Deprescribing: An Application to Medication Management in Older Adults.

abstract：STUDY OBJECTIVES:To characterize the steady-state pharmacokinetics of intravenous levetiracetam in neurocritical care patients requiring seizure prophylaxis after a neurologic injury and to determine which dosing regimens achieve serum concentrations within the recommended therapeutic range of 6-20 μg/ml. DESIGN. Prosp...

journal_title：Pharmacotherapy

authors： Spencer DD,Jacobi J,Juenke JM,Fleck JD,Kays MB

更新日期：2011-10-01 00:00:00

abstract：:Use of the Molecular Adsorbent Recirculating System (MARS) as a liver support device continues to grow worldwide. Various components of the MARS circuit remove both protein-bound and water-soluble molecules. Little is known about the extent of the enhanced clearance mechanisms used in MARS therapy on drug elimination....

journal_title：Pharmacotherapy

authors： Personett HA,Larson SL,Frazee EN,Nyberg SL,El-Zoghby ZM

更新日期：2015-08-01 00:00:00

abstract：:Antithrombin deficiency is a hypercoagulable state that can increase the risk for thrombosis, especially in the presence of other procoagulant triggers. Unfractionated heparin and low-molecular-weight heparins may not provide effective anticoagulation since they require antithrombin for activity. Direct thrombin inhib...

journal_title：Pharmacotherapy

authors： Dager WE,Gosselin RC,Owings JT

更新日期：2004-05-01 00:00:00

abstract：:Aneurysmal subarachnoid hemorrhage (SAH) accounts for a significant percentage of morbidity and mortality among patients admitted to neurosurgical centers throughout the world. Even for individuals surviving beyond the initial presentation and intervention for aneurysmal SAH, the occurrence of cerebral vasospasm has t...

journal_title：Pharmacotherapy

authors： Weant KA,Ramsey CN 3rd,Cook AM

更新日期：2010-04-01 00:00:00

abstract：:Outpatient transesophageal echocardiography was performed in a 69-year-old man with a history of aortic valve repair. During the procedure the patient became markedly cyanotic and hypotensive. Oxygen saturation measured by pulse oximetry decreased from 97% to the mid-80s. The man's condition continued to deteriorate. ...

journal_title：Pharmacotherapy

authors： Wurdeman RL,Mohiuddin SM,Holmberg MJ,Shalaby A

更新日期：2000-06-01 00:00:00

abstract：STUDY OBJECTIVE:To describe the pharmacokinetic disposition of tobramycin in children undergoing stem cell transplantation (SCT) after intravenous administration either every 24 hours or every 8 hours, and to use this information to create initial dosing guidelines for administration every 24 hours in this patient popu...

journal_title：Pharmacotherapy

authors： Dupuis LL,Sung L,Taylor T,Abdolell M,Allen U,Doyle J,Taddio A

更新日期：2004-05-01 00:00:00

abstract：STUDY OBJECTIVES:To evaluate hepatic cytochrome P450 (CYP) 3A4 activity in patients infected with the human immunodeficiency virus (HIV) using the erythromycin breath test (ERMBT), and to examine the relationship of the ERMBT to plasma concentrations of indinavir and nelfinavir. DESIGN:Prospective observational study....

journal_title：Pharmacotherapy

authors： Slain D,Pakyz A,Israel DS,Monroe S,Polk RE

更新日期：2000-08-01 00:00:00

abstract：:Diazepam is frequently the subject of review by various agencies and institutions charged with determining whether or not to substitute another, more economical drug--in most instances, chlordiazepoxide. A review of the comparative literature has shown that, on clinical and pharmacokinetic grounds, chlordiazepoxide is...

journal_title：Pharmacotherapy

authors： Baskin SI,Esdale A

更新日期：1982-03-01 00:00:00

abstract：:Anticoagulation clinics emerged as a means to optimize warfarin effectiveness and minimize bleeding risks. Anticoagulation clinics have traditionally been warfarin-based models due to the need for frequent blood-level monitoring, drug interactions, dietary considerations, and periprocedural management with warfarin. T...

journal_title：Pharmacotherapy

authors： Mohammad I,Korkis B,Garwood CL

更新日期：2017-10-01 00:00:00

abstract：:Hormonal emergency contraceptives have been used to prevent unwanted pregnancy for more than 3 decades. The mechanisms of action of the regimen containing a combination of estrogen and progestin, known as the Yuzpe regimen, and those of the levonorgestrel regimen continue to be controversial, especially over the possi...

