Abstract:
:This study investigated the effect of the serotonin selective reuptake inhibitors (SSRIs) fluoxetine, sertraline, fluvoxamine and the tricyclic antidepressant (TCA) impiramine on oxidative stress in brain and liver induced by lipopolysaccharide administration in mice. Each drug was administered subcutaneously at doses of 10 or 20 mg/kg, for two days prior to intraperitoneal (i.p.) administration of lipopolysaccharide E (LPS: 200 µg/kg). Mice were euthanized 4 h after administration of the lipopolysaccharide. Lipid peroxidation (malondialdehyde; MDA), reduced glutathione (GSH) and nitric oxide (nitrite/nitrate) concentrations were measured in brain and liver. Results: The administration of lipopolysaccharide increased oxidative stress in brain and liver; it increased brain MDA by 36.1 and liver MDA by 159.8 %. GSH decreased by 34.1 % and 64.8 % and nitric oxide increased by 78.7 % and 103.8 % in brain and liver, respectively. In brain, MDA decreased after the administration of sertraline and by the lower dose of fluoxetine or fluvoxamine, but increased after the higher dose of imipramine. Reduced glutathione increased after sertraline, fluvoxamine and the lower dose of fluoxetine or imipramine. Nitric oxide decreased by sertraline, fluoxetine, fluvoxamine and by the lower dose of imipramine. In the liver, all drugs decreased MDA and increased GSH level. Nitric oxide is decreased by sertraline, fluvoxamine and by the lower dose of fluoxetine or imipramine. It is concluded that, during mild systemic inflammatory illness induced by peripheral bacterial endotoxin injection, the SSRIs fluoxetine, sertraline and fluvoxamine reduced, while the TCA impiramine increased oxidative stress induced in the brain. The SSRIs as well as imipramine reduced oxidative stress due to lipopolysaccharide in liver tissue.
journal_name
EXCLI Jjournal_title
EXCLI journalauthors
Abdel-Salam OME,Morsy SMY,Sleem AAsubject
Has Abstractpub_date
2011-12-08 00:00:00pages
290-302issn
1611-2156journal_volume
10pub_type
杂志文章相关文献
EXCLI Journal文献大全abstract::The aim of this study was the design and evaluation of a novel plasma stable, pH-sensitive niosomal formulation of Mitoxantrone by a modified ethanol injection method. Cholesterol hemisuccinate was added instead of cholesterol in order to produce pH-sensitivity property and using PEG-Poly (monomethyl itaconate)-CholC6...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2013-609
更新日期:2015-01-06 00:00:00
abstract::Corn cob is a major component of agricultural and domestic waste in many parts of the world. It is composed mainly of cellulose which can be converted to energy in form of bioethanol as an efficient and effective means of waste management. Production of cellulolytic enzymes were induced in the fungi Aspergillus niger ...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2012-08-15 00:00:00
abstract::Bladder cancer (BC) is the sixth most common malignancy in men and 17th in women. Exosomal long non-coding RNAs (lncRNAs) have been defined as a novel biomarker for BC. The aim of this study is to evaluate the clinical significance of urine exosomal PVT-1, ANRIL and PCAT-1 as a biomarker in BC patients with tumors cla...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2019-1683
更新日期:2020-03-04 00:00:00
abstract::Sleep deprivation affects all aspects of health. Adverse health effects by sleep deviation are still underestimated and undervalued in clinical practice and, to a much greater extent in monitoring human health. We hypothesized that sleep deprivation-induced mild organ injuries; oxidative stress and inflammation might ...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2015-245
更新日期:2015-05-18 00:00:00
abstract::Five Calligonum species endemic to the Tarim Basin - C. roborowskii, C. kuerlese, C. juoqiangense,C. yengisaricum, and C. taklimakanense - were compared using 14 morphological characteristics and nrDNA ITS and cpDNA trnL-F molecular data. Intraspecific and interspecific morphological variation was uncovered, with vari...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2012-12-20 00:00:00
abstract::This study was undertaken to determine whether exposure of operating room personnel to inhalation anesthetics, including nitrous oxide, isoflurane, and sevoflurane was associated with any hepatotoxic or nephrotoxic changes. Fifty-two operating room personnel and 52 non-exposed subjects were studied. A questionnaire pe...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2019-1911
更新日期:2020-03-25 00:00:00
abstract::Metabolic syndrome (MS) is a condition associated with metabolic abnormalities that are characterized by central obesity (e.g. waist circumference or body mass index), hypertension (e.g. systolic or diastolic blood pressure), hyperglycemia (e.g. fasting plasma glucose) and dyslipidemia (e.g. triglyceride and high-dens...
