Fluorescence Behavior and Dural Infiltration of Meningioma Analyzed by 5-Aminolevulinic Acid-Based Fluorescence: Operating Microscope Versus Mini-Spectrometer.

Abstract:

OBJECTIVE:To compare fluorescence intensity of tumor specimens, as measured by a fluorescence-guided surgery microscope and a spectrometer, to evaluate tumor infiltration of dura mater around meningiomas with help of these 2 different 5-aminolevulinic acid (5-ALA)-based fluorescence tools, and to correlate fluorescence intensity with histopathologic data. MATERIAL AND METHODS:In a clinical series, meningiomas were resected by 5-ALA fluorescence-guided surgery. Fluorescence intensity was semiquantitatively rated by the surgeon at predefined points. Biopsies were harvested and fluorescence intensity measured by a spectrometer and histopathologically analyzed. Sampling was realized at the level of the dura in a centrifugal direction. RESULTS:A total of 104 biopsies (n = 13 tumors) were analyzed. Specificity and sensitivity of the microscope were 0.96 and 0.53 and of the spectrometer 0.95 and 0.93, respectively. Fluorescence intensity as measured by the spectrometer was correlated to histologically confirmed tumor burden. In a centrifugal direction, tumor burden and fluorescence intensity continuously decreased (along the dural tail). Below a threshold value of 639 arbitrary units no tumor was histologically detectable. CONCLUSIONS:At the level of the dura the spectrometer was highly sensitive for detection of meningioma cells. The surgical microscope showed false negative results and missed residual tumor cells in more than one half of the cases. The complementary use of both fluorescence tools may improve resection quality.

journal_name

World Neurosurg

journal_title

World neurosurgery

authors

Knipps J,Beseoglu K,Kamp M,Fischer I,Felsberg J,Neumann LM,Steiger HJ,Cornelius JF

doi

10.1016/j.wneu.2017.08.140

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

118-127

eissn

1878-8750

issn

1878-8769

pii

S1878-8750(17)31441-9

journal_volume

108

pub_type

杂志文章
  • Operative strategies for minimizing hearing loss and other major complications associated with microvascular decompression for trigeminal neuralgia.

    abstract:OBJECTIVE:To retrospectively assess the surgical outcomes and complication rates following microvascular decompression (MVD) for trigeminal neuralgia, using a targeted, restricted retrosigmoid approach. METHODS:During the period 1994-2009, a total of 119 patients underwent MVD for trigeminal neuralgia. A retrospective...

    journal_title:World neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.wneu.2010.05.001

    authors: Bond AE,Zada G,Gonzalez AA,Hansen C,Giannotta SL

    更新日期:2010-07-01 00:00:00

  • Effects of Curcumin on Bone Loss and Biochemical Markers of Bone Turnover in Patients with Spinal Cord Injury.

    abstract:BACKGROUND:Osteoporosis is one of the most common problems of patients with spinal cord injuries (SCIs). The current study aimed to evaluate the antiosteoporotic effects of curcumin on densitometry parameters and biomarkers of bone turnovers among patients with SCI. MATERIALS AND METHODS:The current controlled clinica...

    journal_title:World neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.wneu.2018.03.081

    authors: Hatefi M,Ahmadi MRH,Rahmani A,Dastjerdi MM,Asadollahi K

    更新日期:2018-06-01 00:00:00

  • The role of laboratory dissection training in neurosurgical residency: results of a national survey.

    abstract:OBJECTIVE:Work hour restrictions and current quality, financial, and legal concerns have reduced resident operative volume and autonomy. Although laboratory (cadaveric or animal) dissection has a rich history in neurosurgery, its current role in resident training is unclear. Recent literature suggests educators have lo...

    journal_title:World neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.wneu.2014.05.028

    authors: Kshettry VR,Mullin JP,Schlenk R,Recinos PF,Benzel EC

    更新日期:2014-11-01 00:00:00

  • Postoperative Ileus: Old and New Observations on Prevention and Treatment in Adult Spinal Deformity Surgery.

    abstract:BACKGROUND:The reported incidence of postoperative ileus (POI) after spine surgery depends on the surgical approach and definition used. It is therefore possible that the overall incidence is substantially higher than previously thought. POI has consequences for both the patient and hospital resources, and can signific...

