Severe disease exacerbations in patients with multiple sclerosis after discontinuing fingolimod.

Abstract:

:Discontinuation of fingolimod in patients with multiple sclerosis (MS) can lead to disease reactivation. In this review, we describe cases of severe exacerbations in patients with MS following discontinuation of fingolimod, including three cases from our center. We consider potential mechanisms of disease reactivation after cessation of fingolimod, and the evidence supporting this rebound effect. We conclude that discontinuation of fingolimod results in the return of disease activity, which then leads to severe exacerbations (i.e., rebounds) in a clinically significant proportion of patients. Lastly, we consider disease-modifying treatment options for patients who discontinue fingolimod.

journal_name

Neurol Neurochir Pol

authors

Członkowska A,Smoliński Ł,Litwin T

doi

10.1016/j.pjnns.2017.01.006

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

156-162

issue

2

eissn

0028-3843

issn

1897-4260

pii

S0028-3843(16)30124-4

journal_volume

51

pub_type

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