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Quantitative evaluation of gadoxetate hepatocyte phase homogeneity: potential imaging markers for detection of early cirrhosis.

Abstract：

OBJECTIVE:Does quantitative analysis of the gadoxetate hepatocyte phase homogeneity, measuring percent standard deviation of hepatocyte phase (SDHP) and liver-to-kidney enhancement ratio (LiKER) detect early hepatic fibrosis? MATERIALS AND METHODS:Retrospective review of gadoxetate liver MRI plus biopsy-proven fibrosis within 6 months included 31 reversible hepatic fibrosis, 33 irreversible hepatic fibrosis, and 15 donors. Parenchymal and vascular SDHP and LiKER were measured on the 20-min hepatocyte phase using region of interest. RESULTS:Parenchymal SDHP, vascular SDHP and LiKER measurements differentiate early hepatic fibrosis from controls (P<.01). CONCLUSION:Quantitative analysis of gadoxetate hepatocyte phase homogeneity using SDHP and LiKER is a promising imaging biomarker for diagnosis of early liver fibrosis.

journal_name

Clin Imaging

journal_title

Clinical imaging

authors

Boddu S,Brylka D,Dutruel SP,Spincemaille P,Prince MR

doi

10.1016/j.clinimag.2016.05.004

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

979-86

issue

5

eissn

0899-7071

issn

1873-4499

pii

S0899-7071(16)30053-5

journal_volume

40

pub_type

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