Abstract:
:1. The aim of the present study was to examine the role of dopaminergic and glutamatergic receptors on different stages of the amphetamine (AMPH) sensitized effect in schedule-induced polydipsia (SIP) in rats. 2. Three experiments were designed to evaluate the roles of DAD2 receptor antagonist haloperidol (HAL) and glutamatergic N-methyl d-aspartate receptor antagonist MK-801 on both the induction and the expression stage of AMPH sensitization in SIP rats. First, the induction of AMPH sensitization in the SIP model was tested again to confirm previous findings. Second, HAL or MK-801 was co-administered with AMPH on five consecutive days and their effect on induction was examined 14 days after withdrawal. Finally, HAL or MK-801 was co-administered with AMPH on the final day of testing in SIP rats in which AMPH sensitization had been established previously. 3. The present results showed that HAL and MK-801 affected the effect of AMPH differently during the process of sensitization. Whereas HAL influenced the sensitization during both the induction and the expression phases, MK-801 affected only the induction phase; thus, once the sensitization had been established, MK-801 had no further influence. 4. These results suggest that the SIP model could be considered useful for the study of sensitization. In addition, the induction and expression of AMPH sensitization is influenced differently by the dopaminergic and glutamatergic systems.
journal_name
Clin Exp Pharmacol Physioljournal_title
Clinical and experimental pharmacology & physiologyauthors
Liu YP,Tung CS,Lin PJ,Wan FJdoi
10.1111/j.1440-1681.2010.05416.xsubject
Has Abstractpub_date
2010-09-01 00:00:00pages
945-52issue
9eissn
0305-1870issn
1440-1681pii
CEP5416journal_volume
37pub_type
杂志文章abstract::1. In a controlled, randomized double-blind trial, 15 patients with essential hypertension were treated with enalapril 5-20 mg/day, or doxazosin 1-8 mg/day, during a 7 week dose titration phase. This was followed by 7 weeks of combined treatment with doxazosin and enalapril. 2. Blood was taken after a 2 week placebo r...
journal_title:Clinical and experimental pharmacology & physiology
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/j.1440-1681.1976.tb00636.x
更新日期:1976-11-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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