Abstract:
:The musculoskeletal system is an incredible machine that protects, supports and moves the human body. However, several diseases can limit its functionality, compromising patient quality of life. Designing novel pathological models would help to clarify the mechanisms driving such diseases, identify new biomarkers and screen potential drug candidates. Miniaturized models in particular can mimic the structure and function of basic tissue units within highly controlled microenvironments, overcoming the limitations of traditional macroscale models and complementing animal studies, which despite being closer to the in vivo situation, are affected by species-specific differences. Here, we discuss the miniaturized models engineered over the past few years to analyze osteochondral and skeletal muscle pathologies, demonstrating how the rationale design of novel systems could provide key insights into the pathological mechanisms behind diseases of the musculoskeletal system.
journal_name
Drug Discov Todayjournal_title
Drug discovery todayauthors
Bersini S,Arrigoni C,Lopa S,Bongio M,Martin I,Moretti Mdoi
10.1016/j.drudis.2016.04.015subject
Has Abstractpub_date
2016-09-01 00:00:00pages
1429-1436issue
9eissn
1359-6446issn
1878-5832pii
S1359-6446(16)30120-9journal_volume
21pub_type
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