimada H,Hattori T,Kuwabara S

    更新日期:2008-06-15 00:00:00

  • Opsoclonus-myoclonus syndrome associated with human herpes virus-6 rhomboencephalitis.

    abstract::Opsoclonus-myoclonus syndrome (OMS) is characterized by opsoclonus and arrhythmic-action myoclonus that predominantly involves the trunk, limbs, and head. Human herpes virus-6 (HHV-6) can rarely cause encephalitis in immunocompetent children and adults. Here we report on a case of OMS associated with HHV-6 rhomboencep...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Belcastro V,Piola M,Binda S,Santoro D,Rezzonico M,Arnaboldi M

    更新日期:2014-06-15 00:00:00

  • Acute nerve compression during limb ischaemia--an experimental study.

    abstract::In 6 baboons the deep peroneal nerve was compressed for 1 hr by a weighted cord laid over the leg just above the ankle. The procedure was carried out on both sides in a single experiment. On one side the whole leg was rendered ischaemic by a cuff round the thigh which was maintained for 3 or 4 hr before and during the...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Williams IR,Jefferson D,Gilliatt RW

    更新日期:1980-05-01 00:00:00

  • Effects of cholinergic drugs on learning impairment in ventral globus pallidus-lesioned rats.

    abstract::The excitotoxin kainic acid (10 nmol/microliter) was used to produce bilateral lesions in the nucleus basalis magnocellularis (NBM) of rats which provides extensive cholinergic innervation to the cerebral cortex. The behavioral effects of physostigmine, THA (9-amino-1,2,3,4-tetrahydroacridine hydrochloride) and NIK-24...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Ueki A,Miyoshi K

    更新日期:1989-03-01 00:00:00

  • Muscle pathology in Marinesco-Sjögren syndrome.

    abstract::Three of 4 adult patients with Marinesco-Sjögren syndrome (MSS; 2 males and 2 females, aged 26-31 years) in 2 families became non-ambulant because of slowly progressive muscular weakness rather than cerebellar ataxia. Other clinical features in these 4 patients were typical for MSS: bilateral cataracts from infancy, m...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Komiyama A,Nonaka I,Hirayama K

    更新日期:1989-01-01 00:00:00

  • A DWI study of the contralateral hemisphere in cerebral hemiatrophy.

    abstract:BACKGROUND AND AIM:Cerebral hemiatrophy (CHA) is a congenital or acquired loss of volume in one hemisphere of the brain. The MR findings of the affected hemisphere have been a subject of many studies, however, the contralateral hemisphere has not been investigated. There is, in fact, an integrity between two hemisphere...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Öztoprak B,Öztoprak İ,Bozkurt H,Çiğdem B,Yıldız ÖK

    更新日期:2016-04-15 00:00:00

  • Multiple cerebral infarctions in a young patient with heroin-induced hypereosinophilic syndrome.

    abstract::Hypereosinophilic syndrome represents a rare cause for cerebral infarctions and inflammatory neurological disorders. Various possible pathogenic mechanisms for cerebral infarctions have already been discussed. Complex mechanisms including a local hypercoagulability by eosinophilic granules as well as a direct damage t...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Bolz J,Meves SH,Kara K,Reinacher-Schick A,Gold R,Krogias C

    更新日期:2015-09-15 00:00:00

  • Baroreflex sensitivity and heart rate variability are predictors of mortality in patients with aneurysmal subarachnoid haemorrhage.

    abstract:OBJECT:We aimed to investigate the link between the autonomic nervous system (ANS) impairment, assessed using baroreflex sensitivity (BRS) and heart rate variability (HRV) indices, and mortality after aneurysmal subarachnoid haemorrhage (aSAH). METHODS:A total of 57 patients (56 ± 18 years) diagnosed with aSAH were re...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Uryga A,Burzyńska M,Tabakow P,Kasprowicz M,Budohoski KP,Kazimierska A,Smielewski P,Czosnyka M,Goździk W

    更新日期:2018-11-15 00:00:00

  • Immunological relationship between a demyelinating RNA enveloped budding virus (Semliki Forest) and brain glycolipids.

    abstract::A monoclonal antibody (MAb) raised against central nervous system (CNS) myelin (212) and a MAb (308) raised against brain with Semliki Forest virus (SFV) were both found to react against the same CNS glycolipids. Both these MAbs were also found to react strongly with SFV and against certain brain glycolipid fractions ...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Khalili-Shirazi A,Gregson N,Webb HE

