Prognostic Evaluation of Vimentin Expression in Correlation with Ki67 and CD44 in Surgically Resected Pancreatic Ductal Adenocarcinoma.

Abstract:

:Purpose. Radical surgical resection with adjuvant chemotherapy or chemo-radiotherapy is the most effective treatment for pancreatic ductal adenocarcinoma (PDAC). However, relatively few studies investigate the prognostic significance of biological markers in PDAC. This study aims to look into the expressions of vimentin, Ki67, and CD44 in PDAC surgical specimens and their potential prognostic implications in survival. Method. The study was designed as retrospective, and vimentin, Ki67, and CD44 expressions were evaluated by immunohistochemistry in 53 pancreatic ductal adenocarcinoma cases. Overall survival was assessed by the Kaplan-Meier method. Results. Patients' median age was 68 years. The median survival was 18 months. The tumors were T3-4 in 40/53 (75.5%), and metastases in lymph nodes were found in 42 out of 53 (79.2%) cases. On multivariate analysis, the size of primary tumor (p < 0.001), the surgical resection margin status (p = 0.042), and vimentin expression (p = 0.011) were independently correlated with overall survival. Conclusions. Long-term survival after resection of PDAC is still about 15%. Vimentin expression is a potential independent adverse prognostic molecular marker and should be included in histopathological reports. Also, CD44 expression correlates with high Ki67, vimentin positivity, and N stage and may represent a potential target of novel therapeutic modalities in pancreatic adenocarcinoma patients.

authors

Myoteri D,Dellaportas D,Lykoudis PM,Apostolopoulos A,Marinis A,Zizi-Sermpetzoglou A

doi

10.1155/2017/9207616

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

9207616

eissn

1687-6121

issn

1687-630X

journal_volume

2017

pub_type

杂志文章
  • Minimal Open Access Ileocolic Resection in Complicated Crohn's Disease of the Terminal Ileum.

    abstract::The objective of this study was to evaluate the possibility to undertake an ileocolic resection in complex Crohn's disease using a minimal open abdominal access using standard laparoscopic instruments. The incision was carried out over the previous McBurney scar, with a mean length of 6 cm. Seventy-two patients with c...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2020/6019435

    authors: Sica GS,Di Carlo S,D'Ugo S,Arcudi C,Siragusa L,Fazzolari L,Biancone L,Monteleone G,Cardi M,Sibio S

    更新日期:2020-02-28 00:00:00

  • Comparison of the Long-Term Outcomes of Endoscopic Papillary Large Balloon Dilation Alone versus Endoscopic Sphincterotomy for Removal of Bile Duct Stones.

    abstract:Background and Aims:Endoscopic papillary large balloon dilation (EPLBD) alone is an alternative to endoscopic sphincterotomy (EST) for treatment of common bile duct (CBD) stones. However, limited data exists regarding comparison of the long-term outcomes for these techniques. In this study, we compared the long-term ou...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2018/6430701

    authors: Li T,Wen J,Bie L,Gong B

    更新日期:2018-07-02 00:00:00

  • Novel Visual Nasogastric Tube Insertion System: A Feasibility and Efficiency Study in a Manikin.

    abstract::Background. Conventional nasogastric tube placement is an essential clinical procedure; however, complications may arise from blind manipulation. We tested the feasibility and efficiency of a visual nasogastric tube insertion system (VNGS) using a manikin. Methods. A microimaging fiber (0.8 mm) was integrated into the...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2016/7532172

    authors: Li Q,Xie J,Wu J,Guo R,Ma W,Xu G,Yang M,Deng H

    更新日期:2016-01-01 00:00:00

  • Variability in Prevalence of Helicobacter pylori Strains Resistant to Clarithromycin and Levofloxacin in Southern Poland.

