Abstract:
:Optical coherence tomography angiography (OCTA) is a new, noninvasive imaging technique that generates real-time volumetric data on chorioretinal vasculature and its flow pattern. With the advent of high-speed optical coherence tomography, established enface chorioretinal segmentation, and efficient algorithms, OCTA generates images that resemble an angiogram. The principle of OCTA involves determining the change in backscattering between consecutive B-scans and then attributing the differences to the flow of erythrocytes through retinal blood vessels. OCTA has shown promise in the evaluation of common ophthalmologic diseases such as diabetic retinopathy, age-related macular degeneration, and retinal vascular occlusions. It quantifies vascular compromise reflecting the severity of diabetic retinopathy. OCTA detects the presence of choroidal neovascularization in exudative age-related macular degeneration and maps loss of choriocapillaris in nonexudative age-related macular degeneration. We describe principles of OCTA and findings in common and some uncommon retinal pathologies. Finally, we summarize its potential future applications. Its current limitations include a relatively small field of view, inability to show leakage, and a tendency for image artifacts. Further larger studies will define OCTAs utility in clinical settings and establish if the technology may offer its utility in decreasing morbidity through early detection and guide therapeutic interventions in retinal diseases.
journal_name
Surv Ophthalmoljournal_title
Survey of ophthalmologyauthors
Sambhav K,Grover S,Chalam KVdoi
10.1016/j.survophthal.2017.05.006subject
Has Abstractpub_date
2017-01-01 00:00:00pages
838-866issue
6eissn
0039-6257issn
1879-3304pii
S0039-6257(16)30110-2journal_volume
62pub_type
杂志文章,评审abstract::A 30-year-old man presented with painless total visual loss in the right eye. Fundus exam and imaging was consistent with total internal carotid artery occlusion and hemispheric stroke. The presentation and management options of retinal vascular occlusive disease in association with asymptomatic stroke are discussed. ...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.survophthal.2014.06.007
更新日期:2015-05-01 00:00:00
abstract::Given the recent interest in complementary and alternative medicine (CAM), some patients may seek such treatments to supplement their traditional glaucoma management. The prevalence of CAM use for glaucoma is approximately 5%. We reviewed the literature to determine the potential benefit of various alternative treatme...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/s0039-6257(01)00233-8
更新日期:2001-07-01 00:00:00
abstract::Topically administered ophthalmic medications are capable of attaining clinically important serum concentrations, as evidenced by the variety of systemic side effects they can produce. These drugs are therefore also capable of interacting with other drugs administered orally and intravenously. This is especially impor...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/0039-6257(90)90090-i
更新日期:1990-11-01 00:00:00
abstract::A 24-year-old woman with acute optic neuritis is presented. Appropriate management and treatment of this case using the Optic Neuritis Treatment Trial guidelines and an evaluation of the cost involved is discussed. ...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0039-6257(97)00117-3
更新日期:1998-01-01 00:00:00
abstract::The onset of scleral necrosis after ocular surgery may have catastrophic ocular and systemic consequences. The two most frequent surgeries causing surgically-induced scleral necrosis (SISN) are pterygium excision and cataract extraction. Several pathogenic mechanisms are involved in surgically induced scleral necrosis...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/j.survophthal.2020.12.008
更新日期:2021-01-07 00:00:00
abstract::Ocular tissues, like those of other organs, exhibit limited morphologic reactions to trauma, i.e., hyperemia, abrupt vasodilation, increased blood flow; increased permeability of blood vessels, edema and increased tissue pressure (disrupted blood-ocular barrier); and later, a cellular inflammatory response. The cystoi...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/0039-6257(84)90236-4
更新日期:1984-05-01 00:00:00
abstract::Recent advances in understanding the pathogenesis of sympathetic ophthalmia are helping to remove the pigmented cloud which has obstructed the view of researchers on this disease for many years. Clinical features, diagnostic testing, histopathologic variations and principles of treatment are evaluated in the context o...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/0039-6257(79)90018-3
更新日期:1979-11-01 00:00:00
