Abstract：
BACKGROUND AND AIMS:Severe decompression sickness (DCS) is a multi-organ injury. This study investigated the preventive effects of rosiglitazone on liver injury following rapid decompression in mice and examined the underlying mechanisms. METHODS:Mice were randomly divided into four groups: a control group, vehicle group, and rosiglitazone (5 and 10 mg·kg⁻¹) groups, the latter three being exposed to a pressure of 911 kPa. Haematoxylin and eosin staining, plasma levels of alanine transaminase (ALT), aspartate transaminase (AST) and lactate dehydrogenase and blood cell counts were used to evaluate liver injury at 30 min after rapid decompression. The expression of endothelial and inducible nitric oxide synthase (iNOS) and its phosphorylation were measured to uncover the underlying molecular mechanisms. RESULTS:A significant increase in plasma ALT, red blood cells and platelets, and a decrease in neutrophils were observed in the vehicle group. Furthermore, the expression of iNOS, E-selectin and the total level of NO in hepatic tissue, and soluble E-selectin in the plasma were significantly elevated in the vehicle group. Rosiglitazone pre-treatment prevented the increases in ALT (and AST), soluble E-selectin concentration, red blood cells and platelet counts. Moreover, rosiglitazone reduced over-expression of iNOS and the NO level, prevented the fall in neutrophil count and promoted the phosphorylation of iNOS in the liver. CONCLUSIONS:Pre-treatment with rosiglitazone ameliorated liver injury from severe DCS. This preventive effect may be partly mediated by stimulating endothelial NO production, improving endothelial function and limiting inflammatory processes.
journal_name
Diving Hyperb Medjournal_title
Diving and hyperbaric medicineauthors
Peng B,Chen MM,Jiang ZL,Li X,Wang GH,Xu LHdoi
10.28920/dhm47.1.17-23subject
Has Abstractpub_date
2017-03-01 00:00:00pages
17-23issue
1eissn
1833-3516issn
2209-1491journal_volume
47pub_type
杂志文章abstract：INTRODUCTION:In-water resuscitation has recently been proposed in the European resuscitation guidelines. Initiation of mechanical ventilation underwater might be considered when an immediate ascent to the surface is impossible or dangerous. The present study evaluated the feasibility of such ventilation underwater. ME...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：
更新日期：2013-06-01 00:00:00
abstract：:Divers suspected of suffering decompression illness (DCI) in locations remote from a recompression chamber are sometimes treated with in-water recompression (IWR). There are no data that establish the benefits of IWR compared to conventional first aid with surface oxygen and transport to the nearest chamber. However, ...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章,评审
doi：10.28920/dhm48.2.84-95
更新日期：2018-06-30 00:00:00
abstract：:A case of a 24-year-old gentleman who had pulmonary barotrauma (PBT) after diving is reported. He presented with chest pain after the second of two uneventful shallow SCUBA dives. Computerized tomography (CT) scan confirmed the diagnosis and he was treated conservatively. Relevant radiology and a discussion of PBT are...
journal_title：Diving and hyperbaric medicine
pub_type：
doi：10.28920/dhm50.1.66-69
更新日期：2020-03-31 00:00:00
abstract：:Gas micronuclei are gas-filled voids in liquids from which bubbles can form at low gas supersaturation. If water is depleted of gas micronuclei, high gas supersaturation is required for bubble formation. This high gas supersaturation is required in part to overcome the Laplace pressure at the point of transition from ...
