Interleukin-17 regulation: an attractive therapeutic approach for asthma.

abstract：BACKGROUND:The home is the predominant environment for exposure to many environmental irritants such as air pollutants and allergens. Exposure to common indoor irritants including volatile organic compounds, formaldehyde and nitrogen dioxide, may increase the risk of snoring for children. The aim of this study was to i...

journal_title：Respiratory research

authors： Zhang G,Spickett J,Rumchev K,Lee AH,Stick S

更新日期：2004-11-04 00:00:00

abstract：BACKGROUND:Various signals are known to participate in the pathogenesis of lung fibrosis. Our aim was to determine which signal is predominantly mobilized in the early inflammatory phase and thereafter modulates the development of lung fibrosis. METHODS:Mice received a single dose of 3 mg/kg body weight of bleomycin (...

journal_title：Respiratory research

authors： Kobayashi T,Tanaka K,Fujita T,Umezawa H,Amano H,Yoshioka K,Naito Y,Hatano M,Kimura S,Tatsumi K,Kasuya Y

更新日期：2015-08-20 00:00:00

abstract：BACKGROUND:During 2007-2010, the National Health and Nutrition Examination Survey (NHANES) conducted a spirometry component which obtained pre-bronchodilator pulmonary lung function data on a nationally representative sample of US adults aged 6-79 years and post-bronchodilator pulmonary lung function data for the subse...

journal_title：Respiratory research

authors： Tilert T,Dillon C,Paulose-Ram R,Hnizdo E,Doney B

更新日期：2013-10-09 00:00:00

abstract：BACKGROUND:Cigarette smoke (CS) is the main cause in the development of chronic obstructive pulmonary disease (COPD), the pathogenesis of which is related to an extended inflammatory response. In this study, we investigated the effect of low and high doses of gas phase cigarette smoke (GPS) on cultured lymphocyte proge...

journal_title：Respiratory research

authors： Sdralia ND,Patmanidi AL,Velentzas AD,Margaritis LH,Baltatzis GE,Hatzinikolaou DG,Stavridou A

更新日期：2009-09-10 00:00:00

abstract：:The aim was to compare the diagnosis of COPD among smokers according to different international guidelines and to compare the outcome when using slow (SVC) and forced vital capacity (FVC). In order to find current smokers a questionnaire was sent to persons who had been on sick leave for more than two weeks. Those who...

journal_title：Respiratory research

authors： Nathell L,Nathell M,Malmberg P,Larsson K

更新日期：2007-12-04 00:00:00

abstract：BACKGROUND:The discrepancy between functional and inflammatory airway response to ozone has been reported in normal subjects, but few data are available for stable asthmatics regularly treated with inhaled corticosteroids. METHODS:Twenty-three well controlled, regularly treated, mild-to-moderate asthmatic patients und...

journal_title：Respiratory research

authors： Vagaggini B,Bartoli ML,Cianchetti S,Costa F,Bacci E,Dente FL,Di Franco A,Malagrinò L,Paggiaro P

更新日期：2010-01-19 00:00:00

abstract：BACKGROUND:Acute respiratory distress syndrome (ARDS) is a life-threatening critical illness, characterised by qualitative and quantitative surfactant compositional changes associated with premature airway collapse, gas-exchange abnormalities and acute hypoxic respiratory failure. The underlying mechanisms for this dys...

journal_title：Respiratory research

authors： Dushianthan A,Goss V,Cusack R,Grocott MP,Postle AD

更新日期：2014-11-07 00:00:00

abstract：BACKGROUND:Using guinea pig tracheal preparations, we have recently shown that endogenous arginase activity attenuates inhibitory nonadrenergic noncholinergic (iNANC) nerve-mediated airway smooth muscle relaxation by reducing nitric oxide (NO) production--due to competition with neuronal NO-synthase (nNOS) for the comm...

journal_title：Respiratory research

authors： Maarsingh H,Leusink J,Bos IS,Zaagsma J,Meurs H

更新日期：2006-01-12 00:00:00

abstract：BACKGROUND:Pulmonary neuroendocrine cells (PNEC) are specialized epithelial cells that are thought to play important roles in lung development and airway function. PNEC occur either singly or in clusters called neuroepithelial bodies. Our aim was to characterize the three dimensional morphology of PNEC, their distribut...

journal_title：Respiratory research

authors： Weichselbaum M,Sparrow MP,Hamilton EJ,Thompson PJ,Knight DA

更新日期：2005-10-10 00:00:00

abstract：BACKGROUND:Initial combination therapy with ambrisentan and tadalafil reduced the risk of clinical failure events for treatment-naïve participants with pulmonary arterial hypertension (PAH) as compared to monotherapy. Previous studies in PAH have demonstrated greater treatment benefits in more symptomatic participants....

journal_title：Respiratory research

authors： White RJ,Vonk-Noordegraaf A,Rosenkranz S,Oudiz RJ,McLaughlin VV,Hoeper MM,Grünig E,Ghofrani HA,Chakinala MM,Barberà JA,Blair C,Langley J,Frost AE

