Comparison of two latex agglutination test kits for serum myoglobin in the exclusion of acute myocardial infarction.


:The Myolex (Orion) and the RapiTex (Behringwerke) latex agglutination tests for the rapid detection of elevated levels of serum myoglobin were studied prospectively in patients suspected of acute myocardial infarction, who were admitted to hospital within 8 h of pain onset. Using admission blood samples drawn 3.4 +/- 2.0 h (mean +/- SD) after onset of symptoms, the negative predictive values of both tests were too low to use these assays in the early exclusion of myocardial infarction in the emergency department. However, the negative predictive values obtained with the second blood samples, drawn 4 h later, indicated that the myoglobin agglutination test could be of value in the exclusion of myocardial infarction.


Ann Clin Biochem


Konings CH,Funke Küpper AJ,Verheugt FW




Has Abstract


1989-05-01 00:00:00








26 ( Pt 3)


  • High-performance liquid chromatography methods for the analysis of endogenous cortisol and cortisone in human urine: comparison of mass spectrometry and fluorescence detection.

    abstract:BACKGROUND:The analysis of steroids in biological matrices is challenging. One can apply immunoassay as well as gas and liquid chromatography with various types of detection, depending on the available equipment and the experience of the analyst. The question is how the methods are interchangeable between themselves. D...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Kosicka K,Siemiątkowska A,Szpera-Goździewicz A,Krzyścin M,Bręborowicz G,Główka F

    更新日期:2019-01-01 00:00:00

  • Simplified gas chromatographic assay for paracetamol.

    abstract::A rapid gas liquid chromatography method has been developed which is suitable for emergency estimations of paracetamol in overdose. The method is compared with a standard ultraviolet method. ...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Stewart MJ,Willis RG

    更新日期:1975-01-01 00:00:00

  • Pregnancy and inherited metabolic disorders: maternal and fetal complications.

    abstract::Some inherited metabolic disorders (IMDs) can cause significant complications during pregnancy, affecting the mother and/or the fetus. Although it appears that only a minority of IMDs have these effects, experience is still being acquired. For some disorders, patients will not have reached child-bearing age. Pregnanci...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章,评审


    authors: Preece MA,Green A

    更新日期:2002-09-01 00:00:00

  • Postoperative serum urea is associated with 30-day mortality in patients undergoing emergency abdominal surgery.

    abstract:BACKGROUND:Emergency abdominal surgery carries considerable postoperative morbidity and mortality. Hypovolaemia is considered to be a cause of renal hypoperfusion, which is associated with a decreased clearance of serum urea and creatinine. This study examines whether the perioperative serum urea and creatinine concent...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Harten J,Hay A,McMillan DC,McArdle CS,O'Reilly DS,Kinsella J

    更新日期:2006-07-01 00:00:00

  • Can we interpret serum thyroglobulin results?

    abstract::Thyroglobulin (Tg) is a tumour marker for differentiated thyroid cancer. Interpretation requires a knowledge of the current thyrotropin (TSH) concentration as secretion is TSH-dependent. While a raised serum Tg may be indicative of residual or recurrent thyroid cancer, trauma to the thyroid (e.g. surgical, biopsy or d...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章,评审


    authors: Clark P,Franklyn J

    更新日期:2012-07-01 00:00:00

  • Comparison of sample types for N-terminal pro-B-type natriuretic peptide measured on the Siemens Immulite 2500 and Dimension Vista LOCI methods.

    abstract:BACKGROUND:Measurement of serum natriuretic peptides is recommended in patients with suspected heart failure. Assays for N-terminal pro-B-type natriuretic peptide (NT-proBNP) are available on several platforms and can be measured in serum or heparinized plasma. Siemens Healthcare Diagnostics do not recommend the use of...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Peake RW,Turner HE,Leaper W,Deans KA,Hannah A,Croal BL

    更新日期:2012-09-01 00:00:00

  • Interference by haemoglobin with the cresolphthalein complexone method for serum calcium measurement.

    abstract::The spectral interference caused by haemoglobin in the calcium-cresolphthalein complexone reaction was investigated. The results show that the nature of the haemoglobin derivative in the reaction mixture influences the degree of interference; in turn, the derivative formed depends on the order in which the sample and ...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Corns CM

