Abstract:
INTRODUCTION:Since exendin-4 (exenatide) was approved for diabetes therapy in 2005, several exendin analogs have been developed for the treatment of type 2 diabetes mellitus. As exenatide is a relatively short-acting injectable agent, major approaches have focused on developing long-acting exendin analogs to improve patient compliance and convenience. AREAS COVERED:In this review, the authors report on patents related to exendins and exendin analogs from 2012 to 2015. The patents have been divided into three categories based on the technologies used to develop the new chemical entities: 1) chemical bioconjugate analogs; 2) recombinant fusion protein analogs; and 3) multifunctional peptide analogs. EXPERT OPINION:Recently, research on exendins and their analogs has grown significantly, leading to the development of long-acting analogs and multifunctional peptides. While long-acting injectable agents are still the major products in the pharmaceutical industry, a significant growth is expected in the development of orally available exendins.
journal_name
Expert Opin Ther Patjournal_title
Expert opinion on therapeutic patentsauthors
Park EJ,Lim SM,Lee KC,Na DHdoi
10.1080/13543776.2016.1192130subject
Has Abstractpub_date
2016-07-01 00:00:00pages
833-42issue
7eissn
1354-3776issn
1744-7674journal_volume
26pub_type
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