    abstract::Background. An increasing resistance of Helicobacter pylori strains to antimicrobial agents is the serious therapeutic problem. The aim of this study was to compare the primary and secondary resistance of H. pylori strains isolated between 2006-2008 (data published) and 2009-2011 to clarithromycin and levofloxacin. Ma...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2012/418010

    authors: Karczewska E,Klesiewicz K,Skiba I,Wojtas-Bonior I,Sito E,Czajecki K,Zwolińska-Wcisło M,Budak A

    更新日期:2012-01-01 00:00:00

  • Clinical outcome of patients with complete pathological response to neoadjuvant chemoradiotherapy for locally advanced rectal cancers: the Indian scenario.

    abstract::Introduction. Neoadjuvant chemoradiotherapy and total mesorectal excision are considered the standard treatment for locally advanced rectal cancer. Various studies have reported pathological downstaging and a complete pathological response rate of 15%-27% following neoadjuvant chemoradiotherapy which has translated in...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2014/867841

    authors: Sinukumar S,Patil P,Engineer R,Desouza A,Saklani A

    更新日期:2014-01-01 00:00:00

  • The interplay of the gut microbiome, bile acids, and volatile organic compounds.

    abstract::Background. There has been an increasing interest in the use of volatile organic compounds (VOCs) as potential surrogate markers of gut dysbiosis in gastrointestinal disease. Gut dysbiosis occurs when pathological imbalances in gut bacterial colonies precipitate disease and has been linked to the dysmetabolism of bile...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2015/398585

    authors: Sagar NM,Cree IA,Covington JA,Arasaradnam RP

    更新日期:2015-01-01 00:00:00

  • Symptomatic abdominal simple cysts: is percutaneous sclerotherapy with hypertonic saline and bleomycin a treatment option?

    abstract::Aim. To evaluate the feasibility of percutaneous sclerotherapy of symptomatic simple abdominal cysts, using hypertonic saline and bleomycin, as an alternative to surgery. Materials and Methods. This study involved fourteen consecutive patients (ten women, four men, mean age: 59.2 y) with nineteen symptomatic simple cy...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2015/489363

    authors: Souftas VD,Kosmidou M,Karanikas M,Souftas D,Menexes G,Prassopoulos P

    更新日期:2015-01-01 00:00:00

  • Nutrition and Helicobacter pylori: Host Diet and Nutritional Immunity Influence Bacterial Virulence and Disease Outcome.

    abstract::Helicobacter pylori colonizes the stomachs of greater than 50% of the world's human population making it arguably one of the most successful bacterial pathogens. Chronic H. pylori colonization results in gastritis in nearly all patients; however in a subset of people, persistent infection with H. pylori is associated ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2016/3019362

    authors: Haley KP,Gaddy JA

    更新日期:2016-01-01 00:00:00

  • Efficacy of 7-Day and 14-Day Triple Therapy Regimens for the Eradication of Helicobacter pylori: A Comparative Study in a Cohort of Romanian Patients.

    abstract::Objective. This study compared the eradication rates of of Helicobacter pylori (HP) infection by a 7-day and 14-day anti-HP regimen. Materials and Methods. An open, randomized, prospective study was performed to evaluate the response to anti-HP treatment in adult HP-positive patients following a 7-day course (Regimen ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2016/5061640

    authors: Arama SS,Tiliscan C,Negoita C,Croitoru A,Arama V,Mihai CM,Pop F,Garg A

    更新日期:2016-01-01 00:00:00

  • Confocal Laser Endomicroscopy in the Study of Colonic Mucosa in IBD Patients: A Review.

    abstract::Confocal laser endomicroscopy (CLE) is one of several novel methods that provide real-time, high-resolution imaging at a micronscale via endoscopes. CLE and related technologies are often termed "virtual biopsy" as they simulate the images seen in traditional histology. Recently, the use of CLE was reported in the stu...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2012/525098

    authors: Salvatori F,Siciliano S,Maione F,Esposito D,Masone S,Persico M,De Palma GD

    更新日期:2012-01-01 00:00:00

  • Comparison of Esophageal Function Tests in Chinese Patients with Functional Heartburn and Reflux Hypersensitivity.

