MO-F-213AB-01: Improving Dose Uniformity in Patch-Field Proton Therapy Using Beam Current Modulation.

Abstract:

PURPOSE:To improve the dose homogeneity in patch-field proton therapy using beam current modulation. METHODS:MCNPX simulations were performed for various configurations of the Mevion S250 beamline. Spread-out Bragg peak (SOBP) dose distributions were calculated, and lateral and distal dose profiles were extracted for through- and patch-field targets at depths ranging from 5.0 to 27.5 cm. We define 'dose non-uniformity' (DNU) as the difference between the maximum and minimum dose relative to the prescription observed in a patched dose distribution. DNU was first calculated for dose distributions combining through-field lateral dose profiles and with patch-field distal dose profiles, assuming a 'standard' delivery with constant beam current. Distal dose profiles were then optimized using beam current modulation to better complement the lateral dose profiles when combined into a patched dose distribution. The DNU for optimized dose distributions was then calculated and compared to the DNU found for standard delivery. RESULTS:Using standard deliveries, DNU was 10% or less when patching lateral profiles 12.5-17.5 cm deep. Significantly greater DNU was observed for patches outside of this range, sometimes exceeding 35%. Using optimized distal profiles, DNU was reduced to 10% or less for all lateral profiles deeper than 12.5 cm. Patches with lateral profiles shallower than 12.5 cm were not improved, as distal dose dropoff could not be improved to better match the sharp lateral dose dropoff. CONCLUSIONS:Optimizing beam current modulation can create distal profiles with more gradual dose falloff than found in a standard delivery, allowing optimized distal dose distributions to sum more homogeneously with lateral dose distributions. Thus, the hot or cold spots that often appear in patched dose distributions from standard deliveries can be mitigated by optimizing beam current. This method may also be applied to feathering methods or scanned beam deliveries to further improve patch-field dose homogeneity. Partially supported by MEVION Medical Systems, Inc.

journal_name

Med Phys

journal_title

Medical physics

authors

Hill P,Klein E,Bloch C

doi

10.1118/1.4735806

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

3871

issue

6Part21

eissn

0094-2405

issn

2473-4209

journal_volume

39

pub_type

杂志文章
  • Projection-based improvement of 3D reconstructions from motion-impaired dental cone beam CT data.

    abstract:PURPOSE:Computed tomography (CT) and, in particular, cone beam CT (CBCT) have been increasingly used as a diagnostic tool in recent years. Patient motion during acquisition is common in CBCT due to long scan times. This results in degraded image quality and may potentially increase the number of retakes. Our aim was to...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.13731

    authors: Niebler S,Schömer E,Tjaden H,Schwanecke U,Schulze R

    更新日期:2019-10-01 00:00:00

  • Dosimetric impact of motion in free-breathing and gated lung radiotherapy: a 4D Monte Carlo study of intrafraction and interfraction effects.

    abstract::The purpose of this study was to investigate if interfraction and intrafraction motion in free-breathing and gated lung IMRT can lead to systematic dose differences between 3DCT and 4DCT. Dosimetric effects were studied considering the breathing pattern of three patients monitored during the course of their treatment ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.2821704

    authors: Seco J,Sharp GC,Wu Z,Gierga D,Buettner F,Paganetti H

    更新日期:2008-01-01 00:00:00

  • Multiscale entropy of laser Doppler flowmetry signals in healthy human subjects.

    abstract:PURPOSE:The cardiovascular system (CVS) regulation can be studied from a central viewpoint, through heart rate variability (HRV) data, and from a peripheral viewpoint, through laser Doppler flowmetry (LDF) signals. Both the central and peripheral CVSs are regulated by several interacting mechanisms, each having its own...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.3512796

    authors: Humeau A,Buard B,Mahé G,Rousseau D,Chapeau-Blondeau F,Abraham P

    更新日期:2010-12-01 00:00:00

  • 4D rotational x-ray imaging of wrist joint dynamic motion.

    abstract::Current methods for imaging joint motion are limited to either two-dimensional (2D) video fluoroscopy, or to animated motions from a series of static three-dimensional (3D) images. 3D movement patterns can be detected from biplane fluoroscopy images matched with computed tomography images. This involves several x-ray ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.2000647

    authors: Carelsen B,Bakker NH,Strackee SD,Boon SN,Maas M,Sabczynski J,Grimbergen CA,Streekstra GJ

    更新日期:2005-09-01 00:00:00

  • WE-G-217BCD-05: Fiducial Marker-Based Motion Compensation for the Acquisition of 3D Knee Geometry Under Weight-Bearing Conditions Using a C-Arm CT Scanner.

