Ablation Strategies for Locally Advanced Pancreatic Cancer.

Abstract:

:With the advent of novel and somewhat effective chemotherapy against pancreas cancer, several groups developed a new interest on locally advanced pancreatic cancer (LAPC). Unresectable tumors constitute up to 80% of pancreatic cancer (PC) at the time of diagnosis and are associated with a 5-year overall survival of less than 5%. To control those tumors locally, with perhaps improved patients survival, significant advances were made over the last 2 decades in the development of ablation methods including cryoablation, radiofrequency ablation, microwave ablation, high intensity focused ultrasound and irreversible electroporation (IRE). Many suggested a call for caution for possible severe or lethal complications in using such techniques on the pancreas. Most fears were on the heating or freezing of the pancreas, while non-thermal ablation (IRE) could offer safer approaches. The multimodal therapies along with high-resolution imaging guidance have created some enthusiasm toward ablation for LAPC. The impact of ablation techniques on primarily non-resectable PC remains, however, unclear.

journal_name

Dig Surg

journal_title

Digestive surgery

authors

Linecker M,Pfammatter T,Kambakamba P,DeOliveira ML

doi

10.1159/000445021

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

351-9

issue

4

eissn

0253-4886

issn

1421-9883

pii

000445021

journal_volume

33

pub_type

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