Abstract:
:Certain phthalates have adverse effects on male reproductive functions in animals, and potentially affect human testicular function and spermatogenesis, but little is known about the active mechanisms. We measured the urinary and seminal phthalate metabolites and explored their associations on insulin-like factor 3 (INSL3) and semen quality. Urine, blood, and semen samples were collected from the male partners of subfertile (n = 253) and fertile (n = 37) couples in a reproductive center in southern Taiwan. INSL3, reproductive hormones, semen-quality, and 11 phthalate metabolites in urine and semen were measured. There were significant correlations in the distribution pattern of metabolites, such as the relative contribution of low or high molecular weight phthalate metabolites. The significantly monotonic trends in semen volume, sperm concentration and motility were associated with increasing quartiles of INSL3 (all p-trend < 0.001). In adjusted regression models, increases in urinary phthalate metabolites levels were adversely associated with sperm concentration (monobenzyl phthalate [MBzP], mono-2-ethylhexyl phthalate [MEHP] and MEHP%), motility (MBzP and MEHP) and INSL3 (MBzP, MEHP and MEHP%) (all p < 0.01). Higher seminal phthalate metabolite levels were associated with decreases in sperm concentration (MEHP and mono-2-ethyl-5-hydroxyhexyl phthalate), motility (mono-ethyl phthalate [MEP] and di-(2-ethylhexyl) phthalate [DEHP] metabolites), normal morphology (MEP), and INSL3 (monomethyl phthalate and MEP) (all p < 0.05). Our data suggest that INSL3 secretion, reproductive hormone balance, and sperm production and quality might be simultaneously adversely affected for individuals excreting increasing levels of phthalates metabolites (especially di-ethyl phthalate, butylbenzyl phthalate, and DEHP) in urine and semen samples.
journal_name
Chemospherejournal_title
Chemosphereauthors
Chang WH,Wu MH,Pan HA,Guo PL,Lee CCdoi
10.1016/j.chemosphere.2017.01.056subject
Has Abstractpub_date
2017-04-01 00:00:00pages
594-602eissn
0045-6535issn
1879-1298pii
S0045-6535(17)30066-8journal_volume
173pub_type
杂志文章相关文献
CHEMOSPHERE文献大全abstract::Microcystins and copper commonly co-exist in the natural environment, but their combined toxicity remains unclear, especially in terrestrial plants. The present study investigated the toxicity effects of microcystin-LR (0, 5, 50, 500, 1000 μg L-1) and copper (0, 50, 500, 1000, 2000 μg L-1), both individually and in mi...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2018.05.051
更新日期:2018-09-01 00:00:00
abstract::This study investigated the degradation efficiency of BTA using combination of ultrasound (US), peroxymonosulfate (PMS), and ozone. The effects of different operational parameters were investigated to optimize the process performance. The results showed that the highest removal efficiency was reached at neutral pH, oz...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2019.125326
更新日期:2020-04-01 00:00:00
abstract::The disinfection of helminth eggs and Escherichia coli contaminated aqueous solutions, was studied using an electro-Fenton reactor equipped with a polarized activated carbon (AC) packed bed and two chambers loaded with cation exchange resins. Experiments using different arrangements and operation conditions, revealed ...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2020.126260
更新日期:2020-07-01 00:00:00
abstract::Target compound analysis with scanning mass spectrometers such as quadrupole or magnetic sector instruments is used extensively in environmental chemistry because of the selectivity, sensitivity, and robustness. Yet, target compound analysis selectively ignores the majority of compounds present in a sample, especially...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2014.02.032
更新日期:2014-12-01 00:00:00
abstract::An in vitro method that simulated the physiological conditions of the digestive process was applied to samples taken from an old mining site, providing information on the levels of metals (Cd, Pb and As) that can be ingested and assimilated by humans. Samples were first characterized by determining pH, texture, minera...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2005.08.017
更新日期:2006-04-01 00:00:00
abstract::The study aimed at to determine the magnitude of the methane (CH(4)) and nitrous oxide (N(2)O) flux rates in soils at Hennequin Point, King George Island, Antarctic, under different slope positions, vegetal covers and presence of skuas, as well as to evaluate the main soil and climate factors that are involved with th...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2012.08.013
更新日期:2013-01-01 00:00:00
abstract::Biochar, as a soil amendment, can increase concentrations of soil organic matter, especially water-extractable organic carbon (WEOC). This can affect the adsorption-desorption equilibrium between the dissolved solid phases in soil organic matter. Dissolved organic carbon (DOC) represents a small proportion of soil org...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2011.12.007