    journal_title:World neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.wneu.2019.08.062

    authors: Wright AK,La Selva D,Nkrumah L,Yanamadala V,Leveque JC,Sethi RK

    更新日期:2019-12-01 00:00:00

  • Remote Leptomeningeal Dissemination in Olfactory Neuroblastoma Mimicking Multiple Parasagittal Meningiomas: Diagnostic and Therapeutic Challenge.

    abstract:BACKGROUND:Olfactory neuroblastoma (ON) is a highly aggressive and locally recurrent neoplasm. Distant systemic metastases are not uncommon, but remote leptomeningeal dissemination is extremely rare. CASE DESCRIPTION:We report 2 cases of ON previously treated with endoscopic endonasal radical surgical resection and ra...

    journal_title:World neurosurgery

    pub_type:

    doi:10.1016/j.wneu.2019.11.042

    authors: Martinez-Perez R,Hardesty DA,Palmer J,Zachariah M,Otto BA,Carrau RL,Prevedello DM

    更新日期:2020-02-01 00:00:00

  • Clinical Features, Treatment, and Prognostic Factors of 56 Intracranial and Intraspinal Clear Cell Meningiomas.

    abstract:OBJECTIVE:Intracranial and intraspinal clear cell meningiomas (CCMs) are rarely reported because of their extremely low incidence, and the current understanding of CCM is poor. The purpose of this study was to analyze the incidence and the clinical, radiologic, pathologic, and prognostic features of intracranial and in...

    journal_title:World neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.wneu.2017.12.173

    authors: Tao X,Dong J,Hou Z,Hao S,Zhang J,Wu Z,Liu B

    更新日期:2018-03-01 00:00:00

  • Revision extension to the pelvis versus primary spinopelvic instrumentation in adult deformity: comparison of clinical outcomes and complications.

    abstract:OBJECTIVE:To evaluate the outcomes and complications of patients with adult spinal deformity treated in a primary versus revision fashion with long fusions to the sacropelvis. METHODS:A retrospective review was performed of a multicenter consecutive series of patients with adult spinal deformity requiring fusion to th...

    journal_title:World neurosurgery

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.wneu.2013.02.059

    authors: Fu KM,Smith JS,Burton DC,Kebaish KM,Shaffrey CI,Schwab F,Lafage V,Arlet V,Hostin R,Boachie O,Akbarnia B,Bess S,International Spine Study Group.

    更新日期:2014-09-01 00:00:00

  • Brain-Machine Interfaces: The Role of the Neurosurgeon.

    abstract::Neurotechnology is set to expand rapidly in the coming years as technological innovations in hardware and software are translated to the clinical setting. Given our unique access to patients with neurologic disorders, expertise with which to guide appropriate treatments, and technical skills to implant brain-machine i...

    journal_title:World neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1016/j.wneu.2020.11.028

    authors: Chari A,Budhdeo S,Sparks R,Barone DG,Marcus HJ,Pereira EAC,Tisdall MM

    更新日期:2020-11-13 00:00:00

  • Long-term outcome of cervical and thoracolumbar dural arteriovenous fistulas with emphasis on sensory disturbance and neuropathic pain.

    abstract:BACKGROUND:Clinical features and prognosis of sensory disturbance in spinal dural arteriovenous fistula (SDAVF) have not been well documented. Here we report long-term outcomes and detailed sensory evaluations of surgically treated SDAVF, including 14 patients with the craniocervical fistulas. METHODS:Thirty-four cons...

    journal_title:World neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.wneu.2010.01.003

    authors: Shinoyama M,Endo T,Takahash T,Shimizu H,Takahashi A,Suzuki M,Tominaga T

    更新日期:2010-04-01 00:00:00

  • Dorsal Root Ganglion Stimulation for the Treatment of Chronic Neuropathic Knee Pain.

    abstract:BACKGROUND:To elucidate the efficacy of dorsal root ganglion stimulation in the treatment of chronic neuropathic pain confined to the knee. METHODS:Retrospective analysis of prospectively collected data of 14 consecutive patients undergoing dorsal root ganglion stimulation for chronic knee pain, in a single center. Th...

    journal_title:World neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.wneu.2020.07.102

    authors: Martin SC,Macey AR,Raghu A,Edwards T,Watson C,Bojanić S,FitzGerald JJ,Green AL