journal_title：Diving and hyperbaric medicine
pub_type： 信件
doi：10.28920/dhm49.1.64
更新日期：2019-03-31 00:00:00
abstract：INTRODUCTION:Scuba diving involves risks, and candidates in Australia usually have a medical evaluation prior to undertaking a diving course. Hyperbaric physicians act as secondary referral practitioners for these assessments. This study aimed to identify reasons for these secondary referrals, and document the assessme...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：
更新日期：2010-09-01 00:00:00
abstract：INTRODUCTION:Decompression illness (DCI) is associated with a right-to-left shunt, such as persistent foramen ovale (PFO), atrial septal defect (ASD) and pulmonary arteriovenous malformations. About one-quarter of the population have a PFO, but considerably less than one-quarter of divers suffer DCI. Our aim was to det...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：
更新日期：2015-06-01 00:00:00
abstract：:Two cases are presented of divers suffering epileptic seizure and loss of consciousness as a result of probable cerebral arterial gas embolism (CAGE). Both cases had apparently problem-free dives with no obvious provocation for CAGE, though one case may have been having repeated embolisms for some time in their diving...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：
更新日期：2008-03-01 00:00:00
abstract：INTRODUCTION:The adverse effects of hyperbaric oxygen (HBO) on cardiac physiology are considered a potential hazard during the treatment of some patients. The haemodynamic effects of HBO are poorly understood and the incompatibility of electrical equipment inside the chamber has made assessment difficult. At Fremantle ...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：
更新日期：2014-09-01 00:00:00
abstract：:Inner-ear decompression sickness (DCS) is an incompletely understood and increasingly recognized condition in compressed-air divers. Previous reports show a high association of inner-ear DCS with persistent foramen ovale (PFO), suggesting that a moderate-to-severe right-to-left shunt might represent a major predisposi...
journal_title：Diving and hyperbaric medicine
pub_type： 信件
doi：
更新日期：2015-06-01 00:00:00
abstract：:Vomiting and aspiration of gastric contents into the airways and lungs is a common and well-known clinicopathological entity. This phenomenon might also occur in underwater diving, where it can lead to life-threatening or fatal situations. This article presents two incidents involving diving-related vomiting with asso...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：10.28920/dhm48.1.36-39
更新日期：2018-03-31 00:00:00
abstract：:Exposure to hyperoxia is associated with oxidative stress and is known to cause inflammation in the lung and the airways. Exhaled nitric oxide concentration (FENO) is a marker of some inflammatory processes in the lung and airways, and is reduced immediately after a single session of hyperbaric oxygen (HBO) exposure. ...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：
更新日期：2009-06-01 00:00:00
abstract：INTRODUCTION:During a hyperbaric oxygen therapy (HBOT) session, every medical device that is used within the hyperbaric chamber is exposed to several hazards, including an increased ambient pressure and partial pressure of oxygen. In Europe, all medical devices marketed and/or sold for use in hyperbaric conditions must...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：10.28920/dhm49.2.137-140
更新日期：2019-06-30 00:00:00
abstract：:Cerebral arterial gas embolism (CAGE) from breath-holding or inadequate exhalation during ascent is a well-recognised complication of scuba diving. It does not usually occur with breath-hold (BH) diving in those with normal lungs, as the volume of gas in the lungs on surfacing cannot exceed what it was on leaving the ...
journal_title：Diving and hyperbaric medicine
pub_type：
doi：10.28920/dhm49.4.304-305
更新日期：2019-12-20 00:00:00
abstract：BACKGROUND:Since 2009, the United Kingdom diving incident data show an increasing number of fatalities in the over-50s age group. Previous studies also suggest some divers take cardiac medications. Since 2001, diving medicals have not been mandatory for UK sport divers. Instead, an annual medical self-certification for...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：
更新日期：2015-09-01 00:00:00
abstract：:Decompression illness (DCI) is a syndrome with diverse clinical manifestations but in which cardiac symptoms are rare. In the presence of cardiac symptoms, the necessity to rule out an acute coronary syndrome (ACS) which requires prompt treatment may result in delay to appropriate recompression treatment. We describe ...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：
更新日期：2013-12-01 00:00:00
abstract：:Sphenoid sinus mucocele is a rare cystic lesion. It grows gradually and causes visual disturbances, ocular motility abnormalities and headache due to cavernous sinus compression. Sudden change in sinus cavity volume by a barotrauma may compress a mucocele and precipitate symptoms that may easily be confused with decom...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：10.28920/dhm50.2.168-172
更新日期：2020-06-30 00:00:00
abstract：:Cerebral arterial gas embolism (CAGE) is a feared complication of ambient depressurisation and can also be a complication of hydrogen peroxide ingestion. We present an unusual case of CAGE in a 57-year-old woman exposed to both of these risk factors. We describe her subsequent successful treatment with hyperbaric oxyg...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：
