Abstract:
INTRODUCTION:Microgravity (μG) exposure and even early recovery from μG in combination with mild hypoxia may increase the alveolar-arterial oxygen (O2) partial pressure gradient. METHODS:Four male astronauts on STS-69 (1995) and four on STS-72 (1996) were exposed on Earth to an acute sequential hypoxic challenge by breathing for 4 min 18.0%, 14.9%, 13.5%, 12.9%, and 12.2% oxygen-balance nitrogen. The 18.0% O2 mixture at sea level resulted in an inspired O2 partial pressure (PIo2) of 127 mmHg. The equivalent PIO2 was also achieved by breathing 26.5% O2 at 527 mmHg that occurred for several days in μG on the Space Shuttle. A Novametrix CO2SMO Model 7100 recorded hemoglobin (Hb) oxygen saturation through finger pulse oximetry (Spo2, %). There were 12 in-flight measurements collected. Measurements were also taken the day of (R+0) and 2 d after (R+2) return to Earth. Linear mixed effects models assessed changes in Spo2 during and after exposure to μG. RESULTS:Astronaut Spo2 levels at baseline, R+0, and R+2 were not significantly different from in flight, about 97% given a PIo2 of 127 mmHg. There was also no difference in astronaut Spo2 levels between baseline and R+0 or R+2 over the hypoxic challenge. CONCLUSIONS:The multitude of physiological changes associated with μG and during recovery from μG did not affect astronaut Spo2 under hypoxic challenge.Conkin J, Wessel JH III, Norcross JR, Bekdash OS, Abercromby AFJ, Koslovsky MD, Gernhardt ML. Hemoglobin oxygen saturation with mild hypoxia and microgravity. Aerosp Med Hum Perform. 2017; 88(6):527-534.
journal_name
Aerosp Med Hum Performjournal_title
Aerospace medicine and human performanceauthors
Conkin J,Wessel JH 3rd,Norcross JR,Bekdash OS,Abercromby AFJ,Koslovsky MD,Gernhardt MLdoi
10.3357/AMHP.4804.2017subject
Has Abstractpub_date
2017-06-01 00:00:00pages
527-534issue
6eissn
2375-6314issn
2375-6322journal_volume
88pub_type
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journal_title:Aerospace medicine and human performance
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journal_title:Aerospace medicine and human performance
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journal_title:Aerospace medicine and human performance
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journal_title:Aerospace medicine and human performance
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journal_title:Aerospace medicine and human performance
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journal_title:Aerospace medicine and human performance
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