Abstract:
OBJECTIVE:To compare fluorescence intensity of tumor specimens, as measured by a fluorescence-guided surgery microscope and a spectrometer, to evaluate tumor infiltration of dura mater around meningiomas with help of these 2 different 5-aminolevulinic acid (5-ALA)-based fluorescence tools, and to correlate fluorescence intensity with histopathologic data. MATERIAL AND METHODS:In a clinical series, meningiomas were resected by 5-ALA fluorescence-guided surgery. Fluorescence intensity was semiquantitatively rated by the surgeon at predefined points. Biopsies were harvested and fluorescence intensity measured by a spectrometer and histopathologically analyzed. Sampling was realized at the level of the dura in a centrifugal direction. RESULTS:A total of 104 biopsies (n = 13 tumors) were analyzed. Specificity and sensitivity of the microscope were 0.96 and 0.53 and of the spectrometer 0.95 and 0.93, respectively. Fluorescence intensity as measured by the spectrometer was correlated to histologically confirmed tumor burden. In a centrifugal direction, tumor burden and fluorescence intensity continuously decreased (along the dural tail). Below a threshold value of 639 arbitrary units no tumor was histologically detectable. CONCLUSIONS:At the level of the dura the spectrometer was highly sensitive for detection of meningioma cells. The surgical microscope showed false negative results and missed residual tumor cells in more than one half of the cases. The complementary use of both fluorescence tools may improve resection quality.
journal_name
World Neurosurgjournal_title
World neurosurgeryauthors
Knipps J,Beseoglu K,Kamp M,Fischer I,Felsberg J,Neumann LM,Steiger HJ,Cornelius JFdoi
10.1016/j.wneu.2017.08.140subject
Has Abstractpub_date
2017-12-01 00:00:00pages
118-127eissn
1878-8750issn
1878-8769pii
S1878-8750(17)31441-9journal_volume
108pub_type
杂志文章abstract:OBJECTIVE:To retrospectively assess the surgical outcomes and complication rates following microvascular decompression (MVD) for trigeminal neuralgia, using a targeted, restricted retrosigmoid approach. METHODS:During the period 1994-2009, a total of 119 patients underwent MVD for trigeminal neuralgia. A retrospective...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2010.05.001
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:Osteoporosis is one of the most common problems of patients with spinal cord injuries (SCIs). The current study aimed to evaluate the antiosteoporotic effects of curcumin on densitometry parameters and biomarkers of bone turnovers among patients with SCI. MATERIALS AND METHODS:The current controlled clinica...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2018.03.081
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:Work hour restrictions and current quality, financial, and legal concerns have reduced resident operative volume and autonomy. Although laboratory (cadaveric or animal) dissection has a rich history in neurosurgery, its current role in resident training is unclear. Recent literature suggests educators have lo...
journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2014.05.028
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journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2019.08.062
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Olfactory neuroblastoma (ON) is a highly aggressive and locally recurrent neoplasm. Distant systemic metastases are not uncommon, but remote leptomeningeal dissemination is extremely rare. CASE DESCRIPTION:We report 2 cases of ON previously treated with endoscopic endonasal radical surgical resection and ra...
journal_title:World neurosurgery
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doi:10.1016/j.wneu.2019.11.042
更新日期:2020-02-01 00:00:00
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journal_title:World neurosurgery
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journal_title:World neurosurgery
pub_type: 杂志文章,多中心研究
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更新日期:2014-09-01 00:00:00
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journal_title:World neurosurgery
pub_type: 杂志文章,评审
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更新日期:2020-11-13 00:00:00
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journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2010.01.003
更新日期:2010-04-01 00:00:00
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journal_title:World neurosurgery
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2018.05.165
更新日期:2018-08-01 00:00:00
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journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2018.11.258
更新日期:2019-01-18 00:00:00
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doi:10.1016/j.wneu.2019.03.124
更新日期:2019-06-01 00:00:00
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journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2018.03.078
更新日期:2018-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.wneu.2017.05.176
更新日期:2017-09-01 00:00:00
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journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2013.01.028
更新日期:2014-07-01 00:00:00
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journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2017.09.028
更新日期:2017-12-01 00:00:00
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journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2011.03.021
更新日期:2011-09-01 00:00:00
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journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2019.07.046
更新日期:2019-10-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2016-12-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2016-12-01 00:00:00
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journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2012.01.038
更新日期:2013-03-01 00:00:00
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journal_title:World neurosurgery
pub_type: 杂志文章
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更新日期:2019-10-01 00:00:00
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journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2018.07.244
更新日期:2018-11-01 00:00:00
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journal_title:World neurosurgery
pub_type: 杂志文章
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更新日期:2019-11-01 00:00:00
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journal_title:World neurosurgery
pub_type: 杂志文章
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更新日期:2019-10-01 00:00:00
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journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2018.12.079
更新日期:2018-12-27 00:00:00
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journal_title:World neurosurgery
pub_type: 杂志文章
doi:10.1016/j.wneu.2017.09.161
更新日期:2018-01-01 00:00:00
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journal_title:World neurosurgery
pub_type: 杂志文章,评审
doi:10.1016/j.wneu.2019.09.014
更新日期:2020-01-01 00:00:00