当前位置： SCI文献检索 > Nutrition Research and Practice期刊下所有文献 > Wheatgrass extract inhibits hypoxia-inducible factor-1-mediated epithelial-mesenchymal transition in A549 cells.

Wheatgrass extract inhibits hypoxia-inducible factor-1-mediated epithelial-mesenchymal transition in A549 cells.

Abstract：

BACKGROUND/OBJECTIVES:Epithelial-mesenchymal transition (EMT) is involved in not only cancer development and metastasis but also non-cancerous conditions. Hypoxia is one of the proposed critical factors contributing to formation of chronic rhinosinusitis or nasal polyposis. Wheatgrass (Triticum aestivum) has antioxidant, anti-aging, and anti-inflammatory effects. In this study, we analyzed whether wheatgrass has an inhibitory effect on the EMT process in airway epithelial cells. MATERIALS/METHODS:A549 human lung adenocarcinoma cells were incubated in hypoxic conditions (CO2 5%/O2 1%) for 24 h in the presence of different concentrations of wheatgrass extract (50, 75, 100, and 150 µg/mL) and changes in expression of epithelial or mesenchymal markers were evaluated by immunoblotting and immunofluorescence. Accordingly, associated EMT-related transcriptional factors, Snail and Smad, were also evaluated. RESULTS:Hypoxia increased expression of N-cadherin and reduced expression of E-cadherin. Mechanistically, E-cadherin levels were recovered during hypoxia by silencing hypoxia inducible factor (HIF)-1α or administering wheatgrass extract. Wheatgrass inhibited the hypoxia-mediated EMT by reducing the expression of phosphorylated Smad3 (pSmad3) and Snail. It suppressed the hypoxia-mediated EMT processes of airway epithelial cells via HIF-1α and the pSmad3 signaling pathway. CONCLUSION:These results suggest that wheatgrass has potential as a therapeutic or supplementary agent for HIF-1-related diseases.

journal_name

Nutr Res Pract

journal_title

Nutrition research and practice

authors

Do NY,Shin HJ,Lee JE

doi

10.4162/nrp.2017.11.2.83

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

83-89

issue

2

eissn

1976-1457

issn

2005-6168

journal_volume

11

pub_type

杂志文章,收录出版

相关文献

Nutrition Research and Practice文献大全
  • Effect of Hominis Placenta on cutaneous wound healing in normal and diabetic mice.

    abstract：BACKGROUND/OBJECTIVES:The number of diabetic patients has recently shown a rapid increase, and delayed wound healing is a major clinical complication in diabetes. In this study, the wound healing effect of Hominis placenta (HP) treatment was investigated in normal and streptozotocin-induced diabetic mice. MATERIALS/ME...

    journal_title：Nutrition research and practice

    pub_type： 杂志文章

    doi：10.4162/nrp.2014.8.4.404

    authors： Park JY,Lee J,Jeong M,Min S,Kim SY,Lee H,Lim Y,Park HJ

    更新日期：2014-08-01 00:00:00

  • Effects of soybean supplementation on blood glucose, plasma lipid levels, and erythrocyte antioxidant enzyme activity in type 2 diabetes mellitus patients.

    abstract：:The purpose of this study was to investigate the effect of soybean on blood glucose and lipid concentrations, and antioxidant enzyme activity in type 2 diabetes mellitus (DM) patients. We divided patients into two groups and fed them, respectively, a basal diet (control group) and a basal diet with 69 g/d of soybean (...

    journal_title：Nutrition research and practice

    pub_type： 杂志文章

    doi：10.4162/nrp.2008.2.3.152

    authors： Chang JH,Kim MS,Kim TW,Lee SS

    更新日期：2008-10-01 00:00:00

  • Effects of excessive dietary methionine on oxidative stress and dyslipidemia in chronic ethanol-treated rats.

    abstract：BACKGROUND/OBJECTIVE:The aim of this study was to examine the effect of high dietary methionine (Met) consumption on plasma and hepatic oxidative stress and dyslipidemia in chronic ethanol fed rats. MATERIALS/METHODS:Male Wistar rats were fed control or ethanol-containing liquid diets supplemented without (E group) or...

    journal_title：Nutrition research and practice

    pub_type： 杂志文章

    doi：10.4162/nrp.2015.9.2.144

    authors： Kim SY,Kim H,Min H

    更新日期：2015-04-01 00:00:00

  • Anti-doping education and dietary supplementation practice in Korean elite university athletes.

