Respiratory failure because of neuromuscular disease.

Abstract:

PURPOSE OF REVIEW:Understanding the mechanisms and abnormalities of respiratory function in neuromuscular disease is critical to supporting the patient and maintaining ventilation in the face of acute or chronic progressive impairment. RECENT FINDINGS:Retrospective clinical studies reviewing the care of patients with Guillain-Barré syndrome and myasthenia have shown a disturbingly high mortality following step-down from intensive care. This implies high dependency and rehabilitation management is failing despite evidence that delayed improvement can occur with long-term care. A variety of mechanisms of phrenic nerve impairment have been recognized with newer investigation techniques, including EMG and ultrasound. Specific treatment for progressive neuromuscular and muscle disease has been increasingly possible particularly for the treatment of myasthenia, metabolic myopathies, and Duchenne muscular dystrophy. For those conditions without specific treatment, it has been increasingly possible to support ventilation in the domiciliary setting with newer techniques of noninvasive ventilation and better airway clearance. There remained several areas of vigorous debates, including the role for tracheostomy care and the place of respiratory muscle training and phrenic nerve/diaphragm pacing. SUMMARY:Recent studies and systematic reviews have defined criteria for anticipating, recognizing, and managing ventilatory failure because of acute neuromuscular disease. The care of patients requiring long-term noninvasive ventilatory support for chronic disorders has also evolved. This has resulted in significantly improved survival for patients requiring domiciliary ventilatory support.

journal_name

Curr Opin Neurol

authors

Howard RS

doi

10.1097/WCO.0000000000000363

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

592-601

issue

5

eissn

1350-7540

issn

1473-6551

journal_volume

29

pub_type

杂志文章,评审
  • The influence of anxiety on ocular motor control and gaze.

    abstract:PURPOSE OF REVIEW:The influence of anxiety on ocular motor control and gaze has received less research attention than its effects on postural control and locomotion. This review summarizes research on trait anxiety, state anxiety, anxiety disorders, ocular motor reflexes, and gaze. It applies these findings to clinical...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0000000000000055

    authors: Staab JP

    更新日期:2014-02-01 00:00:00

  • An update on the leukodsytrophies.

    abstract::This review centers on important recent advances in the understanding of the role of glial fibrillary acidic protein in Alexander disease and of proteolipid protein in hypomyelinating disorders such as Pelizaeus-Merzbacher and spastic paraplegia. We also describe seven novel leukodystrophies. These include childhood a...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/00019052-200112000-00018

    authors: Schiffmann R,Boespflüg-Tanguy O

    更新日期:2001-12-01 00:00:00

  • Surgical approaches to vascular anomalies of the child's brain.

    abstract::The population of pediatric patients with cerebrovascular disease presents a unique set of challenges to the neurosurgeon. The wide scope of pathology, including arteriovenous malformations, cavernous malformations and moyamoya disease, coupled with marked advances in diagnosis and treatment of these conditions over t...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/00019052-200204000-00007

    authors: Smith ER,Butler WE,Ogilvy CS

    更新日期:2002-04-01 00:00:00

  • Pseudoprogression and pseudoresponse in the treatment of gliomas.

    abstract:PURPOSE OF REVIEW:Treatment response of brain tumours is typically evaluated with gadolinium-enhanced MRI using the Macdonald criteria. These criteria depend on changes in the area of enhancement. However, gadolinium enhancement of brain tumours primarily reflects impairment of the blood-brain barrier. RECENT FINDINGS...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0b013e328332363e

    authors: Brandsma D,van den Bent MJ

    更新日期:2009-12-01 00:00:00

  • Neuromuscular problems in the ICU.

    abstract:PURPOSE OF REVIEW:Patients with acute life-threatening neuromuscular disease require close cooperation between neuromuscular and intensive care specialists to achieve the best possible outcomes. The problems encountered by these patients are different from those in traditional neuromuscular practice, and neurologists c...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0000000000000480

    authors: Damian MS,Srinivasan R

    更新日期:2017-10-01 00:00:00

  • Pathogenic mechanisms in inflammatory and paraproteinaemic peripheral neuropathies.

