Abstract:
:Stereotactic Body Radiation Therapy (SBRT) is an important form of cancer therapy with increasingly broad application across a spectrum of tumor types in primary and metastatic settings. In this presentation the radiation biology, clinical experience from various trials, and cautionary updates on normal tissue tolerances will be presented. The effective radiobiology of SBRT and hypofractionated courses of therapy has become more evident with the increasing reports of retrospective clinical outcomes and prospective clinical trial results. Current open multi-institutional national cooperative trials will be reviewed. Accumulating clinical experiences are yielding new insights into practical aspects of tumor and normal tissue responses to high dose per fraction treatment. Indeed, SBRT has produced profound tumoricidal and ablative effects, however there is potential for grave toxicity and this demands that clinicians be knowledgeable regarding normal tissue tolerances for various hypofractionated courses. As a final note, the technology associated with SBRT has evolved remarkably in the last decade, and procedures that originally required hours to plan, with cumbersome quality assurance methods, arduous set-up times, and long protracted deliveries can now be performed in ever shorter time periods. Given these technology improvements and recognizing the great palliative potential of hypofractionated radiation therapy to relieve cancer symptoms quickly and efficiently, a new strategy to deliver SBRT in a single session called STAT RAD is presented for discussion.
journal_name
Med Physjournal_title
Medical physicsauthors
Read Pdoi
10.1118/1.4735812subject
Has Abstractpub_date
2012-06-01 00:00:00pages
3873issue
6Part21eissn
0094-2405issn
2473-4209journal_volume
39pub_type
杂志文章相关文献
MEDICAL PHYSICS文献大全abstract::Pixel size is of great interest in the flat-panel detector design because of its potential impact on image quality. In the particular case of angiographic x-ray fluoroscopy, small pixels are required in order to adequately visualize interventional devices such as guidewires and stents which have wire diameters as smal...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.2169907
更新日期:2006-03-01 00:00:00
abstract:PURPOSE:Polymer-based gel dosimeter (MAGIC type) is a preferable phantom material for PET range verification of proton beam therapy. However, improvement in elemental tissue equivalency (specifically O/C ratio) is very desirable to ensure realistic time-activity measurements. METHODS:Glucose and urea was added to the ...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.3260844
更新日期:2010-01-01 00:00:00
abstract::An indirect flat-panel imager (FPI) with avalanche gain is being investigated for low-dose x-ray imaging. It is made by optically coupling a structured x-ray scintillator CsI(Tl) to an amorphous selenium (a-Se) avalanche photoconductor called HARP (high-gain avalanche rushing photoconductor). The final electronic imag...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.2008428
更新日期:2005-09-01 00:00:00
abstract::Currently, patients with brain neoplasms must undergo both computed tomography (CT) and magnetic resonance (MR) imaging to take advantage of CT's density information and MR's soft tissue imaging capabilities. A method has been developed that allows virtual simulation, digitally reconstructed radiographs (DRRs), and 3-...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.598382
更新日期:1998-10-01 00:00:00
abstract:PURPOSE:The overall goal of this work is to improve the computed tomography (CT) image quality for patients with metal implants or fillings by completing the missing kilovoltage (kV) projection data with selectively acquired megavoltage (MV) data that do not suffer from photon starvation. When both of these imaging sys...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4901551
更新日期:2014-12-01 00:00:00
abstract::Highly focused dose distributions for radiosurgery applications are successfully achieved using either multiple static high-energy particle beams or multiple-arc circular x-ray beams from a linac. It has been suggested that conformal x-ray techniques using dynamically shaped beams with a moving radiation source would ...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.597654
更新日期:1995-12-01 00:00:00
abstract:PURPOSE:The determination of absorbed dose to water from external beam radiotherapy using radiation detectors is currently rooted in calibration protocols that do not account for modulations encountered in patient-specific deliveries. Detector response in composite clinical fields has not been extensively studied due t...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1002/mp.13293
更新日期:2019-02-01 00:00:00
abstract::The contribution of a commercially available diode matrix (MapCHECK, provided by Sun Nuclear, Melbourne, FL) for the commissioning procedures of the voxel based Monte Carlo (VMC++) algorithm for electron beams of MasterPlan treatment planning system was investigated. The attention is mainly focused on the calculation ...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.3081414
更新日期:2009-04-01 00:00:00
abstract:PURPOSE:Having been overlooked for many years, research is now starting to take into account the directional distribution of neutron workplace fields. Existing neutron dosimetry instrumentation does not account for this directional distribution, resulting in conservative estimates of dose in neutron workplace fields (b...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4964456
更新日期:2016-11-01 00:00:00
abstract:PURPOSE:Breast density is a significant breast cancer risk factor. Although various methods are used to estimate breast density, there is no standard measurement for this important factor. The authors are developing a breast density standardization method for use in full field digital mammography (FFDM). The approach c...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.3250842
更新日期:2009-12-01 00:00:00
abstract:PURPOSE:The recent introduction of digital tomosynthesis imaging into routine clinical use has enabled the acquisition of volumetric patient data within a standard radiographic examination. Tomosynthesis requires the acquisition of multiple projection views, requiring additional dose compared to a standard projection e...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.3250907
更新日期:2009-12-01 00:00:00
abstract:PURPOSE:To develop an automated technique for evaluating lung stereotactic body radiotherapy (SBRT) plan quality and predicting achievable lung dose constraints. METHODS:We examined the workflow scripting capabilities of a radiation oncology software package (MIM Software Inc) for automatically generating mean dose gr...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4735279
更新日期:2012-06-01 00:00:00
abstract::One of the important features of the Siemens Virtual Wedge (VW) is that the VW factor (VWF) is approximately equal to unity for all beams with a total deviation for a given wedge no greater than 0.05, as specified by Siemens. In this note we report the observed dependence of VWF on dose calibration (cGy/MU), monitor u...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.1344204
更新日期:2001-02-01 00:00:00
abstract:PURPOSE:To develop and investigate a continuous path optimization methodology to traverse prescribed non-coplanar IMRT beams with variant SADs, by orchestrating the couch and gantry movement with zero-collision, minimal patient motion consequence and machine travel time. METHODS:We convert the given collision zone def...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4735996
更新日期:2012-06-01 00:00:00
abstract::Radiation therapy treatment modalities continue to develop and have become increasingly complex. With this, dose verification and quality assurance (QA) is of great importance to ensure that a prescribed dose is accurately and precisely delivered to a patient. Radiochromic film dosimetry has been adopted as a convenie...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4740126
更新日期:2012-07-01 00:00:00
abstract::AAPM Magnetic Resonance Task Group #9 on proton magnetic resonance spectroscopy (MRS) in the brain was formed to provide a reference document for acquiring and processing proton (1H) MRS acquired from brain tissue. MRS is becoming a common adjunct to magnetic resonance imaging (MRI), especially for the differential di...
