Abstract:
:Rehmannia has been shown to be clinically effective in treating neurodegenerative diseases; however, the neuroprotective mechanisms remain unclear. In this study, we established a model of neurodegenerative disease using PC12 cytotoxic injury induced by glutamate. The cells were treated with 20 mM glutamate in the absence or presence of water extracts of dried Rehmannia root of varying concentrations (70%, 50% and 30%). The different concentrations of Rehmannia water extract significantly increased the activity of glutamate-injured cells, reduced the release of lactate dehydrogenase, inhibited apoptosis, increased the concentrations of NADH, NAD and ATP in cells, ameliorated mitochondrial membrane potential, and reduced the levels of light chain 3. Taken together, our findings demonstrate that Rehmannia water extracts exert a cytoprotective effect against glutamate-induced PC12 cell injury via energy metabolism-related pathways.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Liu Y,Liu L,Ying XX,Wei WJ,Han C,Liu Y,Han CH,Leng AJ,Ma JY,Liu Jdoi
10.4103/1673-5374.213556subject
Has Abstractpub_date
2017-08-01 00:00:00pages
1338-1346issue
8eissn
1673-5374issn
1876-7958pii
NRR-12-1338journal_volume
12pub_type
杂志文章abstract::Visual cortical prostheses have the potential to restore partial vision. Still limited by the low-resolution visual percepts provided by visual cortical prostheses, implant wearers can currently only "see" pixelized images, and how to obtain the specific brain responses to different pixelized images in the primary vis...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.167761
更新日期:2015-10-01 00:00:00
abstract::A significant amount of evidence indicates that microRNAs (miRNAs) play an important role in drug addiction. The nucleus accumbens (NAc) is a critical part of the brain's reward circuit and is involved in a variety of psychiatric disorders, including depression, anxiety, and drug addiction. However, few studies have e...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.224374
更新日期:2018-01-01 00:00:00
abstract::Glaucoma has been recently characterized as a member of the group of anoikis-related diseases. Anoikis, a form of apoptosis, can be triggered by the unfastening of adherent junctions present in astrocytes. In those areas of the central nervous system in which the soma of the neurons or their axons and dendrites are me...
journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.249215
更新日期:2019-06-01 00:00:00
abstract::Brain structure and cognitive function change in the temporal lobe, hippocampus, and prefrontal cortex of patients with mild cognitive impairment and Alzheimer's disease, and brain network-connection strength, network efficiency, and nodal attributes are abnormal. However, existing research has only analyzed the diffe...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2013.30.001
更新日期:2013-10-25 00:00:00
abstract::Research on human glioma stem cells began early in the 21st century and since then has become a rapidly growing research field with the number of publications increasing year by year. The research conducted by our diverse group of investigators focused primarily on cell culture techniques, molecular regulation, signal...
journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.219055
更新日期:2017-11-01 00:00:00
abstract::A potential treatment for retinal diseases is to induce an endogenous Müller glia (MG)-derived regenerative response to replace damaged neurons. In contrast to mammalian MG, zebrafish MG are capable of mediating spontaneous regeneration. We seek to define the mechanisms that enable retina regeneration in zebrafish in ...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.286972
更新日期:2021-02-01 00:00:00
abstract::Traumatic brain injury (TBI) is characterized by primary damage to the brain from the external mechanical force and by subsequent secondary injury due to various molecular and pathophysiological responses that eventually lead to neuronal cell death. Secondary brain injury events may occur minutes, hours, or even days ...
journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.219025
更新日期:2017-11-01 00:00:00
abstract::Epithelial-specific ETS-1 (ESE1), a member of the ETS transcription factor family, is widely expressed in multiple tissues and performs various functions in inflammation. During neuroinflammation, ESE1 promotes neuronal apoptosis; however, the expression and biological functions of ESE1 remain unclear after cerebral i...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.249232
更新日期:2019-05-01 00:00:00
abstract::Cavernous nerve injury is the main cause of erectile dysfunction following radical prostatectomy. The recovery of erectile function following radical prostatectomy remains challenging. Our previous studies found that injecting adipose-derived stem cells (ADSCs) into the cavernosa could repair the damaged cavernous ner...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.264464
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To investigate the factors associated with sensory and motor recovery after the repair of upper limb peripheral nerve injuries. DATA SOURCES:The online PubMed database was searched for English articles describing outcomes after the repair of median, ulnar, radial, and digital nerve injuries in humans with a ...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.130094
更新日期:2014-03-15 00:00:00
abstract::Injury to axons close to the neuronal bodies in the mammalian central nervous system causes a large proportion of parenting neurons to degenerate. It is known that optic nerve transection close to the eye in rodents leads to a loss of about half of retinal ganglion cells in 1 week and about 90% in 2 weeks. Using low l...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.145337
更新日期:2014-11-01 00:00:00
abstract::The signaling mechanisms underlying ischemia-induced nerve cell apoptosis are poorly understood. We investigated the effects of apoptosis-related signal transduction pathways following ischemic spinal cord injury, including extracellular signal-regulated kinase (ERK), serine-threonine protein kinase (Akt) and c-Jun N-...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.170313
更新日期:2015-11-01 00:00:00
abstract::The present study quantitatively analyzed intraspinal cerebrospinal fluid flow patterns in 19 normal adults using fast cine phase-contrast magnetic resonance imaging. Results showed increased downward flow velocity and volume compared with upward flow, and the average downward flow volume of intraspinal cerebrospinal ...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2012.15.007
更新日期:2012-05-25 00:00:00
abstract::Proximal or middle lesions of the ulnar or median nerves are responsible for extensive loss of hand motor function. This occurs even when the most meticulous microsurgical techniques or nerve grafts are used. Previous studies had proposed that nerve transfer was more effective than nerve grafting for nerve repair. Our...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.199007
更新日期:2017-01-01 00:00:00
abstract::We report a patient with severe ataxia due to Dandy-Walker malformation, who showed functional recovery over 10 months corresponding to a change in a cerebellar peduncle lesion. A 20-month-old female patient who was diagnosed with Dandy-Walker syndrome and six age- and sex-matched healthy control subjects were enrolle...
journal_title:Neural regeneration research
pub_type:
doi:10.3969/j.issn.1673-5374.2013.05.012
更新日期:2013-02-15 00:00:00
abstract::The electrical excitability of neural networks is influenced by different environmental factors. Effective and simple methods are required to objectively and quantitatively evaluate the influence of such factors, including variations in temperature and pharmaceutical dosage. The aim of this paper was to introduce 'the...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.233446
更新日期:2018-06-01 00:00:00
abstract::Mental practice is a new rehabilitation method that refers to the mental rehearsal of motor imagery content with the goal of improving motor performance. However, the relationship between activated regions and motor recovery after mental practice training is not well understood. In this study, 15 patients who suffered...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.139465
更新日期:2014-08-01 00:00:00
abstract::Acupuncture can induce changes in the brain. However, the majority of studies to date have focused on a single acupoint at a time. In the present study, we observed activity changes in the brains of healthy volunteers before and after acupuncture at Taichong (LR3) and Taixi (KI3) using resting-state functional magneti...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.152385
更新日期:2015-02-01 00:00:00
