Antimicrobial Protection of Marsupial Pouch Young.

Abstract:

:Marsupials diverged from eutherian mammals about 148 million years ago and represent a unique lineage of mammals with distinctive morphological and reproductive characteristics. Marsupials have significantly shorter gestation periods than eutherians. Pregnancy typically ranges from 15 to 35 days, with young being born at a very early developmental stage and lacking differentiated lymphoid tissues and mature effector cells. Recent microbiome studies of the marsupial pouch revealed that marsupial young can face intense microbial challenges after birth, as the pouch contains a broad range of Gram-positive and Gram-negative bacteria. Antimicrobials are believed to play a significant role in the immune protection of marsupial newborns during their pouch life. The skin of the post-reproductive pouch secretes antimicrobial lysozyme and dermcidin, which may contribute to the decreased density of certain bacteria in the pouch. A range of antimicrobial agents, such as immunoglobulins, lysozyme, transferrin, and cathelicidins, have been identified in marsupial milk. Antimicrobial assays have revealed that marsupial cathelicidins have broad-spectrum activity against a variety of bacteria and fungi, including several multi-drug resistant strains. In this article, we will review the action mechanisms of these antimicrobial compounds and discuss how they protect marsupial newborns from potentially pathogenic bacteria inside the pouch. We will also discuss the potential of marsupial antimicrobial compounds as a source of novel antibiotics.

journal_name

Front Microbiol

authors

Cheng Y,Belov K

doi

10.3389/fmicb.2017.00354

subject

Has Abstract

pub_date

2017-03-07 00:00:00

pages

354

issn

1664-302X

journal_volume

8

pub_type

杂志文章,评审
  • Viral Induced Microbial Mortality in Arctic Hypersaline Spring Sediments.

    abstract::Viruses are a primary influence on microbial mortality in the global ocean. The impacts of viruses on their microbial hosts in low-energy environments are poorly explored and are the focus of this study. To investigate the role of viruses in mediating mortality in low-energy environments where contacts between viruses...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2016.02158

    authors: Colangelo-Lillis J,Wing BA,Raymond-Bouchard I,Whyte LG

    更新日期:2017-01-23 00:00:00

  • Species interactions differ in their genetic robustness.

    abstract::Conflict and cooperation between bacterial species drive the composition and function of microbial communities. Stability of these emergent properties will be influenced by the degree to which species' interactions are robust to genetic perturbations. We use genome-scale metabolic modeling to computationally analyze t...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2015.00271

    authors: Chubiz LM,Granger BR,Segrè D,Harcombe WR

    更新日期:2015-04-14 00:00:00

  • Increased Toxoplasma gondii Intracellular Proliferation in Human Extravillous Trophoblast Cells (HTR8/SVneo Line) Is Sequentially Triggered by MIF, ERK1/2, and COX-2.

    abstract::Macrophage migration inhibitory factor (MIF) is a potent pro-inflammatory cytokine, which mediates the regulation of diverse cellular functions. It is produced by extravillous trophoblastic cells and has been found to be involved in the pathogenesis of diseases caused by some protozoa, including Toxoplasma gondii. Pre...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.00852

    authors: Milian ICB,Silva RJ,Manzan-Martins C,Barbosa BF,Guirelli PM,Ribeiro M,de Oliveira Gomes A,Ietta F,Mineo JR,Silva Franco P,Ferro EAV

    更新日期:2019-04-24 00:00:00

  • Characterization of a Functionally Unknown Arginine-Aspartate-Aspartate Family Protein From Halobacillus andaensis and Functional Analysis of Its Conserved Arginine/Aspartate Residues.

    abstract::Arginine-aspartate-aspartate (RDD) family, representing a category of transmembrane proteins containing one highly conserved arginine and two highly conserved aspartates, has been functionally uncharacterized as yet. Here we present the characterization of a member of this family designated RDD from the moderate halop...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.00807

    authors: Shao L,Abdel-Motaal H,Chen J,Chen H,Xu T,Meng L,Zhang Z,Meng F,Jiang J

    更新日期:2018-04-25 00:00:00

  • Discovery of Novel Biosynthetic Gene Cluster Diversity From a Soil Metagenomic Library.

