Abstract:
:Tony is a practicing frontline National Health Service surgeon and director of medical innovation at Anglia Ruskin University and has founded 4 medical-technology start-ups. He has also cofounded the £500 million Anglia Ruskin MedTech Campus, which will become one of the world's largest health innovation spaces. In 2014, he was appointed as national clinical director for innovation at National Health Service England and in February 2016 became the first national clinical lead for innovation. In this role, he provides clinical leadership and support in delivering improved health outcomes in England, drives the uptake of proven innovations across the National Health Service, promotes economic growth through innovation, and helps make the National Health Service the go-to place on the planet for medical innovation.
journal_name
Surgeryjournal_title
Surgeryauthors
Young Adoi
10.1016/j.surg.2016.07.039subject
Has Abstractpub_date
2017-05-01 00:00:00pages
1179-1182issue
5eissn
0039-6060issn
1532-7361pii
S0039-6060(16)30458-5journal_volume
161pub_type
杂志文章相关文献
SURGERY文献大全abstract:BACKGROUND:Cancer anorexia is influenced by the neuropeptidergic and monoaminergic systems. We hypothesize that serotonin (5-HT), dopamine (DA) and neuropeptide Y (NPY) concentrations in paraventricular (PVN), ventromedial (VMN), and lateral hypothalamus (LHA) areas are abnormal in tumor-bearing rats. METHODS:Fifty-fi...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2004.03.016
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND:Telomerase reverse transcriptase promoter mutations were recently found to be associated with poorer prognosis in patients with papillary thyroid carcinoma. Correlation between telomerase reverse transcriptase messenger RNA expression and survival of patients with papillary thyroid carcinoma has not been det...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2020.04.054
更新日期:2021-01-01 00:00:00
abstract::The standard stainless steel Greenfield filter was modified by extending the limbs at the apex to permit loading into a 12F carrier for percutaneous insertion. This model was tested for fixation and resolution of experimental embolism in dogs (six filters in four dogs) and sheep (eight suprarenal filters in eight shee...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1991-06-01 00:00:00
abstract:BACKGROUND:Only annual mammography and physical examination are recommended for the post-treatment surveillance of early stage breast cancer. METHODS:We used Texas Cancer Registry-Medicare linked data (2001-2007) to identify physician visits and use of mammography, magnetic resonance imaging (MRI), computed tomography...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2013.04.004
更新日期:2013-08-01 00:00:00
abstract::Necrotizing enterocolitis, a highly lethal disease in the newborn infant characterized by ischemic necrosis of the gastrointestinal tract frequently leading to perforation, is seen primarily in low birth weight infants who have undergone stress, such as hypoxia. In an animal model it was demonstrated that cold stress ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1975-05-01 00:00:00
abstract:BACKGROUND:Isolated limb perfusion (ILP) with melphalan is an accepted treatment for intransit melanoma of the extremities. Using an ILP human melanoma xenograft model, we tested the hypothesis that acidosis augments the antitumor effect of melphalan and that nitric oxide (NO) induction mediates tumor regression. METH...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1067/msy.2002.125713
更新日期:2002-08-01 00:00:00
abstract:BACKGROUND:Antigen injected subcutaneously (SQ) results in a strong systemic immune response, whereas antigen infused orally or by the portal vein tends to induce tolerance. Nontransgenic C57BL/6J (H-2(b)), or B6, mice and transgenic 2C mice (that express a cytotoxic T cell receptor against major histocompatibility com...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2005.05.010
更新日期:2005-08-01 00:00:00
abstract:BACKGROUND:The development of pancreatic cancer involves an accumulation of genetic changes, including oncogene activation and mutations in tumor suppressor genes important in cell cycle regulation. As a step to developing gene therapies to restore cell cycle control, we hypothesized that adenoviral-mediated gene trans...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(97)90036-2
更新日期:1997-08-01 00:00:00
abstract:BACKGROUND:The surgical management and follow-up strategy in patients with medullary thyroid carcinoma (MTC) remain controversial because of the lack of data on the natural history of these tumors and their patterns of progression. METHODS:We reviewed the records of all patients who underwent a cervical operation for ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(03)00408-2
更新日期:2003-12-01 00:00:00
abstract:BACKGROUND:K-ras oncogene mutations have been identified in up to 95% of pancreatic cancers, implying their critical role in their molecular pathogenesis. However, the earliest stage in which K-ras mutations can be detected in potential precursor lesions of pancreatic cancer remains unclear. This study evaluates pancre...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(97)90181-1
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:To improve the therapeutic strategy for esophageal squamous cell carcinoma (ESCC), combined neoadjuvant chemotherapy (NAC) followed by operative surgical resection has been applied recently to patients at clinical stages II/III. Our study aimed to elucidate the impact of the circumferential resection margin ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2015.06.044
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Venous thromboembolism, presenting as deep vein thrombosis or pulmonary embolism, can be associated with considerable morbidity after major abdominal and pelvic surgery. Perioperative thromboprophylaxis with low-molecular-weight heparin is well established, but the duration of treatment remains debated. We a...
