Abstract:
BACKGROUND/OBJECTIVE:Chronic hyperglycemia induces oxidative stress via accumulation of reactive oxygen species (ROS) and contributes to diabetic complications. Hyperglycemia induces mitochondrial superoxide anion production through the increased activity of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. This study aimed to determine whether fisetin and luteolin treatments suppress the oxidative stress by modulating the expression of sirtuins (SIRTs) and forkhead box O3a (FOXO3a) under hyperglycemic conditions in human monocytes. MATERIALS/METHODS:Human monocytic cells (THP-1) were cultured under osmotic control (14.5 mmol/L mannitol), normoglycemic (NG, 5.5 mmol/L glucose), or hyperglycemic (HG, 20 mmol/L glucose) conditions, in the absence or presence of fisetin and luteolin for 48 h. To determine the effect of fisetin and luteolin treatments on high glucose-induced oxidative stress, western blotting and intracellular staining were performed. RESULTS:Hyperglycemic conditions increased the ROS production, as compared to normoglycemic condition. However, fisetin and luteolin treatments inhibited ROS production under hyperglycemia. To obtain further insight into ROS production in hyperglycemic conditions, evaluation of p47phox expression revealed that fisetin and luteolin treatments inhibited p47phox expression under hyperglycemic conditions. Conversely, the expression levels of SIRT1, SIRT3, SIRT6, and FOXO3a were decreased under high glucose conditions compared to normal glucose conditions, but exposure to fisetin and luteolin induced the expression of SIRT1, SIRT3, SIRT6, and FOXO3a. The above findings suggest that fisetin and luteolin inhibited high glucose-induced ROS production in monocytes through the activation of SIRTs and FOXO3a. CONCLUSIONS:The results of our study supports current researches that state fisetin and luteolin as potential agents for the development of novel strategies for diabetes.
journal_name
Nutr Res Practjournal_title
Nutrition research and practiceauthors
Kim A,Lee W,Yun JMdoi
10.4162/nrp.2017.11.5.430subject
Has Abstractpub_date
2017-10-01 00:00:00pages
430-434issue
5eissn
1976-1457issn
2005-6168journal_volume
11pub_type
杂志文章abstract::[This corrects the article on p. 57 in vol. 9, PMID: 25671069.]. ...
journal_title:Nutrition research and practice
pub_type: 已发布勘误
doi:10.4162/nrp.2015.9.2.213
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:To compare five indices of adherence to the Mediterranean Diet (MD) among adults living in the Mediterranean region. SUBJECTS/METHODS:A total of 100 healthy Lebanese adults aged between 18 and 65 years. Face-to-face interviews to collect sociodemographic and medical information, to take anthropom...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2019.13.4.333
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Several nutritional screening tools were recently developed to screen the risk of malnutrition in hospitalized children, but have not been validated in Asia. We compared four nutritional screening tools for pediatric patients in evaluating nutritional risks in newly hospitalized children. SUBJECT...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2019.13.5.410
更新日期:2019-10-01 00:00:00
abstract::The Framingham risk score (FRS) has been used to assess the risk of a cardiovascular event and to identify patients for risk factor modifications. Therefore, the purpose of this study was to evaluate the relationship of the FRS with dietary intake and inflammatory biomarkers. We conducted a cross-sectional study of 18...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2012.6.3.246
更新日期:2012-06-01 00:00:00
abstract::The purpose of this study was to examine consumers' behaviors toward ready-to-eat foods and to develop ready-to-eat food market segmentation in Korea. The food-related lifestyle and purchase behaviors of ready-to-eat foods were evaluated using 410 ready-to-eat food consumers in the Republic of Korea. Four factors were...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2010.4.4.332
更新日期:2010-08-01 00:00:00
abstract::We evaluated folate status of child-bearing age women diagnosed with abnormal pap smear in the US post-folic acid (FA) fortification era and assessed the determinants of NTD-protective and supra-physiologic (SP) concentrations of folate. The distribution of 843 women according to NTD-protective concentrations of RBC f...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2013.7.4.315
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Epithelial-mesenchymal transition (EMT) is involved in not only cancer development and metastasis but also non-cancerous conditions. Hypoxia is one of the proposed critical factors contributing to formation of chronic rhinosinusitis or nasal polyposis. Wheatgrass (Triticum aestivum) has antioxidan...