abstract::Mecobalamin, a form of vitamin B12 containing a central metal element (cobalt), is one of the most important mediators of nervous system function. In the clinic, it is often used to accelerate recovery of peripheral nerves, but its molecular mechanism remains unclear. In the present study, we performed sciatic nerve c...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.145379
更新日期:2014-11-15 00:00:00
abstract::The present study recruited 193 patients with ischemic cerebrovascular disease from Inpatient and Outpatient Departments at the Affiliated Hospital of Qingdao University Medical College, China from August 2008 to May 2010, as well as 120 healthy volunteers from the Medical Examination Center at the Affiliated Hospital...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2012.07.009
更新日期:2012-03-05 00:00:00
abstract::Various studies have reported that galanin can promote axonal regeneration of dorsal root ganglion neurons in vitro and inhibit neuropathic pain. However, little is known about its effects on diabetic peripheral neuropathy, and in vivo experimental data are lacking. We hypothesized that repeated applications of exogen...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.191228
更新日期:2016-09-01 00:00:00
abstract::Several studies have demonstrated that the Chinese herb Gastrodia elata Blume can protect against amyloid beta-peptide (Aβ)-induced cell death. To investigate the possible therapeutic effects of Gastrodia elata Blume on Alzheimer's disease, we established a rat model of Alzheimer's disease by injecting Aβ25-35 into bi...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2013.12.001
更新日期:2013-04-25 00:00:00
abstract::Parkinson's disease is characterized by the loss of dopaminergic neurons in the substantia nigra. As a result, intensive efforts have focused upon mechanisms that facilitate the death of mature dopaminergic neurons. Unfortunately, these efforts have been unsuccessful in providing an effective treatment to address neur...
journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.184449
更新日期:2016-06-01 00:00:00
abstract::Ciliary neurotrophic factor is the only known neurotrophic factor that can promote differentiation of hippocampal neural progenitor cells to glial cells and neurons in adult rats. This process is similar to spontaneous differentiation. Therefore, ciliary neurotrophic factor may be involved in spontaneous differentiati...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2013.04.002
更新日期:2013-02-05 00:00:00
abstract::Knowledge of the plasticity of language pathways in patients with low-grade glioma is important for neurosurgeons to achieve maximum resection while preserving neurological function. The current study sought to investigate changes in the ventral language pathways in patients with low-grade glioma located in regions li...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2013.07.009
更新日期:2013-03-05 00:00:00
abstract::Neurotrophins play a major role in the regulation of neuronal growth such as neurite sprouting or regeneration in response to nerve injuries. The role of nerve growth factor, neurotrophin-3, and brain-derived neurotrophic factor in maintaining the survival of peripheral neurons remains poorly understood. In regenerati...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.276338
更新日期:2020-09-01 00:00:00
abstract::Alzheimer's disease is a progressive neurodegenerative disorder, characterized by deposition of amyloid beta, neurofibrillary tangles, astrogliosis and microgliosis, leading to neuronal dysfunction and loss in the brain. Current treatments for Alzheimer's disease primarily focus on enhancement of cholinergic transmiss...
journal_title:Neural regeneration research
pub_type: 杂志文章,评审
doi:10.4103/1673-5374.162686
更新日期:2015-08-01 00:00:00
abstract::Multiple regeneration of axonal buds has been shown to exist during the repair of peripheral nerve injury, which confirms a certain repair potential of the injured peripheral nerve. Therefore, a systematic nerve transposition repair technique has been proposed to treat severe peripheral nerve injury. During nerve tran...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.4103/1673-5374.247473
更新日期:2019-04-01 00:00:00
abstract::Amyloid β peptide binding alcohol dehydrogenase (ABAD) decoy peptide (DP) can competitively antagonize binding of amyloid β peptide to ABAD and inhibit the cytotoxic effects of amyloid β peptide. Based on peptide aptamers, the present study inserted ABAD-DP into the disulfide bond of human thioredoxin (TRX) using mole...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2013.01.005
更新日期:2013-01-05 00:00:00
abstract::LIM homeobox transcription factor 1a (Lmx1a) has the capacity to initiate the development program of neuronal cells and promote the differentiation of embryonic stem cells into dopaminergic neurons. In this study, rhesus adipose stem cells were infected with recombinant adenovirus carrying the Lmx1a gene and co-cultur...
journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2012.34.001
更新日期:2012-12-05 00:00:00