Abstract:
:One of the most common examples of audiovisual speech integration is the McGurk effect. As an example, an auditory syllable /ba/ recorded over incongruent lip movements that produce "ga" typically causes listeners to hear "da". This report hypothesizes reasons why certain clinical and listeners who are hard of hearing might be more susceptible to visual influence. Conversely, we also examine why other listeners appear less susceptible to the McGurk effect (i.e., they report hearing just the auditory stimulus without being influenced by the visual). Such explanations are accompanied by a mechanistic explanation of integration phenomena including visual inhibition of auditory information, or slower rate of accumulation of inputs. First, simulations of a linear dynamic parallel interactive model were instantiated using inhibition and facilitation to examine potential mechanisms underlying integration. In a second set of simulations, we systematically manipulated the inhibition parameter values to model data obtained from listeners with autism spectrum disorder. In summary, we argue that cross-modal inhibition parameter values explain individual variability in McGurk perceptibility. Nonetheless, different mechanisms should continue to be explored in an effort to better understand current data patterns in the audiovisual integration literature.
journal_name
J Comput Neuroscijournal_title
Journal of computational neuroscienceauthors
Altieri N,Yang CTdoi
10.1007/s10827-016-0610-zsubject
Has Abstractpub_date
2016-10-01 00:00:00pages
143-55issue
2eissn
0929-5313issn
1573-6873pii
10.1007/s10827-016-0610-zjournal_volume
41pub_type
杂志文章abstract::Neuron modeling may be said to have originated with the Hodgkin and Huxley action potential model in 1952 and Rall's models of integrative activity of dendrites in 1964. Over the ensuing decades, these approaches have led to a massive development of increasingly accurate and complex data-based models of neurons and ne...
journal_title:Journal of computational neuroscience
pub_type: 杂志文章,评审
doi:10.1007/s10827-016-0623-7
更新日期:2017-02-01 00:00:00
abstract::The existence of electrical communication among pyramidal cells (PCs) in the adult cortex has been debated by neuroscientists for several decades. Gap junctions (GJs) among cortical interneurons have been well documented experimentally and their functional roles have been proposed by both computational neuroscientists...
journal_title:Journal of computational neuroscience
pub_type: 杂志文章
doi:10.1007/s10827-020-00762-5
更新日期:2020-11-01 00:00:00
abstract::The influence of unreliable synapses on the dynamic properties of a neural network is investigated for a homogeneous integrate-and-fire network with delayed inhibitory synapses. Numerical and analytical calculations show that the network relaxes to a state with dynamic clusters of identical size which permanently exch...
journal_title:Journal of computational neuroscience
pub_type: 杂志文章
doi:10.1007/s10827-008-0127-1
更新日期:2009-08-01 00:00:00
abstract::Information transfer may not be limited only to synapses. Therefore, the processes and dynamics of biological neuron-astrocyte coupling and intercellular interaction within this domain are worth investigating. Existing models of tripartite synapse consider an astrocyte as a point process. Here, we extended the tripart...
journal_title:Journal of computational neuroscience
pub_type: 杂志文章
doi:10.1007/s10827-019-00734-4
更新日期:2020-02-01 00:00:00
abstract::Following a flashed stimulus, I show that a simple neurophysiological mechanism in the primary visual system can generate orientation selectivity based on the first incoming spikes. A biological model of the lateral geniculate nucleus generates an asynchronous wave of spikes, with the most strongly activated neurons f...
journal_title:Journal of computational neuroscience
pub_type: 杂志文章
doi:10.1023/a:1027420012134
更新日期:2003-11-01 00:00:00
abstract::During posture control, reflexive feedback allows humans to efficiently compensate for unpredictable mechanical disturbances. Although reflexes are involuntary, humans can adapt their reflexive settings to the characteristics of the disturbances. Reflex modulation is commonly studied by determining reflex gains: a set...
journal_title:Journal of computational neuroscience
pub_type: 杂志文章
doi:10.1007/s10827-010-0278-8
更新日期:2011-06-01 00:00:00
abstract::When two-frame apparent motion stimuli are presented with an appropriate inter-stimulus interval (ISI), motion is perceived in the direction opposite to the actual image shift. Herein, we measured a simple eye movement, ocular following responses (OFRs), in macaque monkeys to examine the ISI reversal effect on oculomo...
journal_title:Journal of computational neuroscience
pub_type: 杂志文章
doi:10.1007/s10827-020-00756-3
更新日期:2020-07-17 00:00:00
abstract::The resistive or non-resistive nature of the extracellular space in the brain is still debated, and is an important issue for correctly modeling extracellular potentials. Here, we first show theoretically that if the medium is resistive, the frequency scaling should be the same for electroencephalogram (EEG) and magne...
