A 10-year cohort analysis of routine paediatric ART data in a rural South African setting.

Abstract:

:South Africa's paediatric antiretroviral therapy (ART) programme is managed using a monitoring and evaluation tool known as TIER.Net. This electronic system has several advantages over paper-based systems, allowing profiling of the paediatric ART programme over time. We analysed anonymized TIER.Net data for HIV-infected children aged <15 years who had initiated ART in a rural district of South Africa between 2005 and 2014. We performed Kaplan-Meier survival analysis to assess outcomes over time. Records of 5461 children were available for analysis; 3593 (66%) children were retained in care. Losses from the programme were higher in children initiated on treatment in more recent years (P < 0·0001) and in children aged ≤1 year at treatment initiation (P < 0·0001). For children aged <3 years, abacavir was associated with a significantly higher rate of loss from the programme compared to stavudine (hazard ratio 1·9, P < 0·001). Viral load was suppressed in 48-52% of the cohort, with no significant change over the years (P = 0·398). Analysis of TIER.Net data over time provides enhanced insights into the performance of the paediatric ART programme and highlights interventions to improve programme performance.

journal_name

Epidemiol Infect

authors

Lilian RR,Mutasa B,Railton J,Mongwe W,McINTYRE JA,Struthers HE,Peters RP

doi

10.1017/S0950268816001916

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

170-180

issue

1

eissn

0950-2688

issn

1469-4409

pii

S0950268816001916

journal_volume

145

pub_type

杂志文章
  • Incidence of childhood pneumonia and serotype and sequence-type distribution in Streptococcus pneumoniae isolates in Japan.

    abstract::The 7-valent pneumococcal conjugate vaccine (PCV7) is reported to decrease the incidence of community-acquired pneumonia (CAP) in children. To determine the annual incidence of CAP before the introduction of PCV7, we counted the number of children hospitalized with CAP between 2008 and 2009 in Chiba City, Japan. We in...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268811001592

    authors: Tanaka J,Ishiwada N,Wada A,Chang B,Hishiki H,Kurosaki T,Kohno Y

    更新日期:2012-06-01 00:00:00

  • Emergence of multidrug-resistant Salmonella enterica serotype Typhi with decreased ciprofloxacin susceptibility in Bangladesh.

    abstract::During 1989-2002, we studied the antimicrobial resistance of 3928 blood culture isolates of Salmonella enterica serotype Typhi (S. Typhi) in Dhaka, Bangladesh. Overall 32% (1270) of the strains were multidrug-resistant (MDR, resistant to chloramphenicol, ampicillin and trimethoprim-sulphamethoxazole); first detected i...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268805004759

    authors: Rahman M,Siddique AK,Shoma S,Rashid H,Salam MA,Ahmed QS,Nair GB,Breiman RF

    更新日期:2006-04-01 00:00:00

  • Horizontal transmission of Campylobacter jejuni amongst broiler chicks: experimental studies.

    abstract::Horizontal transmission of Campylobacter jejuni was investigated in campylobacter-free broiler chicks. One hundred and twenty chicks housed individually, were provided with water containing 10(2)-10(9) c.f.u./ml C. jejuni. Colonization was rapid [47 of 73 (64%) positive cloacal cultures within 3 days and 65 of 73 (89%...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268800054571

    authors: Shanker S,Lee A,Sorrell TC

    更新日期:1990-02-01 00:00:00

  • Source attribution of human campylobacteriosis in Denmark.

    abstract::SUMMARY This study assesses the contribution of different sources of human campylobacteriosis in Denmark using two different source-attribution approaches. In total, 794 non-human isolates and 406 isolates from human cases (domestic, travel related, and cases with unknown travel history) were collected. Isolates were ...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268813002719

    authors: Boysen L,Rosenquist H,Larsson JT,Nielsen EM,Sørensen G,Nordentoft S,Hald T

    更新日期:2014-08-01 00:00:00

  • Bartonella infection in urban and rural dogs from the tropics: Brazil, Colombia, Sri Lanka and Vietnam.

    abstract::Dogs can be infected by a wide range of Bartonella spp., but limited studies have been conducted in tropical urban and rural dog populations. We aimed to determine Bartonella antibody prevalence in 455 domestic dogs from four tropical countries and detect Bartonella DNA in a subset of these dogs. Bartonella antibodies...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268812000519

    authors: Brenner EC,Chomel BB,Singhasivanon OU,Namekata DY,Kasten RW,Kass PH,Cortés-Vecino JA,Gennari SM,Rajapakse RP,Huong LT,Dubey JP

    更新日期:2013-01-01 00:00:00

  • High prevalence of Legionella in non-passenger merchant vessels.