    abstract:PURPOSE:Imaging the knee under realistic load-bearing conditions can be carried out in a horizontal plane using a C-arm CT scanner. Human subjects can be scanned in a standing position and acquired data successfully reconstructed. However, reconstructing this data is a challenge due to significant artifacts that are in...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4736213

    authors: Choi JH,Keil A,Maier A,Pal S,McWalter EJ,Fahrig R

    更新日期:2012-06-01 00:00:00

  • Model-based geometric calibration for medical x-ray systems.

    abstract:PURPOSE:Currently applied calibration approaches lead to satisfying 3D roadmapping overlay and 3D reconstruction accuracies; however, the required calibration times are extensive. The aim of this paper is the introduction of a novel model-based approach for geometric system calibrations, leading to a significant reduct...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4931964

    authors: van der Maas R,de Jager B,Steinbuch M,Dries J

    更新日期:2015-11-01 00:00:00

  • A delivery quality assurance tool based on the actual leaf open times in tomotherapy.

    abstract:PURPOSE:To validate a delivery quality assurance (DQA) protocol for tomotherapy based on the measurement of the leaf open times (LOTs). In addition, to show the correlation between the mean relative LOT discrepancy and the dose deviation in the planning target volume (PTV). MATERIALS AND METHODS:We used a LOT measurem...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.14348

    authors: Schopfer M,Bochud FO,Bourhis J,Moeckli R

    更新日期:2020-09-01 00:00:00

  • Optimization of radiography applications using x-ray beams emitted by compact accelerators. Part I. Monte Carlo study of the hard x-ray spectrum.

    abstract:PURPOSE:A 3-year project called LABSYNC has been recently funded by the European Commission, with the aim of designing a radiation facility based on a compact light source, i.e., a laboratory-sized commercial synchrotron, capable of accelerating electrons up to 6 or 20 MeV. An accurate spectral description of hard x ra...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.3223357

    authors: Marziani M,Taibi A,Di Domenico G,Gambaccini M

    更新日期:2009-10-01 00:00:00

  • Validation of Monte Carlo calculated surface doses for megavoltage photon beams.

    abstract::Recent work has shown that there is significant uncertainty in measuring build-up doses in mega-voltage photon beams especially at high energies. In this present investigation we used a phantom-embedded extrapolation chamber (PEEC) made of Solid Water to validate Monte Carlo (MC)-calculated doses in the dose build-up ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.1829401

    authors: Abdel-Rahman W,Seuntjens JP,Verhaegen F,Deblois F,Podgorsak EB

    更新日期:2005-01-01 00:00:00

  • Choice of material for HVL measurements in megavoltage x-ray beams.

    abstract::The relative sensitivity of the half-value layer (HVL) method as a quality index for megavoltage x-ray beams is examined by theoretical calculation and experimental measurements for 4-, 6-, 10-, and 25-MV x-ray beams. It is shown that lower atomic number materials are more sensitive to beam quality changes than higher...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.595794

    authors: Meli JA,Nath R

    更新日期:1985-01-01 00:00:00

  • Radiofrequency transmit calibration: A multi-center evaluation of vendor-provided radiofrequency transmit mapping methods.

    abstract:PURPOSE:To determine the accuracy and test-retest repeatability of fast radiofrequency (RF) transmit measurement approaches used in Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI). Spatial variation in the transmitted RF field introduces bias and increased variance in quantitative DCE-MRI metrics includi...

    journal_title:Medical physics

    pub_type: 杂志文章,多中心研究

    doi:10.1002/mp.13518

    authors: Bliesener Y,Zhong X,Guo Y,Boss M,Bosca R,Laue H,Chung C,Sung K,Nayak KS

    更新日期:2019-06-01 00:00:00

  • An outlook on x-ray CT research and development.

    abstract::Over the past decade, computed tomography (CT) theory, techniques and applications have undergone a rapid development. Since CT is so practical and useful, undoubtedly CT technology will continue advancing biomedical and non-biomedical applications. In this outlook article, we share our opinions on the research and de...

    journal_title:Medical physics

    pub_type: 杂志文章,评审

    doi:10.1118/1.2836950

    authors: Wang G,Yu H,De Man B

    更新日期:2008-03-01 00:00:00

  • Performance characteristics of an orthovoltage x-ray therapy machine.

    abstract::Performance characteristics sufficient to provide physical data base specific to the Siemen's Stabilipan 2 orthovoltage x-ray therapy machine are presented. Operating conditions covering the working range of the unit from 100 to 300 kVp are selected. Beam quality, output, the central axis depth dose, relative output f...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.596016

    authors: Niroomand-Rad A,Gillin MT,Lopez F,Grimm DF

    更新日期:1987-09-01 00:00:00

  • Automated polyp segmentation for colonoscopy images: A method based on convolutional neural networks and ensemble learning.

