Abstract:
AIM:To evaluate the clinical impact of combined 2-[18F]-fluoro-2-deoxy-d-glucose (FDG) positron-emission tomography/computed tomography (PET/CT) brain imaging performed in selected patients with cognitive impairment at a tertiary referral centre in the UK, and to assess the accuracy of FDG PET/CT to correctly establish the diagnosis of Alzheimer's dementia (AD) in "real-world" clinical practice. METHODS AND MATERIALS:Using an institutional radiology database, 136 patients were identified for inclusion in the study. FDG PET/CT was performed using a standard technique and interpreted by dual-trained radiologists and nuclear medicine physicians. Standardised questionnaires were sent to the referring clinicians to establish the final clinical diagnosis and to obtain information about the clinical impact of FDG PET/CT. RESULTS:There was a 72% questionnaire return (98/136), with mean patient follow-up of 471 (standard deviation 205) days. FDG PET/CT had an impact on patient management in 81%, adding confidence to the pre-test diagnosis in 43%, changing the pre-test diagnosis in 35%, reducing the need for further investigations in 42%, and resulting in a change in therapy in 32%. There was substantial correlation between the PET/CT diagnosis and final clinical diagnosis with a correlation (k) coefficient of 0.78 (p<0.0001). The accuracy of FDG PET/CT in diagnosis of AD was 94% (95% confidence interval [CI]: 87-99), with a sensitivity of 87% (95% CI: 75-92) and a specificity of 97% (95% CI: 87-99). CONCLUSION:FDG PET/CT brain imaging has a significant clinical impact when performed selectively in patients with cognitive impairment and shows high accuracy in the diagnosis of AD in "real-world" clinical practice.
journal_name
Clin Radioljournal_title
Clinical radiologyauthors
Motara H,Olusoga T,Russell G,Jamieson S,Ahmed S,Brindle N,Pillai A,Scarsbrook AF,Patel CN,Chowdhury FUdoi
10.1016/j.crad.2016.08.003subject
Has Abstractpub_date
2017-01-01 00:00:00pages
63-73issue
1eissn
0009-9260issn
1365-229Xpii
S0009-9260(16)30321-Xjournal_volume
72pub_type
杂志文章abstract:AIM:To undertake a pilot study assessing whether tumour heterogeneity evaluated using computed tomography texture analysis (CTTA) has the potential to provide a marker of tumour aggression and prognosis in oesophageal cancer. MATERIALS AND METHODS:In 21 patients, unenhanced CT images of the primary oesophageal lesion ...
journal_title:Clinical radiology
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doi:10.1016/j.crad.2011.08.012
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abstract::Duplex Doppler imaging was used to study the effect of pancreatic and bile duct tumours on portal vein and hepatic artery blood flow and the specific Doppler signals recorded from these tumours. Chaotic portal vein flow occurred in 35% (14) of pancreatic and 20% (6) of biliary tumours and complete portal vein occlusio...
journal_title:Clinical radiology
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abstract:AIM:To ascertain whether magnetic resonance imaging (MRI) can be used to suggest a diagnosis of endometrial carcinosarcoma. MATERIALS AND METHODS:A retrospective imaging review was performed of the MRI images of 39 patients with endometrial carcinosarcoma. Anteroposterior and longitudinal dimensions of the uterus and ...
journal_title:Clinical radiology
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doi:10.1016/s0009-9260(05)83052-1
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doi:10.1016/s0009-9260(05)81832-x
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journal_title:Clinical radiology
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journal_title:Clinical radiology
pub_type: 杂志文章,评审
doi:10.1016/j.crad.2004.01.004
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journal_title:Clinical radiology
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journal_title:Clinical radiology
pub_type: 杂志文章,评审
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更新日期:2020-10-17 00:00:00
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journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(05)83313-6
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doi:10.1016/j.crad.2010.09.006
更新日期:2011-02-01 00:00:00
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journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(05)81114-6
更新日期:1993-12-01 00:00:00
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journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(89)80189-8
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pub_type: 杂志文章
doi:10.1016/s0009-9260(80)80022-5
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journal_title:Clinical radiology
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doi:10.1016/s0009-9260(98)80170-0
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journal_title:Clinical radiology
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doi:10.1016/s0009-9260(05)81454-0
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journal_title:Clinical radiology
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doi:10.1016/s0009-9260(05)81880-x
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journal_title:Clinical radiology
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journal_title:Clinical radiology
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doi:10.1016/j.crad.2014.11.008
更新日期:2015-03-01 00:00:00
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journal_title:Clinical radiology
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doi:10.1016/s0009-9260(87)80388-4
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doi:10.1016/s0009-9260(05)80934-1
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abstract::The results are presented of a five-year prospective trial of 411 patients with breast carcinoma treated by mastectomy and post-operative radiotherapy. Twice or thrice weekly dose-fractionation techniques were used, i.e. 12 fractions in 28 days and six fractions in 18 days. The results show that, in terms of survival ...
journal_title:Clinical radiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1975-07-01 00:00:00
abstract::Currarino et al. in 1981 described an association between an anterior sacral defect, congenital anorectal stenosis or another type of low anorectal malformation and a presacral mass. We are only aware of one previous report in the English literature of the association of a rectovaginal fistula with this triad and to o...
journal_title:Clinical radiology
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更新日期:1994-04-01 00:00:00
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更新日期:1985-03-01 00:00:00
abstract::The cavernous sinus can be affected by a wide range of conditions including tumours, infection, inflammation, and trauma. Disease in the cavernous sinus can produce characteristic signs and symptoms, which relate to the numerous crucial structures traversing and surrounding the cavernous sinus. Imaging, with the use o...
journal_title:Clinical radiology
pub_type: 杂志文章,评审
doi:10.1016/j.crad.2010.06.009
更新日期:2010-11-01 00:00:00