abstract::Scleritis is typically a severe painful inflammatory process centered in the sclera that may involve the cornea, adjacent episclera, and underlying uvea; it poses a significant threat to vision. Careful clinical history taking, detailed ocular examination, appropriate investigation for ocular disease with or without u...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/j.survophthal.2005.04.001
更新日期:2005-07-01 00:00:00
abstract::In addition to the original and highly popular instrument designed by Goldmann, three other projection perimeters are now available. Features of the Goldmann, Topcon, Marco and Rodenstock machines are examined and compared. ...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/0039-6257(75)90005-3
更新日期:1975-11-01 00:00:00
abstract::Corneal lymphangiogenesis is the extension of lymphatic vessels into the normally alymphatic cornea, a process that compromises the cornea's immune-privileged state and facilitates herpetic stromal keratitis (HSK). HSK results most commonly from infection by herpes simplex virus-1 (HSV-1) and is characterized by immun...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/j.survophthal.2014.06.001
更新日期:2015-01-01 00:00:00
abstract::The development of nuclear magnetic resonance imaging techniques provides the physician with a non-invasive means of obtaining anatomic, physiologic and biochemical information about neuro-ophthalmic disorders. The authors summarize the principles of nuclear magnetic resonance imaging and present a case report illustr...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/0039-6257(84)90116-4
更新日期:1984-07-01 00:00:00
abstract::There are numerous unresolved issues and controversies regarding the management of open-globe injuries involving the posterior segment. These areas include, but are not limited to, the following issues. Although vitrectomy has been shown to improve visual outcomes and allow retention of the eye in many cases, the exte...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/s0039-6257(99)00104-6
更新日期:1999-11-01 00:00:00
abstract::Two short visual field tests were performed on 106 subjects approximately 5 minutes apart with or without a hand vibration stimulus between the field tests. There were 31 eyes in the control group (10 without glaucoma, eight glaucoma suspects, 10 with primary open-angle glaucoma, and three with secondary open-angle gl...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0039-6257(99)00051-x
更新日期:1999-06-01 00:00:00
abstract::William Ellergy Briggs was California's preeminent ophthalmologist for more than fifty years. A student of Ernst Fuchs, he was a clinician, scholar, and innovator who transplanted the best of European ophthalmology to the Western United States. ...
journal_title:Survey of ophthalmology
pub_type: 传,历史文章,杂志文章
doi:10.1016/0039-6257(90)90029-u
更新日期:1990-01-01 00:00:00
abstract::Transcorneal drug transport is normally limited by the intrinsic permeation characteristics of the corneal epithelium. However, liposomes, i.e., phospholipid vesicles composed of phospholipid membranes, have recently attracted attention as carriers of topically applied agents. The present study therefore describes a q...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0039-6257(05)80068-2
更新日期:1995-05-01 00:00:00
abstract::A 34-year-old man with AIDS was admitted to the hospital with a one-week history of cough, chest pain, and fever. Radiography revealed a cavitating left upper lobe lesion. Two weeks later he developed a headache associated with a contrast enhancing lesion in the right parietal lobe. The patient had a progressive downh...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0039-6257(05)80043-8
更新日期:1994-07-01 00:00:00
abstract::Testicular lymphoma is a rare neoplasm of the testis that is most commonly seen in older patients. It metastasizes preferentially to extranodal sites, including the skin, central nervous system, Waldeyer ring, contralateral testis, and lung. Two case reports of patients with a history of testicular lymphoma who develo...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.survophthal.2005.11.002
更新日期:2006-01-01 00:00:00
abstract::The cornea's intense innervation is responsible for corneal trophism and ocular surface hemostasis maintenance. Corneal diabetic neuropathy affects subbasal nerve plexus, with progressive alteration of nerves' morphology and density. The quantitative analysis of nerve fibers can be performed with in vivo corneal confo...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/j.survophthal.2020.09.003
更新日期:2020-09-19 00:00:00
abstract::The practical value of any therapy depends upon a combination of effectiveness of the agent (or procedure) and the extent to which the patient complies in its proper administration. Thus, it might be said that the multiple of effectiveness times compliance equals the "usefulness product." Among the various glaucoma th...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/0039-6257(79)90236-4
