FOXN1 Duplication and Congenital Hypertrichosis.

Abstract:

:We report a case of congenital hypertrichosis and FOXN1 duplication. FOXN1 is a member of the forkhead box gene family, located on chromosome 17. Its function includes differentiation of epithelial cells and regulation of keratinocytes, especially hair keratins. Loss of function of these transcription factors leads to a disruption in hair growth. As far as we are aware, this is the first case of FOXN1 duplication associated with congenital hypertrichosis to be reported in the literature.

journal_name

Pediatr Dermatol

journal_title

Pediatric dermatology

authors

Gilhooley E,Gormally S,Irvine A,Lynch SA,Collins S

doi

10.1111/pde.13078

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

e77-e79

issue

2

eissn

0736-8046

issn

1525-1470

journal_volume

34

pub_type

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