更新日期：2016-06-01 00:00:00
abstract：:Basic life support (BLS) in a diving bell (DB) or deck decompression chamber (DDC) is difficult due to the confined space and limited equipment. Retrieval of the unconscious diver into the DB requires the use of a pulley system. Once inside the bell, space limitations dictate that any resuscitative efforts are attempt...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：
更新日期：2008-06-01 00:00:00
abstract：:Livedoid vasculopathy is a painful, ulcerating condition of the lower legs, ankles and feet with the typical histological feature of hyalinising vascular change of dermal blood vessels with minimal inflammation. Therapeutic interventions have been diverse and varyingly successful. We report a biopsy-proven case in a 2...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：
更新日期：2013-03-01 00:00:00
abstract：:We present a case of cerebral venous gas embolism. Our patient made a complete neurological recovery after hyperbaric oxygen therapy (HBOT). The principles of HBOT, compressing and eliminating air bubbles and decreasing Β-2 integrin function, thus improving microcirculation, can only be beneficial in a situation where...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：
更新日期：2012-06-01 00:00:00
abstract：INTRODUCTION:Running out of air, buoyancy problems and rapid ascents are known risk factors for diving morbidity and mortality. The effects of the diving environment and equipment and the influence of individual diver characteristics on these risks were studied. METHODS:Between 1995 and 2004, Project Dive Exploration ...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：
更新日期：2009-12-01 00:00:00
abstract：INTRODUCTION:Various prescribed and over-the-counter medications may theoretically be incompatible with the diving environment. Anecdotally, it is known divers regularly take medications around the time of their diving activities for different health conditions, possibly ignoring the recommendations not to do so. As pa...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：
更新日期：2011-03-01 00:00:00
abstract：:Dear Editor, By focussing on the details of the Watson case, I believe Bryan Walpole has missed the thrust of my earlier letter. I agree this was a complex case, which is why I deliberately avoided the murky specifics in order to consider the 'big-picture' ramifications of the judgement. My concerns relate to the pote...
journal_title：Diving and hyperbaric medicine
pub_type： 信件
doi：
更新日期：2011-12-01 00:00:00
abstract：:Recreational scuba diving is a popular leisure activity with the number of divers reaching several millions worldwide. Scuba diving represents a huge challenge for integrative physiology. In mammalian evolution, physiological reflexes developed to deal with lack of oxygen, rather than with an excess, which makes adapt...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章,评审
doi：
更新日期：2013-09-01 00:00:00
abstract：INTRODUCTION:After a maximal apnoea, breath-hold divers must restore O2 levels and clear CO2 and lactic acid produced. High intensity interval training (HIIT) and inspiratory muscle training (IMT) could be employed with the aim of increasing recovery capacity. This study aimed to evaluate the relative effects of IMT ve...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章,随机对照试验
doi：10.28920/dhm50.4.318-324
更新日期：2020-12-20 00:00:00
abstract：:Commercial or occupational breath-hold (BH) harvest divers along the coast and islands of Japan are collectively called Ama divers. Repetitive BH diving by Ama divers may place them at risk of developing neurological decompression sickness (DCS). We report a 74-year-old Ama diver who demonstrated right hemiparesis dur...
journal_title：Diving and hyperbaric medicine
pub_type：
doi：10.28920/dhm48.4.262-263
更新日期：2018-12-24 00:00:00
abstract：INTRODUCTION:An individual case review of diving-related deaths reported as occurring in Australia in 2006 was conducted as part of the Divers Alert Network Asia-Pacific (DAN AP) dive fatality reporting project. METHOD:The case studies were compiled using reports from witnesses, the police and coroners. In each case, ...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：
更新日期：2011-06-01 00:00:00
abstract：INTRODUCTION:When a standard water-seal pleural drain unit (PDU) is used under hyperbaric conditions there are scenarios where excessive negative intrapleural pressure (IPP) and/or fluid reflux can be induced, risking significant morbidity. We developed and tested a pleural vacuum relief (PVR) device which automaticall...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：10.28920/dhm47.3.191-197
更新日期：2017-09-01 00:00:00
abstract：:Divers are exposed to circulatory stress that directly affects the endothelial lining of blood vessels, and even asymptomatic dives are associated with inflammatory responses, microparticle release and endothelial dysfunction. As humans age, there is a relative increase in the risk of cardiovascular disease, attribute...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章,评审
doi：
更新日期：2015-12-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to further the understanding of the opening of the Eustachian tube in relation to changes in barometric pressure. DESIGN:An ear canal microphone was used to measure the specific sounds related to tube opening and possible eardrum movements. Five subjects with normal tube functio...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：
更新日期：2016-03-01 00:00:00