    更新日期:2020-11-01 00:00:00

  • Basilar Perforator Aneurysms: Presentation of 4 Cases and Review of the Literature.

    abstract:OBJECTIVE:Basilar perforator aneurysms (BPAs) are rare lesions that present a therapeutic challenge. We present 4 cases of ruptured BPAs treated either conservatively or by flow diverter deployment and review the literature. METHODS:Patients (age 78, 59, 53, and 62 years) presented with World Federation of Neurologica...

    journal_title:World neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1016/j.wneu.2016.10.038

    authors: Finitsis S,Derelle AL,Tonnelet R,Anxionnat R,Bracard S

    更新日期:2017-01-01 00:00:00

  • Radiological and Clinical Comparison of Posterolateral Fusion and Transforaminal Interbody Fusion Techniques in Degenerative Lumbar Stenosis.

    abstract:OBJECTIVE:Fusion surgery for lumbar degenerative stenosis is an established treatment mode. Despite comparable patient-related outcomes and radiologic results, the necessity of adding interbody fusion to posterolateral fusion remains controversial. We aimed to compare the clinical and radiologic outcomes of posterolate...

    journal_title:World neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.wneu.2018.05.165

    authors: Bozkurt G,Isikay I,Hanalioglu S

    更新日期:2018-08-01 00:00:00

  • A suprasellar colloid cyst over an 11-year follow-up: case report and literature review.

    abstract:BACKGROUND:Colloid cysts (CCs) are rare cystic lesions derived from the endoderm of the central nervous system. Although they appear most commonly in the anterior roof of the third ventricle, there are only a few reports of CCs located in the suprasellar region. Although CCs are considered to be slow-growing benign tum...

    journal_title:World neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.wneu.2018.11.258

    authors: Uno T,Hayashi Y,Sasagawa Y,Miyamori T,Oishi M,Nakada M

    更新日期:2019-01-18 00:00:00

  • Outpatient and Inpatient Readmission Rates of 1- and 2-Level Anterior Cervical Discectomy and Fusion Surgeries.

    abstract:OBJECTIVE:This study looks at the various comorbidities and postoperative complications and their impact on readmission rates of patients undergoing outpatient versus inpatient 1- and 2-level anterior cervical discectomy and fusion (ACDF). With increasing costs within the United States medical system, one emerging cost...

    journal_title:World neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.wneu.2019.03.124

    authors: Khalid SI,Carlton A,Wu R,Kelly R,Peta A,Adogwa O

    更新日期:2019-06-01 00:00:00

  • Tumor Volume Changes During and After Temozolomide Treatment for Newly Diagnosed Higher-Grade Glioma (III and IV).

    abstract:BACKGROUND:A standard post-concomitant radiochemotherapy involving adjuvant temozolomide (TMZ) was stopped after 6 cycles for high-grade gliomas (HGG). Several studies demonstrated that prolonged TMZ treatment increased survival for these patients. METHODS:This retrospective study aimed to compare changes in tumor vol...

    journal_title:World neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.wneu.2018.03.078

    authors: Wang HC,Lin YT,Lin WC,Ho RW,Lin YJ,Tsai NW,Ho JT,Lu CH

    更新日期:2018-06-01 00:00:00

  • Ruptured Distal Anterior Choroidal Artery Aneurysm Treated with Superselective Provocative Testing and Coil Embolization.

    abstract:BACKGROUND AND IMPORTANCE:Aneurysms of the anterior choroidal artery are uncommon, and distal anterior choroidal artery aneurysms are even rarer, with only 34 cases reported in the medical literature. These lesions have been most commonly reported in association with moyamoya disease or arteriovenous malformations. Mos...

    journal_title:World neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.wneu.2017.05.176

    authors: Schmalz PGR,Alturki A,Ogilvy CS,Thomas AJ

    更新日期:2017-09-01 00:00:00

  • Surgically induced SMART syndrome: case report and review of the literature.

    abstract:BACKGROUND:Strokelike migraine attack after radiation therapy is a recently described clinical entity characterized by transient hemispheric dysfunction manifesting as, but not limited to, visuospatial deficits, confusion, hemisensory deficits, hemiparesis, aphasia, seizures, and, most prominently, headache in patients...

