当前位置： SCI文献检索 > ORAL ONCOLOGY期刊下所有文献 > Predictors of severe long-term toxicity after re-irradiation for head and neck cancer.

Predictors of severe long-term toxicity after re-irradiation for head and neck cancer.

Abstract：

OBJECTIVE:To identify predictive factors of severe long-term toxicity after re-irradiation of recurrent/persistent or second-primary head and neck cancer. METHODS:Outcomes and treatment plans of patients who underwent modern IMRT based re-irradiation to the head and neck from 2008-2015 were reviewed. Co-variables including demographic, clinical and oncologic factors, as well as interval to re-irradiation and re-irradiated planning tumor volume (PTV) were analyzed as predictors of developing severe (CTCAE grade⩾3) long-term toxicity with death as a competing risk. RESULTS:A total of 66 patients who met inclusion criteria were eligible for analysis. A median re-irradiation dose of 70Gy was delivered at a median of 37.5months after initial radiotherapy. Re-irradiation followed surgical resection in 25 (38%) patients, and concurrent chemotherapy was delivered to 41 (62%) patients. Median follow-up after re-irradiation was 23months and median overall survival was 22months (predicted 2year overall survival 49%). Of the 60 patients who survived longer than 3months after re-irradiation, 16 (25%) patients experienced severe long-term toxicity, with the majority (12 of 16) being feeding tube -dependent dysphagia. In multivariable analysis, shorter intervals to re-irradiation (<20months) and larger re-irradiated PTVs (>100cm(3)) were independent predictors of developing severe long-term toxicity. Patients with longer disease-free intervals and smaller PTVs had a 94% probability of being free of severe toxicity at two years. CONCLUSION:Selection of patients with longer re-irradiation intervals and requiring smaller re-irradiated PTVs can independently predict avoidance of severe long-term toxicity.

journal_name

Oral Oncol

journal_title

Oral oncology

authors

Lee JY,Suresh K,Nguyen R,Sapir E,Dow JS,Arnould GS,Worden FP,Spector ME,Prince ME,McLean SA,Shuman AG,Malloy KM,Casper K,Bradford CR,Schipper MJ,Eisbruch A

doi

10.1016/j.oraloncology.2016.06.017

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

32-40

eissn

1368-8375

issn

1879-0593

pii

S1368-8375(16)30091-4

journal_volume

60

pub_type

杂志文章

相关文献

ORAL ONCOLOGY文献大全
  • A novel algorithm for lymph node status prediction of oral cancer before surgery.

    abstract：:An algorithm was developed to predict lymph node metastasis in patients with oral squamous cell carcinoma. To improve the diagnostic accuracy of lymph node status, we suggest a criterion for the prediction of lymph node status by combining clinical and molecular information. To develop a model to predict lymph node me...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2011.07.017

    authors： Kim KY,Cha IH

    更新日期：2011-11-01 00:00:00

  • Elective neck dissection for salvage laryngectomy: A systematic review and meta-analysis.

    abstract：OBJECTIVE:Elective neck dissection (END) for salvage laryngectomy remains controversial due to variability in reported occult nodal metastasis rates and postoperative complications. We performed a meta-analysis to examine the role of END for treatment of the clinically N0 (cN0) neck in the salvage setting. METHODS:A P...

    journal_title：Oral oncology

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.oraloncology.2019.07.008

    authors： Lin C,Puram SV,Bulbul MG,Sethi RK,Rocco JW,Old MO,Kang SY

    更新日期：2019-09-01 00:00:00

  • Imbalance between proliferation and apoptosis may be responsible for treatment failure after postoperative radiotherapy in squamous cell carcinoma of the oropharynx.

    abstract：:To assess the prognostic value of apoptosis, proliferation and clinical factors in squamous cell carcinoma of the oropharynx after radical surgery and postoperative radiotherapy (RT). Between 1985 and 1995, a total of 82 patients with 84 tumors were entered onto the study. Forty-two primary tumors (50%) involved the t...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/s1368-8375(03)00005-8

    authors： Grabenbauer GG,Suckorada O,Niedobitek G,Rödel F,Iro H,Sauer R,Rödel C,Schultze-Mosgau S,Distel L

    更新日期：2003-07-01 00:00:00

  • Accuracy of intraoperative tissue staining in delineating deep surgical margins in oral carcinoma surgery.