更新日期：2019-09-12 00:00:00

abstract：BACKGROUND:Several studies have implicated a role of inflammation in the pathogenesis of lung damage in idiopathic pulmonary fibrosis (IPF). Parenchymal lung damage leads to defects in mechanics and gas exchange and clinically manifests with exertional dyspnea. Investigations of inflammatory cells in IPF have shown tha...

journal_title：Respiratory research

authors： Daniil Z,Kitsanta P,Kapotsis G,Mathioudaki M,Kollintza A,Karatza M,Milic-Emili J,Roussos C,Papiris SA

更新日期：2005-07-24 00:00:00

abstract：:Despite much information on their catalytic properties and gene regulation, we actually know very little of what matrix metalloproteinases (MMPs) do in tissues. The catalytic activity of these enzymes has been implicated to function in normal lung biology by participating in branching morphogenesis, homeostasis, and r...

journal_title：Respiratory research

authors： Parks WC,Shapiro SD

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Debate continues as to whether acute bronchodilator responsiveness (BDR) predicts long-term outcomes in COPD. Furthermore, there is no consensus on a threshold for BDR. METHODS:At baseline and during the 4-year Understanding Potential Long-term Improvements in Function with Tiotropium (UPLIFT®) trial, patie...

journal_title：Respiratory research

authors： Hanania NA,Sharafkhaneh A,Celli B,Decramer M,Lystig T,Kesten S,Tashkin D

更新日期：2011-01-11 00:00:00

abstract：BACKGROUND:Adolescence is a period of change, which coincides with disease remission in a significant proportion of subjects with childhood asthma. There is incomplete understanding of the changing characteristics underlying different adolescent asthma transitions. We undertook pathophysiological characterization of tr...

journal_title：Respiratory research

authors： Arshad SH,Raza A,Lau L,Bawakid K,Karmaus W,Zhang H,Ewart S,Patil V,Roberts G,Kurukulaaratchy R

更新日期：2014-11-29 00:00:00

abstract：BACKGROUND:Accumulation of profibrotic myofibroblasts in fibroblastic foci (FF) is a crucial process for development of fibrosis during idiopathic pulmonary fibrosis (IPF) pathogenesis, and transforming growth factor (TGF)-β plays a key regulatory role in myofibroblast differentiation. Reactive oxygen species (ROS) has...

journal_title：Respiratory research

authors： Sato N,Takasaka N,Yoshida M,Tsubouchi K,Minagawa S,Araya J,Saito N,Fujita Y,Kurita Y,Kobayashi K,Ito S,Hara H,Kadota T,Yanagisawa H,Hashimoto M,Utsumi H,Wakui H,Kojima J,Numata T,Kaneko Y,Odaka M,Morikawa T,Na

更新日期：2016-08-30 00:00:00

abstract：:Diagnosis of acute lung allograft rejection is currently based on transbronchial lung biopsies. Additional methods to detect acute allograft dysfunction derived from plasma and bronchoalveolar lavage samples might facilitate diagnosis and ultimately improve allograft survival. This review article gives an overview of ...

journal_title：Respiratory research

authors： Speck NE,Schuurmans MM,Murer C,Benden C,Huber LC

更新日期：2016-06-21 00:00:00

abstract：BACKGROUND:Allergic asthma is characterized by airway inflammation in response to antigen exposure, leading to airway remodeling and lung dysfunction. Epithelial-mesenchymal transition (EMT) may play a role in airway remodeling through the acquisition of a mesenchymal phenotype in airway epithelial cells. TGF-β1 is kno...

journal_title：Respiratory research

authors： Johnson JR,Nishioka M,Chakir J,Risse PA,Almaghlouth I,Bazarbashi AN,Plante S,Martin JG,Eidelman D,Hamid Q

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:For decades, there is an unresolved debate about adequate prescription of antibiotics for patients suffering from exacerbations of chronic obstructive pulmonary disease (COPD). The aim of this systematic review was to analyse randomised controlled trials investigating the clinical benefit of antibiotics for ...

journal_title：Respiratory research

authors： Puhan MA,Vollenweider D,Latshang T,Steurer J,Steurer-Stey C

更新日期：2007-04-04 00:00:00

abstract：BACKGROUND:Airway clearance techniques (ACTs) are an important aspect of the treatment of children with chronic obstructive lung diseases. Unfortunately, a sound evidence base is lacking and airway clearance strategies are largely based on clinical expertise. One of the reasons for the limited evidence is the lack of a...

journal_title：Respiratory research

authors： Lauwers E,Ides K,Van Hoorenbeeck K,Verhulst S

更新日期：2020-08-17 00:00:00

abstract：BACKGROUND:Tobacco smoke and genetic susceptibility are risk factors for asthma and wheezing. The aim of this study was to investigate whether there is a combined effect of interleukin-13 gene (IL13) polymorphisms and tobacco smoke on persistent childhood wheezing and asthma. METHODS:In the Isle of Wight birth cohort ...