journal_title:EXCLI journal
pub_type: 杂志文章,评审
doi:10.17179/excli2017-911
更新日期:2018-01-10 00:00:00
abstract::There are abundant studies indicating that blocking gap junctions (GJs) containing connexin 36 (Cx36) inhibit seizures. However, recent evidences demonstrate proconvulsant effect of such intervention. Electrical coupling between GABAergic interneurons in CA1 region of hippocampus is mediated through Cx36 GJs. We inves...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2013-03-14 00:00:00
abstract::The essential oil obtained from leaves of Melissa officinalis L. (Family of Lamiaceae) growing in Algeria, was investigated for its chemical composition and in vitro antimicrobial activity. The chemical composition was determined by hydrodistillation and analyzed by GC/MS and GC-FID. Sixty-three compounds were identif...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2014-07-17 00:00:00
abstract::The liver is famous for its strong regenerative capacity, employing different modes of regeneration according to type and extent of injury. Mature liver cells are able to proliferate in order to replace the damaged tissue allowing the recovery of the parenchymal function. In more severe scenarios hepatocytes are belie...
journal_title:EXCLI journal
pub_type: 杂志文章,评审
doi:10.17179/excli2014-576
更新日期:2015-01-06 00:00:00
abstract::Endometriosis is defined by presence of endometrial-like-tissue outside the uterus. Recently, ectopic endometriotic lesions have been suggested to originate by abnormal differentiation of endometrial mesenchymal stem cells (eMSCs). MicroRNAs (miRNAs) play an important role in the pathophysiology of endometriosis. Thro...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2017-101
更新日期:2017-06-14 00:00:00
abstract::Pharmaceutical effluents contain toxic xenobiotics capable of contaminating aquatic environments. Untreated effluents are illegally discharged into aquatic environment in most developing countries. Pharmaceutical effluent induced alterations in biomarkers of genetic and systemic damage on rodents. However, information...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2019-02-06 00:00:00
abstract::R273H mutant p53 is a DNA-contact mutant that renders p53 dysfunctional due to a single substitution of Arg273 for His273. Rescuing R273 mutant p53 implies that a competent molecule would have to bind to the site of DNA-contact hot spots to complement the loss of contact with the DNA-binding domain. Here, curcumin, fl...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2017-299
更新日期:2017-12-08 00:00:00
abstract::Vitamin D deficiency, common in the population with irritable bowel syndrome (IBS), can induce the main factors that lead to IBS clinical symptoms, such as depression, anxiety, and inflammation. Serotonin (5-HT) plays an important role in the pathophysiology of IBS, and its production and secretion are increased from ...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2020-2247
更新日期:2020-05-19 00:00:00
abstract::An enzyme-coupled colorimetric assay for quantification of urinary sarcosine was developed. The proposed method is a specific reaction based on hydrogen peroxide (H2O2) formation via sarcosine oxidase (SOX). The liberated H2O2 reacts with Amplex Red in the presence of horseradish peroxidase (HRP) to produce the red-fl...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2018-145
更新日期:2018-05-17 00:00:00
abstract::Aromatase is a rate-limiting enzyme for estrogen biosynthesis that is overproduced in breast cancer tissue. To block the growth of breast tumors, aromatase inhibitors (AIs) are employed to bind and inhibit aromatase in order to lower the amount of estrogen produced in the body. Although a number of synthetic aromatase...