    更新日期:1990-03-01 00:00:00

  • Comparison of cardiac troponin T and I and CK-MB for the detection of minor myocardial damage during interventional cardiac procedures.

    abstract::A number of cardiac interventional procedures are available for the treatment of angina, including percutaneous transluminal coronary angioplasty (PTCA), stent insertion and rotational atherectomy (RA). Variable degrees of myocardial cell injury during PTCA and stent insertion have been observed, based on rises in cre...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Harris BM,Nageh T,Marsden JT,Thomas MR,Sherwood RA

    更新日期:2000-11-01 00:00:00

  • A method for measuring glycerol-blanked triglyceride concentrations by using gas chromatography-isotope dilution mass spectrometry.

    abstract:BACKGROUND:Serum triglyceride concentrations are measured as total glycerides content in many Western countries. In Japan, glycerol-blanked triglycerides (TG-GB) are measured to identify postprandial hypertriglyceridaemia and to minimize the influence of glycerol formulation on serum triglyceride values. However, TG-GB...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Koyama I,Imano H,Nakamura M,Kitamura A,Kiyama M,Miyamoto Y,Iso H

    更新日期:2020-05-01 00:00:00

  • An unusual cause of interference in a salicylate assay caused by mitochondrial acetoacetyl-CoA thiolase deficiency.

    abstract::Mitochondrial acetoacetyl-CoA thiolase deficiency (or beta-ketothiolase deficiency) is a rare metabolic disorder characterized by acute episodes of severe acidosis and ketosis. A case is presented of an 18-month-old boy who presented with vomiting and diarrhoea and was found to be markedly acidotic. When the acidosis ...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Tilbrook LK,Slater J,Agarwal A,Cyriac J

    更新日期:2008-09-01 00:00:00

  • Revised national guidelines for analysis of cerebrospinal fluid for bilirubin in suspected subarachnoid haemorrhage.

    abstract::It is crucially important to detect subarachnoid haemorrhage (SAH) in all patients in whom it has occurred to select patients for angiography and preventative surgery. A computerized tomography (CT) scan is positive in up to 98% of patients with SAH presenting within 12 h, but is positive in only 50% of those presenti...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Cruickshank A,Auld P,Beetham R,Burrows G,Egner W,Holbrook I,Keir G,Lewis E,Patel D,Watson I,White P,UK NEQAS Specialist Advisory Group for External Quality Assurance of CSF Proteins and Biochemistry.

    更新日期:2008-05-01 00:00:00

  • Glycosylated haemoglobin by affinity chromatography in diabetic and non-diabetic children.

    abstract::We have made an evaluation of glycosylated haemoglobin measurements by affinity chromatography in a paediatric population. Age-related reference values for non-diabetic infants and children are reported. A poor correlation (r = 0.24) was found between glycosylated haemoglobin values in 26 insulin-dependent diabetic ch...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: van Heyningen C,Hanid TK,Hopkinson I

    更新日期:1986-07-01 00:00:00

  • Bromocresol purple and the measurement of albumin. Falsely high plasma albumin concentrations eliminated by increased reagent ionic strength.

    abstract::This study was undertaken to investigate the extent of the reported discrepancy between serum and plasma albumin concentrations measured by the bromocresol purple (BCP) method. We have shown that plasma albumin concentrations are falsely increased by turbidity due to the precipitation of fibrinogen when plasma is dilu...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Hill PG,Wells TN

    更新日期:1983-09-01 00:00:00

  • Comparison of simple acid-ethanol precipitation with gel exclusion chromatography for measuring leptin binding in serum of normal subjects and cancer patients.

    abstract:BACKGROUND:In humans, leptin circulates in a free form and is also bound to macromolecules. The aim of the present study was to compare a rapid acid-ethanol precipitation (AEP) method of measuring bound leptin with the more laborious gel exclusion chromatography (GEC) reference procedure. Serum samples collected from h...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Jamieson NB,McMillan DC,Brown DJ,Wallace AM

    更新日期:2003-03-01 00:00:00

  • Enzyme activities of the mitochondrial energy generating system in skeletal muscle tissue of preterm and fullterm neonates.