    abstract：:The purpose of this study was to assess the accuracy of this tissue staining assessment of surgical specimens in delineating deep surgical margins in oral cancer surgery. Fifteen patients who underwent surgery for oral carcinoma were included in the study. Once the tumor was resected, a vertical section of the surgica...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2007.12.008

    authors： Kurita H,Sakai H,Kamata T,Koike T,Kobayashi H,Kurashina K

    更新日期：2008-10-01 00:00:00

  • Risk of contralateral nodal failure following ipsilateral IMRT for node-positive tonsillar cancer.

    abstract：PURPOSE:To determine the risk of contralateral nodal failure following ipsilateral radiotherapy in a series of patients with node-positive tonsillar squamous cell carcinoma. METHODS:Retrospective review was used to identify 34 patients with well-lateralized node-positive tonsillar squamous cell carcinoma treated with ...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2017.10.010

    authors： Gottumukkala S,Pham NL,Sumer B,Myers L,Truelson J,Nedzi L,Khan S,Hughes R,Sher DJ

    更新日期：2017-12-01 00:00:00

  • A gene expression profile associated with perineural invasion identifies a subset of HNSCC at risk of post-surgical recurrence.

    abstract：OBJECTIVES:Perineural invasion (PNI) is a common histopathological finding in head and neck squamous cell carcinoma (HNSCC). We aimed to explore the molecular mechanisms involved in PNI and the role of PNI as an aggressive pathological feature. MATERIALS AND METHODS:We used data from The Cancer Genome Atlas (TCGA) to ...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2018.09.005

    authors： Saidak Z,Clatot F,Chatelain D,Galmiche A

    更新日期：2018-11-01 00:00:00

  • A predictive survival model for patients with head and neck squamous cell carcinoma treated with immune check point inhibitors.

    abstract：BACKGROUND:ICIs have expanded treatment options for HNSCC. A minority of the patients respond to these expensive treatments. PATIENTS AND METHODS:This is a single institutional retrospective review on 121 unresectable or metastatic HNSCC patients treated with ICIs. We predicted that inflammatory markers available thro...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2020.104900

    authors： Bonomi M,Bhateja P,Issa M,Klamer B,Pan X,Blakaj A,Karivedu V,Mousa L,Mitchell D,Gamez M,Kang S,Seim NB,Old M,Carrau R,Rocco J,Blakaj D

    更新日期：2020-11-01 00:00:00

  • Clinical significance of molecular alterations in histologically negative surgical margins of head and neck cancer patients.

    abstract：:The development of locoregional recurrence is the main reason for treatment failure in head and neck squamous cell carcinomas (HNSCC) and the remaining of tumor cells in surgical margins is associated with recurrence. Surgical margins are considered negative based on histologic assessment of the pathological specimen....

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2011.10.018

    authors： de Carvalho AC,Kowalski LP,Campos AH,Soares FA,Carvalho AL,Vettore AL

    更新日期：2012-03-01 00:00:00

  • Characterization of four cell lines derived from a human malignant fibrous histiocytoma of the maxillary sinus.

    abstract：:We have established four cell lines from a human malignant fibrous histiocytoma. Each cell line had human aneuploid karyotype and DNA aneuploidy. Cells in all lines expressed CD13, CD68 and vimentin but lacked CD11, CD14, CD15, CD16, CD45, HLA class II and other mesenchymal and epithelial markers such as desmin, alpha...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/s1368-8375(01)00004-5

    authors： Mori A,Tagawa T,Kamei T,Murata T,Inui M,Ohse S

    更新日期：2001-09-01 00:00:00

  • Natural course of distant metastases following radiotherapy or chemoradiotherapy in HPV-related oropharyngeal cancer.

    abstract：OBJECTIVES:To describe the natural course of distant metastases (DMs) following radiotherapy (RT) or chemoradiotherapy (CRT) in HPV(+) oropharyngeal carcinoma (OPC). METHODS:OPC treated with RT/CRT from 1/1/2000 to 5/31/2010 were reviewed. The natural course of DM were compared between HPV(+) and HPV(-) cohorts. RESU...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2012.07.015

    authors： Huang SH,Perez-Ordonez B,Weinreb I,Hope A,Massey C,Waldron JN,Kim J,Bayley AJ,Cummings B,Cho BC,Ringash J,Dawson LA,Siu LL,Chen E,Irish J,Gullane P,Hui A,Liu FF,Shen X,Xu W,O'Sullivan B