journal_title:Journal of computational neuroscience
pub_type: 杂志文章
doi:10.1007/s10827-010-0263-2
更新日期:2010-12-01 00:00:00
abstract::It is widely believed that the theta rhythm in the hippocampus is caused by the rhythmic input from the medial septum-diagonal band of Broca (MSDB). The main MSDB output is formed by GABAergic projection neurons which are divided into two subpopulations and fire at different phases of the hippocampal theta rhythm. The...
journal_title:Journal of computational neuroscience
pub_type: 杂志文章
doi:10.1007/s10827-015-0564-6
更新日期:2015-08-01 00:00:00
abstract::Voltage-sensitive dye imaging (VSDi) has revealed fundamental properties of neocortical processing at macroscopic scales. Since for each pixel VSDi signals report the average membrane potential over hundreds of neurons, it seems natural to use a mean-field formalism to model such signals. Here, we present a mean-field...
journal_title:Journal of computational neuroscience
pub_type: 杂志文章
doi:10.1007/s10827-017-0668-2
更新日期:2018-02-01 00:00:00
abstract::Purkinje cells aligned on the medio-lateral axis share a large proportion of their approximately 175,000 parallel fiber inputs. This arrangement has led to the hypothesis that movement timing is coded in the cerebellum by beams of synchronously active parallel fibers. In computer simulations I show that such synchrono...
journal_title:Journal of computational neuroscience
pub_type: 杂志文章
doi:10.1023/a:1023217111784
更新日期:2003-05-01 00:00:00
abstract::We explore the effects of stochastic sodium (Na) channel activation on the variability and dynamics of spiking and bursting in a model neuron. The complete model segregates Hodgin-Huxley-type currents into two compartments, and undergoes applied current-dependent bifurcations between regimes of periodic bursting, chao...
journal_title:Journal of computational neuroscience
pub_type: 杂志文章
doi:10.1023/B:JCNS.0000014104.08299.8b
更新日期:2004-03-01 00:00:00
abstract::A population of uncoupled neurons can often be brought close to synchrony by a single strong inhibitory input pulse affecting all neurons equally. This mechanism is thought to underlie some brain rhythms, in particular gamma frequency (30-80 Hz) oscillations in the hippocampus and neocortex. Here we show that synchron...
journal_title:Journal of computational neuroscience
pub_type: 杂志文章
doi:10.1007/s10827-010-0233-8
更新日期:2010-06-01 00:00:00
abstract::The effect of a non-symmetric waveform on nerve conduction block induced by high-frequency biphasic stimulation is investigated using a lumped circuit model of the unmyelinated axon based on Hodgkin-Huxley equations. The simulation results reveal that the block threshold monotonically increases with the stimulation fr...
journal_title:Journal of computational neuroscience
pub_type: 杂志文章
doi:10.1007/s10827-014-0510-z
更新日期:2014-10-01 00:00:00
abstract::We investigated the effect of mean firing on the information rate of a spiking motion-sensitive neuron in the fly (H1-cell). In the control condition, the cell was stimulated repeatedly by identical zero-symmetrical white-noise motion. The mean firing rate was manipulated by adding a constant velocity offset either in...
journal_title:Journal of computational neuroscience
pub_type: 杂志文章
doi:10.1023/a:1011225232120
更新日期:2001-03-01 00:00:00
abstract::In this paper, we investigate the dynamics of a neuron-glia cell system and the underlying mechanism for the occurrence of seizures. For our mathematical and numerical investigation of the cell model we will use bifurcation analysis and some computational methods. It turns out that an increase of the potassium concent...
journal_title:Journal of computational neuroscience
pub_type: 杂志文章
doi:10.1007/s10827-020-00746-5
更新日期:2020-05-01 00:00:00
abstract::Retinal ganglion cells (RGCs) display differences in their morphology and intrinsic electrophysiology. The goal of this study is to characterize the ionic currents that explain the behavior of ON and OFF RGCs and to explore if all morphological types of RGCs exhibit the phenomena described in electrophysiological data...
journal_title:Journal of computational neuroscience
pub_type: 杂志文章
doi:10.1007/s10827-013-0463-7
更新日期:2014-04-01 00:00:00
abstract::The phase relationship between the activity of hippocampal place cells and the hippocampal theta rhythm systematically processes as the animal runs through the region in an environment called the place field of the cell. We present a minimal biophysical model of the phase precession of place cells in region CA3 of the...
journal_title:Journal of computational neuroscience
pub_type: 杂志文章
doi:10.1023/a:1008976210366
更新日期:2000-07-01 00:00:00
abstract::We have presented a new generation mechanism of slow spiking or repetitive discharges with extraordinarily long inter-spike intervals using the modified Hodgkin-Huxley equations (Doi and Kumagai, 2001). This generation process of slow firing is completely different from that of the well-known potassium A-current in th...