更新日期:2012-04-01 00:00:00
abstract::The potential toxicity of copper nanoparticles (CuNPs) to early stages of fishes is not fully understood, and little is known about their effects on ionocytes and associated functions. This study used zebrafish embryos as a model to investigate the toxic effects of CuNPs on two subtypes of ionocytes. Zebrafish embryos...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2020.128051
更新日期:2020-12-01 00:00:00
abstract::Mine wastes from abandoned exploitations are sources of high concentrations of hazardous metal(oid)s. Although these contaminants can be attenuated by sorbing to secondary minerals, in this work we identified a mechanism for long-distance dispersion of arsenic and metals through their association to mobile colloids. W...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2018.01.100
更新日期:2018-04-01 00:00:00
abstract::Herein, a facile strategy to fabricate the novel manganese oxide-imprinted mesoporous carbons (MOPCx, x presents for pyrolysis temperature) was described via the direct pyrolysis of Mn2(BDC)2(DMF)2 (BDC = 1,4-benzenedicarboxylate, DMF = N,N-dimethylformamide) as a self-sacrificed template at various temperatures (x = ...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2019.04.079
更新日期:2019-07-01 00:00:00
abstract::Organochlorine pesticides are persistent lipophilic organic pollutants and tend to accumulate in growing plants. During growth, cork is in contact with the open air for long periods (9-12 years). Owing to the previous widespread use of organochlorine pesticides and their high persistence in the environment, there is a...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2011.11.009
更新日期:2012-02-01 00:00:00
abstract::The bioaccumulation of six metals (Fe, Mn, Zn, Cd, Pb and Cu) was studied as part of the monitoring of the Aznalcóllar mining spill (April 1998) on the Guadalquivir estuary and in other estuaries located in the Gulf of Cádiz. Fish, clams and oysters were collected during different seasonal periods along the years 2000...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2004.02.015
更新日期:2005-02-01 00:00:00
abstract::To determine the toxicity of the anti-rheumatic drug diclofenac to Daphnia magna, acute toxicity tests according to the OECD guideline 202 were combined with biochemical investigations of the hsp70 level as a biomarker for proteotoxicity. Particular attention was paid to the impact of the solvent DMSO as a confounding...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2008.05.062
更新日期:2008-09-01 00:00:00
abstract::Random amplified polymorphic DNA (RAPD) test is a feasible method to evaluate the toxicity of environmental pollutants on vegetal organisms. Herein, Arabidopsis thaliana (Arabidopsis) plantlets following Cadmium (Cd) treatment for 26 d were screened for DNA genetic alterations by DNA fingerprinting. Four primers ampli...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2012.05.068
更新日期:2012-11-01 00:00:00
abstract::This study presents the first systematic information on the degradation patterns of clandestine drug laboratory chemicals in soil. The persistence of five compounds - parent drugs (methamphetamine, 3,4-methylenedioxymethamphetamine (MDMA)), precursor (pseudoephedrine), and synthetic by-products N-formylmethylamphetami...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2011.06.102
更新日期:2011-10-01 00:00:00
abstract::Increasing studies have established the toxic effects of BPA on development and reproduction in animals. In present study, we investigated epigenetic effects on the transcription of several ovarian steroidogenic genes in rare minnows Gobiocypris rarus after BPA exposure at 15 μgL-1 for 21, 42 and 63 d. Results showed ...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2019.124935
更新日期:2020-02-01 00:00:00
abstract::This study quantified the masses of 14 pesticides deposited as wet (precipitation) versus dry (gaseous and particle) atmospheric deposition at a research farm in southwestern Manitoba, Canada. The concentration in air of these pesticides was also measured. Total bulk deposition amounts (wet+dry) ranged from 0.009 to 2...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2012.10.071
更新日期:2013-02-01 00:00:00
abstract::Rice grains are a methylmercury (MeHg) intake route for humans, especially in certain mercury (Hg)-contaminated areas. For rice plant growth, animal manure is commonly used as an organic fertilizer; however, its role in the formation of MeHg in paddy soils remains poorly understood. The aims of this study were thus to...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2020.126166
更新日期:2020-06-01 00:00:00