    abstract：:This study was conducted to investigate relationships and gender differences in dietary supplement (DS) and oriental supplement (OS) prevalence as well as anti-doping awareness during training and the game period. Korea National Sport University athletes (343 male and 136 female) participated in this study and complet...

    journal_title：Nutrition research and practice

    pub_type： 杂志文章

    doi：10.4162/nrp.2011.5.4.349

    authors： Kim J,Lee N,Kim EJ,Ki SK,Yoon J,Lee MS

    更新日期：2011-08-01 00:00:00

  • Comparison of five international indices of adherence to the Mediterranean diet among healthy adults: similarities and differences.

    abstract：BACKGROUND/OBJECTIVES:To compare five indices of adherence to the Mediterranean Diet (MD) among adults living in the Mediterranean region. SUBJECTS/METHODS:A total of 100 healthy Lebanese adults aged between 18 and 65 years. Face-to-face interviews to collect sociodemographic and medical information, to take anthropom...

    journal_title：Nutrition research and practice

    pub_type： 杂志文章

    doi：10.4162/nrp.2019.13.4.333

    authors： Aoun C,Papazian T,Helou K,El Osta N,Khabbaz LR

    更新日期：2019-08-01 00:00:00

  • Relationship between dietary intakes and the double burden of malnutrition in adults of Malang, Indonesia: An exploratory study.

    abstract：BACKGROUND/OBJECTIVES:Urbanization and lifestyle changes have resulted in nutrition transition. Over-nutrition causes obesity increase, although malnutrition still exists. This phenomenon is called a double burden of malnutrition (DBM). This study was conducted to confirm the existence of DBM and to investigate the die...

    journal_title：Nutrition research and practice

    pub_type： 杂志文章

    doi：10.4162/nrp.2018.12.5.426

    authors： Lee SJ,Ryu HK

    更新日期：2018-10-01 00:00:00

  • Dietary intake of fat and fatty acids by 1-5-year-old children in Korea: a cross-sectional study based on data from the sixth Korea National Health and Nutrition Examination Survey.

    abstract：BACKGROUND/OBJECTIVES:We examined dietary fat intake and the major food sources by young children in Korea. SUBJECTS/METHODS:A total of 1,041 children aged 1-5 years were identified from the 2013-2015 Korea National Health and Nutrition Examination Survey. Data on total fat and fatty acid intake were obtained by a sin...

    journal_title：Nutrition research and practice

    pub_type： 杂志文章

    doi：10.4162/nrp.2018.12.4.324

    authors： Baek Y,Shim JE,Song S

    更新日期：2018-08-01 00:00:00

  • Effects of developmental iron deficiency and post-weaning iron repletion on the levels of iron transporter proteins in rats.

    abstract：BACKGROUND/OBJECTIVES:Iron deficiency in early life is associated with developmental problems, which may persist until later in life. The question of whether iron repletion after developmental iron deficiency could restore iron homeostasis is not well characterized. In the present study, we investigated the changes of ...

    journal_title：Nutrition research and practice

    pub_type： 杂志文章

    doi：10.4162/nrp.2015.9.6.613

    authors： Oh S,Shin PK,Chung J

    更新日期：2015-12-01 00:00:00

  • Fruit and vegetable intakes in relation to behavioral outcomes associated with a nutrition education intervention in preschoolers.

    abstract：BACKGROUND/OBJECTIVES:Although a lot of effort has been put into increasing fruit and vegetable intakes in preschool children, vegetable intake in this group is still low. This study investigated whether nutrition education focusing on fruit and vegetable intakes can affect preschoolers' fruit and vegetable intakes as ...

    journal_title：Nutrition research and practice

    pub_type： 杂志文章

    doi：10.4162/nrp.2018.12.6.521

    authors： Choi EB,Lee JE,Hwang JY

    更新日期：2018-12-01 00:00:00

  • Effect of nutritional supplement formula on catch-up growth in young children with nonorganic faltering growth: a prospective multicenter study.

    abstract：BACKGROUND/OBJECTIVES:Inadequate nutrition in infants and young children affects physical growth and neurocognitive development. Therefore, early nutritional intervention is important to promote catch-up growth in young children with faltering growth. The aim of this study was to evaluate the effect of nutritional supp...

    journal_title：Nutrition research and practice

    pub_type： 杂志文章

    doi：10.4162/nrp.2020.14.3.230

    authors： Shim JO,Kim S,Choe BH,Seo JH,Yang HR

    更新日期：2020-06-01 00:00:00

  • Antioxidant action of soy isoflavones on oxidative stress and antioxidant enzyme activities in exercised rats.

