Vitamin D status and 3-month Glasgow Outcome Scale scores in patients in neurocritical care: prospective analysis of 497 patients.

Abstract:

:OBJECTIVE Vitamin D deficiency has been associated with a variety of negative outcomes in critically ill patients, but little focused study on the effects of hypovitaminosis D has been performed in the neurocritical care population. In this study, the authors examined the effect of vitamin D deficiency on 3-month outcomes after discharge from a neurocritical care unit (NCCU). METHODS The authors prospectively analyzed 25-hydroxy vitamin D levels in patients admitted to the NCCU of a quaternary care center over a 6-month period. Glasgow Outcome Scale (GOS) scores were used to evaluate their 3-month outcome, and univariate and multivariate logistic regression was used to evaluate the effects of vitamin D deficiency. RESULTS Four hundred ninety-seven patients met the inclusion criteria. In the binomial logistic regression model, patients without vitamin D deficiency (> 20 ng/dl) were significantly more likely to have a 3-month GOS score of 4 or 5 than those who were vitamin D deficient (OR 1.768 [95% CI 1.095-2.852]). Patients with a higher Simplified Acute Physiology Score (SAPS II) (OR 0.925 [95% CI 0.910-0.940]) and those admitted for stroke (OR 0.409 [95% CI 0.209-0.803]) or those with an "other" diagnosis (OR 0.409 [95% CI 0.217-0.772]) were significantly more likely to have a 3-month GOS score of 3 or less. CONCLUSIONS Vitamin D deficiency is associated with worse 3-month postdischarge GOS scores in patients admitted to an NCCU. Additional study is needed to determine the role of vitamin D supplementation in the NCCU population.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Guan J,Karsy M,Brock AA,Eli IM,Manton GM,Ledyard HK,Hawryluk GWJ,Park MS

doi

10.3171/2017.2.JNS163037

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

1635-1641

issue

6

eissn

0022-3085

issn

1933-0693

pii

2017.2.JNS163037

journal_volume

128

pub_type

杂志文章
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    doi:10.3171/jns.1986.64.4.0662

    authors: Alexander JJ,Glagov S,Zarins CK

    更新日期:1986-04-01 00:00:00

  • Postendarterectomy heparin-induced thrombocytopenia. Case report.

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    doi:10.3171/jns.1988.69.4.0632

    authors: Rogers LA

    更新日期:1988-10-01 00:00:00

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    doi:10.3171/2017.6.JNS17943

    authors: Ernst G,Qeadan F,Carlson AP

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  • Treatment of intracranial gliomas with bone marrow-derived dendritic cells pulsed with tumor antigens.

    abstract:OBJECT:An approach toward the treatment of intracranial gliomas was developed in a rat experimental model. The authors investigated the ability of "professional" antigen-presenting cells (dendritic cells) to enhance host antitumor immune responses when injected as a vaccine into tumor-bearing animals. METHODS:Dendriti...

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    doi:10.3171/jns.1999.90.6.1115

    authors: Liau LM,Black KL,Prins RM,Sykes SN,DiPatre PL,Cloughesy TF,Becker DP,Bronstein JM

    更新日期:1999-06-01 00:00:00

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    abstract::The effect of suppression of postischemic reactive hyperemia on the blood-brain barrier (BBB) and ischemic brain edema after temporary focal cerebral ischemia was studied in cats under ketamine and alpha-chloralose anesthesia. Regional cerebral blood flow (rCBF) was measured by a thermal diffusion method and a hydroge...

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    doi:10.3171/jns.1989.70.1.0073

    authors: Kuroiwa T,Shibutani M,Okeda R

    更新日期:1989-01-01 00:00:00

  • Five-year institutional bibliometric profiles for 103 US neurosurgical residency programs.

    abstract:OBJECT:Various bibliometric indices based on the citations accumulated by scholarly articles, including the h-index, g-index, e-index, and Google's i10-index, may be used to evaluate academic productivity in neurological surgery. The present article provides a comprehensive assessment of recent academic publishing outp...

    journal_title:Journal of neurosurgery

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    doi:10.3171/2014.10.JNS141025

    authors: Taylor DR,Venable GT,Jones GM,Lepard JR,Roberts ML,Saleh N,Sidiqi SK,Moore A,Khan N,Selden NR,Michael LM 2nd,Klimo P Jr

    更新日期:2015-09-01 00:00:00

  • Selection and combination of various endovascular techniques in the treatment of giant aneurysms.

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    doi:10.3171/jns.1992.77.1.0037

    authors: Taki W,Nishi S,Yamashita K,Sadatoh A,Nakahara I,Kikuchi H,Iwata H

    更新日期:1992-07-01 00:00:00

  • Dural-cortical anastomosis in pial arteriovenous malformation. Case report.

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    doi:10.3171/jns.1979.50.4.0522

    authors: Waga S,Morikawa A,Kojima T

    更新日期:1979-04-01 00:00:00

  • Neurosurgical implications of mannitol accumulation within a meningioma and its peritumoral region demonstrated by magnetic resonance spectroscopy: case report.

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    更新日期:2008-05-01 00:00:00

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    doi:10.3171/2009.10.JNS09915

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    更新日期:2010-10-01 00:00:00

  • Seizure freedom after functional hemispherectomy and a possible role for the insular cortex: the Dutch experience.

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    更新日期:2007-10-01 00:00:00

  • The science of cerebral ischemia and the quest for neuroprotection: navigating past failure to future success.

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  • The effect of hospital safety-net burden on outcomes, cost, and reportable quality metrics after emergent clipping and coiling of ruptured cerebral aneurysms.

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  • Risks associated with preoperative anemia and perioperative blood transfusion in open surgery for intracranial aneurysms.

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    pub_type: 杂志文章,多中心研究

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    更新日期:1980-11-01 00:00:00

  • Management of meralgia paresthetica.

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    pub_type: 杂志文章

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    更新日期:1983-12-01 00:00:00

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    doi:10.3171/jns.1986.65.6.0860

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