Abstract:
:South Africa's paediatric antiretroviral therapy (ART) programme is managed using a monitoring and evaluation tool known as TIER.Net. This electronic system has several advantages over paper-based systems, allowing profiling of the paediatric ART programme over time. We analysed anonymized TIER.Net data for HIV-infected children aged <15 years who had initiated ART in a rural district of South Africa between 2005 and 2014. We performed Kaplan-Meier survival analysis to assess outcomes over time. Records of 5461 children were available for analysis; 3593 (66%) children were retained in care. Losses from the programme were higher in children initiated on treatment in more recent years (P < 0·0001) and in children aged ≤1 year at treatment initiation (P < 0·0001). For children aged <3 years, abacavir was associated with a significantly higher rate of loss from the programme compared to stavudine (hazard ratio 1·9, P < 0·001). Viral load was suppressed in 48-52% of the cohort, with no significant change over the years (P = 0·398). Analysis of TIER.Net data over time provides enhanced insights into the performance of the paediatric ART programme and highlights interventions to improve programme performance.
journal_name
Epidemiol Infectjournal_title
Epidemiology and infectionauthors
Lilian RR,Mutasa B,Railton J,Mongwe W,McINTYRE JA,Struthers HE,Peters RPdoi
10.1017/S0950268816001916subject
Has Abstractpub_date
2017-01-01 00:00:00pages
170-180issue
1eissn
0950-2688issn
1469-4409pii
S0950268816001916journal_volume
145pub_type
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