journal_title:Nutrition research and practice
pub_type: 杂志文章,收录出版
doi:10.4162/nrp.2017.11.2.83
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:The number of diabetic patients has recently shown a rapid increase, and delayed wound healing is a major clinical complication in diabetes. In this study, the wound healing effect of Hominis placenta (HP) treatment was investigated in normal and streptozotocin-induced diabetic mice. MATERIALS/ME...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2014.8.4.404
更新日期:2014-08-01 00:00:00
abstract::Synurus deltoides (Aiton) Nakai, belonging to the Compositae family, is an edible plant widely distributed in Northeast Asia. In this study, we examined the mechanisms underlying the immunomodulative effects of the ethanol extract of S. deltoides (SDE). The SDE extract strongly down-regulated the mRNA expression of th...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2014.8.1.11
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:The type of sweet snack incorporated into an energy-restricted diet (ERD) may produce differential effects on metabolic improvements associated with body weight (BW) loss. This study compared effects of incorporating either twice daily energy-controlled dark chocolate snacks plus once daily sugar-...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2014.8.6.695
更新日期:2014-12-01 00:00:00
abstract::Dietary intakes and plasma concentrations of retinol and carotenoids were estimated in assessing the vitamin A status of Korean adults living in Seoul and the metropolitan area. Three consecutive 24-h food recalls were collected from 106 healthy subjects (33 males and 73 females) aged 20-59 years. Fasting blood sample...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2012.6.1.45
更新日期:2012-02-01 00:00:00
abstract::The purpose of this study was to compare the beverage consumption by gender and season in elementary school children and to investigate the role of beverage consumption patterns on their daily nutrient intakes and BMIs. Beverage consumption and dietary energy intake in 160 elementary school students in the Gyeongnam a...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2009.3.3.234
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Oligonol, mainly found in lychee fruit, is an antioxidant polyphenolic compound which has been shown to have anti-inflammatory and anti-cancer properties. The detailed mechanisms by which oligonol may act as an anti-aging molecule have not been determined. MATERIALS/METHODS:In this study, we eval...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2016.10.1.3
更新日期:2016-02-01 00:00:00
abstract::The most critical point in the assessment of adherence to dietary guidelines is the development of a practical definition for adherence, such as a dietary pattern score. The purpose of this study was to develop the Korean Diet Score (KDS) based on the Korean Food Balance Wheel and to examine the association of KDS wit...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2013.7.1.49
更新日期:2013-02-01 00:00:00
abstract::Obesity may be the consequence of various environmental or genetic factors, which may be highly correlated with each other. We aimed to examine whether grandmaternal and maternal obesity and environmental risk factors are related to obesity in daughters. Daughters (n = 182) recruited from female students, their mother...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2013.7.5.400
更新日期:2013-10-01 00:00:00
abstract:BACKGROUD/OBJECTIVES:Hepatic steatosis is the most common liver disorder, particularly in postmenopausal women. This study investigated the protective effects of standardized rice bran extract (RBS) on ovariectomized (OVX)-induced hepatic steatosis in rats. MATERIALS/METHODS:HepG2 cells were incubated with 200 µM olei...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2020.14.6.568
更新日期:2020-12-01 00:00:00
abstract::This study was conducted to investigate relationships and gender differences in dietary supplement (DS) and oriental supplement (OS) prevalence as well as anti-doping awareness during training and the game period. Korea National Sport University athletes (343 male and 136 female) participated in this study and complet...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2011.5.4.349
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Isoflavones are widely believed to be beneficial to human health, in relation to their antioxidant potentials. Exercise can cause an imbalance between reactive oxygen species (ROS) and antioxidants. This study was conducted in order to investigate the ability of isoflavones in amelioration of oxid...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2014.8.6.618