journal_title：Respiratory research

authors： Sadeghnejad A,Karmaus W,Arshad SH,Kurukulaaratchy R,Huebner M,Ewart S

更新日期：2008-01-10 00:00:00

abstract：BACKGROUND:Human beta-defensin-4 (hBD-4), a new member of the beta-defensin family, was discovered by an analysis of the genomic sequence. The objective of this study was to clarify hBD-4 expression in human lung tissue, along with the inducible expression in response to infectious stimuli, localization, and antimicrob...

journal_title：Respiratory research

authors： Yanagi S,Ashitani J,Ishimoto H,Date Y,Mukae H,Chino N,Nakazato M

更新日期：2005-11-04 00:00:00

abstract：BACKGROUND:The variability in the inflammatory burden of the lung in cystic fibrosis (CF) patients together with the variable effect of glucocorticoid treatment led us to hypothesize that glucocorticoid receptor (GR) gene polymorphisms may affect glucocorticoid sensitivity in CF and, consequently, may contribute to var...

journal_title：Respiratory research

authors： Corvol H,Nathan N,Charlier C,Chadelat K,Le Rouzic P,Tabary O,Fauroux B,Henrion-Caude A,Feingold J,Boelle PY,Clement A

更新日期：2007-11-29 00:00:00

abstract：BACKGROUND:Hepcidin serves as a major regulator of systemic iron metabolism and immune function. Airway epithelial cells have an extensive interface with the environment, and so must be able to respond locally to the presence of particulates, infection, and inflammation. Therefore, we hypothesized that hepcidin is expr...

journal_title：Respiratory research

authors： Frazier MD,Mamo LB,Ghio AJ,Turi JL

更新日期：2011-08-02 00:00:00

abstract：BACKGROUND:Recent studies have indicated the presence of multipotent mesenchymal stromal cells (MSCs) in human lung diseases. Excess airway smooth muscle, myofibroblasts and activated fibroblasts have each been noted in asthma, suggesting that mesenchymal progenitor cells play a role in asthma pathogenesis. We therefor...

journal_title：Respiratory research

authors： Bentley JK,Popova AP,Bozyk PD,Linn MJ,Baek AE,Lei J,Goldsmith AM,Hershenson MB

更新日期：2010-09-21 00:00:00

abstract：BACKGROUND:The differential diagnosis of tuberculous pleural effusion (TPE) is challenging. In recent years, artificial intelligence (AI) machine learning algorithms have started being used to an increasing extent in disease diagnosis due to the high level of efficiency, objectivity, and accuracy that they offer. METH...

journal_title：Respiratory research

authors： Ren Z,Hu Y,Xu L

更新日期：2019-10-16 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is characterised by pulmonary and systemic inflammation which flare-up during episodes of acute exacerbation (AECOPD). Given the role of Toll-like receptors (TLRs) in the induction of inflammatory responses we investigated the involvement of TLRs in COPD pathogene...

journal_title：Respiratory research

authors： Pons J,Sauleda J,Regueiro V,Santos C,López M,Ferrer J,Agustí AG,Bengoechea JA

更新日期：2006-04-10 00:00:00

abstract：BACKGROUND:Nintedanib is an approved therapy for idiopathic pulmonary fibrosis (IPF). Some patients treated with nintedanib experience weight loss. Exploratory data suggest that low body mass index or weight loss are associated with worse outcomes in patients with IPF. We investigated whether BMI at baseline or weight ...

journal_title：Respiratory research

authors： Jouneau S,Crestani B,Thibault R,Lederlin M,Vernhet L,Valenzuela C,Wijsenbeek M,Kreuter M,Stansen W,Quaresma M,Cottin V

更新日期：2020-11-25 00:00:00

abstract：BACKGROUND:Inhaled corticosteroids are the recommended first-line treatment for asthma but adherence to therapy is suboptimal. The objectives of this study were to compare the efficacy and safety of once-daily (OD) evening and twice-daily (BD) regimens of the novel inhaled corticosteroid fluticasone furoate (FF) in ast...

journal_title：Respiratory research

authors： Woodcock A,Bleecker ER,Busse WW,Lötvall J,Snowise NG,Frith L,Jacques L,Haumann B,Bateman ED

更新日期：2011-12-21 00:00:00

abstract：BACKGROUND:Possible variation in bronchodilator response (BDR) according to age at the diagnosis of adult-onset asthma is unknown. Our aim was to assess if BDR in FEV1 is related to age at diagnosis of adult-onset asthma and how many subjects fulfill the 400 mL criterion of BDR, the suggested cut-off for asthma-like re...

journal_title：Respiratory research

authors： Tommola M,Won HK,Ilmarinen P,Jung H,Tuomisto LE,Lehtimäki L,Niemelä O,Kim TB,Kankaanranta H

更新日期：2020-07-13 00:00:00

abstract：BACKGROUND:Induced and spontaneous sputum are used to evaluate the airways microbiota. Whether the sputum types can be used interchangeably in microbiota research is unknown. Our aim was to compare microbiota in induced and spontaneous sputum from COPD patients sampled during the same consultation. METHODS:COPD patien...

journal_title：Respiratory research

authors： Tangedal S,Aanerud M,Grønseth R,Drengenes C,Wiker HG,Bakke PS,Eagan TM

更新日期：2017-08-29 00:00:00