    abstract:PURPOSE OF REVIEW:This review summarizes the major recent developments in understanding of pathogenic mechanisms in inflammatory and paraproteinaemic neuropathies. RECENT FINDINGS:In the inflammatory neuropathies, there has been a particular focus on antibody-mediated disease affecting the nodal/paranodal regions. Dis...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0000000000000137

    authors: Rinaldi S,Bennett DL

    更新日期:2014-10-01 00:00:00

  • Amyotrophic lateral sclerosis: an update.

    abstract:PURPOSE OF REVIEW:The aim is to review recent publications on amyotrophic lateral sclerosis (ALS). RECENT FINDINGS:The Awaji recommendations for electrophysiological diagnosis will permit earlier clinical trials entry. The use of ultrasound to visualize fasciculations, even in deep muscles, will contribute to earlier ...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0b013e32834916a9

    authors: de Carvalho M,Swash M

    更新日期:2011-10-01 00:00:00

  • Skin biopsy as a diagnostic tool.

    abstract:PURPOSE OF REVIEW:To give an overview of recent data on the use of skin biopsy as a diagnostic tool in neuropathies. RECENT FINDINGS:The sensitivity and specificity of skin biopsy in detecting small fiber neuropathy is supported by new data. In many patients with small fiber neuropathy, a treatable disorder can be ide...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0b013e328309000c

    authors: Sommer C

    更新日期:2008-10-01 00:00:00

  • Axonal Charcot-Marie-Tooth disease.

    abstract:PURPOSE OF REVIEW:The aim is to specify the genetic causes of dominantly and recessively inherited axonal forms of Charcot-Marie-Tooth disease (CMT) and review the biological basis for these disorders. RECENT FINDINGS:More than 10 genes that cause axonal CMT have been identified over the past decade. Many of these gen...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0b013e32834aa331

    authors: Shy ME,Patzkó A

    更新日期:2011-10-01 00:00:00

  • Myasthenia and the neuromuscular junction.

    abstract:PURPOSE OF REVIEW:Myasthenic syndromes are distinct disorders at the neuromuscular junction, most often with well characterized autoimmune or genetic pathology. New aspects of the dysfunctions give insight into the normal neuromuscular function in addition to giving therapeutic clues and tailoring the therapy to the pa...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0b013e3283572588

    authors: Gilhus NE

    更新日期:2012-10-01 00:00:00

  • Which patients with asymptomatic carotid stenosis benefit from revascularization?

    abstract:PURPOSE OF REVIEW:To summarize why there are polarized opinions regarding the management of patients with asymptomatic carotid disease and whether it is possible to identify patients who might benefit from carotid interventions. RECENT FINDINGS:Carotid Revascularization Endarterectomy Versus Stenting Trial and Asympto...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0000000000000408

    authors: Naylor AR

    更新日期:2017-02-01 00:00:00

  • Chemotherapy of brain tumors.

    abstract::This is a review of chemotherapy options for patients with brain tumors, both at the time of initial diagnosis and at recurrence. Gliomas, the most common malignant brain tumors, represent the main focus of the review; chemotherapeutic options for supratentorial, brain stem, and optic track gliomas are discussed. ...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/00019052-200012000-00002

    authors: Galanis E,Buckner JC

    更新日期:2000-12-01 00:00:00

  • Myelin repair strategies: a cellular view.

    abstract:PURPOSE OF REVIEW:The development of successful myelin repair strategies depends on the detailed knowledge of the cellular and molecular processes underlying demyelination and remyelination in the central nervous system of animal models and in patients with multiple sclerosis (MS). Based on the complexity of the demyel...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0b013e3282fd1875

    authors: Gallo V,Armstrong RC

    更新日期:2008-06-01 00:00:00

  • Emery-Dreifuss muscular dystrophy: focal point nuclear envelope.

