Deep and future insights into neuromodulation therapies for heart failure.

Abstract:

:Major pathophysiology of heart failure is an autonomic nervous system dysfunction as a result of excess sympathoexcitation and/or withdrawal of vagal nerve activity. Although we already have various pharmacological and non-pharmacological therapies for heart failure, survival of heart failure patients remains around 50%. To achieve further reductions in morbidity and mortality of heart failure, neuromodulations with devices, such as baroreflex activating therapy, vagal nerve stimulation, renal sympathetic denervation, spinal cord stimulation, and left cardiac sympathetic denervation, have been expected. Although all of these neuromodulations have benefits on heart failure, efficacy, and safety in preclinical and small-sized clinical studies, the benefits on heart failure have been insufficient and controversial compared to our expectations in large-sized randomized trials. However, we should develop and apply these novel therapies for the patients with heart failure in the near future.

journal_name

J Cardiol

journal_title

Journal of cardiology

authors

Kishi T

doi

10.1016/j.jjcc.2016.05.010

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

368-372

issue

5

eissn

0914-5087

issn

1876-4738

pii

S0914-5087(16)30093-4

journal_volume

68

pub_type

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