    journal_title:World neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.wneu.2013.01.028

    authors: Maloney PR,Rabinstein AA,Daniels DJ,Link MJ

    更新日期:2014-07-01 00:00:00

  • The Influence of Parkinson Disease on Lumbar Decompression Surgery: A Retrospective Case Control Study.

    abstract:BACKGROUND:Parkinson disease (PD) is a major risk factor during spine surgery, and its frequency is increasing as the population ages. The study aim was to examine the influence of PD specifically on lumbar decompression surgery. METHODS:A retrospective review was performed of all patients with PD who underwent electi...

    journal_title:World neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.wneu.2017.09.028

    authors: Westermann L,Eysel P,Hantscher J,Baschera D,Simons M,Herren C,Zarghooni K,Siewe J

    更新日期:2017-12-01 00:00:00

  • Giant olfactory groove meningiomas: extent of frontal lobes damage and long-term outcome after the pterional approach.

    abstract:OBJECTIVE:The treatment of giant olfactory groove meningiomas (OGMs; maximum diameter ≥ 6 cm) poses special problems and represents a surgical challenge. We discuss the long-term results in a series of 18 patients with giant OGMs and report our experience on a global strategy encompassing the pterional approach to mana...

    journal_title:World neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.wneu.2011.03.021

    authors: Tomasello F,Angileri FF,Grasso G,Granata F,De Ponte FS,Alafaci C

    更新日期:2011-09-01 00:00:00

  • Hydrocephalus Secondary to Intradural Extramedullary Malignant Melanoma of Spinal Cord.

    abstract:BACKGROUND:Hydrocephalus secondary to spinal cord tumors is rare. CASE DESCRIPTION:We present a 39-year-old male with gradual-onset headache whose initial diagnosis was cerebral aneurysm and communicating hydrocephalus. The correct diagnosis was primary intradural extramedullary malignant melanoma of the spinal cord. ...

    journal_title:World neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.wneu.2019.07.046

    authors: Hironaka K,Tateyama K,Tsukiyama A,Adachi K,Morita A

    更新日期:2019-10-01 00:00:00

  • Invasive Giant Cell Tumor of the Lateral Skull Base: A Systematic Review, Meta-Analysis, and Case Illustration.

    abstract:BACKGROUND:The current literature regarding cranial giant cell tumor (GCT) management includes scattered case reports and small case series. We present a comprehensive literature review and meta-analysis on this subject, along with a case report describing our management of a patient with temporal GCT. METHODS:A syste...

    journal_title:World neurosurgery

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.wneu.2016.05.086

    authors: Freeman JL,Oushy S,Schowinsky J,Sillau S,Youssef AS

    更新日期:2016-12-01 00:00:00

  • Aneurysm Surgery with Preoperative Three-Dimensional Planning in a Virtual Reality Environment: Technique and Outcome Analysis.

    abstract:OBJECTIVE:Aneurysm surgery demands precise spatial understanding of the vascular anatomy and its surroundings. We report on a decade of experience planning clipping procedures preoperatively in a virtual reality (VR) workstation and present outcomes with respect to mortality, morbidity, and aneurysm occlusion rate. ME...

    journal_title:World neurosurgery

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.wneu.2016.08.124

    authors: Kockro RA,Killeen T,Ayyad A,Glaser M,Stadie A,Reisch R,Giese A,Schwandt E

    更新日期:2016-12-01 00:00:00

  • Rationale for treating unruptured intracranial aneurysms: actuarial analysis of natural history risk versus treatment risk for coiling or clipping based on 14,050 patients in the Nationwide Inpatient Sample database.

    abstract:OBJECTIVE:The treatment of small unruptured intracranial aneurysms has been questioned based on the results of the International Study of Unruptured Intracranial Aneurysms. Our objective was to compare natural history rupture risk versus treatment risk for coiling and clipping small unruptured aneurysms using data in t...

    journal_title:World neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.wneu.2012.01.038

    authors: Lawson MF,Neal DW,Mocco J,Hoh BL

    更新日期:2013-03-01 00:00:00

  • Orphaned Middle Cerebral Artery Side-to-Side In Situ Bypass as a Favorable Alternative Approach for Complex Middle Cerebral Artery Aneurysm Treatment: A Case Series.