    abstract:OBJECTIVE:To investigate the differences in the results of esophageal function tests for functional heartburn (FH) and reflux hypersensitivity (RH). METHODS:Patients with FH and RH and healthy volunteers (HVs) from the Department of Gastroenterology, Beijing Anzhen Hospital and Beijing Chao-Yang hospital, who underwen...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2017/3596148

    authors: Gao F,Gao Y,Chen X,Qian J,Zhang J

    更新日期:2017-01-01 00:00:00

  • Efficacy of i-Scan Imaging for the Detection and Diagnosis of Early Gastric Carcinomas.

    abstract::We determined comparative efficacy of i-Scan for detection and diagnosis of gastric cancer. Ten patients diagnosed with early gastric cancer based on histopathological findings were analyzed. White light and i-Scan moving images recorded from these patients in twin mode were separated into white light and i-Scan. Twel...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2014/819395

    authors: Nishimura J,Nishikawa J,Nakamura M,Goto A,Hamabe K,Hashimoto S,Okamoto T,Suenaga M,Fujita Y,Hamamoto Y,Sakaida I

    更新日期:2014-01-01 00:00:00

  • Role of Baicalin and Liver X Receptor Alpha in the Formation of Cholesterol Gallstones in Mice.

    abstract::This study was aimed at investigating the effect of baicalin on experimental cholesterol gallstones in mice. The mouse gallstone model was induced by feeding with a lithogenic diet, and cholesterol stones were found in the gallbladder. The lithogenic diet caused elevation of triglycerides, cholesterol, and low-density...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2020/1343969

    authors: Chen G,Wu S

    更新日期:2020-04-21 00:00:00

  • Prognostic Significance of Microvessel Density Determining by Endoglin in Stage II Rectal Carcinoma: A Retrospective Analysis.

    abstract::Background. The role of endoglin in the Dukes B rectal cancer is still unexplored. The aim of this study was to examine the expression of endoglin (CD105) in resected rectal cancer and to evaluate the relationship between microvessels density (MVD), clinicopathological factors, and survival rates. Methods. The study i...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2015/504179

    authors: Martinovic Z,Kovac D,Martinovic M

    更新日期:2015-01-01 00:00:00

  • Beneficial Effects of Probiotic Treatment on Gut Microbiota in Very Low Birth Weight Infants.

    abstract::The very low birth weight (VLBW) infant is at great risk for marked dysbiosis of the gut microbiota. In the present study, a total of 36 VLBW infants were randomly divided into two groups, who were treated with combined probiotics and placebo, and 72 fecal specimens on days 14 and 28 of life were collected from them. ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2019/3682836

    authors: Li YF,Zhu CR,Gong XL,Li HL,Xiong LK,Wang KJ,Liu GS

    更新日期:2019-10-17 00:00:00

  • Endosonographic features of histologically proven gastric ectopic pancreas.

    abstract::Gastric ectopic pancreas is an uncommon developmental anomaly and its histological diagnosis is usually difficult by using a conventional biopsy forceps. In the literature, most cases of gastric ectopic pancreas were usually diagnosed by gross pattern during endoscopic examination or features of endoscopic ultrasound....

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2014/160601

    authors: Chou JW,Cheng KS,Ting CF,Feng CL,Lin YT,Huang WH

    更新日期:2014-01-01 00:00:00

  • Does Colonic Diverticulosis Raise the Risk of Colorectal Adenoma in Patients with Colorectal Cancer?

    abstract:Background:The aim of this study was to evaluate the risk of development of colorectal adenomas in patients with colorectal cancer (CRC) with and without colonic diverticulosis. Methods:We performed a retrospective cohort study that included patients with CRC between 2008 and 2011. All patients underwent preoperative ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2019/8901026

    authors: Kim YJ,Kim DB,Chung WC,Lee JM

    更新日期:2019-05-20 00:00:00

  • Combined EUS-Guided Abdominal Cavity Drainage and Cystogastrostomy for the Ruptured Pancreatic Pseudocyst.

