Abstract:
:Endosomes and lysosomes play a critical role in various aspects of cell physiology such as nutrient sensing, receptor recycling, protein/lipid catabolism, and cell death. In drug delivery, endosomal release of therapeutic payloads from nanocarriers is also important in achieving efficient delivery of drugs to reach their intracellular targets. Recently, we invented a library of ultra pH-sensitive (UPS) nanoprobes with exquisite fluorescence response to subtle pH changes. The UPS nanoprobes also displayed strong pH-specific buffer effect over small molecular bases with broad pH responses (e.g., chloroquine and NH4Cl). Tunable pH transitions from 7.4 to 4.0 of UPS nanoprobes cover the entire physiological pH of endocytic organelles (e.g., early and late endosomes) and lysosomes. These unique physico-chemical properties of UPS nanoprobes allowed a 'detection and perturbation' strategy for the investigation of luminal pH in cell signaling and metabolism, which introduces a nanotechnology-enabled paradigm for the biological studies of endosomes and lysosomes.
journal_name
Adv Drug Deliv Revjournal_title
Advanced drug delivery reviewsauthors
Wang C,Zhao T,Li Y,Huang G,White MA,Gao Jdoi
10.1016/j.addr.2016.08.014subject
Has Abstractpub_date
2017-04-01 00:00:00pages
87-96eissn
0169-409Xissn
1872-8294pii
S0169-409X(16)30255-1journal_volume
113pub_type
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