Abstract:
:Autism spectrum disorder (ASD) is marked by a strong genetic heterogeneity, which is underlined by the low overlap between ASD risk gene lists proposed in different studies. In this context, molecular networks can be used to analyze the results of several genome-wide studies in order to underline those network regions harboring genetic variations associated with ASD, the so-called "disease modules." In this work, we used a recent network diffusion-based approach to jointly analyze multiple ASD risk gene lists. We defined genome-scale prioritizations of human genes in relation to ASD genes from multiple studies, found significantly connected gene modules associated with ASD and predicted genes functionally related to ASD risk genes. Most of them play a role in synapsis and neuronal development and function; many are related to syndromes that can be in comorbidity with ASD and the remaining are involved in epigenetics, cell cycle, cell adhesion and cancer.
journal_name
Front Genetjournal_title
Frontiers in geneticsauthors
Mosca E,Bersanelli M,Gnocchi M,Moscatelli M,Castellani G,Milanesi L,Mezzelani Adoi
10.3389/fgene.2017.00129subject
Has Abstractpub_date
2017-09-25 00:00:00pages
129issn
1664-8021journal_volume
8pub_type
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