journal_title:Journal of computational neuroscience
pub_type: 杂志文章
doi:10.1007/s10827-005-2895-1
更新日期:2005-12-01 00:00:00
abstract::Stellate cells in the cat antero-ventral cochlear nucleus (AVCN) maintain a robust rate-place representation of vowel spectra over a wide range of stimulus levels. This rate-place representation resembles that of low threshold, high spontaneous rate (SR) auditory nerve fibers (ANFs) at low stimulus levels, and that of...
journal_title:Journal of computational neuroscience
pub_type: 杂志文章,评审
doi:10.1007/BF00961733
更新日期:1994-08-01 00:00:00
abstract::Transcranial Direct brain stimulation (tDCS) is commonly used in order to modulate cortical networks activity during physiological processes through the application of weak electrical fields with scalp electrodes. Cathodal stimulation has been shown to decrease brain excitability in the context of epilepsy, with varia...
journal_title:Journal of computational neuroscience
pub_type: 杂志文章
doi:10.1007/s10827-020-00745-6
更新日期:2020-05-01 00:00:00
abstract::We developed a multicompartmental Hodgkin-Huxley model of the Hermissenda type-B photoreceptor and used it to address the relative contributions of reductions of two K+ currents, IA and IC, to changes in cellular excitability and synaptic strength that occur in these cells after associative learning. We found that red...
journal_title:Journal of computational neuroscience
pub_type: 杂志文章
doi:10.1007/BF00160809
更新日期:1996-06-01 00:00:00
abstract::Nonlinear dynamics provides a complementary framework to control theory for the quantitative analysis of the oculomotor control system. This paper presents a number of findings relating to the aetiology and mechanics of the pathological ocular oscillation jerk congenital nystagmus (jerk CN). A range of time series ana...
journal_title:Journal of computational neuroscience
pub_type: 杂志文章
doi:10.1007/s10827-006-7816-4
更新日期:2006-10-01 00:00:00
abstract::The background activity of a cortical neural network is modeled by a homogeneous integrate-and-fire network with unreliable inhibitory synapses. For the case of fast synapses, numerical and analytical calculations show that the network relaxes into a stationary state of high attention. The majority of the neurons has ...
journal_title:Journal of computational neuroscience
pub_type: 杂志文章
doi:10.1007/s10827-007-0049-3
更新日期:2008-02-01 00:00:00
abstract::During slow-wave sleep, brain electrical activity is dominated by the slow (< 1 Hz) electroencephalogram (EEG) oscillations characterized by the periodic transitions between active (or Up) and silent (or Down) states in the membrane voltage of the cortical and thalamic neurons. Sleep slow oscillation is believed to pl...
journal_title:Journal of computational neuroscience
pub_type: 杂志文章
doi:10.1007/s10827-017-0663-7
更新日期:2018-02-01 00:00:00
abstract::We developed a physiologically plausible model of the first steps of spatial visual information processing in the fovea of the human retina. With the predictions of this model we could support the hypothesis that, for moderate contracts (< or = 40%), hyperacuity is mediated by the magnocellular (MC-) pathway. Despite ...
journal_title:Journal of computational neuroscience
pub_type: 杂志文章
doi:10.1007/BF00158338
更新日期:1996-03-01 00:00:00
abstract::Calmodulin (CaM) is a major Ca(2+) binding protein involved in two opposing processes of synaptic plasticity of CA1 pyramidal neurons: long-term potentiation (LTP) and depression (LTD). The N- and C-terminal lobes of CaM bind to its target separately but cooperatively and introduce complex dynamics that cannot be well...
journal_title:Journal of computational neuroscience
pub_type: 杂志文章
doi:10.1007/s10827-009-0173-3
更新日期:2009-12-01 00:00:00
abstract::We have developed compact analog integrated circuits that simulate two synaptic excitatory conductances. A four-transistor circuit captures the dynamics of an excitatory postsynaptic current caused by a real AMPA conductance. A six-transistor circuit simulates the effects of a real voltage-dependent NMDA conductance. ...
journal_title:Journal of computational neuroscience
pub_type: 杂志文章
doi:10.1023/a:1008963426194
更新日期:1999-07-01 00:00:00
abstract::A neuron receives input from other neurons via electrical pulses, so-called spikes. The pulse-like nature of the input is frequently neglected in analytical studies; instead, the input is usually approximated to be Gaussian. Recent experimental studies have shown, however, that an assumption underlying this approximat...
journal_title:Journal of computational neuroscience
pub_type: 杂志文章
doi:10.1007/s10827-017-0649-5
更新日期:2017-08-01 00:00:00
abstract::We introduce a method for computing probabilities for spontaneous activity and propagation failure of the action potential in spatially extended, conductance-based neuronal models subject to noise, based on statistical properties of the membrane potential. We compare different estimators with respect to the quality of...
journal_title:Journal of computational neuroscience
pub_type: 杂志文章
doi:10.1007/s10827-015-0586-0
更新日期:2016-02-01 00:00:00