journal_title:EXCLI journal
pub_type: 杂志文章,评审
doi:10.17179/excli2018-1417
更新日期:2018-07-20 00:00:00
abstract::As a dynamic system in which different factors affect human performance via dynamic interactions, mental workload needs a dynamic measure to monitor its factors and evidence in a complicated system, an approach that is lacking in the literature. The present study introduces a system dynamics-based model for designing ...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2019-1372
更新日期:2019-07-11 00:00:00
abstract::Dynamin 2 is a GTPase protein that has been implicated in cancer progression through its various roles such as endocytosis, morphogenesis, epithelial-mesenchymal transition (EMT), cellular contractions, and focal adhesion maturation. The increased expression levels of this molecule have been demonstrated with the deve...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2020-2762
更新日期:2020-10-29 00:00:00
abstract::This study aims to develop two alternate forms for Malay version of Auditory Verbal Learning Test (MAVLT) and to determine their equivalency and practice effect. Ninety healthy volunteers were subjected to the following neuropsychological tests at baseline, and at one month interval according to their assigned group; ...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2015-280
更新日期:2015-07-07 00:00:00
abstract::Objective: Although osteoarthritis (OA) is widely accepted as a degenerative disease, autoimmune processes are believed to be involved in the pathogenesis. There are limited studies in this area and most of them focused on antibodies against chondrocyte membrane. In an attempt to address the paucity of evidence in thi...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2012-09-07 00:00:00
abstract::DNA methylation, an epigenetic modification, is mediated by DNA methyltransferases (DNMTs), a family of enzymes. Inhibitions of these enzymes are considered a promising strategy for the treatment of several diseases. In this study, a quantitative structure-activity relationship (QSAR) modeling was employed to understa...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2020-1096
更新日期:2020-04-02 00:00:00
abstract::We present the case of a 77 year old male patient with metastatic pancreatic neuroendocrine tumor (NET). The patient was initially treated by extensive surgical resection that however, led to severe complications with delayed recovery. During follow-up, a number of new liver metastases were detected, one of which was ...
journal_title:EXCLI journal
pub_type:
doi:10.17179/excli2019-1220
更新日期:2019-05-21 00:00:00
abstract::The present study is conducted to determine the potential mechanisms of Boron compounds, boric acid (BA) and borax (BX), on genotoxicity of zebrafish Danio rerio for 24, 48, 72 and 96-hours acute exposure (level:1, 4, 16, 64 mg/l BA and BX) in semi-static bioassay experiment. For that purpose, peripheral erythrocytes ...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2015-404
更新日期:2015-07-30 00:00:00
abstract::From both the structural and functional points of view, β-turns play important biological roles in proteins. In the present study, a novel two-stage hybrid procedure has been developed to identify β-turns in proteins. Binary logistic regression was initially used for the first time to select significant sequence param...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2012-07-05 00:00:00
abstract::DNA and chromosomal damage in peripheral blood leukocytes of patients with coronary artery disease (CAD) were investigated by using the single cell gel electrophoresis assay /comet and cytokinesis- block micronucleus (CBMN) assays, respectively. The case-control study comprised patients with CAD (n = 46; average age 5...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2013-10-08 00:00:00
abstract::Recently, bioinformatics has advanced to the level that it allows almost accurate prediction of molecular interactions that hold together a protein and a ligand in the bound state. For instance, the program AutoDock has been developed to provide a procedure for predicting the interaction of small molecules with macrom...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2013-09-23 00:00:00
abstract::Renin Angiotensin Aldosterone System (RAAS) plays an important role in the development of hypertension. On the other hand, hypertension is a well-known and independent risk factor for cognitive impairment. The aim of the present study was to evaluate the relationship of blood pressure control, plasma angiotensin pepti...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2016-725
更新日期:2017-03-10 00:00:00
abstract::Experimentally-induced total sleep deprivation (TSD) and chronic partial sleep restriction (CPSR) leads to the emergence of cognitive impairments. This is hypothesized to result from a consequent neuroinflammation which may also hasten the neurodegenerative processes. Neuroinflammatory markers such as tumor necrosis f...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2013-04-14 00:00:00
abstract::The aim was to establish a cell culture of adult primary bovine hepatocytes obtained from liver following slaughter and to cultivate the cells in a sandwich culture. Cells and medium samples were taken after separation of cells (day 0), during monolayer (days 1, 2 and 3) and during sandwich culture (days 1, 2, 3, 4, 7...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2016-794
更新日期:2016-12-22 00:00:00
abstract::Hepatitis C is a major global health burden and Egypt has the highest prevalence of hepatitis C virus (HCV) worldwide. The current study was designed to evaluate the beneficial therapeutic effects of ethanolic extracts of Nigella sativa, Zingiber officinale and their mixture in Egyptian HCV patients. Sixty volunteer p...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2013-11-11 00:00:00