abstract::To ascertain whether zearalenone (ZEA) could induce intestinal inflammation and investigate its possible mechanism, we investigated inflammatory cytokine release and the activation of the NLRP3 inflammasome after ZEA treatment both in vitro or in vivo. First, intestinal porcine enterocyte cell line (IPEC-J2) cells and...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2017.09.145
更新日期:2018-01-01 00:00:00
abstract::Associations between air pollution and blood pressure (BP) traits can be modified by several candidate genes, which might explain differences in individual genetic susceptibility. Based on recent evidence hypothesized to link air pollution and BP traits, we examined whether the polymorphisms of CDH13-a candidate gene-...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2018.11.125
更新日期:2019-03-01 00:00:00
abstract::Atrazine (ATZ) and its main metabolites, i.e., diaminochlorotriazine (DACT), deisopropylatrazine (DIP), and deethylatrazine (DE), have been widely detected in surface water around the world. In the present study, to determine their immunotoxic effects, zebrafish during the early developmental stage were exposed to ATZ...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2016.09.100
更新日期:2017-01-01 00:00:00
abstract::The migration of uranium(VI) in subsurface environments is strongly influenced by its adsorption/desorption reactions at the solid/solution interface. Phosphate is often present in subsurface systems and was shown to significantly affect U(VI) adsorption in previous batch experiments. In this study, column experiments...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2007.01.063
更新日期:2007-07-01 00:00:00
abstract::Nonylphenol (NP) is a commercially produced nonionic surfactant that has become a global environmental pollutant due to poor biodegradability. Many studies have confirmed that NP has detrimental effects on the central nervous system. However, the damaging roles of NP on the cerebellum and the underlying mechanisms rem...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2018.08.007
更新日期:2018-11-01 00:00:00
abstract::Mercury (Hg) is a well-known neurotoxicant but its toxicity depends on the species present. A steady emergence of inorganic Hg in the brain following chronic and accidental exposure to methylmercury (MeHg) has suggested that MeHg can undergo demethylation. The objective of this study is to develop an in vitro model to...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2008.09.019
更新日期:2008-12-01 00:00:00
abstract::Ciprofloxacin (CIP) biodegradation was investigated using enrichments obtained in the presence of magnetite nanoparticles, CIP and human fecal sewage. CIP addition inhibited methanogenic activity and altered the bacterial community composition. The magnetite-supplemented enrichments significantly promoted CIP biodegra...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2017.08.159
更新日期:2017-12-01 00:00:00
abstract::Various mathematical relationships have been used to assess exposure concentrations of organic chemicals when emissions occur via wastewater treatment. These relationships range from a simple removal factor calculation to more sophisticated approaches using kinetic based mathematical models. While these existing appro...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/s0045-6535(97)10198-9
更新日期:1998-04-01 00:00:00
abstract::Triadimenol is an effective meatabolite derived from the triazole fungicide triadimenfon. It is an agriculturally important reagent of environmentally emerging concern because of its broad use, persistent occurrence in the environment and greater fungicidal or toxic potency than the parent compound. However, the ecoto...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2016.02.078
更新日期:2016-06-01 00:00:00
abstract::Microorganisms play a key role in the redox transformation of arsenic (As) in aquifers. In this study, the impact of indigenous bacteria, especially the prevailing nitrate respirers, on arsenite (As(III)) oxidation was explored during groundwater filtration using granular TiO2 and subsequent spent TiO2 anaerobic landf...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2017.12.158
更新日期:2018-04-01 00:00:00
abstract::The ready biodegradability of twenty food additives, belonging to the classes of artificial sweeteners, natural sweeteners, preservatives and colorings, was investigated using activated sludge as inoculum and OECD 301F respirometric test. According to the results, saccharin, aspartame, sodium cyclamate, xylitol, eryth...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2019.125071
更新日期:2020-02-01 00:00:00
abstract::Passive sampling is increasingly applied for monitoring neutral hydrophobic compounds (HOC) in various environmental media like water, sediment, air and also soft biota tissue. Passive samplers for HOC are often constructed from permeable polymers like silicone and polyethylene (PE), while also SPMD are often applied....
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2019.01.164
更新日期:2019-05-01 00:00:00