    abstract:OBJECTIVE:Middle cerebral artery (MCA) aneurysms have continued to be primarily managed microsurgically. In cases of complex MCA aneurysms, revascularization could facilitate effective aneurysm treatment. The MCA candelabra provides excellent candidates for in situ side-to-side bypass. In the present case series, we ha...

    journal_title:World neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.wneu.2019.07.053

    authors: Ravina K,Rennert RC,Kim PE,Strickland BA,Chun A,Russin JJ

    更新日期:2019-10-01 00:00:00

  • Transforaminal Endoscopic Excision of Intradural Lumbar Disk Herniation and Dural Repair.

    abstract:BACKGROUND:Intradural disk herniation is a rare entity with <0.3%-1% of all disk herniations and at an L2-L3 level even rarer. The dural defects repairs on ventral aspect are technically challenging and may not be possible after durotomy, so many authors have placed fascia, muscle, or plugging by the hemostatic materia...

    journal_title:World neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.wneu.2018.07.244

    authors: Kim HS,Pradhan RL,Adsul N,Jang JS,Jang IT,Oh SH

    更新日期:2018-11-01 00:00:00

  • Rechallenging Recurrent Glioblastoma with Intra-Arterial Bevacizumab with Blood Brain-Barrier Disruption Results in Radiographic Response.

    abstract:BACKGROUND:High-dose bevacizumab delivered via super selective intra-arterial cerebral infusion (SIACI) is one promising clinical trial combination for patients with glioblastoma (GBM). Although both continuous intravenous and intra-arterial administration of bevacizumab, and rechallenge with intravenous bevacizumab, h...

    journal_title:World neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.wneu.2019.07.137

    authors: Faltings L,Kulason KO,Patel NV,Wong T,Fralin S,Li M,Schneider JR,Filippi CG,Langer DJ,Ortiz R,Boockvar JA

    更新日期:2019-11-01 00:00:00

  • Formation of de Novo Symptomatic Premedullary Arachnoid Cyst in Adult.

    abstract:BACKGROUND:Intracranial de novo arachnoid cysts in adults are rare, suggesting the involvement of head trauma and inflammatory diseases. We report a symptomatic adult case of nontraumatic de novo arachnoid cyst on the ventral medulla oblongata. CASE DESCRIPTION:A 56-year-old man came to our hospital complaining of dys...

    journal_title:World neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.wneu.2019.07.029

    authors: Yokoyama K,Sugie A,Yamada M,Tanaka H,Ito Y,Yamashita M,Kawanishi M

    更新日期:2019-10-01 00:00:00

  • Implementation of Intraoperative Computed Tomography for Deep Brain Stimulation: Pitfalls and Optimization of Workflow, Accuracy, and Radiation Exposure.

    abstract:OBJECTIVE:Deep brain stimulation (DBS) is an effective treatment for movement disorders. Stereotactic electrode placement can be guided by intraoperative imaging, which also allows for immediate intraoperative quality control. This article is about implementation and refining a workflow applying intraoperative computed...

    journal_title:World neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.wneu.2018.12.079

    authors: Carl B,Bopp M,Gjorgjevski M,Oehrn C,Timmermann L,Nimsky C

    更新日期:2018-12-27 00:00:00

  • Intracranial Meningioma in Patients Age

    abstract:BACKGROUND:Intracranial meningiomas are most common among patients in their fifth to seventh decade of life and rare in children and young adults. They constitute 1.5% of all neoplasms in patients age <20 years, but account for 13.5% of all neoplasms in patients age 20-34 years. They are often associated with hereditar...

    journal_title:World neurosurgery

    pub_type: 杂志文章

    doi:10.1016/j.wneu.2017.09.161

    authors: Motebejane MS,Kaminsky I,Choi IS

    更新日期:2018-01-01 00:00:00

  • Multiple Intracranial Aneurysms Caused by Myxoma: Case Report and Literature Review.

    abstract:OBJECTIVE:We present a case of multiple myxoma-related intracranial aneurysms and reviewed the recent relevant literature to investigate their natural course and develop a reasonable treatment algorithm. METHODS:We have reported a new case of multiple myxoma-related intracranial aneurysms and performed a search of cur...

    journal_title:World neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1016/j.wneu.2019.09.014

    authors: Gai S,Lv N,Zhang Q,Zuo Q,Liu J,Huang Q

    更新日期:2020-01-01 00:00:00