    更新日期:1986-11-01 00:00:00

  • Clinical and histological findings in proteolipid protein-induced experimental autoimmune encephalomyelitis (EAE) in the Lewis rat. Distribution of demyelination differs from that in EAE induced by other antigens.

    abstract::Proteolipid protein (PLP) is the major protein of central nervous system (CNS) myelin. In some species, intradermal inoculation with PLP and adjuvants causes experimental autoimmune encephalomyelitis (PLP-EAE) characterized by neurological signs of tail and limb weakness and by inflammation and demyelination in the CN...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Chalk JB,McCombe PA,Smith R,Pender MP

    更新日期:1994-05-01 00:00:00

  • Brain MRI findings in patients with Fabry disease.

    abstract:BACKGROUND:To evaluate the presence of ischemic and hemorrhagic lesions in brain MRI of patients with Fabry disease (FD). METHODS:Brain MRI studies in 46 consecutive patients were evaluated using classic sequences as well as GRE-weighted images, for ischemic lesions and chronic microbleed detection. Of the 36 adult pa...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Reisin RC,Romero C,Marchesoni C,Nápoli G,Kisinovsky I,Cáceres G,Sevlever G

    更新日期:2011-06-15 00:00:00

  • Effects of naftopidil on inhibitory transmission in substantia gelatinosa neurons of the rat spinal dorsal horn in vitro.

    abstract:OBJECTIVE:Naftopidil is used clinically for the treatment of voiding disorders in benign prostatic hyperplasia. Previous in vivo experiments in which naftopidil was applied intrathecally abolished rhythmic bladder contraction, suggesting that naftopidil might inhibit a voiding reflex through interaction with spinal dor...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Uta D,Xie DJ,Hattori T,Kasahara KI,Yoshimura M

    更新日期:2017-09-15 00:00:00

  • The vasculature of experimental brain tumours. Part 1. A sequential light and electron microscope study of angiogenesis.

    abstract::The process of vascularisation was studied in transplanted astrocytomas in BD-IX rats. The development of blood vessels was followed from the earliest signs of angiogenesis throughout tumour growth. On the basis of tumour vasculature, 3 consecutive stages of tumour growth could be distinguished; avascular, early vascu...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Deane BR,Lantos PL

    更新日期:1981-01-01 00:00:00

  • Enzyme and protein studies of demyelination in diabetes.

    abstract::Neuropathological evidence of demyelination was found in the brain and sciatic nerve of diabetic patients at autopsy. The activity of acid proteinase was somewhat increased in the white matter but decreased in the gray matter of diabetic patients. No increase was observed in the activity of neutral proteinase in diabe...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Palo J,Reske-Nielsen E,Riekkinen P

    更新日期:1977-08-01 00:00:00

  • Zika virus infection and risk of Guillain-Barré syndrome: A meta-analysis.

    abstract:OBJECTIVE:Findings from studies of the association between Zika virus (ZIKV) infection and Guillain-Barré syndrome (GBS) are inconsistent. I conducted a systematic review and meta-analysis to clarify the nature of this association. METHODS:I searched PubMed, Scopus, Cochrane, CINAHL, Web of Science, Scielo, and DOAJ f...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章,meta分析


    authors: Bautista LE

    更新日期:2019-08-15 00:00:00

  • New development in diagnosis of vascular cognitive impairment.

    abstract::Despite availability of harmonized criteria for the investigation of patients with presumed "vascular cognitive impairment (VCI)" there exists no clear definition of VCI. The challenge lies in the definition of those vascular components being responsible for the cognitive-behavioural decline of elderly patients. We ad...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Cavalieri M,Schmidt R

    更新日期:2010-12-15 00:00:00

  • Multisequence-imaging protocols to detect cortical lesions of patients with multiple sclerosis: observations from a post-mortem 3 Tesla imaging study.

    abstract::Neocortical lesions (NLs) are an important component of multiple sclerosis (MS) pathology and may account for part of the physical and cognitive disability. Visualizing NLs of patients with MS using magnetic resonance imaging (MRI) poses several significant challenges. We optimized the inversion time (TI) of T(1)-base...

    journal_title:Journal of the neurological sciences

    pub_type: 杂志文章


    authors: Bagnato F,Yao B,Cantor F,Merkle H,Condon E,Montequin M,Moore S,Quezado M,Tkaczyk D,McFarland H

    更新日期:2009-07-15 00:00:00