    abstract:PURPOSE OF REVIEW:Emery-Dreifuss muscular dystrophy (EDMD) is caused by mutations in EMD encoding emerin and LMNA encoding A-type lamins, proteins of the nuclear envelope. In the past decade, there has been an extraordinary burst of research on the nuclear envelope. Discoveries resulting from this basic research have i...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0000000000000741

    authors: Muchir A,Worman HJ

    更新日期:2019-10-01 00:00:00

  • Advances in the understanding of headache in idiopathic intracranial hypertension.

    abstract:PURPOSE OF REVIEW:To review the most relevant developments in the understanding of headache in idiopathic intracranial hypertension (IIH). RECENT FINDINGS:The phenotype of the typical IIH headache is diverging from the historical thinking of a raised intracranial pressure headache, with the majority being classified a...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0000000000000651

    authors: Mollan SP,Hoffmann J,Sinclair AJ

    更新日期:2019-02-01 00:00:00

  • New approaches to molecular therapy of brain tumors.

    abstract::Little progress has been made in the treatment outcome of patients with glioblastoma in the past 10 to 15 years, despite an aggressive multimodality regimen using surgery, radiation, and chemotherapy. New approaches, particularly molecular strategies, have become the clinicians' and scientists' hope for the future in ...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/00019052-199412000-00005

    authors: Yung WK

    更新日期:1994-12-01 00:00:00

  • Cognitive impairment in multiple sclerosis.

    abstract:PURPOSE OF REVIEW:For a long time, cognitive impairment in multiple sclerosis patients has been considered less important than, for instance, physical disability. This is no longer true because of the crucial role that cognitive deficits play in the good day-to-day adjustment of patients. This review highlights recent ...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0b013e32810c8e87

    authors: Hoffmann S,Tittgemeyer M,von Cramon DY

    更新日期:2007-06-01 00:00:00

  • Genetic treatments in muscular dystrophies.

    abstract:PURPOSE OF REVIEW:The search for a cure for Duchenne muscular dystrophy and other muscular dystrophies is progressing rapidly despite significant challenges posed by some genes and the complexity of targeting all skeletal muscles. This review focuses on three areas in which experimental clinical studies are in progress...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0b013e3282efc157

    authors: Muntoni F,Wells D

    更新日期:2007-10-01 00:00:00

  • Rehabilitation of hemianopia.

    abstract:PURPOSE OF REVIEW:Homonymous hemianopia is the commonest form of acquired homonymous visual field defect; the usual causes are stroke, head injury and intracranial tumours. This impairment can affect a variety of cognitive visual functions, including visual search, safe navigation through changing environments and read...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0b013e32831f1b2c

    authors: Schofield TM,Leff AP

    更新日期:2009-02-01 00:00:00

  • Optic neuritis as a phase 2 paradigm for neuroprotection therapies of multiple sclerosis: update on current trials and perspectives.

    abstract:PURPOSE OF REVIEW:In multiple sclerosis as the most common inflammatory demyelinating disease in Western countries, major therapeutic success has been achieved with regard to strategies targeting immunological master switches. These approaches effectively reduce inflammatory disease activity but fail to address ongoing...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0000000000000327

    authors: Aktas O,Albrecht P,Hartung HP

    更新日期:2016-06-01 00:00:00

  • Neurochemistry of cocaine withdrawal.

    abstract::Neural circuits comprised of dopamine-containing and dopamine-receptive neurons are altered functionally after the repeated intermittent administration of cocaine and its withdrawal. The characterization of these neuroadaptive changes at various times after repeated exposure to cocaine is important because they may re...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/00019052-199712000-00017

    authors: Pilotte NS

    更新日期:1997-12-01 00:00:00

  • Intelligent use of antiepileptic drugs is beneficial to patients.

    abstract:PURPOSE OF REVIEW:To describe the most important issues a clinician must consider whenever selecting and administering antiepileptic drugs (AEDs). There is no available algorithm that identifies how to individualize selection of AEDs. Proper selection and administration can make an enormous difference in both effective...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0000000000000532

    authors: Cheng JY,French JA

    更新日期:2018-04-01 00:00:00

  • Autoimmune ataxic neuropathies (sensory ganglionopathies).