journal_title:Surgery
pub_type: 杂志文章,meta分析
doi:10.1016/j.surg.2018.05.028
更新日期:2018-12-01 00:00:00
abstract:INTRODUCTION:Posthepatectomy liver failure (PHLF) is a severe complication after hepatectomy for colorectal liver metastases. This study evaluated its actual incidence and its effects on short- and long-term overall survival (OS) in a specialized center. MATERIALS AND METHODS:Between 2006 and 2008, 193 patients who un...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2013.05.039
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Tumor necrosis factor (TNF) is rapidly gaining recognition as one of the early, critical mediators of several inflammatory conditions, most notably endotoxic shock. The purposes of this study were to determine whether TNF levels are raised in severe acute pancreatitis, thus pointing to its role as a potentia...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND:The aim of this study was to review and discuss our observations on 33 patients who underwent surgical treatment for Caroli's disease (CD), focusing on diagnosis, current surgical management, and long-term outcome. METHODS:Between May 1993 and June 2004, 642 liver resections and 286 liver transplantations i...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2005.05.002
更新日期:2005-11-01 00:00:00
abstract::Complete axillary dissection was performed in 287 patients undergoing modified radical mastectomy between 1984 and 1987 to identify patterns of axillary node metastases, as well as discontinuous axillary node ("skip") metastases. Positive pathologic findings were compared with preoperative clinical examinations in 266...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1990-10-01 00:00:00
abstract::Insulin-glucose homeostasis was examined in 62 patients with chronic pancreatitis (CP). All patients were graded on the basis of test results from five studies: (1) endoscopic retrograde cholangiopancreatography, (2) fat-stimulated release of pancreatic polypeptide (PP), (3) NBT-bentiromide PABA test, (4) 72-hour feca...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1988-12-01 00:00:00
abstract:BACKGROUND:The prognosis of neuroblastoma patients remains unsatisfactory. Therefore, developing an effective treatment strategy is important. Resveratrol, a natural polyphenol, possesses chemopreventive and antitumor effects. We investigated the effects of resveratrol on the proliferation, apoptosis, and cell cycle al...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2004.01.017
更新日期:2004-07-01 00:00:00
abstract::Background Insulin-like growth factor 1 (IGF-1) is an autocrine regulator of carcinoid tumors. Blockade of IGF-1 signaling has been proposed as a therapeutic target in the treatment of patients with carcinoid syndrome. We hypothesized that the induction of parallel raf-1/MEK1 pathways will block IGF-1-mediated chromog...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2004.06.061
更新日期:2004-12-01 00:00:00
abstract::The term big data has been popularized over the past decade and is often used to refer to data sets that are too large or complex to be analyzed by traditional means. Although the term has been utilized for some time in business and engineering, the concept of big data is relatively new to medicine. The reception from...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2018.06.022
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Detecting metastases to the cervical lymph nodes is the main problem in the management of squamous cell carcinoma of the tongue. We investigated the ability of sentinel node (SN) biopsy to predict neck status in 11 patients with lateral T1-T2, N0, and M0 squamous cell carcinoma of the tongue who underwent ip...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1067/msy.2000.106809
更新日期:2000-07-01 00:00:00
abstract:INTRODUCTION:Policies that mandate colorectal screening coverage by private insurers are associated with increased use of screening procedures. We seek to understand whether such mandates have improved access to care and short-term operative outcomes for patients undergoing operations of the colon and rectum (OCR). ME...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2013.04.037
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Laparoscopic techniques are being used increasingly in the repair of ventral hernias and offer the potential benefits of a shorter hospital stay, decreased wound complications, and possibly a lower recurrence rate. Despite good results from high-volume centers, significant complications may occur with this a...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2005.06.054
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:After sphincter-saving operation for rectal cancer, the impact of anastomotic leakage on function has been well studied. The purpose of the present work was to assess the influence of symptomatic and asymptomatic anastomotic leakage on bowel function and health-related quality of life using the Low Anterior ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2016.09.037
更新日期:2017-04-01 00:00:00
abstract::We estimated ambulatory venous pressure (AVP) noninvasively with a new technique of quantitative photoplethysmography (PPG). Postural changes of hydrostatic pressure permitted in vivo calibration of the PPG. We recorded quantitative PPG and AVP in 14 normal subjects and 14 patients with postthrombotic chronic venous i...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1983-11-01 00:00:00
abstract::One hundred five patients with obstructive jaundice have undergone percutaneous transhepatic internal biliary drainage at the Johns Hopkins Hospital. Many of these patients subsequently underwent corrective or palliative surgery, whereas other died of malignant disease after relatively short periods of catheter decomp...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1982-06-01 00:00:00
abstract:BACKGROUND:The purpose of the present study is to compare postoperative pain and functional outcomes in patients undergoing inguinal herniorrhaphy who receive a continuous wound infusion of bupivacaine to those who receive an infusion of saline. METHODS:A prospective, randomized, blinded, placebo-controlled trial was ...
journal_title:Surgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.surg.2004.06.016
更新日期:2004-10-01 00:00:00
abstract::Rats, with their liver DNA labeled with 3H-thymidine, were subjected to hemorrhagic shock. In nine rats reversible hemorrhagic shock with a blood pressure of 40 mm Hg for 30 minutes resulted in no breaks in the DNA. Twenty-seven animals were subjected to severe hemorrhagic shock. Blood pressures of 40 mm Hg were maint...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1979-03-01 00:00:00
abstract:BACKGROUND:Muscle protein catabolism, reflected by a decrease in glutamine (GLN), a decrease in muscle protein synthesis, and a negative nitrogen balance can be reduced by either administration of GLN or growth hormone (GH). In this study, the effects of a combination of GH and GLH were studied. METHODS:Patients (n = ...
journal_title:Surgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1067/msy.2001.112593
更新日期:2001-05-01 00:00:00
abstract::Patients with primary and recurrent carcinomas of the breast were studied by the human tumor stem cell assay to determine if (1) colonies would form from breast cancer specimens, (2) growth in the culture would equate with aggressiveness of disease, (3) the assay would yield specific information on drug responsiveness...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1983-08-01 00:00:00