    abstract：BACKGROUND/OBJECTIVES:Isoflavones are widely believed to be beneficial to human health, in relation to their antioxidant potentials. Exercise can cause an imbalance between reactive oxygen species (ROS) and antioxidants. This study was conducted in order to investigate the ability of isoflavones in amelioration of oxid...

    journal_title：Nutrition research and practice

    pub_type： 杂志文章

    doi：10.4162/nrp.2014.8.6.618

    authors： Yoon GA,Park S

    更新日期：2014-12-01 00:00:00

  • Effect of coenzyme Q10 and Ardisia japonica Blume on plasma and liver lipids, platelet aggregation, and erythrocyte Na efflux channels in simvastatin-treated guinea pigs.

    abstract：:Forty guinea pigs were divided into four groups and fed 0.04% cholesterol based control diet, plus 0.05% simvastatin, and statin plus 0.1% CoQ10 or 10% Ardisia Japonica Blume (AJB) leave powder for 4 weeks. Plasma total cholesterol levels decreased significantly in all groups fed the statin-containing diet compared wi...

    journal_title：Nutrition research and practice

    pub_type： 杂志文章

    doi：10.4162/nrp.2012.6.5.414

    authors： Kang MS,Yang HM,Kang JY,Ryou SH,Kang JS

    更新日期：2012-10-01 00:00:00

  • Parents' meal choices for their children at fast food and family restaurants with different menu labeling presentations.

    abstract：BACKGROUND/OBJECTIVES:This study examined the effect of nutrition labeling formats on parents' food choices for their children at different restaurant types. SUBJECTS/METHODS:An online survey was conducted with 1,980 parents of children aged 3-12 years. Participants were randomly assigned to fast food or family restau...

    journal_title：Nutrition research and practice

    pub_type： 杂志文章

    doi：10.4162/nrp.2018.12.3.243

    authors： Lee K,Lee Y

    更新日期：2018-06-01 00:00:00

  • Korean consumers' perceptions of health/functional food claims according to the strength of scientific evidence.

    abstract：:In this study, we investigated that consumers could differentiate between levels of claims and clarify how a visual aid influences consumer understanding of the different claim levels. We interviewed 2,000 consumers in 13 shopping malls on their perception of and confidence in different levels of health claims using s...

    journal_title：Nutrition research and practice

    pub_type： 杂志文章

    doi：10.4162/nrp.2010.4.5.428

    authors： Kim JY,Kang EJ,Kwon O,Kim GH

    更新日期：2010-10-01 00:00:00

  • Anti-inflammatory effects of proanthocyanidin-rich red rice extract via suppression of MAPK, AP-1 and NF-κB pathways in Raw 264.7 macrophages.

    abstract：BACKGROUND/OBJECTIVES:Several pharmacological properties of red rice extract have been reported including anti-oxidant, anti-tumor, and reduced cancer cell invasion. This study was conducted to evaluate the anti-inflammatory effects of red rice extract on the production of inflammatory mediators in lipopolysaccharide (...

    journal_title：Nutrition research and practice

    pub_type： 杂志文章

    doi：10.4162/nrp.2016.10.3.251

    authors： Limtrakul P,Yodkeeree S,Pitchakarn P,Punfa W

    更新日期：2016-06-01 00:00:00

  • Association between dietary sodium intake and disease burden and mortality in Koreans between 1998 and 2016: The Korea National Health and Nutrition Examination Survey.

    abstract：BACKGROUND/OBJECTIVES:Sodium intake is positively associated with blood pressure, which may increase the risk for cardiovascular disease (CVD). Therefore, we assessed the disease burden of CVD attributable to sodium intakes above 2,000 mg/day and prospectively investigated the association between dietary/urinary sodium...

    journal_title：Nutrition research and practice

    pub_type： 杂志文章

    doi：10.4162/nrp.2020.14.5.501

    authors： Park CY,Jo G,Lee J,Singh GM,Lee JT,Shin MJ

    更新日期：2020-10-01 00:00:00

  • Survey of American food trends and the growing obesity epidemic.

    abstract：:The rapid rise in the incidence of obesity has emerged as one of the most pressing global public health issues in recent years. The underlying etiological causes of obesity, whether behavioral, environmental, genetic, or a combination of several of them, have not been completely elucidated. The obesity epidemic has be...

    journal_title：Nutrition research and practice

    pub_type： 杂志文章

    doi：10.4162/nrp.2011.5.3.253

    authors： Shao Q,Chin KV

    更新日期：2011-06-01 00:00:00

  • Effect of Chlorella vulgaris on lipid metabolism in Wistar rats fed high fat diet.

