Abstract:
OBJECTIVE:The vision of bioelectronic medicine is to treat disease by modulating the signaling of visceral nerves near various end organs. In small animal models, the nerves of interest can have small diameters and limited surgical access. New high-resolution methods for building nerve interfaces are desirable. In this study, we present a novel nerve interface and demonstrate its use for stimulation and recording in small nerves. APPROACH:We design and fabricate micro-scale electrode-laden nanoclips capable of interfacing with nerves as small as 50 µm in diameter. The nanoclips are fabricated using a direct laser writing technique with a resolution of 200 nm. The resolution of the printing process allows for incorporation of a number of innovations such as trapdoors to secure the device to the nerve, and quick-release mounts that facilitate keyhole surgery, obviating the need for forceps. The nanoclip can be built around various electrode materials; here we use carbon nanotube fibers for minimally invasive tethering. MAIN RESULTS:We present data from stimulation-evoked responses of the tracheal syringeal (hypoglossal) nerve of the zebra finch, as well as quantification of nerve functionality at various time points post implant, demonstrating that the nanoclip is compatible with healthy nerve activity over sub-chronic timescales. SIGNIFICANCE:Our nerve interface addresses key challenges in interfacing with small nerves in the peripheral nervous system. Its small size, ability to remain on the nerve over sub-chronic timescales, and ease of implantation, make it a promising tool for future use in the treatment of disease.
journal_name
J Neural Engjournal_title
Journal of neural engineeringauthors
Lissandrello CA,Gillis WF,Shen J,Pearre BW,Vitale F,Pasquali M,Holinski BJ,Chew DJ,White AE,Gardner TJdoi
10.1088/1741-2552/aa5a5bsubject
Has Abstractpub_date
2017-06-01 00:00:00pages
036006issue
3eissn
1741-2560issn
1741-2552journal_volume
14pub_type
杂志文章abstract:OBJECTIVE:Haptic perception of a prosthetic limb or hand is a crucial, but often unmet, need which impacts the utility of the prostheses. In this study, we seek to evaluate the feasibility of a non-invasive transcutaneous nerve stimulation method in generating haptic feedback in a transradial amputee subject as well as...
journal_title:Journal of neural engineering
pub_type: 杂志文章
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更新日期:2018-08-01 00:00:00
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journal_title:Journal of neural engineering
pub_type: 杂志文章
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journal_title:Journal of neural engineering
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journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/abc3a9
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journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aa7df9
更新日期:2017-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1088/1741-2552/abce3c
更新日期:2020-11-26 00:00:00
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journal_title:Journal of neural engineering
pub_type: 杂志文章,评审
doi:10.1088/1741-2552/aa6cbb
更新日期:2017-08-01 00:00:00
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doi:10.1088/1741-2552/abae8b
更新日期:2020-10-14 00:00:00
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journal_title:Journal of neural engineering
pub_type: 杂志文章
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更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:Among electrophysiological signals, local field potentials (LFPs) are extensively used to study brain activity, either in vivo or in vitro. LFPs are recorded with extracellular electrodes implanted in brain tissue. They reflect intermingled excitatory and inhibitory processes in neuronal assemblies. In cortic...
journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aafbfb
更新日期:2019-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1088/1741-2560/8/2/025025
更新日期:2011-04-01 00:00:00
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journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/aacdbb
更新日期:2018-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1088/1741-2552/aae4b9
更新日期:2019-02-01 00:00:00
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更新日期:2015-12-01 00:00:00
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journal_title:Journal of neural engineering
pub_type: 杂志文章,随机对照试验
doi:10.1088/1741-2560/10/1/016014
更新日期:2013-02-01 00:00:00
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journal_title:Journal of neural engineering
pub_type: 杂志文章
doi:10.1088/1741-2552/abb3b4
更新日期:2020-10-15 00:00:00
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pub_type: 杂志文章
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更新日期:2020-08-25 00:00:00
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更新日期:2020-08-04 00:00:00
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journal_title:Journal of neural engineering
pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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更新日期:2011-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1088/1741-2552/ab8dd6
更新日期:2020-06-12 00:00:00
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doi:10.1088/1741-2560/8/6/065008
更新日期:2011-12-01 00:00:00
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更新日期:2020-01-06 00:00:00
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pub_type: 杂志文章,评审
doi:10.1088/1741-2552/ab094a
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