更新日期:1979-05-01 00:00:00
abstract::It is generally accepted that postoperatively radiographic examinations be limited to the area of pathology. The patient presented here complained of visual difficulties two years after transphenoidal removal of a pituitary prolactinoma. His endocrinologist ordered what he believed to be the appropriate computed tomog...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/0039-6257(85)90090-6
更新日期:1985-07-01 00:00:00
abstract::Sarcoidosis is an uncommon cause of childhood uveitis. However, the ophthalmologist familiar with the clinical features of childhood sarcoidosis can play a key role in the diagnosis and treatment of this disorder. Two subsets of pediatric sarcoidosis are identified. The 8-15 year age group has almost universal lung in...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/0039-6257(86)90118-9
更新日期:1986-01-01 00:00:00
abstract::The purpose of the article is to describe the optics of the contact wide-angle lens system with stereo-reinverter for vitreous surgery. A panoramic viewing system is made up of two components; an indirect ophthalmoscopy lens system for fundus image viewing, which is placed on the patient's cornea as a contact lens, an...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/j.survophthal.2004.04.010
更新日期:2004-07-01 00:00:00
abstract::A ten-day ophthalmology clerkship for third-year medical students is described. The curriculum, detailed in a day-by-day syllabus, sets specific student goals, evaluates attainment of the goals by a pre-post test, utilizes a student-oriented study guide keyed to major textbrooks as core material with slide-tape and vi...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/0039-6257(77)90090-x
更新日期:1977-09-01 00:00:00
abstract::A 30-year-old woman developed left-sided headaches and ipsilateral oculosympathetic paresis (Horner's syndrome) secondary to carotid dissection. Although she initially denied preceding trauma, further questioning revealed a pattern of physical abuse by her boyfriend, including an attempted strangulation shortly before...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0039-6257(97)00054-4
更新日期:1997-09-01 00:00:00
abstract::Advances in immunology, particularly ocular immunology, have been accompanied by the emergence of safer, more specific immunosuppressive drugs, notably, cyclophosphamide, chlorambucil, methotrexate, azathioprine, cyclosporine A, bromocriptine, dapsone, and colchicine. These drugs have become an important, and often es...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/0039-6257(91)90186-j
更新日期:1991-03-01 00:00:00
abstract::The published evidence that instilled drugs can affect the blood supply to the retina and optic nerve head in humans is examined. As a background, seven techniques that have been used to measure flow are briefly described and criticized. For timolol, the corresponding measurements, obtained by a number of investigator...
journal_title:Survey of ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/s0039-6257(02)00326-0
更新日期:2002-08-01 00:00:00
abstract::A 32-year-old woman experienced dizziness and headache for 5 months. She also complained of painless, progressive bilateral visual loss for several weeks. Before developing the initial symptoms, she had an uncomplicated pregnancy except for dizziness and systemic hypotension during the first term. Fundus examination d...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.survophthal.2017.03.001
更新日期:2018-01-01 00:00:00
abstract::A 47-year-old man presented with sudden visual loss, optic disk edema, retinal ischemia, and limited upgaze in the left eye. Initial MRI revealed thickened, enhancing left optic nerve. Extensive work-up for an inflammatory and infiltrative etiology was positive only for Borrelia burgdorferi IgM by Western blot. Six we...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.survophthal.2013.12.003
更新日期:2014-09-01 00:00:00
abstract::The court decisions included in this article reflect judicial attitudes towards medicolegal cases in most states. The courts have defined and amplified issues of informed consent, the physician's duty to warn patients and protect third parties, the limitations of the "Good Samaritan" statute, the responsibility of the...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/0039-6257(87)90071-3
更新日期:1987-07-01 00:00:00
abstract::The clinical and pathologic features of 13 patients with biopsy-proven reticulum cell sarcoma of the orbit are reviewed. All of the patients were adults, in contrast to many previous reports that have emphasized how common this tumor is in children. Eight patients presented with proptosis and without prior diagnosis o...
journal_title:Survey of ophthalmology
pub_type: 杂志文章
doi:10.1016/0039-6257(78)90072-3
更新日期:1978-01-01 00:00:00