    abstract::Quadriceps muscle specimens from autopsy of 28 neonates (gestational age 25-42 weeks) were investigated to determine pyruvate and malate oxidation rates and several enzymes of the mitochondrial oxidative process. In general, the levels of all mitochondrial parameters measured, including carnitine levels, were lower in...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Sperl W,Sengers RC,Trijbels JM,Ruitenbeek W,Doesburg WH,Smeitink JA,Kollée LA,Boon JM

    更新日期:1992-11-01 00:00:00

  • Development of a rapid liquid chromatography tandem mass spectrometry method for the quantitation of serum dexamethasone and its clinical verification.

    abstract::Background Measurement of serum dexamethasone during the overnight dexamethasone-suppression test has been recommended to reduce false-positive results when investigating Cushing's syndrome or increasingly commonly found adrenal incidentalomas. Despite this, there remains a paucity of well-validated dexamethasone meth...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Hawley JM,Owen LJ,Debono M,Newell-Price J,Keevil BG

    更新日期:2018-11-01 00:00:00

  • Interpreting indicators of iron status during an acute phase response--lessons from malaria and human immunodeficiency virus.

    abstract::Iron status is influenced by inflammation when the normal control of iron metabolism is reorganized by the primary mediators of the acute phase response, tumour necrosis factor-alpha and interleukin-1. The objective of this review is to show how indices of iron status, particularly haemoglobin, serum ferritin and solu...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章,评审


    authors: Northrop-Clewes CA

    更新日期:2008-01-01 00:00:00

  • A combined laboratory and field evaluation of the Cholestech LDX and CardioChek PA point-of-care testing lipid and glucose analysers.

    abstract:BACKGROUND:Combined lipid and glucose point-of-care testing (POCT) devices could facilitate widespread population screening for cardiovascular disease (CVD) and diabetes as part of the NHS Vascular Risk Assessment and Management Program (NHS Health Checks). An evaluation of the Cholestech LDX and CardioChek PA POCT ana...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Whitehead SJ,Ford C,Gama R

    更新日期:2014-01-01 00:00:00

  • An evaluation of measured and calculated serum free cortisol in a group of patients with known adrenal suppression.

    abstract:BACKGROUND:Since more than 90% of cortisol is bound to protein, serum free cortisol (SFC) may be a more appropriate marker of adrenal status than total cortisol. However, measurement of SFC is technically difficult and calculated SFC may offer a more practical alternative. METHODS:SFC, measured by equilibrium dialysis...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Barlow NL,Holme J,Stockley RA,Clark PM

    更新日期:2010-05-01 00:00:00

  • A novel five-microlitre capillary system for home glucose monitoring.

    abstract::Improvement in the control of diabetic patients is aided by a knowledge of blood glucose levels during a 'normal' (non-hospitalised) day. We have devised a 5 microliter capillary tube collection system as a 'kit' for home use by diabetics. Blood collected into 5 microliter capillary tubes is washed into a protein prec...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Williams CP,Davies GK,Child DF

    更新日期:1981-09-01 00:00:00

  • A rapid anion exchange high-performance liquid chromatography method for the measurement of HbA2 in whole blood.

    abstract::We developed a binary gradient high-performance liquid chromatography (HPLC) method for measuring HbA2 in whole blood samples using a Pharmacia Mono Q column (1 mL) and measurement at 415 nm. The assay requires a simple lysis and centrifugation step before injection onto the column. We found good agreement of results ...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Keevil BG,Maylor PW,Rowlands D

    更新日期:1996-05-01 00:00:00

  • Serum and plasma 5-hydroxyindoleacetic acid as an alternative to 24-h urine 5-hydroxyindoleacetic acid measurement.

    abstract:BACKGROUND:Neuroendocrine tumours are slow growing tumours known to secrete a variety of vasoactive peptides which give rise to symptoms of the carcinoid syndrome. The diagnosis and monitoring of patients with neuroendocrine tumours is undertaken in many centres using 24 h urinary measurement of 5-hydroxyindoleacetic a...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Adaway JE,Dobson R,Walsh J,Cuthbertson DJ,Monaghan PJ,Trainer PJ,Valle JW,Keevil BG

    更新日期:2016-09-01 00:00:00

  • A meta-analysis of leptin reference ranges in the healthy paediatric prepubertal population.