    abstract:PURPOSE:To automatically and efficiently segment the lesion area of the colonoscopy polyp image, a polyp segmentation method has been presented. METHODS:An ensemble model of pretrained convolutional neural networks was proposed, using Unet-VGG, SegNet-VGG, and PSPNet. Firstly, the Unet-VGG is obtained by the first 10 ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.13865

    authors: Guo X,Zhang N,Guo J,Zhang H,Hao Y,Hang J

    更新日期:2019-12-01 00:00:00

  • Comparison of exposure standards in the mammography x-ray region.

    abstract::Direct comparisons of the National Institute of Standards and Technology's (NIST) Ritz 20 kV to 100 kV standard free-air ionization chamber and a portable variable-length free-air ionization chamber designed by the University of Wisconsin-Madison Accredited Dosimetry Calibration Laboratory (UW-ADCL) were made on NISTs...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.598148

    authors: Coletti JG,Pearson DW,DeWerd LA,O'Brien CM,Lamperti PJ

    更新日期:1997-08-01 00:00:00

  • Deconvolution techniques for removing the effects of chemical shift in 19F nuclear magnetic resonance imaging of perfluorocarbon compounds.

    abstract::Nuclear magnetic resonance (NMR) imaging of perfluorocarbon (PFC) emulsions and neat liquids has shown potential for in vivo oxygen imaging in blood and organ tissue. PFC compounds exhibit complicated NMR spectra caused by chemical shifts and spin-spin couplings which can lead to artifacts and degraded spatial resolut...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.595960

    authors: Busse LJ,Thomas SR,Pratt RG,Clark LC Jr,Ackerman JL,Samaratunga RC,Hoffmann RE

    更新日期:1986-07-01 00:00:00

  • Improved quantification of radionuclide uptake using deconvolution and windowed subtraction techniques for scatter compensation in single photon emission computed tomography.

    abstract::A comparison of two methods of scatter compensation in single photon emission computed tomography (SPECT) imaging is made on the basis of improvements in quantification. The methods, scatter-window subtraction and constrained deconvolution of an average point source response function (PSRF), are described; the theoret...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.596453

    authors: Yanch JC,Flower MA,Webb S

    更新日期:1990-11-01 00:00:00

  • The influence of phantom size on output, peak scatter factor, and percentage depth dose in large-field photon irradiation.

    abstract::Machine outputs, peak scatter factors, and central axis percentage depth dose distributions were measured for various phantom sizes in large radiation fields produced at extended distances by cobalt, 6-MV, and 10-MV photon beams. The results can be applied to practical total body irradiation procedures which usually i...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.595686

    authors: Podgorsak EB,Pla C,Evans MD,Pla M

    更新日期:1985-09-01 00:00:00

  • The x-ray time of flight method for investigation of ghosting in amorphous selenium-based flat panel medical x-ray imagers.

    abstract::Amorphous selenium (a-Se) based real-time flat-panel imagers (FPIs) are finding their way into the digital radiology department because they offer the practical advantages of digital x-ray imaging combined with an image quality that equals or outperforms that of conventional systems. The temporal imaging characteristi...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.2042248

    authors: Rau AW,Bakueva L,Rowlands JA

    更新日期:2005-10-01 00:00:00

  • Review and evaluation of MRI nonuniformity corrections for brain tumor response measurements.

    abstract::Current MRI nonuniformity correction techniques are reviewed and investigated. Many approaches are used to remedy this artifact, but it is not clear which method is the most appropriate in a given situation, as the applications have been with different MRI coils and different clinical applications. In this work four w...

    journal_title:Medical physics

    pub_type: 杂志文章,评审

    doi:10.1118/1.598357

    authors: Velthuizen RP,Heine JJ,Cantor AB,Lin H,Fletcher LM,Clarke LP

    更新日期:1998-09-01 00:00:00

  • Comparison of planned dose on different CT image sets to four-dimensional Monte Carlo dose recalculation using the patient's actual breathing trace for lung stereotactic body radiation therapy.

    abstract:PURPOSE:The need for four-dimensional (4D) treatment planning becomes indispensable when it comes to radiation therapy for moving tumors in the thoracic and abdominal regions. The primary purpose of this study is to combine the actual breathing trace during each individual treatment fraction with the Linac's log file i...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.13579

    authors: Freislederer P,von Münchow A,Kamp F,Heinz C,Gerum S,Corradini S,Söhn M,Reiner M,Roeder F,Floca R,Alber M,Belka C,Parodi K