    更新日期：2013-01-01 00:00:00

  • Oral squamous cell carcinoma of the tongue dorsum with multiple cancer-associated mutations in the TP53 gene.

    abstract：OBJECTIVES:Squamous cell carcinoma (SCC) of the tongue is one of the most common oral cancers, tongue dorsum being a site of low incidence of primary SCC. We report a rare case of SCC of the tongue dorsum in a 69-year-old man having a history of multiple cancers, including esophageal cancer, gastric cancer, and renal c...

    journal_title：Oral oncology

    pub_type： 信件

    doi：10.1016/j.oraloncology.2020.104774

    authors： Yamasaki S,Tani R,Sakurai S,Toratani S,Okamoto T

    更新日期：2020-10-01 00:00:00

  • Basic fibroblast growth factor and angiogenesis in squamous carcinoma of the tongue.

    abstract：:The relationship between basic fibroblast growth factor (bFGF), receptors for bFGF and neoangiogenesis was investigated in 51 patients with squamous cell carcinoma of the tongue, 26 of whom had metastatic disease in cervical lymph nodes. Vessels were demonstrated by immunocytochemical labelling for CD34 and expressed ...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/s1368-8375(00)00032-4

    authors： Forootan SS,Ke Y,Jones AS,Helliwell TR

    更新日期：2000-09-01 00:00:00

  • Mutation of p53 gene codon 63 in saliva as a molecular marker for oral squamous cell carcinomas.

    abstract：:The inactivation of tumor suppressor gene (TSG) is important during multistage carcinogenesis. The p53 TSG is frequently mutated in oral squamous cell carcinomas. These mutations can serve as very specific markers for the presence of tumor cells in a background of normal cells. In this study, 10 oral squamous cell car...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/s1368-8375(00)00005-1

    authors： Liao PH,Chang YC,Huang MF,Tai KW,Chou MY

    更新日期：2000-05-01 00:00:00

  • Inhibition of experimental tobacco carcinogen induced head and neck carcinogenesis.

    abstract：:Oral cancer models have attempted to demonstrate inhibition of oral carcinogenesis. These models used synthetic carcinogens, lacked a specific mechanism of activity or used non-physiologic doses for carcinogen or inhibitor. To correct these problems the tobacco and environmental carcinogen, dibenzo[a,l]pyrene (DB[a,l]...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2003.12.012

    authors： Schwartz J,Baker V,Larios E,Desai D,Amin S

    更新日期：2004-07-01 00:00:00

  • Silencing Id-1 inhibits lymphangiogenesis through down-regulation of VEGF-C in oral squamous cell carcinoma.

    abstract：:Our previous study demonstrated that overexpression of Id-1 (inhibitor of differentiation/DNA binding) was associated with lymphatic metastasis in human oral squamous cell carcinoma (OSCC). In this study, we further unveiled the association of Id-1 with vascular endothelial growth factor-C (VEGF-C) and peritumoral lym...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2010.10.012

    authors： Dong Z,Wei F,Zhou C,Sumida T,Hamakawa H,Hu Y,Liu S

    更新日期：2011-01-01 00:00:00

  • Is alcohol responsible for more intra-oral cancer?

    abstract：:The role of the major risk factors, tobacco smoking and alcohol consumption, on trends in intra-oral cancer mortality in England and Wales between 1911 and 1990 was investigated, using lung cancer and liver cirrhosis as surrogate markers for smoking and drinking. Standardised mortality data on lung cancer and liver ci...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/s1368-8375(00)00020-8

    authors： Hindle I,Downer MC,Moles DR,Speight PM

    更新日期：2000-07-01 00:00:00

  • Correlation of p16 expression and HPV type with survival in oropharyngeal squamous cell cancer.

