Dried Rehmannia root protects against glutamate-induced cytotoxity to PC12 cells through energy metabolism-related pathways.

Abstract:

:Rehmannia has been shown to be clinically effective in treating neurodegenerative diseases; however, the neuroprotective mechanisms remain unclear. In this study, we established a model of neurodegenerative disease using PC12 cytotoxic injury induced by glutamate. The cells were treated with 20 mM glutamate in the absence or presence of water extracts of dried Rehmannia root of varying concentrations (70%, 50% and 30%). The different concentrations of Rehmannia water extract significantly increased the activity of glutamate-injured cells, reduced the release of lactate dehydrogenase, inhibited apoptosis, increased the concentrations of NADH, NAD and ATP in cells, ameliorated mitochondrial membrane potential, and reduced the levels of light chain 3. Taken together, our findings demonstrate that Rehmannia water extracts exert a cytoprotective effect against glutamate-induced PC12 cell injury via energy metabolism-related pathways.

journal_name

Neural Regen Res

authors

Liu Y,Liu L,Ying XX,Wei WJ,Han C,Liu Y,Han CH,Leng AJ,Ma JY,Liu J

doi

10.4103/1673-5374.213556

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

1338-1346

issue

8

eissn

1673-5374

issn

1876-7958

pii

NRR-12-1338

journal_volume

12

pub_type

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