    abstract::Background. Endoscopic-Ultrasonography- (EUS-) guided puncture and drainage of pancreatic pseudocyst is currently one of the most widely accepted nonsurgical treatments. To date, this technique has only been used for pancreatic pseudocysts adhesive to the gastric wall. This study introduces the technique of EUS-guided...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2013/785483

    authors: Nan G,Siyu S,Xiang L,Sheng W,Guoxin W

    更新日期:2013-01-01 00:00:00

  • Alterations of blood-brain barrier and associated factors in acute liver failure.

    abstract::Brain edema in acute liver failure (ALF) remains lethal. Cytotoxic mechanisms associated with brain edema have been well recognized, but the role of vasogenic mechanisms of brain edema has not been explored. Intact tight junctions (TJs) between brain capillary endothelial cells are critical for normal BBB function. Re...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2013/841707

    authors: Cui W,Sun CM,Liu P

    更新日期:2013-01-01 00:00:00

  • Sustained Clinical Efficacy and Mucosal Healing of Thiopurine Maintenance Treatment in Ulcerative Colitis: A Real-Life Study.

    abstract:Background and Aims:Thiopurines are commonly used for treating ulcerative colitis (UC), despite the fact that controlled evidence supporting their efficacy is limited. The aim of this study was to evaluate the long-term outcome of thiopurines as maintenance therapy in a large cohort of UC patients. Methods:All UC pati...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2018/4195968

    authors: Pugliese D,Aratari A,Festa S,Ferraro PM,Monterubbianesi R,Guidi L,Scribano ML,Papi C,Armuzzi A

    更新日期:2018-10-03 00:00:00

  • Nucleotide Analogue-Related Proximal Renal Tubular Dysfunction during Long-Term Treatment of Chronic Hepatitis B: A Cross-Sectional Study.

    abstract::Background. There have been few reports of nucleotide analogue-related renal tubular dysfunction (RTD) in CHB patients. We assessed the prevalence and presentation of nucleotide analogue-related proximal RTD. Methods. A cross-sectional study was performed in CHB patients taking nucleotide analogues. Inclusion criteria...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2016/2952635

    authors: Sobhonslidsuk A,Wanichanuwat J,Numthavaj P,Sophonsritsuk A,Petraksa S,Pugasub A,Jittorntam P,Kongsomgan A,Roytrakul S,Phakdeekitcharoen B

    更新日期:2016-01-01 00:00:00

  • Manometric Measurement of the Sphincter of Oddi in Patients with Common Bile Duct Stones: A Consecutive Study of the Han Population of China.

    abstract::Objective. Role of dysfunction of the sphincter of Oddi (SO) in choledocholithiasis is controversial. This study was to evaluate SO motor activity in patients with common bile duct (CBD) stones in the Han population of China. Patients and Methods. In this study, 76 patients with CBD stones were enrolled in a single te...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2017/9031438

    authors: Feng Y,Zhang J,Jiao C,Zhu H,Cheng W,Xu S,Xiao B,Ni J,Chen X

    更新日期:2017-01-01 00:00:00

  • Hepatorenal syndrome: aetiology, diagnosis, and treatment.

    abstract::Acute renal impairment is common in patients with chronic liver disease, occurring in approximately 19% of hospitalised patients with cirrhosis. A variety of types of renal impairment are recognised. The most important of these is the hepatorenal syndrome, a functional renal impairment due to circulatory and neurohorm...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2015/207012

    authors: Low G,Alexander GJ,Lomas DJ

    更新日期:2015-01-01 00:00:00

  • Probiotics and Alcoholic Liver Disease: Treatment and Potential Mechanisms.

