Abstract:
:Secondary progressive multiple sclerosis (SPMS) is diagnosed retrospectively and involves a clinical course characterized by a progressive accumulation of neurological disability, independent of relapses, following an initial relapsing-remitting (RR) phase. Our incomplete understanding of the pathological mechanisms underlying neurodegeneration in multiple sclerosis (MS) may explain why, to date, there is no definitive imaging or laboratory test that is able to inform us when the disease is clearly entering into a progressive phase and why the vast majority of clinical trials testing immunosuppressant and immunomodulating drugs in SPMS patients has so far yielded disappointing or mixed results. Here we discuss the definition(s) of SPMS and how it may vary, outcome measurements (current and emerging) and modern trial design.
journal_name
CNS Drugsjournal_title
CNS drugsauthors
Plantone D,De Angelis F,Doshi A,Chataway Jdoi
10.1007/s40263-016-0340-9subject
Has Abstractpub_date
2016-06-01 00:00:00pages
517-26issue
6eissn
1172-7047issn
1179-1934pii
10.1007/s40263-016-0340-9journal_volume
30pub_type
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