    abstract:OBJECTIVE:The initial discovery of leptin (1994) has given rise to a substantial number of published studies. This study aimed at identifying the published data on the reference ranges of total, free and bound leptin concentration in the healthy prepubertal population. METHODS:A search was conducted on original Englis...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章,meta分析


    authors: Venner AA,Doyle-Baker PK,Lyon ME,Fung TS

    更新日期:2009-01-01 00:00:00

  • The effect of eccentric exercise on serum creatine kinase activity in different ethnic groups.

    abstract::Eccentric exercise causes release of muscle creatine kinase (CK) 3-4 days after exercise. Racial variation in basal serum CK has been reported but the reasons for this are unknown. We studied 30 subjects of different ethnic origin (Caucasian, Afro-Caribbean, Asian) before and after eccentric exercise. Basal serum CK w...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Sherwood RA,Lambert A,Newham DJ,Wassif WS,Peters TJ

    更新日期:1996-07-01 00:00:00

  • Identification of molecular species of cholesteryl ester hydroperoxides in very low-density and intermediate-density lipoproteins.

    abstract:BACKGROUND:Oxidation of lipoproteins is thought to play a crucial role in atherogenesis. Role for triglyceride-rich lipoproteins in atherogenesis is unclear. Thus, we aimed to investigate whether cholesteryl ester hydroperoxides (CEOOH) are present in very low-density lipoproteins (VLDL) and intermediate-density lipopr...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Shrestha R,Hui SP,Sakurai T,Yagi A,Takahashi Y,Takeda S,Jin S,Fuda H,Chiba H

    更新日期:2014-11-01 00:00:00

  • Diagnostic value of pleural effusion ischaemia-modified albumin in patients with cardiac failure.

    abstract:BACKGROUND:Ischaemia-modified albumin (IMA) is a relatively new marker of ischaemia. IMA has not been studied previously in pleural effusions due to congestive heart failure (CHF). The aim of our study was to assess the diagnostic value of IMA in the pleural fluid (PF) and serum for the identification of pleural effusi...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Ozsu S,Gulsoy A,Karahan SC,Mentese A,Nuhoglu I,Ozlu T

    更新日期:2011-01-01 00:00:00

  • A novel method for measuring serum ornithine carbamoyltransferase.

    abstract:BACKGROUND:Serum ornithine carbamoyltransferase is a diagnostic marker of hepatic disorders due to its localization in periportal mitochondria. METHODS:We have developed a new method for the determination of serum ornithine carbamoyltransferase. It is based on the reverse reaction of ornithine carbamoyltransferase, us...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Ishikawa H,Matsuzawa T,Ohashi K,Nagamura Y

    更新日期:2003-05-01 00:00:00

  • Identification of glucagon-like peptide-1(7-36) amide in rat brain.

    abstract::Acid-urea extract of rat brain was examined by glucagon-like peptide-1 (GLP-1) specific radioimmunoassay. A single peak was observed which co-eluted with GLP-1(7-36)amide on gel filtration and anion exchange chromatography. In contrast, GLP-1(1-37) was not detected under our experimental conditions. The fact that GLP-...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Yoshimoto S,Hirota M,Ohboshi C,Shima K

    更新日期:1989-03-01 00:00:00

  • High-density lipoprotein, lipid, and carbohydrate metabolism during increasing fitness.

    abstract::Eleven unfit bank executives in sedentary employment exercised daily for 10 weeks according to the Canadian Air-Force 5BX Exercise Programme. Over this period no changes were observed in the glucose or insulin responses to a standard breakfast or to intravenous glucose, or in the glucose response to intravenous insuli...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Moore RA,Penfold WA,Simpson RD,Simpson RW,Mann JI,Turner RC

    更新日期:1979-03-01 00:00:00

  • A study of high-, middle- and low-molecular weight adiponectin in urine as a surrogate marker for early diabetic nephropathy using ultrasensitive immune complex transfer enzyme immunoassay.

    abstract::Background For the early identification of patients at risk of developing diabetic nephropathy, we have developed an ultrasensitive immune complex transfer enzyme immunoassay to measure adiponectin in urine. Methods We developed immune complex transfer enzyme immunoassay for adiponectin and measured urinary adiponecti...

    journal_title:Annals of clinical biochemistry

    pub_type: 杂志文章


    authors: Yamamoto M,Fujimoto Y,Hayashi S,Hashida S

    更新日期:2018-09-01 00:00:00