    abstract：:This study was performed to investigate effects of Chlorella vulgaris on lipid metabolism in rats fed high fat diet. Sixty 6-week-old male Wistar rats were divided into two groups; normal diet group and high fat diet group, then the rats in each group were further divided into three subgroups and fed 0%, 5% and 10% (w...

    journal_title：Nutrition research and practice

    pub_type： 杂志文章

    doi：10.4162/nrp.2008.2.4.204

    authors： Lee HS,Park HJ,Kim MK

    更新日期：2008-01-01 00:00:00

  • Anti-bacterial effects of enzymatically-isolated sialic acid from glycomacropeptide in a Helicobacter pylori-infected murine model.

    abstract：BACKGROUND/OBJECTIVES:Helicobacter pylori (H. pylori) colonization of the stomach mucosa and duodenum is the major cause of acute and chronic gastroduodenal pathology in humans. Efforts to find effective anti-bacterial strategies against H. pylori for the non-antibiotic control of H. pylori infection are urgently requi...

    journal_title：Nutrition research and practice

    pub_type： 杂志文章

    doi：10.4162/nrp.2017.11.1.11

    authors： Noh HJ,Koh HB,Kim HK,Cho HH,Lee J

    更新日期：2017-02-01 00:00:00

  • Changes in body weight, blood pressure and selected metabolic biomarkers with an energy-restricted diet including twice daily sweet snacks and once daily sugar-free beverage.

    abstract：BACKGROUND/OBJECTIVES:The type of sweet snack incorporated into an energy-restricted diet (ERD) may produce differential effects on metabolic improvements associated with body weight (BW) loss. This study compared effects of incorporating either twice daily energy-controlled dark chocolate snacks plus once daily sugar-...

    journal_title：Nutrition research and practice

    pub_type： 杂志文章

    doi：10.4162/nrp.2014.8.6.695

    authors： Nickols-Richardson SM,Piehowski KE,Metzgar CJ,Miller DL,Preston AG

    更新日期：2014-12-01 00:00:00

  • Dietary evaluation of a low-iodine diet in Korean thyroid cancer patients preparing for radioactive iodine therapy in an iodine-rich region.

    abstract：BACKGROUND/OBJECTIVES:Despite the importance of a low-iodine diet (LID) for thyroid cancer patients preparing for radioactive iodine (RAI) therapy, few studies have evaluated dietary intake during LID. This study evaluated the amount of dietary iodine intake and its major food sources during a typical diet and during L...

    journal_title：Nutrition research and practice

    pub_type： 杂志文章

    doi：10.4162/nrp.2016.10.2.167

    authors： Ju DL,Park YJ,Paik HY,Kim MJ,Park S,Jung KY,Kim TH,Choi HS,Song YJ

    更新日期：2016-04-01 00:00:00

  • Awareness, knowledge, and use of folic acid among non-pregnant Korean women of childbearing age.

    abstract：BACKGROUND/OBJECTIVES:Folic acid supplementation before pregnancy is known to reduce the risk of neural tube defects. The purposes of this study were to investigate the awareness, knowledge, and use of folic acid supplements along with their associated factors among non-pregnant Korean women of childbearing age. SUBJE...

    journal_title：Nutrition research and practice

    pub_type： 杂志文章

    doi：10.4162/nrp.2018.12.1.78

    authors： Kim MJ,Kim J,Hwang EJ,Song Y,Kim H,Hyun T

    更新日期：2018-02-01 00:00:00

  • Comparison of four nutritional screening tools for Korean hospitalized children.

    abstract：BACKGROUND/OBJECTIVES:Several nutritional screening tools were recently developed to screen the risk of malnutrition in hospitalized children, but have not been validated in Asia. We compared four nutritional screening tools for pediatric patients in evaluating nutritional risks in newly hospitalized children. SUBJECT...

    journal_title：Nutrition research and practice

    pub_type： 杂志文章

    doi：10.4162/nrp.2019.13.5.410

    authors： Lee YJ,Yang HR

    更新日期：2019-10-01 00:00:00

  • Is the association of continuous metabolic syndrome risk score with body mass index independent of physical activity? The CASPIAN-III study.

    abstract：BACKGROUND/OBJECTIVES:Although the association of body mass index (BMI) with metabolic syndrome (MetS) is well documented, there is little knowledge on the independent and joint associations of BMI and physical activity with MetS risk based on a continuous scoring system. This study was designed to explore the effect o...

