Monoclonal antibody therapy in sinonasal disease.

abstract：:Background The cribriform plate (CP) is a common site of spontaneous cerebrospinal fluid (SCSF) leaks. Radiographic assessment of the anterior and lateral skull base has shown thinner bone in patients with SCSFs; however, prior assessment of the CP has required postmortem cadaver dissection. Objective To develop novel...

journal_title：American journal of rhinology & allergy

authors： Ganjaei KG,Soler ZM,Mappus ED,Taylor RJ,Worley ML,Mulligan JK,Mattos JL,Rowan NR,Garcia GJM,Dubno JR,Eckert MA,Matthews LJ,Schlosser RJ

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Smoking status has been established as a known irritant of the upper and lower respiratory tracts, leading to inflammation throughout the respiratory system. Tobacco smoking is one comorbidity encountered among chronic rhinosinusitis (CRS) patients. The histopathologic features of CRS and comorbid smoking st...

journal_title：American journal of rhinology & allergy

authors： Kuhar HN,Ganti A,Brown HJ,Gattuso P,Ghai R,Mahdavinia M,Batra PS,Tajudeen BA

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Multiple methods exist for nasal septoplasty. Proliferation of endoscopic technology has broadened these options. METHODS:Technical description of two techniques for endoscopic septoplasty. RESULTS:The endoscope can be utilized for visualization under the flaps after, a Killian or hemitransfixion incision,...

journal_title：American journal of rhinology & allergy

authors： Chandra RK

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Major histocompatibility complex (MHC) class II is involved in T-cell activation, cytokine secretion, and induction of immune responses. Cytokines, staphylococcus super antigens, and eosinophil activation are proposed to play important roles in aspirin-exacerbated respiratory disease (AERD). OBJECTIVES:This...

journal_title：American journal of rhinology & allergy

authors： Esmaeilzadeh H,Nabavi M,Amirzargar AA,Aryan Z,Arshi S,Bemanian MH,Fallahpour M,Mortazavi N,Rezaei N

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Although nasal steroids are the mainstay treatments in nasal polyposis, up to one-half of patients do not respond and need surgical treatment. This study aimed to evaluate whether oxymetazoline administration produces any additive effect on nasal steroid therapy and whether rebound congestion develops after ...

journal_title：American journal of rhinology & allergy

authors： Kirtsreesakul V,Khanuengkitkong T,Ruttanaphol S

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVE:To evaluate the amount and type of osteitis observed in chronic rhinosinusitis with nasal polyposis (CRSwNP) and compare it with that of chronic rhinosinusitis without nasal polyposis (CRSnNP). SETTING:Sisli Etfal Research and Education Hospital, Istanbul, Turkey. STUDY DESIGN:Prospective, single-blind, coh...

journal_title：American journal of rhinology & allergy

authors： Emre IE,Celebi I,Ercan I

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Fibrin glue has been a favorable hydrogel in cartilage tissue engineering, but implantation of chondrocyte-fibrin suspensions have resulted in volume loss. In this study, human septal cartilage chips were seeded onto a fibrin scaffold, and cellular proliferation and production of cartilaginous extracellular ...

journal_title：American journal of rhinology & allergy

authors： Sage A,Chang AA,Schumacher BL,Sah RL,Watson D

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:The identification of anatomic landmarks in endoscopic skull base or revision sinus surgery can be challenging. Normal anatomy is significantly altered with many paranasal tumors. Traditional endoscopic surgical landmarks extrapolated from inflammatory disease, such as the superior turbinate, may have been p...

journal_title：American journal of rhinology & allergy

authors： Harvey RJ,Shelton W,Timperley D,Debnath NI,Byrd K,Buchmann L,Gallagher RM,Orlandi RR,Sacks R,Schlosser RJ

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:It is not fully understood how sinonasal epithelial cells detect the presence of pathogens and activate innate defense responses necessary for protecting the upper airway from infection. One mechanism is through bitter taste receptors (T2Rs), which are expressed in the sinonasal cavity. One T2R isoform, T2R3...

journal_title：American journal of rhinology & allergy

authors： Lee RJ,Cohen NA

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Conclusive evidence exists that biofilms are present on the mucosa of chronic rhinosinusitis (CRS) patients. Less is known about the species constituting these biofilms. This study developed a fluorescence in situ hybridization (FISH) protocol for characterization of bacterial and fungal biofilms in CRS. ME...

