Abstract:
:Objectives Congenital infection with Toxoplasma gondii is known to result in neurological and brain disorders including ophthalmic disorders later in life. Research in Ghana revealed high sero-prevalence among pregnant women and eye patients. This study determines the risk of congenital transmission of T. gondii infection in Accra, Ghana. Methods One hundred consented pregnant women aged 18-45 years (mean 29.85 ± 5.76) participated. Venous blood and tissue samples were taken from the maternal side of each placenta after delivery. Cord blood samples were also taken after they were separated from the infants. Finger-prick blood was taken from infants of participating women at 2 or 6 weeks post-natal. ELISA was used to detect T. gondii antibodies in all blood samples while Nested-PCR was used to detect T. gondii DNA from placental tissues. Data was analysed using SPSS v. 16. Results Overall, 37.6 % of maternal blood, 39.5 % of umbilical cord blood, and 57.5 % of post-natal infant blood were positive for anti-T. gondii IgG. No anti-T. gondii IgM was detected in any of those samples. Toxoplasma gondii DNA was detected in 39.8 % of placental tissue samples. Strong association was observed in the occurrence of placental T. gondii DNA and anti-T. gondii IgG positive women (ø = 0.810, p < 0.00001) as well as high Relative risk shown in the likelihood of foetal exposure to infection in latently-infected women (RR 10.39; CI 4.47-24.17; p < 0.00001). Conclusions for Practice The presence of anti-T. gondii IgG antibodies only, and T. gondii DNA in placental tissues indicate the women might have been infected early during the pregnancy, placing about 39.8 % of the babies at risk. These results can strongly influence policy to screen and treat pregnant women for T. gondii infection.
journal_name
Matern Child Health Jjournal_title
Maternal and child health journalauthors
Kwofie KD,Ghansah A,Osei JH,Frempong KK,Obed S,Frimpong EH,Boakye DA,Suzuki T,Ohta N,Ayi Idoi
10.1007/s10995-016-2084-zsubject
Has Abstractpub_date
2016-12-01 00:00:00pages
2581-2588issue
12eissn
1092-7875issn
1573-6628pii
10.1007/s10995-016-2084-zjournal_volume
20pub_type
杂志文章abstract:OBJECTIVE:Lack of local data on pregnancy intendedness poses a serious problem for those responsible for regional program development and evaluation. This article demonstrates how the Boulder County Health Department addressed this problem by conducting its own assessment. The information gathered served as the basis f...
journal_title:Maternal and child health journal
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pub_type: 杂志文章,随机对照试验
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更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:Children with special health care needs (CSHCN) benefit from a medical home, however, a subset, those children with high intensity needs, have medical and social service issues beyond the capacity of most primary care practices. We describe a novel medical home center that is designed to meet the needs of chi...
journal_title:Maternal and child health journal
pub_type: 杂志文章
doi:10.1007/s10995-007-0271-7
更新日期:2008-09-01 00:00:00
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doi:10.1007/s10995-018-2612-0
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doi:10.1007/s10995-012-1213-6
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journal_title:Maternal and child health journal
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doi:10.1007/s10995-009-0442-9
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journal_title:Maternal and child health journal
pub_type: 杂志文章
doi:10.1007/s10995-018-2673-0
更新日期:2019-04-01 00:00:00
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journal_title:Maternal and child health journal
pub_type: 评论,杂志文章
doi:10.1023/a:1025180203483
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journal_title:Maternal and child health journal
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doi:10.1007/s10995-014-1478-z
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journal_title:Maternal and child health journal
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doi:10.1007/s10995-019-02789-2
更新日期:2019-11-01 00:00:00
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journal_title:Maternal and child health journal
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doi:10.1007/s10995-012-1066-z
更新日期:2013-07-01 00:00:00
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journal_title:Maternal and child health journal
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doi:10.1007/s10995-016-2090-1
更新日期:2017-01-01 00:00:00
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journal_title:Maternal and child health journal
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更新日期:2020-11-17 00:00:00
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doi:10.1007/s10995-018-2544-8
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journal_title:Maternal and child health journal
pub_type: 杂志文章
doi:10.1007/s10995-013-1386-7
更新日期:2014-08-01 00:00:00
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journal_title:Maternal and child health journal
pub_type: 杂志文章
doi:10.1007/s10995-013-1383-x
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journal_title:Maternal and child health journal
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更新日期:2013-04-01 00:00:00
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更新日期:2020-04-01 00:00:00
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doi:10.1007/s10995-016-2220-9
更新日期:2017-05-01 00:00:00
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journal_title:Maternal and child health journal
pub_type: 杂志文章
doi:10.1007/s10995-013-1391-x
更新日期:2014-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s10995-017-2360-6
更新日期:2018-01-01 00:00:00
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journal_title:Maternal and child health journal
pub_type: 杂志文章
doi:10.1007/s10995-012-1142-4
更新日期:2013-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-10-01 00:00:00
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journal_title:Maternal and child health journal
pub_type: 杂志文章
doi:10.1007/s10995-015-1777-z
更新日期:2015-12-01 00:00:00