Zerumbone inhibits melanoma cell proliferation and migration by altering mitochondrial functions.

Abstract:

:It has been reported that zerumbone (ZER) has marked effects on the regulation of cell proliferation and migration in multiple types of cancer, and has anti-cancer effects on various types of malignant cell. However, the effects and underlying molecular mechanisms of treatment with ZER on melanoma cells remain unclear. In the present study, the effect of treatment with ZER on the proliferation, migration and mitochondrial function of the human melanoma cell line CHL-1 was investigated. The results of the present study indicated that treatment with ZER significantly inhibited CHL-1 cell proliferation (P<0.001). Cell migration analysis further demonstrated that ZER inhibited the migration of CHL-1 cells (P<0.001). Treatment with ZER significantly increased cellular reactive oxygen species levels (P<0.001), reduced matrix membrane potential (P<0.001), decreased ATP (P<0.001) and mitochondrial DNA (P<0.001) levels, and decreased mitochondrial transcription factor A mRNA levels (P=0.002). The results of the present study suggested that the inhibition of proliferation and migration was mediated by altered mitochondrial function. In conclusion, the results of the present study suggested that ZER has chemotherapeutic effects on human melanoma cells by altering mitochondrial function.

journal_name

Oncol Lett

journal_title

Oncology letters

authors

Yan H,Ren MY,Wang ZX,Feng SJ,Li S,Cheng Y,Hu CX,Gao SQ,Zhang GQ

doi

10.3892/ol.2017.5742

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

2397-2402

issue

4

eissn

1792-1074

issn

1792-1082

pii

OL-0-0-5742

journal_volume

13

pub_type

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