journal_title：American journal of rhinology & allergy

authors： Foreman A,Psaltis AJ,Tan LW,Wormald PJ

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Aspirin-exacerbated respiratory disease (AERD) affects 7% of asthmatics. Usual therapies are inadequate for asthma and/or nasal polyposis, leading to decreased quality of life. OBJECTIVE:Our objective was to evaluate the efficacy of dupilumab in AERD patients with uncontrolled, chronic rhinosinusitis with n...

journal_title：American journal of rhinology & allergy

authors： Mustafa SS,Vadamalai K,Scott B,Ramsey A

更新日期：2020-09-23 00:00:00

abstract：BACKGROUND:Allergen immunotherapy (AIT) has been in practice for more than 100 years. However, research in novel routes and delivery methods of immunotherapy to treat allergic rhinitis (AR) and conjunctivitis has only recently occurred in the United States, where the predominant form of AIT provided is largely via a su...

journal_title：American journal of rhinology & allergy

authors： Lee S,Nolte H,Benninger MS

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVES:Inadvertent intracranial injury from nasogastric tube (NGT) placement is a described and potentially fatal complication following endoscopic transsphenoidal hypophysectomy (TSH). This cadaver study assessed the role of middle turbinate (MT) preservation and medialization in preventing accidental skull base i...

journal_title：American journal of rhinology & allergy

authors： Shah J,Tang D,Grafmiller K,Cappello ZJ,Roxbury C,Sindwani R

更新日期：2021-01-01 00:00:00

abstract：BACKGROUNDS:Diagnosis of allergic fungal rhinosinusitis (AFRS) is complicated because of the presence of fungi on mucosal surfaces of sinonasal passages. The objectives of this study were to define, using immunohistochemistry, lymphocyte populations associated with noninvasive fungal-related chronic rhinosinusitis (CRS...

journal_title：American journal of rhinology & allergy

authors： Ragab A,Samaka RM

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Nasal septal deviation (NSD) is a very common deformity. Because it may induce chronic upper airway obstruction in the nose, clinicians encounter some patients who have concerns about whether this can be a risk factor for general health. However, the influence of NSD on general health has rarely been studied...

journal_title：American journal of rhinology & allergy

authors： Ahn JC,Lee WH,We J,Rhee CS,Lee C,Kim JW

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Chronic rhinosinusitis with nasal polyps (CRSwNPs) is the most challenging form of CRS to treat. Clinical practices vary widely among physicians around the world, often with little evidence to support current therapies. METHODS:This study evaluates various medical and surgical treatments with a focus on the...

journal_title：American journal of rhinology & allergy

authors： Schlosser RJ,Soler ZM

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Biofilm formation has been implicated as an etiologic factor in the development of chronic rhinosinusitis (CRS). Nasal irrigation with surfactants including dilute baby shampoo have been proposed as an antibiofilm treatment for CRS patients. The effect of dilute baby shampoo on normal sinonasal mucosal funct...

journal_title：American journal of rhinology & allergy

authors： Isaacs S,Fakhri S,Luong A,Whited C,Citardi MJ

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Endoscopic skull base surgery (ESBS) provides a safe, minimally invasive approach to treat benign and malignant skull base lesions. The significance of concomitant sinonasal pathology on imaging in patients undergoing ESBS and its effect on perioperative management is not well described. We sought to ident...

journal_title：American journal of rhinology & allergy

authors： Shah J,Cappello ZJ,Roxbury C,Tang D,Woodard TD,Kshettry VR,Recinos PF,Sindwani R

更新日期：2020-08-11 00:00:00

abstract：PURPOSE:To assess the efficacy and safety of bupivacaine compared with lidocaine in local anesthesia of nasopharynx through meta-analysis. METHODS:A number of medical literature data bases were searched electronically. Relevant journals and references of included studies were manually searched. Two reviewers independe...

journal_title：American journal of rhinology & allergy

authors： Yu X,Wang J,Huang L,Yu X,He Z

更新日期：2016-09-30 00:00:00

abstract：BACKGROUND:Recent years have witnessed significant expansion in office-based rhinology. This study assesses practice patterns of the American Rhinologic Society (ARS) membership regarding office-based rhinologic procedures. METHODS:A 24-item survey was disseminated to the ARS membership from March 15 to May 31, 2016. ...