    abstract：OBJECTIVES:Examine the effect of concordance between p16 overexpression and HR (high risk) HPV DNA status on overall survival in a large series of oropharyngeal squamous cell carcinoma (OPSCC) cases. MATERIALS AND METHODS:A total of 185 patients with primary OPSCC had genomic DNA tested by PCR for the HPV16 E6 and E7 ...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2015.06.014

    authors： Liu SZ,Zandberg DP,Schumaker LM,Papadimitriou JC,Cullen KJ

    更新日期：2015-09-01 00:00:00

  • Salivary secretory leukocyte protease inhibitor (SLPI) and head and neck cancer: The Cancer Prevention Study II Nutrition Cohort.

    abstract：OBJECTIVES:Secretory leukocyte protease inhibitor (SLPI) is an innate-immunity protein displaying antimicrobial and anti-inflammatory properties that is found in high concentrations in saliva. The role of extracellular salivary SLPI in head and neck squamous cell carcinoma (HNSCC) remains unclear. Thus, we aimed to eva...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2016.02.004

    authors： Pierce Campbell CM,Giuliano AR,Torres BN,O'Keefe MT,Ingles DJ,Anderson RL,Teras LR,Gapstur SM

    更新日期：2016-04-01 00:00:00

  • A novel evaluation system of metastatic potential of oral squamous cell carcinoma according to the histopathological and histochemical grading.

    abstract：:We established a new evaluation system for metastatic potential of oral squamous cell carcinoma (SCC), utilizing a combined examination of histopathological grades of the carcinomas based on cell differentiation and invasive mode according to Yamamoto's criteria, and the cellular expressions of CD44, E-cadherin (E-cad...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/s1368-8375(98)00048-7

    authors： Mori S,Nose M,Morikawa H,Sato A,Saito T,Song ST,Tanda N,Teshima T

    更新日期：1998-11-01 00:00:00

  • miR-29b suppresses proliferation, migration, and invasion of tongue squamous cell carcinoma through PTEN-AKT signaling pathway by targeting Sp1.

    abstract：OBJECTIVES:miR-29b has been implicated in various cancers. However, the role of miR-29b in tongue squamous cell carcinoma (TSCC) remains unclear. This study aimed to investigate the role of miR-29b in TSCC progression. MATERIALS AND METHODS:The expression of miR-29b was analyzed in TSCC tissues and cells. Functional s...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2014.07.010

    authors： Jia LF,Huang YP,Zheng YF,Lyu MY,Wei SB,Meng Z,Gan YH

    更新日期：2014-11-01 00:00:00

  • Classification of three prognostically different groups of head and neck cancer patients based on their metabolic response to induction chemotherapy (IC-1).

    abstract：OBJECTIVES:There exist no uniform decision criteria for conservative organ preservation treatments in head and neck cancer patients. Even with 18F-FDG-PET/CT after induction chemotherapy patient selection is challenging. This study correlated metabolic tumor response with treatment types and recurrence patterns. MATER...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2019.104479

    authors： Semrau S,Schmidt D,Hecht M,Haderlein M,Kitzsteiner C,Müller S,Traxdorf M,Agaimy A,Iro H,Kuwert T,Fietkau R

    更新日期：2020-01-01 00:00:00

  • Reconstruction design before tumour resection: A new concept of through-and-through cheek defect reconstruction.

    abstract：OBJECTIVE:To explore a new method of reconstruction of through-and-through cheek defects and to evaluate this method's efficacy and patient prognosis. MATERIALS AND METHODS:This retrospective study included 70 patients who underwent reconstruction of through-and-through cheek defects. The surgical approach, design of ...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2017.09.023

    authors： Gong ZJ,Ren ZH,Wang K,Tan HY,Zhang S,Wu HJ

    更新日期：2017-11-01 00:00:00

  • Hyalinizing clear cell carcinoma of salivary glands: a study of extracellular matrix.

    abstract：:Hyalinizing clear cell carcinoma (HCCC) is a recently described low-grade carcinoma of the salivary glands presenting two main histological features: clear neoplastic cells and prominent hyalinized stroma. Our aim was to characterize the composition of the hyalinized stroma in three cases of HCCC. An immuno-histochemi...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/s1368-8375(01)00072-0

    authors： Félix A,Rosa JC,Nunes JF,Fonseca I,Cidadão A,Soares J

    更新日期：2002-06-01 00:00:00

  • The roles of excision repair cross-complementation group1 in objective response after cisplatin-based concurrent chemoradiotherapy and survival in head and neck cancers: a systematic review and meta-analysis.