journal_title:Medical physics
pub_type: 指南,杂志文章,实务指引,评审
doi:10.1118/1.1501822
更新日期:2002-09-01 00:00:00
abstract:PURPOSE:Photon counting arrays (PCAs), capable of measuring the spectral information of individual x-ray photons and recording that information digitally, provide a number of advantages compared to conventional, energy-integrating active matrix flat-panel imagers - such as reducing the undesirable effects of electronic...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1002/mp.13128
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:Motion is a major confound of image quality in MRI. A method of retrospectively correcting the effects of rotations and translations on the acquired k-space data is presented. METHODS:In two phantom experiments of well-controlled translation and rotation, two MRI-compatible infrared cameras recorded motion dat...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.3254189
更新日期:2009-12-01 00:00:00
abstract:PURPOSE:Planning for the delivery of intensity-modulated radiation therapy (IMRT) to a moving target, referred to as four-dimensional (4D) IMRT planning, is a crucial step for achieving the treatment objectives for sites that move during treatment delivery. The authors proposed a simplistic method that accounts for bot...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.3319498
更新日期:2010-05-01 00:00:00
abstract::The image display is an important component of the Picture Archiving and Communication System (PACS) and of digital imaging in general. In this paper, we assess the display performance of 32 different flat panel LCD devices, in terms of their reflection, luminance response, luminance uniformity, resolution, noise, vei...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.1764946
更新日期:2004-07-01 00:00:00
abstract:PURPOSE:Prostate biopsy, performed using two-dimensional (2D) transrectal ultrasound (TRUS) guidance, is the clinical standard for a definitive diagnosis of prostate cancer. Histological analysis of the biopsies can reveal cancerous, noncancerous, or suspicious, possibly precancerous, tissue. During subsequent biopsy s...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.3298010
更新日期:2010-02-01 00:00:00
abstract::Energy imparted is a measure of the total ionizing energy deposited in the patient during a radiologic examination and may be used to quantify the patient dose in diagnostic radiology. Values of the energy imparted per unit exposure-area product, omega (z), absorbed by a semi-infinite water phantom with a thickness z,...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.597939
更新日期:1997-04-01 00:00:00
abstract::Noise, partial volume (PV) effect, and image-intensity inhomogeneity render a challenging task for segmentation of brain magnetic resonance (MR) images. Most of the current MR image segmentation methods focus on only one or two of the above-mentioned effects. The objective of this paper is to propose a unified framewo...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.1944912
更新日期:2005-07-01 00:00:00
abstract:PURPOSE:The authors investigate performance of thin-film cadmium telluride (CdTe) in detecting high-energy (6 MV) x rays. The utilization of this material has become technologically feasible only in recent years due to significant development in large area photovoltaic applications. METHODS:The CdTe film is combined w...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.3438082
更新日期:2010-08-01 00:00:00
abstract::A restricted angular scattering model for electron penetration in dense media is presented. In the model, the Fermi-Eyges transport equation is modified through the addition of an extra term which may be interpreted as representing an apparent force opposing the scattering of electrons into wider angles. The introduct...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.596747
更新日期:1991-01-01 00:00:00
abstract::An automated technique has been developed for the verification of treatment field size and shape in external beam radiation therapy. Portal images from film or digital on-line imaging system are analyzed, and basic parameters are derived to describe the field size and shape from the contour points on the field boundar...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.597017
更新日期:1993-05-01 00:00:00
abstract:PURPOSE:The need for an accurate lesion segmentation tool in 18FDG PET is a prerequisite for the estimation of lesion response to therapy, for radionuclide dosimetry, and for the application of 18FDG PET to radiotherapy planning. In this work, the authors have developed an iterative method based on a mathematical fit d...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.3222732
更新日期:2009-10-01 00:00:00
abstract::Single kernel scatter correction algorithms are based on the model that the scatter field can be predicted by convolution of the primary intensity (Iprim) with a spatially invariant scatter point-spread function (PSF). Practical limitations (Iprim unknown) suggest the substitution of the total detected intensity (Idet...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.597297
更新日期:1994-02-01 00:00:00
abstract::In this study we address the problem of predicting the position of a moving lung tumor during respiration on the basis of external breathing signals--a technique used for beam gating, tracking, and other dynamic motion management techniques in radiation therapy. We demonstrate the use of neural network filters to corr...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.2134958
更新日期:2005-12-01 00:00:00
abstract::A technique was developed to reduce the size and magnitude of the hot and cold spots in the abutting regions of photon and electron fields. The photon and electron fields were set up such that the photon field extended approximately 2 cm into the electron field in the abutting region. The region of the photon beam tha...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.598753
更新日期:1999-11-01 00:00:00