    abstract::Autoimmune ataxic neuropathies are a subset of the sensory ataxic neuropathies which are characterized by ataxia as the dominant presenting feature. The major known causes of autoimmune ataxic neuropathies include sensory variants of the Guillain-Barré syndrome, including Miller-Fisher syndrome, subsets of immunoglobu...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/00019052-199710000-00002

    authors: O'Leary CP,Willison HJ

    更新日期:1997-10-01 00:00:00

  • Migraine and estrogen.

    abstract:PURPOSE OF REVIEW:The aim is to systematically and critically review the relationship between migraine and estrogen, the predominant female sex hormone, with a focus on studies published in the last 18 months. RECENT FINDINGS:Recent functional MRI (fMRI) studies of the brain support the existence of anatomical and fun...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0000000000000091

    authors: Chai NC,Peterlin BL,Calhoun AH

    更新日期:2014-06-01 00:00:00

  • Cognitive abilities and behaviour of children exposed to antiepileptic drugs in utero.

    abstract:PURPOSE OF REVIEW:The last two decades have witnessed a growing concern over the treatment of epilepsy in women of childbearing age, with an increased risk of major congenital malformations and possible cognitive difficulties associated with certain antiepileptic drugs. The aim here is to review the literature regardin...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0b013e3283292401

    authors: Bromley RL,Baker GA,Meador KJ

    更新日期:2009-04-01 00:00:00

  • Diffusion tensor magnetic resonance imaging tractography in cognitive disorders.

    abstract:PURPOSE OF REVIEW:The advent of novel techniques for tracing connections in vivo, such as diffusion tensor magnetic resonance imaging tractography, allows us, for the first time in the human brain, to study the microstructural integrity of white matter fibres and perform virtual dissections of large scale neurocognitiv...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/01.wco.0000247610.44106.3f

    authors: Catani M

    更新日期:2006-12-01 00:00:00

  • Skeletal muscle channelopathies: new insights into the periodic paralyses and nondystrophic myotonias.

    abstract:PURPOSE OF REVIEW:To summarize advances in our understanding of the clinical phenotypes, genetics, and molecular pathophysiology of the periodic paralyses, the nondystrophic myotonias, and other muscle channelopathies. RECENT FINDINGS:The number of pathogenic mutations causing periodic paralysis, nondystrophic myotoni...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0b013e32832efa8f

    authors: Platt D,Griggs R

    更新日期:2009-10-01 00:00:00

  • Interventional treatment of brain ischemia related to intracranial cerebrovascular occlusive lesions.

    abstract:PURPOSE OF REVIEW:This review discusses the present use of interventional transcatheter strategies to treat patients with acute brain ischemia and severe stenosis of intracranial large arteries. RECENT FINDINGS:The benefits and risks of opening freshly occluded intracranial large arteries in patients with brain ischem...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0000000000000044

    authors: Caplan LR,Thomas AJ,Inoa V

    更新日期:2014-02-01 00:00:00

  • Surgical treatment of Parkinson's disease.

    abstract::Ablative surgery and deep brain stimulation for Parkinson's disease can be performed in the thalamus, the pallidum and the subthalamic nucleus. The efficacy and safety of unilateral pallidotomy is well established. Deep brain stimulation has a lower morbidity and is preferred for bilateral surgery. The subthalamic nuc...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/00019052-199908000-00008

    authors: Krack P,Hamel W,Mehdorn HM,Deuschl G

    更新日期:1999-08-01 00:00:00

  • An update on thrombolytic therapy for acute stroke.

    abstract:PURPOSE OF REVIEW:Stroke is the third leading cause of death after myocardial infarction and cancer, and is the leading cause of permanent disability and disability-adjusted loss of independent life-years in western countries. Thrombolysis is the treatment of choice for acute stroke within 3 h after the onset of sympto...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/00019052-200402000-00012

    authors: Schellinger PD,Kaste M,Hacke W

    更新日期:2004-02-01 00:00:00