    abstract::Soil microorganisms historically have been a rich resource for natural product discovery, yet the majority of these microbes remain uncultivated and their biosynthetic capacity is left underexplored. To identify the biosynthetic potential of soil microorganisms using a culture-independent approach, we constructed a la...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.585398

    authors: Santana-Pereira ALR,Sandoval-Powers M,Monsma S,Zhou J,Santos SR,Mead DA,Liles MR

    更新日期:2020-12-07 00:00:00

  • Differences between the rhizosphere microbiome of Beta vulgaris ssp. maritima-ancestor of all beet crops-and modern sugar beets.

    abstract::The structure and function of the plant microbiome is driven by plant species and prevailing environmental conditions. Effectuated by breeding efforts, modern crops diverge genetically and phenotypically from their wild relatives but little is known about consequences for the associated microbiota. Therefore, we studi...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2014.00415

    authors: Zachow C,Müller H,Tilcher R,Berg G

    更新日期:2014-08-26 00:00:00

  • Time-Resolved Transcriptomics and Constraint-Based Modeling Identify System-Level Metabolic Features and Overexpression Targets to Increase Spiramycin Production in Streptomyces ambofaciens.

    abstract::In this study we have applied an integrated system biology approach to characterize the metabolic landscape of Streptomyces ambofaciens and to identify a list of potential metabolic engineering targets for the overproduction of the secondary metabolites in this microorganism. We focused on an often overlooked growth p...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.00835

    authors: Fondi M,Pinatel E,Talà A,Damiano F,Consolandi C,Mattorre B,Fico D,Testini M,De Benedetto GE,Siculella L,De Bellis G,Alifano P,Peano C

    更新日期:2017-05-12 00:00:00

  • Dual Identification and Analysis of Differentially Expressed Transcripts of Porcine PK-15 Cells and Toxoplasma gondii during in vitro Infection.

    abstract::Toxoplasma gondii is responsible for causing toxoplasmosis, one of the most prevalent zoonotic parasitoses worldwide. The mechanisms that mediate T. gondii infection of pigs (the most common source of human infection) and renal tissues are still unknown. To identify the critical alterations that take place in the tran...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2016.00721

    authors: Zhou CX,Elsheikha HM,Zhou DH,Liu Q,Zhu XQ,Suo X

    更新日期:2016-05-13 00:00:00

  • Oral Supplementation of Lead-Intolerant Intestinal Microbes Protects Against Lead (Pb) Toxicity in Mice.

    abstract::Oral exposure to the heavy metal lead (Pb) causes various dysfunctions in animals. However, the influence of gut bacteria on Pb absorption, bioaccumulation, and excretion is largely unknown. In this study, we use a mouse model to investigate the relationship between gut microbiota, Pb-intolerant intestinal microbes an...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.03161

    authors: Zhai Q,Qu D,Feng S,Yu Y,Yu L,Tian F,Zhao J,Zhang H,Chen W

    更新日期:2020-01-22 00:00:00

  • Whole Genome Sequence Analysis Reveals Lower Diversity and Frequency of Acquired Antimicrobial Resistance (AMR) Genes in E. coli From Dairy Herds Compared With Human Isolates From the Same Region of Central Zambia.

    abstract::Antibiotic treatment of sick dairy cattle is critical for the sustainability of this production system which is vital for food security and societal prosperity in many low and middle-income countries. Given the increasingly high levels of antibiotic resistance worldwide and the challenge this presents for the treatmen...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.01114

    authors: Mainda G,Lupolova N,Sikakwa L,Richardson E,Bessell PR,Malama SK,Kwenda G,Stevens MP,Bronsvoort BMD,Muma JB,Gally DL