    abstract::Despite extensive research, alcohol remains one of the most common causes of liver disease in the United States. Alcoholic liver disease (ALD) encompasses a broad spectrum of disorders, including steatosis, steatohepatitis, and cirrhosis. Although many agents and approaches have been tested in patients with ALD and in...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2016/5491465

    authors: Li F,Duan K,Wang C,McClain C,Feng W

    更新日期:2016-01-01 00:00:00

  • Transitioning the Adolescent with IBD from Pediatric to Adult Care: A Review of the Literature.

    abstract::The incidence of inflammatory bowel disease (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), has increased in pediatric populations over the last decade. Patients diagnosed during childhood often survive well into adulthood, and therefore their healthcare requires transfer to an adult gastroenterolo...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2015/853530

    authors: Bollegala N,Nguyen GC

    更新日期:2015-01-01 00:00:00

  • Prognostic Analysis of Duodenal Gastrointestinal Stromal Tumors.

    abstract:Aim:This study aims to analyze factors possibly related to the prognosis of duodenal gastrointestinal stromal tumors (DGISTs). Methods:We collected and retrospectively analyzed clinical and pathological data of 62 patients with primary DGISTs. All the patients were hospitalized and received complete surgical resection...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2018/4812703

    authors: Hong L,Zhang T,Lin Y,Fan R,Zhang M,Cheng M,Zhou X,Sun J,Sun P,Wu Q,Wang L,Wang Z,Zhong J

    更新日期:2018-02-20 00:00:00

  • Clinical Evaluation of Specific Oral Manifestations in Pediatric Patients with Ascertained versus Potential Coeliac Disease: A Cross-Sectional Study.

    abstract::Patients involved on coeliac disease (CD) have atypical symptoms and often remain undiagnosed. Specific oral manifestations are effective risk indicators of CD and for this reason an early diagnosis with a consequent better prognosis can be performed by the dentist. There are not researches analysing the frequency of ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2014/934159

    authors: Bramanti E,Cicciù M,Matacena G,Costa S,Magazzù G

    更新日期:2014-01-01 00:00:00

  • Hepatitis B virus-related glomerulonephritis: not a predominant cause of proteinuria in korean patients with chronic hepatitis B.

    abstract::Background/Aims. Hepatitis B virus (HBV) can form immune complexes which may result in various types of glomerulonephritis (GN). However, proteinuria can occur because of other kidney diseases besides HBV-related GN (HBV-GN). The aim of this study is to elucidate the causes of proteinuria and report on the clinical ou...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2015/126532

    authors: Yoo JJ,Lee JH,Yoon JH,Lee M,Lee DH,Cho Y,Jang ES,Cho EJ,Yu SJ,Kim YJ,Lee HS

    更新日期:2015-01-01 00:00:00

  • Optimization of Deep Sedation with Spontaneous Respiration for Therapeutic Endoscopy Combining Propofol and Bispectral Index Monitoring.

    abstract::Background/Aims. This study aimed to establish optimal propofol anesthesia for therapeutic endoscopy, which has not been established. Methodology. We retrospectively investigated data on 89 patients who underwent upper-GI endoscopic submucosal dissection or endoscopic mucosal resection under anesthesia with propofol. ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2015/282149

    authors: Matsumoto K,Nagahara A,Matsumoto K,Akazawa Y,Komori H,Nakagawa Y,Takeda T,Ueyama H,Shimada Y,Asaoka D,Hojo M,Watanabe S

    更新日期:2015-01-01 00:00:00

  • Immunohistochemical Markers as Predictors of Histopathologic Response and Prognosis in Rectal Cancer Treated with Preoperative Adjuvant Therapy: State of the Art.

    abstract::We explain the state of the art of the immunohistochemical markers of response in rectal cancers treated with neoadjuvant medical therapies and its implication with prognosis. Neoadjuvant chemoradiotherapy is widely used to improve the outcome of patients with locally advanced rectal cancer, and the evaluation of the ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2017/2808235

    authors: Del Gobbo A,Ferrero S

    更新日期:2017-01-01 00:00:00