    journal_title：Nutrition research and practice

    pub_type： 杂志文章

    doi：10.4162/nrp.2015.9.4.404

    authors： Heshmat R,Shafiee G,Kelishadi R,Babaki AE,Motlagh ME,Arefirad T,Ardalan G,Ataie-Jafari A,Asayesh H,Mohammadi R,Qorbani M

    更新日期：2015-08-01 00:00:00

  • Plasma, tissue and urinary levels of aloin in rats after the administration of pure aloin.

    abstract：:Aloin is a physiologically active anthraquinone present in aloe. There are two isomers of aloin, aloin A and aloin B, occurring as a mixture of diastereomers. The objective of this study was to determine the bioavailability and tissue distribution of aloin. Rats were gavaged with 11.8g/kg aloin, and the levels of aloi...

    journal_title：Nutrition research and practice

    pub_type： 杂志文章

    doi：10.4162/nrp.2008.2.1.17

    authors： Park MY,Kwon HJ,Sung MK

    更新日期：2008-04-01 00:00:00

  • Improvement of andropause symptoms by dandelion and rooibos extract complex CRS-10 in aging male.

    abstract：:Many aging male suffer various andropause symptoms including loss of physical and mental activities. This study evaluated the putative alleviative effects of CRS-10 dandelion and rooibos extract complex (CRS-10) on the symptoms of andropause. The survival rate of TM3 Leydig cells (TM3 cells) treated with CRS-10 was me...

    journal_title：Nutrition research and practice

    pub_type： 杂志文章

    doi：10.4162/nrp.2012.6.6.505

    authors： Noh YH,Kim DH,Kim JY,Park J,Kim OH,Han D,Kim WY,Kim SS,Lee MY,Heo SH,Kim M,Lee WB,Jeong Y,Myung SC

    更新日期：2012-12-01 00:00:00

  • Dietary sodium intake in young Korean adults and its relationship with eating frequency and taste preference.

    abstract：:Dietary sodium intake is considered one of the major causal factors for hypertension. Thus, to control the increase of blood pressure and reduce the risk of hypertension-related clinical complications, a reduction in sodium intake is recommended. The present study aimed at determining the association of dietary sodium...

    journal_title：Nutrition research and practice

    pub_type： 杂志文章

    doi：10.4162/nrp.2013.7.3.192

    authors： Shim E,Ryu HJ,Hwang J,Kim SY,Chung EJ

    更新日期：2013-06-01 00:00:00

  • Inorganic sulfur reduces cell proliferation by inhibiting of ErbB2 and ErbB3 protein and mRNA expression in MDA-MB-231 human breast cancer cells.

    abstract：:Dietary inorganic sulfur is the minor component in our diet, but some studies suggested that inorganic sulfur is maybe effective to treat cancer related illness. Therefore, this study aims to examine the effects of inorganic sulfur on cell proliferation and gene expression in MDA-MB-231 human breast cancer cells. MDA-...

    journal_title：Nutrition research and practice

    pub_type： 杂志文章

    doi：10.4162/nrp.2013.7.2.89

    authors： Ha AW,Hong KH,Kim HS,Kim WK

    更新日期：2013-04-01 00:00:00

  • Diet of children under the government-funded meal support program in Korea.

    abstract：:The purpose of this study was to investigate the diet of children under the government-funded meal support program. The 143 children (67 boys and 76 girls) participated in this study among 4(th)-6(th) elementary school students receiving free lunches during the summer vacation of 2007 and living in Gwanak-gu, Seoul, K...

    journal_title：Nutrition research and practice

    pub_type： 杂志文章

    doi：10.4162/nrp.2010.4.6.515

    authors： Kwon S,Lee K,Yoon J

    更新日期：2010-12-01 00:00:00

  • Circulating microRNA expression profiling in young obese Korean women.

    abstract：BACKGROUND/OBJECTIVES:This study investigates correlations between circulating microRNAs (miRNAs) and obesity-related parameters among young women (aged 20-30 years old) in Korea. SUBJECTS/METHODS:We analyzed TaqMan low density arrays (TLDAs) of circulating miRNAs in 9 lean (body mass index [BMI] < 25 kg/m2) and 15 ob...

    journal_title：Nutrition research and practice

    pub_type： 杂志文章

    doi：10.4162/nrp.2020.14.4.412

    authors： Choi WH,Ahn J,Um MY,Jung CH,Jung SE,Ha TY

    更新日期：2020-08-01 00:00:00