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:This study aimed to investigate the association of dietary patterns with overweight risk and all-cause mortality in pediatric cancer patients. SUBJECTS/METHODS:Prospective cohort study was undertaken; 83 cancer patients admitted to the pediatric cancer ward at a university hospital in Seoul were ...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2017.11.6.492
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:A higher frequency of family meals is associated with good dietary habits in young people. This study focused on the relationships of family meal frequency with food neophobia and personality traits in adolescents. SUBJECTS/METHOD:For this purpose, we administered a survey to 495 middle school students in S...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2014.8.4.476
更新日期:2014-08-01 00:00:00
abstract::The objective of this study was to evaluate the inhibitory activity of natural products, against growth of Escherichia coli (ATCC 25922) and Salmonella typhimurium (KCCM 11862). Chitosan, epigallocatechin gallate (EGCG), and garlic were used as natural bioactives for antibacterial activity. The testing method was carr...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2007.1.4.273
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Urbanization and lifestyle changes have resulted in nutrition transition. Over-nutrition causes obesity increase, although malnutrition still exists. This phenomenon is called a double burden of malnutrition (DBM). This study was conducted to confirm the existence of DBM and to investigate the die...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2018.12.5.426
更新日期:2018-10-01 00:00:00
abstract::Dietary inorganic sulfur is the minor component in our diet, but some studies suggested that inorganic sulfur is maybe effective to treat cancer related illness. Therefore, this study aims to examine the effects of inorganic sulfur on cell proliferation and gene expression in MDA-MB-231 human breast cancer cells. MDA-...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2013.7.2.89
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:This cross-sectional study assessed household food security status and determined its association with diet quality and weight status among indigenous women from the Mah Meri tribe in Peninsular Malaysia. SUBJECTS/METHODS:The Radimer/Cornell Hunger and Food Insecurity Instrument and the Malaysian...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2018.12.2.135
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:This study examined the effect of nutrition labeling formats on parents' food choices for their children at different restaurant types. SUBJECTS/METHODS:An online survey was conducted with 1,980 parents of children aged 3-12 years. Participants were randomly assigned to fast food or family restau...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2018.12.3.243
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Groundwater is believed to possess many beneficial effects due to its natural source of various minerals. In this study, we examined the effects of natural Jeju groundwater S1 (Samdasoo™), S2 and S3 pumped up from different locations of Jeju Island, Korea, along with local tap water, on body weight gain, ser...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2014.8.2.165
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Increased serum homocysteine (Hcy) levels have been reported to be related to the occurrence of cardio- and cerebrovascular diseases. High serum Hcy levels are also related to the development of secondary stroke and all-cause mortality. The purpose of this study was to investigate the prevalence o...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2015.9.5.503
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Sodium intake is positively associated with blood pressure, which may increase the risk for cardiovascular disease (CVD). Therefore, we assessed the disease burden of CVD attributable to sodium intakes above 2,000 mg/day and prospectively investigated the association between dietary/urinary sodium...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2020.14.5.501
更新日期:2020-10-01 00:00:00
abstract::The aim of this study was to investigate the influencing factors that characterize low density lipoprotein (LDL) phenotype and the levels of LDL particle size in healthy Korean women. In 57 healthy Korean women (mean age, 57.4 ± 13.1 yrs), anthropometric and biochemical parameters such as lipid profiles and LDL partic...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2012.6.2.120
更新日期:2012-04-01 00:00:00
abstract::The rapid rise in the incidence of obesity has emerged as one of the most pressing global public health issues in recent years. The underlying etiological causes of obesity, whether behavioral, environmental, genetic, or a combination of several of them, have not been completely elucidated. The obesity epidemic has be...
journal_title:Nutrition research and practice
pub_type: 杂志文章
doi:10.4162/nrp.2011.5.3.253
更新日期:2011-06-01 00:00:00