    更新日期:2019-07-01 00:00:00

  • Differences in the lesion formation process between focused ultrasound and microwave ablations.

    abstract::The objective is to understand the differences in the lesion formation processes between microwave and high-intensity focused ultrasound (HIFU) ablation. The lesions formed by microwaves and HIFU were real-time monitored and compared using transparent tissue-mimicking phantoms at 60 and 70 W of driving electrical powe...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.2193689

    authors: Chen WS,Wu CC,Fang HY,Liu HL

    更新日期:2006-05-01 00:00:00

  • Monte Carlo dose calculations in homogeneous media and at interfaces: a comparison between GEPTS, EGSnrc, MCNP, and measurements.

    abstract::Three Monte Carlo photon/electron transport codes (GEPTS, EGSnrc, and MCNP) are bench-marked against dose measurements in homogeneous (both low- and high-Z) media as well as at interfaces. A brief overview on physical models used by each code for photon and electron (positron) transport is given. Absolute calorimetric...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.1473134

    authors: Chibani O,Li XA

    更新日期:2002-05-01 00:00:00

  • A practical technique for verification of three-dimensional conformal dose distributions in stereotactic radiosurgery.

    abstract::The trend toward conformal techniques in stereotactic radiosurgery necessitates an accurate and practical method for verification of irregular three-dimensional dose distributions. This work presents the design and evaluation of a phantom system facilitating the measurement of conformal dose distributions using one or...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.598962

    authors: Robar JL,Clark BG

    更新日期:2000-05-01 00:00:00

  • X-ray imaging technique for in vitro tissue composition measurements using saline/iodine displacement: technique optimization.

    abstract::An in vitro radiographic technique which uses saline/iodine displacement has been developed to study the thickness of bone-equivalent and soft-tissue-equivalent materials within atherosclerotic plaques in arterial specimens which have been cut open longitudinally and laid flat. Results concerning the optimization of t...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.597916

    authors: Moreau M,Holdsworth DW,Fenster A

    更新日期:1997-01-01 00:00:00

  • Inverse planning incorporating organ motion.

    abstract::Accurate targeting is important in intensity-modulated radiation therapy (IMRT). The positional uncertainties of structures with respect to the external beams arise in part from random organ motion and patient setup errors. While it is important to improve immobilization and reduce the influence of organ motion, the r...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.599023

    authors: Li JG,Xing L

    更新日期:2000-07-01 00:00:00

  • SU-E-T-619: A Network-Flow Solution Approach to VMAT Treatment Plan Optimization.

    abstract:PURPOSE:To add mathematical rigor to the merging phase of the recently published two-stage VMAT optimization method called VMERGE. Using an exact merging method, we are able to better characterize the tradeoff between delivery efficiency and dose quality. METHODS:VMERGE begins with an IMRT plan that uses 180 equi-spac...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4735709

    authors: Salari E,Craft D

    更新日期:2012-06-01 00:00:00

  • Clinical implementation of a Monte Carlo treatment planning system.

    abstract::The purpose of this study was to implement the Monte Carlo method for clinical radiotherapy dose calculations. We used the EGS4/BEAM code to obtain the phase-space data for 6-20 MeV electron beams and 4, 6, and 15 MV photon beams for Varian Clinac 1800, 2100C, and 2300CD accelerators. A multiple-source model was used ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.598729

    authors: Ma CM,Mok E,Kapur A,Pawlicki T,Findley D,Brain S,Forster K,Boyer AL

    更新日期:1999-10-01 00:00:00

  • Ultrasound viscoelasticity assessment using an adaptive torsional shear wave propagation method.

    abstract:PURPOSE:Different approaches have been used in dynamic elastography to assess mechanical properties of biological tissues. Most techniques are based on a simple inversion based on the measurement of the shear wave speed to assess elasticity, whereas some recent strategies use more elaborated analytical or finite elemen...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4942813

    authors: Ouared A,Kazemirad S,Montagnon E,Cloutier G

    更新日期:2016-04-01 00:00:00

  • Technical and dosimetric realization of in vivo x-ray microbeam irradiations at the Munich Compact Light Source.

    abstract:PURPOSE:X-ray microbeam radiation therapy is a preclinical concept for tumor treatment promising tissue sparing and enhanced tumor control. With its spatially separated, periodic micrometer-sized pattern, this method requires a high dose rate and a collimated beam typically available at large synchrotron radiation faci...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.14433

    authors: Burger K,Urban T,Dombrowsky AC,Dierolf M,Günther B,Bartzsch S,Achterhold K,Combs SE,Schmid TE,Wilkens JJ,Pfeiffer F

    更新日期:2020-10-01 00:00:00