journal_title：Pharmacotherapy

authors： Leung VW,Levine M,Soon JA

更新日期：2010-02-01 00:00:00

abstract：:Calcium channel blockers, nitrates, and beta blockers are the primary agents used for the treatment of angina. Calcium has a central role in excitation-contraction, action potential generation, and ischemic cell death. The three currently available calcium antagonists are nifedipine, verapamil, and diltiazem. Second-g...

journal_title：Pharmacotherapy

authors： Angaran D

更新日期：1987-01-01 00:00:00

abstract：:Methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia is associated with high morbidity and mortality. Traditionally, antistaphylococcal penicillins (ASPs) have been considered the agents of choice for the treatment of MSSA bacteremia. Vancomycin has been demonstrated to have poorer outcomes in several studi...

journal_title：Pharmacotherapy

authors： Li J,Echevarria KL,Traugott KA

更新日期：2017-03-01 00:00:00

abstract：:Aortic stenosis (AS) is the most common form of valvular heart disease. A detailed diagnostic workup is necessary to promptly stage and classify disease severity to determine optimal management. Medical therapy and valvuloplasty are options that fail to delay or reverse disease progression. Surgical aortic valve repla...

journal_title：Pharmacotherapy

authors： Kalich BA,Allender JE,Hollis IB

更新日期：2018-01-01 00:00:00

abstract：:In patients infected with chronic hepatitis B virus (HBV) that goes untreated, therapeutic options are limited once the disease decompensates, and orthotopic liver transplantation is often the only treatment available to save the patient's life. After liver transplantation, combined therapy with hepatitis B immune glo...

journal_title：Pharmacotherapy

authors： McGonigal KH,Bajjoka IE,Abouljoud MS

更新日期：2013-09-01 00:00:00

abstract：:The antiretroviral combination of emtricitabine-tenofovir disoproxil fumarate (FTC/TDF) was approved by the U.S. Food and Drug Administration for use as pre-exposure prophylaxis (PrEP) in individuals at high risk for acquiring human immunodeficiency virus (HIV) in July 2012. Since then, Centers for Disease Control and...

journal_title：Pharmacotherapy

authors： Adams JL,Shelley K,Nicol MR

更新日期：2019-04-01 00:00:00

abstract：STUDY OBJECTIVES:To evaluate the safety and efficacy of aerosolized ceftazidime for prevention of ventilator-associated pneumonia (VAP) and to evaluate the effects of the drug on the proinflammatory response. DESIGN:Prospective, randomized, double-blind, placebo-controlled clinical trial. SETTING:University teaching ...

journal_title：Pharmacotherapy

authors： Wood GC,Boucher BA,Croce MA,Hanes SD,Herring VL,Fabian TC

更新日期：2002-08-01 00:00:00

abstract：:The effect of treatment for hepatitis C viral infection on hemoglobin A(1c) (A1C) levels is not well described in the literature. We describe a 59-year-old man with type 2 diabetes mellitus whose A1C level became falsely low when ribavirin and peginterferon alfa-2b therapy were started for treatment of hepatitis C. Af...

journal_title：Pharmacotherapy

authors： Gross BN,Cross LB,Foard JC,Wood YA

更新日期：2009-01-01 00:00:00

abstract：:A 58-year-old woman who had been taking digoxin 0.25 mg/day for more than 35 years for heart palpitations after mitral valve repair was prescribed a 5-day course of telithromycin for acute bronchitis. On the sixth day of therapy, she came to the emergency department complaining of general malaise and having experience...

journal_title：Pharmacotherapy

authors： Nenciu LM,Laberge P,Thirion DJ

更新日期：2006-06-01 00:00:00

abstract：STUDY OBJECTIVES:To determine if low-dose lovastatin in combination with niacin causes a greater percentage reduction in low-density lipoprotein (LDL) cholesterol than lovastatin alone, and to determine if the combination increases the risk of serious adverse effects. design. Prospective, randomized, open-label, clinic...

journal_title：Pharmacotherapy

authors： Gardner SF,Schneider EF,Granberry MC,Carter IR

更新日期：1996-05-01 00:00:00

abstract：:Many physiologic differences between children and adults can result in age-related differences in pharmacokinetics. Understanding the effects of age on bioavailability, volume of distribution, protein binding, hepatic metabolic isoenzymes, and renal elimination can provide insight into optimizing doses for pediatric p...