    abstract::There is a paucity of information on the risk from potable water in non-passenger merchant vessels (NPMVs) particularly with regard to Legionella and other bacteria. This retrospective study examined water samples from 550 NPMVs docked in eight UK ports. A total of 1027 samples from 412 NPMVs were examined for total a...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268816002715

    authors: Collins SL,Stevenson D,Mentasti M,Shaw A,Johnson A,Crossley L,Willis C

    更新日期:2017-03-01 00:00:00

  • Estimating transmission parameters of F4+ E. coli for F4-receptor-positive and -negative piglets: one-to-one transmission experiment.

    abstract::F4+ Escherichia coli is an important agent of post-weaning diarrhoea in piglets. Piglets that express an adhesion site for F4+ E. coli in their small intestine (F4R+) shed higher numbers of F4+ E. coli than piglets lacking this site (F4R-). We hypothesized that F4R+ piglets are more infectious and more susceptible for...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268804002675

    authors: Geenen PL,Van der Meulen J,Bouma A,De Jong MC

    更新日期:2004-12-01 00:00:00

  • Risk factors associated with hepatitis C virus infection in Taiwanese government employees.

    abstract::This study evaluated the roles of multiple factors in hepatitis C virus (HCV) infection, with emphasis on the modification of various individual characteristics on the risk associated with percutaneous exposure to blood. Serum samples taken from 4869 men in Taiwan within a cohort study were tested for HCV antibody. Th...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268801005362

    authors: Chang HC,Yu MW,Lu CF,Chiu YH,Chen CJ

    更新日期:2001-04-01 00:00:00

  • Detection of Mycobacterium avium subspecies paratuberculosis in environmental samples by faecal culture and real-time PCR in relation to apparent within-herd prevalence as determined by individual faecal culture.

    abstract::SUMMARY Environmental samples are a cost-saving and easy-to-use approach to diagnose paratuberculosis at the herd level. Detailed knowledge concerning its uncertainties in herds with a low prevalence of Mycobacterium avium spp. paratuberculosis (MAP) is required to design sampling strategies in control programmes. Thi...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268814002465

    authors: Donat K,Kube J,Dressel J,Einax E,Pfeffer M,Failing K

    更新日期:2015-04-01 00:00:00

  • Time to Rt < 1 for COVID-19 public health lockdown measures.

    abstract::The epidemiological target of lockdowns is to drive down the effective reproduction number (Rt) to less than 1. A key unknown is the duration that lockdowns need to be in place to achieve this and which lockdown measures are effective. Daily number of laboratory confirmed community coronavirus 2019 cases were extracte...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268820002964

    authors: Yung CF,Saffari E,Liew C

    更新日期:2020-12-09 00:00:00

  • Morphometrical parameters of gut microflora in human volunteers.

    abstract::The morphology of faecal microflora of nine healthy human volunteers was studied by digital image analysis of microscopic slides. Weekly specimens were collected during an 8-week period. Seven morphometrical parameters were derived: the means and medians of components 1, 2 and 3, and morphometrical entropy. Statistica...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268800049025

    authors: Meijer BC,Kootstra GJ,Wilkinson MH

    更新日期:1991-10-01 00:00:00

  • Virucidal effect of chlorinated water containing cyanuric acid.

    abstract::The inhibitory influence of cyanuric acid on the virucidal effect of chlorine was studied. The time required for 99.9% inactivation of ten enteroviruses and two adenoviruses by 0.5 mg/l free available chlorine at pH 7.0 and 25 degrees C was prolonged approximately 4.8-28.8 times by the addition of 30 mg/l cyanuric aci...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268800029502

    authors: Yamashita T,Sakae K,Ishihara Y,Isomura S,Inoue H

    更新日期:1988-12-01 00:00:00

  • Increase of immunity to rubella and interruption of rubella transmission in Gipuzkoa (Basque Country, Spain) after an enhanced vaccination programme.

    abstract::In Spain, vaccination against rubella was initiated in schoolgirls in the mid-1970s. In Gipuzkoa, subsequent extensions to the vaccination schedule culminated in 1992 with the introduction of the two-dose measles, mumps and rubella vaccine in children and adolescents of both sexes. Moreover, in 1985 a programme for th...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268804002158

    authors: Cilla G,Dorronsoro M,Sáenz-Domínguez JR,Serrano E,Pérez-Trallero E

    更新日期:2004-08-01 00:00:00

  • Bloodstream infection as a predictor for mortality in severe burn patients: an 11-year study.