    更新日期:2019-05-31 00:00:00

  • High Aluminum Drives Different Rhizobacterial Communities Between Aluminum-Tolerant and Aluminum-Sensitive Wild Soybean.

    abstract::Aluminum (Al)-resistant plant cultivars can recruit beneficial microbes to alleviate the stresses. However, the mechanism of how rhizobacterial communities strengthen Al tolerance of wild soybean has not been addressed. The aim of this study was to investigate the bacterial community structure in the rhizosphere of Al...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.01996

    authors: Shi Q,Jin J,Liu Y,Zhang Y,Cai Z,Ma Q,Cheng Y,Wen R,Nian H,Lian T

    更新日期:2020-08-19 00:00:00

  • Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros.

    abstract::Human settlement of Madagascar traces back to the beginning of the first millennium with the arrival of Austronesians from Southeast Asia, followed by migrations from Africa and the Middle East. Remains of these different cultural, genetic, and linguistic legacies are still present in Madagascar and other islands of t...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.00711

    authors: Avanzi C,Lécorché E,Rakotomalala FA,Benjak A,Rapelanoro Rabenja F,Ramarozatovo LS,Cauchoix B,Rakoto-Andrianarivelo M,Tió-Coma M,Leal-Calvo T,Busso P,Boy-Röttger S,Chauffour A,Rasamoelina T,Andrianarison A,Sendrasoa F,Spen

    更新日期:2020-05-11 00:00:00

  • Prevalence and Antibiotic Resistance of Non-typhoidal Salmonella Isolated from Raw Chicken Carcasses of Commercial Broilers and Spent Hens in Tai'an, China.

    abstract::The present study was aimed to determine the prevalence and characteristics of Salmonella isolated from meat samples of commercial broilers (CB) and spent hens (SH). Between March and June 2016, 200 retail raw chicken carcasses (100 from CB and 100 from SH) were obtained from local supermarkets in Tai'an city of China...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.02106

    authors: Li S,Zhou Y,Miao Z

    更新日期:2017-10-31 00:00:00

  • Who possesses drug resistance genes in the aquatic environment?: sulfamethoxazole (SMX) resistance genes among the bacterial community in water environment of Metro-Manila, Philippines.

    abstract::Recent evidence has shown that antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs) are ubiquitous in natural environments, including sites considered pristine. To understand the origin of ARGs and their dynamics, we must first define their actual presence in the natural bacterial assemblage. Her...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2013.00102

    authors: Suzuki S,Ogo M,Miller TW,Shimizu A,Takada H,Siringan MA

    更新日期:2013-04-30 00:00:00

  • To Construct an Engineered (S)-Equol Resistant E. coli for in Vitro (S)-Equol Production.

    abstract::(S)-equol is one of the major metabolites of daidzein that is produced by human and animal gut bacteria. Most of the physiological functions of soybean isoflavones, such as anti-oxidative activity, anti-cancer activity, and cardiovascular protection have been ascribed to (S)-equol. However, only 30-50% people contain ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.01182

    authors: Li H,Mao S,Chen H,Zhu L,Liu W,Wang X,Yin Y

    更新日期:2018-06-04 00:00:00

  • Pika Population Density Is Associated with the Composition and Diversity of Gut Microbiota.

    abstract::Host population density is positively associated with the strength of social interactions or the frequency of physical contacts, and thus potentially influences microbial transmission among individuals. However, the relationship between host density and gut microbiota remains unknown. Here, we characterized the gut mi...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2016.00758

    authors: Li H,Qu J,Li T,Li J,Lin Q,Li X

    更新日期:2016-05-18 00:00:00

  • Multiple Ribosomal RNA Operons in Bacteria; Their Concerted Evolution and Potential Consequences on the Rate of Evolution of Their 16S rRNA.