    abstract：:Our aim of the study was to investigate the precise relationship of repair cross-complementation group 1 (ERCC1) expression and the survival as well as objective response rate to cisplatin-based concurrent chemoradiotherapy (CCRT) and a meta-analysis was conducted to analysis ERCC1's prognostic roles in head and neck ...

    journal_title：Oral oncology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.oraloncology.2015.03.009

    authors： Gao Y,Liu D

    更新日期：2015-06-01 00:00:00

  • Serum C-reactive protein as a prognostic indicator in patients with oral squamous cell carcinoma.

    abstract：:Preoperative elevation of serum C-reactive protein (CRP) has been demonstrated as a prognostic indicator in oesophageal, gastric and colorectal cancer. This study was designed to establish if elevated preoperative levels of serum CRP could predict the prognosis of patients treated with primary surgery for oral squamou...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2009.03.015

    authors： Khandavilli SD,Ceallaigh PO,Lloyd CJ,Whitaker R

    更新日期：2009-10-01 00:00:00

  • (18)FDG-PET/CT for detecting distant metastases and second primary cancers in patients with head and neck cancer. A meta-analysis.

    abstract：:We performed a meta-analysis to evaluate the role of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)FDG-PET/CT) in detecting distant metastases and second primary cancers in patients with head and neck cancer (HNC) at staging. Studies about (18)FDG-PET/CT for detecting distant metastase...

    journal_title：Oral oncology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.oraloncology.2011.04.021

    authors： Xu GZ,Guan DJ,He ZY

    更新日期：2011-07-01 00:00:00

  • The association between hypoxia inducible factor-1alpha gene polymorphisms and increased susceptibility to oral cancer.

    abstract：:The aim of this study was to estimate the relations between hypoxia inducible factor-1alpha (HIF-1alpha) gene polymorphisms, C1772T and G1790A, to the susceptibility and clinicopathological status of oral cancer. A total of 521 subjects, including 347 controls and 174 oral cancer patients, were recruited in this study...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2009.07.015

    authors： Chen MK,Chiou HL,Su SC,Chung TT,Tseng HC,Tsai HT,Yang SF

    更新日期：2009-12-01 00:00:00

  • Midkine expression in malignant salivary gland tumors and its role in tumor angiogenesis.

    abstract：:The aims of this study were to investigate midkine (MK) expression patterns in salivary gland tumors (SGTs) and to evaluate the correlation between MK expression and the degree of malignancy. We performed immunohistochemistry to examine MK expression in specimens of adenoid cystic carcinoma (ACC), mucoepidermoid carci...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2010.06.004

    authors： Ota T,Ota K,Jono H,Fujimori H,Ueda M,Shinriki S,Sueyoshi T,Shinohara M,Ando Y

    更新日期：2010-09-01 00:00:00

  • Evaluation of the immunogenicity of ALDH(high) human head and neck squamous cell carcinoma cancer stem cells in vitro.

    abstract：OBJECTIVES:To establish the concept that the antigenicity/immunogenicity of ALDH(high) human head and neck squamous cell carcinoma (HNSCC) cancer stem cells (CSC) is distinct from that of ALDH(low) non-CSCs. METHODS:We generated CSC-loaded dendritic cells (DCs) to sensitize autologous peripheral blood T, B lymphocytes...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2016.05.013

    authors： Prince MEP,Zhou L,Moyer JS,Tao H,Lu L,Owen J,Etigen M,Zheng F,Chang AE,Xia J,Wolf G,Wicha MS,Huang S,Ren X,Li Q

    更新日期：2016-08-01 00:00:00

  • Transoral robotic total laryngopharyngectomy and free jejunal flap reconstruction for hypopharyngeal cancer.

    abstract：BACKGROUND:To report on the feasibility of total laryngopharyngectomy and free jejunal flap transfer for patient with hypopharyngeal cancer via the transoral robotic surgery (TORS) approach. MATERIAL AND METHODS:A patient with hypopharyngeal cancer involving the post-cricoid region is used for demonstration of the TOR...

    journal_title：Oral oncology

    pub_type： 信件

    doi：10.1016/j.oraloncology.2017.06.028

    authors： Chan JYW,Chan RCL,Chow VLY,Tsang RKY,Wong STS,Wei WI

    更新日期：2017-09-01 00:00:00