    abstract::In this study we collected and analysed data of the severe burn patients at our institution over an 11-year period in order to shed light on the controversial role of bloodstream infection (BSI) as a predictive factor for mortality in this burn population. The factors examined were age, total body surface area, smoke ...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268813002501

    authors: Egozi D,Hussein K,Filson S,Mashiach T,Ullmann Y,Raz-Pasteur A

    更新日期:2014-10-01 00:00:00

  • Evaluating sub-typing methods for pathogenic Yersinia enterocolitica to support outbreak investigations in New Zealand.

    abstract::Incidence of human yersiniosis in New Zealand has increased between 2013 and 2017. For surveillance and outbreak investigations it is essential that an appropriate level of discrimination between pathogenic Yersinia enterocolitica isolates is provided, in order to support epidemiological linking of connected cases. Su...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268819000773

    authors: Strydom H,Wang J,Paine S,Dyet K,Cullen K,Wright J

    更新日期:2019-01-01 00:00:00

  • Transmission of bovine herpesvirus 1 within and between herds on an island with a BHV1 control programme.

    abstract::Transmission of bovine herpesvirus 1 (BHV1) within and between herds was studied on the island of Ameland, The Netherlands. There were 50 herds with 3300 head of cattle on the island. Herds were divided into three groups: (1) only containing seronegative cattle, (2) containing seronegative cattle and vaccinated seropo...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:

    authors: Hage JJ,Schukken YH,Schols H,Maris-Veldhuis MA,Rijsewijk FA,Klaassen CH

    更新日期:2003-06-01 00:00:00

  • A modified case-control study of cryptosporidiosis (using non-Cryptosporidium-infected enteric cases as controls) in a community setting.

    abstract::Data from the first sentinel site (Waterloo Region, Ontario) of the Canadian Integrated Enteric Disease Surveillance System (C-EnterNet) were used in a secondary-based case-control study of laboratory-confirmed Cryptosporidium infections to study the role of various exposure factors. The incidence of cryptosporidiosis...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268809990197

    authors: Pintar KD,Pollari F,Waltner-Toews D,Charron DF,McEwen SA,Fazil A,Nesbitt A

    更新日期:2009-12-01 00:00:00

  • Applications of machine learning techniques to predict filariasis using socio-economic factors.

    abstract::Filariasis is one of the major public health concerns in India. Approximately 600 million people spread across 250 districts of India are at risk of filariasis. To predict this disease, a pilot scale study was carried out in 30 villages of Karimnagar district of Telangana from 2004 to 2007 to collect epidemiological a...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268819001481

    authors: Kondeti PK,Ravi K,Mutheneni SR,Kadiri MR,Kumaraswamy S,Vadlamani R,Upadhyayula SM

    更新日期:2019-09-02 00:00:00

  • The prevalence of antibodies to hepatitis A virus and its determinants in The Netherlands: a population-based survey.

    abstract::The prevalence of antibodies to hepatitis A virus was assessed in a Dutch nationwide sample (n = 7367). A questionnaire was used to study the association with various sociodemographic characteristics. Overall, 33.8% (95% CI 31.6-36%) of the population had hepatitis A antibodies. The seroprevalence was less than 10% in...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268899003842

    authors: Termorshuizen F,Dorigo-Zetsma JW,de Melker HE,van den Hof S,Conyn-Van Spaendonck MA

    更新日期:2000-06-01 00:00:00

  • Contribution of Meat Inspection to the surveillance of poultry health and welfare in the European Union.

    abstract::In the European Union, Meat Inspection (MI) aims to protect public health by ensuring that minimal hazardous material enters in the food chain. It also contributes to the detection and monitoring of animal diseases and welfare problems but its utility for animal surveillance has been assessed partially for some diseas...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268814003379

    authors: Huneau-Salaün A,Stärk KD,Mateus A,Lupo C,Lindberg A,LE Bouquin-Leneveu S

    更新日期:2015-08-01 00:00:00

  • Characterization of a new genotype of measles virus detected in China and England.

    abstract::We report the co-circulation of a new lineage of measles virus (MV) and an Edmonston-like (Ed-like) genotype of MV in China during 1995-7. Sequence analysis of 25 strains was performed on a 282 nucleotides (nt) region of the nucleoprotein (N) gene, a 450-nt region of the haemagglutinin (H) gene and a 152-nt region of ...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268898001666

    authors: Jin L,Sun YJ,Ge L,Brown DW

    更新日期:1998-12-01 00:00:00

  • Risk factors for typhoid fever in a slum in Dhaka, Bangladesh.