    abstract::Bacterial species differ greatly in the number and location of the rRNA operons which may be present in the bacterial chromosomes and plasmids. Most bacterial species contain more than one ribosomal RNA operon copy in their genomes, with some species containing up to 15 such copies. We review the number and location o...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.01232

    authors: Espejo RT,Plaza N

    更新日期:2018-06-08 00:00:00

  • Reduction-Induced Suppression of Electron Flow (RISE) Is Relieved by Non-ATP-Consuming Electron Flow in Synechococcus elongatus PCC 7942.

    abstract::Photosynthetic organisms oxidize P700 to suppress the production of reactive oxygen species (ROS) in photosystem I (PSI) in response to the lower efficiency of photosynthesis under high light and low CO2 conditions. Previously, we found a positive relationship between reduction of plastoquinone (PQ) pool and oxidation...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.00886

    authors: Shimakawa G,Shaku K,Miyake C

    更新日期:2018-05-07 00:00:00

  • The N-Terminus of Human Lactoferrin Displays Anti-biofilm Activity on Candida parapsilosis in Lumen Catheters.

    abstract::Candida parapsilosis is a major cause of hospital-acquired infection, often related to parenteral nutrition administered via catheters and hand colonization of health care workers, and its peculiar biofilm formation ability on plastic surfaces. The mortality rate of 30% points to the pressing need for new antifungal d...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.02218

    authors: Fais R,Di Luca M,Rizzato C,Morici P,Bottai D,Tavanti A,Lupetti A

    更新日期:2017-11-13 00:00:00

  • Variation in the nuclear effects of infection by different human rhinovirus serotypes.

    abstract::Human rhinovirus (HRV) is a positive sense RNA virus, which, despite replicating in the cytoplasm, has a significant impact on nuclear transport and nuclear localization of host proteins. A number of studies have identified differences between HRV serotypes, with respect to host response, protease activity and replica...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2015.00875

    authors: Walker EJ,Jensen LM,Croft S,Ghildyal R

    更新日期:2015-08-24 00:00:00

  • Antiviral Mechanism and Biochemical Basis of the Human APOBEC3 Family.

    abstract::The human APOBEC3 (A3) family (A, B, C, DE, F, G, and H) comprises host defense factors that potently inhibit the replication of diverse retroviruses, retrotransposons, and the other viral pathogens. HIV-1 has a counterstrategy that includes expressing the Vif protein to abrogate A3 antiviral function. Without Vif, A3...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2012.00250

    authors: Imahashi M,Nakashima M,Iwatani Y

    更新日期:2012-07-09 00:00:00

  • Lactococcin B Is Inactivated by Intrinsic Proteinase PrtP Digestion in Lactococcus lactis subsp. lactis BGMN1-501.

    abstract::In our previous study we demonstrated that proteinase PrtP is able to impair bacteriocin LcnB activity, despite being produced by the same organism and encoded by the same plasmid. However, precise mechanism of this action, i.e., the exact cleavage site within LcnB bacteriocin, as well as its effect on antimicrobial a...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.00874

    authors: Vukotic G,Polovic N,Mirkovic N,Jovcic B,Stanisavljevic N,Fira D,Kojic M

    更新日期:2019-04-24 00:00:00

  • Seasonal and Spatial Variations in Bacterial Communities From Tetrodotoxin-Bearing and Non-tetrodotoxin-Bearing Clams.

    abstract::Tetrodotoxin (TTX) is one of the most potent naturally occurring compounds and is responsible for many human intoxications worldwide. Paphies australis are endemic clams to New Zealand which contain varying concentrations of TTX. Research suggests that P. australis accumulate the toxin exogenously, but the source rema...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.01860

    authors: Biessy L,Pearman JK,Smith KF,Hawes I,Wood SA

    更新日期:2020-08-05 00:00:00

  • Atypical Porcine Pestivirus as a Novel Type of Pestivirus in Pigs in China.

    abstract::Pestiviruses are highly variable RNA viruses. A growing number of novel pestiviruses has been discovered in domestic and wild species in the last two decades. Recently, a novel atypical porcine pestivirus (APPV) linked with the development of congenital tremor (CT) in neonatal pigs was described in Europe and the Amer...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.00862

    authors: Yuan J,Han Z,Li J,Huang Y,Yang J,Ding H,Zhang J,Zhu M,Zhang Y,Liao J,Zhao M,Chen J

