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Gut microbiome-based medical methodologies for early-stage disease prevention.

Abstract：

:Recent advancements highlight the important role of gut microbiome in human health. However, a variety of endogenous and exogenous factors, such as genes, foods, drugs, environmental pollutions, oxidative stress, etc., may interfere with the gut microbiome in vivo and increase risks of digestive system diseases, cardiovascular diseases, neurological diseases, obesity, diabetes, cancers, and so on. Abundant discoveries listed in this work support that changes in the composition of the gut microbiome may be potentially used as sensitive early-stage diagnostic biomarkers and that the gut microbiome could be a promising therapeutic target for systemic prevention of multiple human diseases. Interestingly, the microbial culturomics revolution makes it possible to identify much more species and several new species in the gut microbiome. Several innovative articles published by Science and Nature in 2016 further put forward the feasibility of these perspectives, lay grounds for establishing standardized human gut microbiome compositions, and are particularly important for monitoring dysbiosis of the gut microbiome and for precisely reshaping a dysfunctional gut microbiome. Hypothetically, keeping and reconstructing an optimized gut microbiome would be essential to prevent the occurrence of various human diseases. Hence, these advancements have impressive clinical implications for predicting abnormal healthy status of human beings and for preventing the initiation of systemic disorders at an early stage.

journal_name

Microb Pathog

journal_title

Microbial pathogenesis

authors

Wang JZ,Du WT,Xu YL,Cheng SZ,Liu ZJ

doi

10.1016/j.micpath.2017.02.024

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

122-130

eissn

0882-4010

issn

1096-1208

pii

S0882-4010(16)30945-7

journal_volume

105

pub_type

杂志文章,评审

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