Abstract:
:Therapeutic options for the treatment of melioidosis caused by Burkholderia pseudomallei are limited due to the inherent resistance conferred by this pathogen to various groups of antibiotics. Witnessing an increase in the number of microbiological culture-confirmed cases of melioidosis at our settings in the past few years, we undertook this study to estimate the minimum inhibitory concentrations of clinical isolates of B. pseudomallei against the four commonly employed antimicrobial agents in the patient management at our settings, namely, ceftazidime, meropenem, trimethoprim-sulfamethoxazole and doxycycline. All isolates were susceptible to the antibiotics tested, except for one isolate which showed resistance to doxycycline (minimum inhibitory concentration [MIC]: 32 μg/ml). MIC50 and 90 for all the four antibiotics were estimated. From this study, we conclude that the clinical isolates of B. pseudomallei from the southern part of India are well susceptible to the commonly employed antimicrobial agents for therapy.
journal_name
Indian J Med Microbioljournal_title
Indian journal of medical microbiologyauthors
Shaw T,Tellapragada C,Eshwara VK,Bhat HV,Mukhopadhyay Cdoi
10.4103/0255-0857.188340subject
Has Abstractpub_date
2016-07-01 00:00:00pages
353-4issue
3eissn
0255-0857issn
1998-3646pii
IndianJMedMicrobiol_2016_34_3_353_188340journal_volume
34pub_type
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