    更新日期:2017-05-11 00:00:00

  • Infection Strategies of Intestinal Parasite Pathogens and Host Cell Responses.

    abstract::Giardia lamblia, Cryptosporidium sp., and Entamoeba histolytica are important pathogenic intestinal parasites and are amongst the leading causes worldwide of diarrheal illness in humans. Diseases caused by these organisms, giardiasis, cryptosporidiosis, and amoebiasis, respectively, are characterized by self-limited d...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审

    doi:10.3389/fmicb.2016.00256

    authors: Di Genova BM,Tonelli RR

    更新日期:2016-03-03 00:00:00

  • Functional Analysis of the Citrate Activator CitO from Enterococcus faecalis Implicates a Divalent Metal in Ligand Binding.

    abstract::The regulator of citrate metabolism, CitO, from Enterococcus faecalis belongs to the FCD family within the GntR superfamily. In the presence of citrate, CitO binds to cis-acting sequences located upstream of the cit promoters inducing the expression of genes involved in citrate utilization. The quantification of the m...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2016.00101

    authors: Blancato VS,Pagliai FA,Magni C,Gonzalez CF,Lorca GL

    更新日期:2016-02-09 00:00:00

  • Swine Enteric Colibacillosis in Spain: Pathogenic Potential of mcr-1 ST10 and ST131 E. coli Isolates.

    abstract::This is a wide epidemiological study of 499 E. coli isolates recovered from 179 outbreaks of enteric colibacillosis from pig production farms in Spain during a period of 10 years. Most samples were of diarrheagenic cases occurred during the post-wean period (PWD) which showed to be significantly associated with ETEC (...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.02659

    authors: García-Meniño I,García V,Mora A,Díaz-Jiménez D,Flament-Simon SC,Alonso MP,Blanco JE,Blanco M,Blanco J

    更新日期:2018-11-05 00:00:00

  • Biogenesis, Function, and Applications of Virus-Derived Small RNAs in Plants.

    abstract::RNA silencing, an evolutionarily conserved and sequence-specific gene-inactivation system, has a pivotal role in antiviral defense in most eukaryotic organisms. In plants, a class of exogenous small RNAs (sRNAs) originating from the infecting virus called virus-derived small interfering RNAs (vsiRNAs) are predominantl...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审

    doi:10.3389/fmicb.2015.01237

    authors: Zhang C,Wu Z,Li Y,Wu J

    更新日期:2015-11-09 00:00:00

  • The Role of Candida albicans Secreted Polysaccharides in Augmenting Streptococcus mutans Adherence and Mixed Biofilm Formation: In vitro and in vivo Studies.

    abstract::The oral cavity is a complex environment harboring diverse microbial species that often co-exist within biofilms formed on oral surfaces. Within a biofilm, inter-species interactions can be synergistic in that the presence of one organism generates a niche for another enhancing colonization. Among these species are th...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.00307

    authors: Khoury ZH,Vila T,Puthran TR,Sultan AS,Montelongo-Jauregui D,Melo MAS,Jabra-Rizk MA

    更新日期:2020-02-28 00:00:00

  • New Genes Involved in Osmotic Stress Tolerance in Saccharomyces cerevisiae.

    abstract::Adaptation to changes in osmolarity is fundamental for the survival of living cells, and has implications in food and industrial biotechnology. It has been extensively studied in the yeast Saccharomyces cerevisiae, where the Hog1 stress activated protein kinase was discovered about 20 years ago. Hog1 is the core of th...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2016.01545

    authors: Gonzalez R,Morales P,Tronchoni J,Cordero-Bueso G,Vaudano E,Quirós M,Novo M,Torres-Pérez R,Valero E

    更新日期:2016-09-28 00:00:00