Abstract:
BACKGROUND:To analyze predictive factors suggesting transient congenital hypothyroidism (TCH) compared to permanent congenital hypothyroidism (PCH) or transient thyroid function test (TFT) abnormalities among children who had positive screening results at our centers over the past decade. METHODS:A retrospective chart review of 105 subjects who presented elevated TSH levels on a newborn screening test (NST) was done. TCH was defined when a trial-off therapy was successful, and PCH was defined when a trial failed or when the subject was kept on medication beyond 3 years of age. A transient TFT abnormality was defined when follow-up TFTs were normalized without levothyroxine (LT4) therapy. RESULTS:Congenital hypothyroidism (CH) was diagnosed in 75.2% (TCH 35.2% and PCH 40.0%) of all subjects; the others (24.8%) showed transient TFT abnormalities. Initial NST-TSH levels (optimal cutoff point, 31.0 μIU/mL), the LT4 dose at 2 years of age (4.1 μg/kg/day), and the maximal LT4 dose (50 μg/day) merged as significant predictive factors discriminating between TCH and PCH. The initial serum level of free T4 (1.06 ng/dL) and not TSH (27.2 μIU/mL) was the only discriminating factor between transient TFT abnormalities and TCH. CONCLUSION:Earlier re-evaluation might be possible when a patient's initial NST-TSH levels and maximal or 2-year LT4 doses are low, as both are important predictors of successful trial-off therapy in CH patients. When the initial serum level of free T4 is above the average value in neonates with mildly elevated TSH levels, TFTs may be more likely to normalize on their own.
journal_name
Pediatr Neonatoljournal_title
Pediatrics and neonatologyauthors
Kang MJ,Chung HR,Oh YJ,Shim YS,Yang S,Hwang ITdoi
10.1016/j.pedneo.2017.01.002subject
Has Abstractpub_date
2017-10-01 00:00:00pages
442-448issue
5eissn
1875-9572issn
2212-1692pii
S1875-9572(17)30178-Xjournal_volume
58pub_type
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journal_title:Pediatrics and neonatology
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journal_title:Pediatrics and neonatology
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journal_title:Pediatrics and neonatology
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journal_title:Pediatrics and neonatology
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journal_title:Pediatrics and neonatology
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journal_title:Pediatrics and neonatology
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journal_title:Pediatrics and neonatology
pub_type: 杂志文章
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journal_title:Pediatrics and neonatology
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journal_title:Pediatrics and neonatology
pub_type: 杂志文章
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journal_title:Pediatrics and neonatology
pub_type: 杂志文章
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journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2012.06.003
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journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2013.01.005
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journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2017.02.003
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journal_title:Pediatrics and neonatology
pub_type: 杂志文章
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更新日期:2018-08-01 00:00:00
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journal_title:Pediatrics and neonatology
pub_type: 杂志文章,评审
doi:10.1016/j.pedneo.2017.05.003
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:The gastroesophageal reflux disease (GERD) questionnaire (GerdQ) is a validated questionnaire that was developed recently to help identify GERD patients. The sensitivity and specificity of GerdQ for the diagnosis of GERD in adult patients were 65% and 71%, respectively. Because the application of GerdQ in pe...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2014.01.004
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:The diagnosis of neonatal sepsis still considered to be a challenge for both clinicians and the laboratory due to the non-specific clinical presentations. The present study aimed to compare and assess the diagnostic & prognostic values of C-reactive protein (CRP), high sensitivity CRP (hsCRP), presepsin, int...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
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journal_title:Pediatrics and neonatology
pub_type: 杂志文章
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journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2015.08.001
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journal_title:Pediatrics and neonatology
pub_type: 杂志文章,评审
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journal_title:Pediatrics and neonatology
pub_type: 杂志文章
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更新日期:2013-06-01 00:00:00
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journal_title:Pediatrics and neonatology
pub_type: 杂志文章,随机对照试验
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更新日期:2018-10-01 00:00:00
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journal_title:Pediatrics and neonatology
pub_type: 杂志文章,随机对照试验
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更新日期:2013-10-01 00:00:00
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journal_title:Pediatrics and neonatology
pub_type: 杂志文章
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journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2018.03.010
更新日期:2019-02-01 00:00:00
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journal_title:Pediatrics and neonatology
pub_type: 杂志文章
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journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2016.08.005
更新日期:2017-08-01 00:00:00
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journal_title:Pediatrics and neonatology
pub_type: 杂志文章
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journal_title:Pediatrics and neonatology
pub_type: 杂志文章,meta分析
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更新日期:2017-02-01 00:00:00