journal_title：Pharmacotherapy

authors： Anderson GD,Lynn AM

更新日期：2009-06-01 00:00:00

abstract：:Thrombin, a serine protease, is the keystone of the twin processes of hemostasis and thrombosis. Through procoagulant, anticoagulant, and antifibrinolytic mechanisms, thrombin helps maintain vascular integrity in the face of hemorrhage. These same mechanisms, however, allow for the pathologic formation of thrombi in r...

journal_title：Pharmacotherapy

authors： Nappi J

更新日期：2002-06-01 00:00:00

abstract：:Pseudomonas aeruginosa is one of the leading gram-negative organisms associated with nosocomial infections. The increasing frequency of multi-drug-resistant Pseudomonas aeruginosa (MDRPA) strains is concerning as efficacious antimicrobial options are severely limited. By searching MEDLINE from January 1966-February 20...

journal_title：Pharmacotherapy

authors： Obritsch MD,Fish DN,MacLaren R,Jung R

更新日期：2005-10-01 00:00:00

abstract：:The statins are widely used to treat dyslipidemias. They are generally associated with mild adverse effects, but rarely, more serious reactions may occur. A 51-year-old man experienced delayed-onset, progressive memory loss while receiving simvastatin for hypercholesterolemia. His therapy was switched to pravastatin, ...

journal_title：Pharmacotherapy

authors： Orsi A,Sherman O,Woldeselassie Z

更新日期：2001-06-01 00:00:00

abstract：:Ketorolac tromethamine is a highly potent member of a class of compounds having both analgesic and antiinflammatory activity. In animal pain models using underlying inflammation, ketorolac markedly inhibited the pain response and increased the pain threshold; it did not exhibit any narcotic or central nervous system d...

journal_title：Pharmacotherapy

authors： Rooks WH 2nd

更新日期：1990-01-01 00:00:00

abstract：STUDY OBJECTIVES:To characterize patient sociodemographics and health, describe vancomycin treatment parameters and clinician-rated outcomes, and determine costs associated with treatment including preparation and administration, adverse events, and toxicity. DESIGN:A prospective study to develop a model for costs ass...

journal_title：Pharmacotherapy

authors： Garrelts JC,Horst WD,Silkey B,Gagnon S

更新日期：1994-07-01 00:00:00

abstract：:We cared for a patient in whom iron dextran administration interfered with the determination of total serum calcium concentration. An unexpected elevation in serum phosphorus concentration also occurred after the iron dextran infusion. A MEDLINE search from 1966 to present was conducted, and the manufacturer of the ir...

journal_title：Pharmacotherapy

authors： Newsom L,Erstad BL,Nakazato PZ,Daller JA

更新日期：1995-11-01 00:00:00

abstract：:Thirty-six indigent patients hospitalized within 6 months of study initiation and who met criteria were enrolled in a 6-month assistance program to determine if provision of both medical care and prescription drugs at no cost would be associated with a change in overall health care charges secondary to a change in the...

journal_title：Pharmacotherapy

authors： Nykamp D,Ruggles D

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND:Infections with adenoviruses (ADVs) can result in considerable mortality and morbidity in solid organ transplant (SOT) recipients. Standard therapy for ADV infections in transplant recipients is not established. At our institution, intravenous cidofovir and immunoglobulin have been used to treat disseminated...

journal_title：Pharmacotherapy

authors： Permpalung N,Mahoney MV,Alonso CD

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:To identify and describe the scope of practice that characterizes the critical care pharmacist and critical care pharmacy services. Specifically, the goals were to define the level of clinical practice and specialized skills characterizing the critical care pharmacist as clinician, educator, researcher, and m...

journal_title：Pharmacotherapy

authors：

更新日期：2000-11-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the effect of fluoxetine on the pharmacokinetics and cardiovascular safety of cisapride at steady state in healthy men. DESIGN:Open-label, three-phase, sequential study. SETTING:Clinical research center. SUBJECTS:Twelve healthy male volunteers. INTERVENTIONS:Each subject was treated acco...

journal_title：Pharmacotherapy

authors： Zhao Q,Wojcik MA,Parier JL,Pesco-Koplowitz L

更新日期：2001-02-01 00:00:00