    abstract::We systematically investigated risk factors for typhoid fever in Kamalapur, a poor urban area of Bangladesh, to inform targeted public health measures for its control. We interviewed patients with typhoid fever and two age-matched controls per case about exposures during the 14 days before the onset of illness. The mu...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268806007114

    authors: Ram PK,Naheed A,Brooks WA,Hossain MA,Mintz ED,Breiman RF,Luby SP

    更新日期:2007-04-01 00:00:00

  • A case-control study on the occurrence of Salmonella spp. in the environment of pigs.

    abstract::The objective of this study was to compare the occurrence of Salmonella spp. found in the animal environment in pig herds with different Salmonella risks (61 herds with low seroprevalence, 81 herds with high seroprevalence) on a broad scale. The environmental samples were divided into two types: direct (n=1105) and in...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268811000239

    authors: Gotter V,Blaha T,Klein G

    更新日期:2012-01-01 00:00:00

  • Characterization of cholera outbreak isolates from Namibia, December 2006 to February 2007.

    abstract::We report on the first recorded outbreak of cholera in Namibia. From December 2006 to February 2007, more than 250 cases of cholera were reported from the Omusati and Kunene provinces of Namibia. However, only nine bacterial isolates were obtainable for analysis. Isolates were all identified as Vibrio cholerae O1 sero...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268807009685

    authors: Smith AM,Keddy KH,De Wee L

    更新日期:2008-09-01 00:00:00

  • An audit of rubella IgG antibody status in antenatal women in a NHS Trust over 5 years (2005-2009).

    abstract::Rubella, a vaccine-preventable infection. This study examined the antibody status of 11 987 pregnant women during 2005-2009. Results showed a non-significant decrease in those with antibody levels of <4·0 IU/ml from 29/2312 (1·3%) in 2005 to 21/2447 (0·9%) in 2009 (χ² for linear trend=0·279, P=0·56) but a significant ...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268810002748

    authors: Matthews LA,Lawrance LM,Gray D,Gray S

    更新日期:2011-11-01 00:00:00

  • The occurrence of hepatitis B and C viruses in Pakistani patients with chronic liver disease and hepatocellular carcinoma.

    abstract::To study the occurrence of hepatitis B virus (HBV) and hepatitis C virus (HCV) in patients with chronic liver disease (CLD) and hepatocellular carcinoma (HCC) in Pakistan, blood samples from 105 sequential patients with biopsy-proven CLD (n = 82) and HCC (n = 23) were tested for HBV and HCV markers. Of the 105, 87 (83...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268800001503

    authors: Tong CY,Khan R,Beeching NJ,Tariq WU,Hart CA,Ahmad N,Malik IA

    更新日期:1996-10-01 00:00:00

  • A viral infection of the hand commonly seen after the feast of sacrifice: human orf (orf of the hand).

    abstract::Orf of the hand is an uncommon zoonotic infection caused by a dermotropic DNA virus that belongs to the Parapoxvirus genus of the family Poxviridae. It is transmitted to humans through contact with infected sheep and goats and is reported as an occupational disease. We report nine cases of human orf seen in the hands ...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268805003778

    authors: Uzel M,Sasmaz S,Bakaris S,Cetinus E,Bilgic E,Karaoguz A,Ozkul A,Arican O

    更新日期:2005-08-01 00:00:00

  • Acquisition and invasiveness of different serotypes of Streptococcus pneumoniae in young children.

    abstract::Rates of acquisition and mean duration of nasal carriage of different serotypes of Streptococcus pneumoniae have been estimated by fitting a stochastic model to longitudinal carriage data in children from Papua New Guinea. Immunogenicity and two indices of relative invasiveness were determined for each serotype. Immun...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/s0950268800056648

    authors: Smith T,Lehmann D,Montgomery J,Gratten M,Riley ID,Alpers MP

    更新日期:1993-08-01 00:00:00

  • Varicella vaccine uptake and associated factors in children in Hong Kong.

    abstract::Varicella is a common and highly contagious childhood disease which impacts the public worldwide. Hong Kong children can only be vaccinated against the disease in private practice. The varicella vaccination rate of local children in preschool is uncertain. Therefore a cross-sectional kindergarten-based parent-administ...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268813001994

    authors: Chan JY,Leung KM,Tam WW,Lee A

    更新日期:2014-05-01 00:00:00

  • The importance of distinguishing COVID-19 from more common respiratory illnesses.

    abstract::We recruited 1591 patients who presented to our fever clinics from 23 January 2020 to 16 February 2020. The different imaging findings between COVID-19 pneumonia and influenza A viruses, influenza B virus pneumonia were also investigated. Most patients were infected by influenza A and B viruses in the flu-season. A la...

    journal_title:Epidemiology and infection

    pub_type: 杂志文章

    doi:10.1017/S0950268820001971

    authors: Zhao W,Xie X,Liu J

    更新日期:2020-09-02 00:00:00