Monte Carlo dosimetry for I125 and Pd103 eye plaque brachytherapy.

Abstract:

:A Monte Carlo study of dosimetry for eye plaque brachytherapy is performed. BrachyDose, an EGSnrc user code which makes use of Yegin's multi-geometry package, is used to fully model I125 (model 6711) and Pd103 (model 200) brachytherapy seeds and the standardized plaques of the Collaborative Ocular Melanoma Study (COMS). Three-dimensional dose distributions in the eye region are obtained. In general, dose to water is scored; however, the implications of replacing water with eye tissues are explored. The effect of the gold alloy (Modulay) backing is investigated and the dose is found to be sensitive to the elemental composition of the backing. The presence of the silicone polymer (Silastic) seed carrier results in substantial dose decreases relative to water, particularly for Pd103. For a 20mm plaque with a Modulay backing and Silastic insert, fully loaded with 24 seeds, the dose decrease relative to water is of the order of 14% for I125 and 20% for Pd103 at a distance of 1cm from the inner sclera along the plaque's central axis. For the configurations of seeds used in COMS plaques, interseed attenuation is a small effect within the eye region. The introduction of an air interface results in a dose reduction in its vicinity which depends on the plaque's position within the eye and the radionuclide. Introducing bone in the eye's vicinity also causes dose reductions. The dose distributions in the eye for the two different radionuclides are compared and, for the same prescription dose, Pd103 generally offers a lower dose to critical normal structures. BrachyDose is sufficiently fast to allow full Monte Carlo dose calculations for routine clinical treatment planning.

journal_name

Med Phys

journal_title

Medical physics

authors

Thomson RM,Taylor REP,Rogers DWO

doi

10.1118/1.3002412

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

5530-5543

issue

12

eissn

0094-2405

issn

2473-4209

journal_volume

35

pub_type

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