Abstract:
:The aim of the present study was to determine the anti-inflammatory effect of IFN-τ on endometritis using a mouse model of S. aureus-induced endometritis and to elucidate the mechanism of action underlying these effects. In the present study, the effect of IFN-τ on S. aureus growth was monitored by turbidimeter at 600 nm. IFN-τ did not affect S. aureus growth. The histopathological changes indicated that IFN-τ had a protective effect on uterus tissues with S. aureus infection. The ELISA and qPCR results showed the production of the proinflammatory cytokines TNF-α, IL-1β, and IL-6 was decreased with IFN-τ treatment. In contrast, the level of the anti-inflammatory cytokine IL-10 was increased. We further studied the signaling pathway associated with these observations, and the qPCR results showed that the expression of TLR2 was repressed by IFN-τ. Furthermore, the western blotting results showed the phosphorylation of IκB, NF-κB p65, and MAPKs (p38, JNK, and ERK) was inhibited by IFN-τ treatment. The results suggested that IFN-τ may be a potential drug for the treatment of uterine infection due to S. aureus or other infectious inflammatory diseases.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Zhang Z,Guo Y,Liu Y,Li C,Guo M,Deng Gdoi
10.1155/2017/2350482subject
Has Abstractpub_date
2017-01-01 00:00:00pages
2350482eissn
2314-6133issn
2314-6141journal_volume
2017pub_type
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journal_title:BioMed research international
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更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章,meta分析
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