journal_title：American journal of rhinology & allergy

authors： Lee JT,DelGaudio J,Orlandi RR

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:The impact of middle turbinate resection (MTR) on olfaction remains a point of debate in the current literature. Few studies have objectively evaluated olfactory cleft airflow following MTR; thus, the mechanism by which MTR may impact olfaction is poorly understood. It is not known whether the postsurgical c...

journal_title：American journal of rhinology & allergy

authors： Alam S,Li C,Bradburn KH,Zhao K,Lee TS

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Platelet-activating factor (PAF) is a lipid mediator produced by most inflammatory cells. Clinical and experimental findings suggest that PAF participates in allergic rhinitis (AR) pathogenesis. The aim was to assess the PAF ability to induce clinical response in nasal airway after local stimulation. METHOD...

journal_title：American journal of rhinology & allergy

authors： Muñoz-Cano R,Valero A,Roca-Ferrer J,Bartra J,Sanchez-Lopez J,Mullol J,Picado C

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Because nasal function and shape are so closely intertwined, quantitative assessments can better define their relationship and how they are affected by septorhinoplasty. OBJECTIVE:The aim of this prospective study was to perform an analysis of the nasal airflow resistances and a three-dimensional (3D) evalu...

journal_title：American journal of rhinology & allergy

authors： Pecorari G,Riva G,Bianchi FA,Cavallo G,Revello F,Bironzo M,Verzè L,Garzaro M,Ramieri G

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Skin prick test (SPT) or Phadiatop, a multi-allergen IgE screening test, was used as a tool for detecting aeroallergen sensitization. OBJECTIVE:To compare SPT and Phadiatop as a tool for diagnosis allergic rhinitis (AR) using the nasal provocation test (NPT) as a comparative standard. METHODS:Children aged...

journal_title：American journal of rhinology & allergy

authors： Traiyan S,Manuyakorn W,Kanchongkittiphon W,Sasisakulporn C,Jotikasthira W,Kiewngam P,Kamchaisatian W,Benjaponpitak S

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Sex hormones are known to have some influence on nasal functions, but their effect on the decongestive response of the nasal mucosa during menstrual cycle is still undetermined. OBJECTIVES:The aim of this study was to examine the nasal physiology, the interconnectedness of olfactory and respiratory nasal fu...

journal_title：American journal of rhinology & allergy

authors： Bogdan MS,Slavic DO,Babovic SS,Zvezdin BS,Kolarov VP,Kljajic VL

更新日期：2021-01-26 00:00:00

abstract：PURPOSE:Activation of adenosine monophosphate-activated protein kinase (AMPK) by metformin, as a master regulator of metabolism, is involved in airway tissue remodeling. Here, we investigated the physical role of AMPK on cell migration, matrix contraction, and the production of matrix metalloproteinases (MMP) in nasal ...

journal_title：American journal of rhinology & allergy

authors： Um JY,Lee SA,Park JH,Shin JM,Park IH,Lee HM

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Epiphora has a significant impact on the patient's quality of life and is commonly caused by nasolacrimal duct obstruction. Dacryocystorhinostomy (DCR) has traditionally been performed via an external approach, which involves a skin incision. With the advent of endoscopes, the endonasal approach to DCR has g...

journal_title：American journal of rhinology & allergy

authors： Wong WK,Dean S,Nair S

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Assessing surgical competency in otolaryngology is challenging, and residency programs are now responsible for ensuring the surgical competency of their graduates. Therefore, more objective assessment tools are being incorporated into the evaluation process. Objective structured assessment of technical skill...

journal_title：American journal of rhinology & allergy

authors： Obeid AA,Al-Qahtani KH,Ashraf M,Alghamdi FR,Marglani O,Alherabi A

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:The treatment of chronic rhinosinusitis (CRS) often requires chronic or intermittent oral steroid therapy, which has the potential for adverse skeletal effects, including osteoporosis and increased risk of fragility fractures. The purpose of this study was to determine the prevalence of osteopenia/osteoporos...

journal_title：American journal of rhinology & allergy

authors： Rajasekaran K,Seth R,Abelson A,Batra PS

更新日期：2010-05-01 00:00:00

abstract：:Chronic rhinosinusitis (CRS) is the second most common chronic medical condition in the United States. It represents a group of disorders characterized by inflammation of the nasal mucosa and paranasal sinuses of at least 12 weeks duration. CRS with or without nasal polyps is defined as inflammation of the nose charac...

journal_title：American journal of rhinology & allergy

authors： Settipane RA,Peters AT,Chandra R

更新日期：2013-05-01 00:00:00