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[Cryoglobulinemic vasculitis in chronic hepatitis C: Genetic aspects].

Abstract：

:Cryoglobulinemia (CG) is detected in more than 50% of patients with chronic hepatitis C (CHC); however, only 15-25% of them develop cryoglobulinemic vasculitis (CV) that is a systemic vasculitis due to the formation of immune deposits, which affects small (less than medium-sized) vessels and which is frequently fatal for the patient. The causes of CG only in some patients with CHC and the pathogenesis of CV remain unstudied; however, the accumulated data allow one to identify the special contribution of the patient's genetic factors to the development of the disease. The paper considers the genetic aspects of the development of CG and CV in CHC. :Криоглобулинемия (КГ) выявляется более чем у 50% больных хроническим гепатитом С (ХГС), однако лишь у 15-25% из них развивается криоглобулинемический васкулит (КВ) - системный васкулит, обусловленный образованием иммунных депозитов, поражающий сосуды мелкого (реже среднего) калибра, нередко являющийся фатальным для больного. Причины формирования КГ только у отдельных больных ХГС и патогенез КВ остаются не изученными, однако накопленные данные позволяют выделить особый вклад генетических факторов пациента в развитие болезни. В статье рассмотрены генетические аспекты формирования КГ и КВ при ХГС.

journal_name

Ter Arkh

journal_title

Terapevticheskii arkhiv

authors

Artemova MG,Abdurakhmanov DT

doi

10.17116/terarkh2017894110-114

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

110-114

issue

4

eissn

0040-3660

issn

2309-5342

journal_volume

89

pub_type

杂志文章

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